4761 publications

Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish
Banote RK, Chebli J, Şatır TM, ..., Abramsson A, Zetterberg H
Sci Rep 10 (1) - [2020-12-00; online 2020-06-23]
Genome Engineering Zebrafish [Collaborative]
Primary cell wall inspired micro containers as a step towards a synthetic plant cell
Paulraj T, Wennmalm S, Wieland DCF, ..., Cárdenas M, Svagan AJ
Nat Commun 11 (1) - [2020-12-00; online 2020-02-19]
Advanced Light Microscopy (ALM) [Collaborative]
Distinct pre-initiation steps in human mitochondrial translation
Khawaja A, Itoh Y, Remes C, ..., Amunts A, Rorbach J
Nat Commun 11 (1) 1-10 [2020-12-00; online 2020-06-10]
Cryo-EM [Service]
Clonal competition within complex evolutionary hierarchies shapes AML over time
Sandén C, Lilljebjörn H, Orsmark Pietras C, ..., Ågerstam H, Fioretos T
Nat Commun 11 (1) - [2020-12-00; online 2020-02-05]
Clinical Genomics Lund [Service]
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1.
Pontén E, Frisk S, Taylan F, ..., Lagerstedt-Robinson K, Nordgren A
pii: jmedgenet-2020-107385
J. Med. Genet. - (-) - [2020-11-18; online 2020-11-18]
Clinical Genomics Stockholm [Service]
Cryo‐EM structure of native human uromodulin, a zona pellucida module polymer
Stsiapanava A, Xu C, Brunati M, ..., Wu B, Jovine L
EMBO J - (-) e106807 [2020-11-16; online 2020-11-16]
Cryo-EM [Collaborative]
Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer.
Mehmeti-Ajradini M, Bergenfelz C, Larsson AM, ..., Bexell D, Leandersson K
pii: 3/11/e202000893
Life Sci. Alliance 3 (11) - [2020-11-00; online 2020-09-21]
Mass Cytometry [Service]
Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9
Winkelmann I, Matsuoka R, Meier PF, ..., Beckstein O, Drew D
EMBO J - (-) - [2020-10-29; online 2020-10-29]
Cryo-EM [Service]
Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.
Flygaard RK, Mühleip A, Tobiasson V, Amunts A
pii: 10.1038/s41467-020-18993-6
Nat Commun 11 (1) 5342 [2020-10-22; online 2020-10-22]
Cryo-EM [Service]
Optotracing for selective fluorescence-based detection, visualization and quantification of live S. aureus in real-time.
Butina K, Tomac A, Choong FX, ..., Löffler S, Richter-Dahlfors A
pii: 10.1038/s41522-020-00150-y
NPJ Biofilms Microbiomes 6 (1) 35 [2020-10-09; online 2020-10-09]
Advanced Light Microscopy (ALM) [Service]
SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.
Rudberg AS, Havervall S, Månberg A, ..., Hober S, Thålin C
pii: 10.1038/s41467-020-18848-0
Nat Commun 11 (1) 5064 [2020-10-08; online 2020-10-08]
Autoimmunity Profiling [Collaborative]
A latent lineage potential in resident neural stem cells enables spinal cord repair.
Llorens-Bobadilla E, Chell JM, Le Merre P, ..., Carlén M, Frisén J
pii: 370/6512/eabb8795
Science 370 (6512) - [2020-10-02; online 2020-10-03]
Advanced Light Microscopy (ALM) [Service]
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality.
Hong MG, Dodig-Crnković T, Chen X, ..., Magnusson PK, Schwenk JM
pii: 3/10/e202000817
Life Sci. Alliance 3 (10) - [2020-10-00; online 2020-07-31]
Autoimmunity Profiling [Service]
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, ..., Murrell B, McInerney GM
pii: 10.1038/s41467-020-18174-5 PDB: 6ZXN
Nat Commun 11 (1) 4420 [2020-09-04; online 2020-09-04]
Protein Science Facility (PSF) [Service]
Structural basis of mitochondrial translation
Aibara S, Singh V, Modelska A, Amunts A
Elife 9 (-) 1-17 [2020-08-19; online 2020-08-19]
Cryo-EM [Service]
Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
Zhang Y, Cedervall J, Hamidi A, ..., Dimberg A, Olsson AK
Cancer Res 80 (16) 3345-3358 [2020-08-15; online 2020-06-25]
PLA and Single Cell Proteomics [Service]
Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy.
Mikus M, Zandian A, Sjöberg R, ..., van Hage M, Ohlin M
pii: S0091-6749(20)31108-8
J. Allergy Clin. Immunol. - (-) - [2020-08-10; online 2020-08-10]
Autoimmunity Profiling [Collaborative]
SLC12A2 mutations cause NKCC1 deficiency with encephalopathy and impaired secretory epithelia.
Stödberg T, Magnusson M, Lesko N, ..., Stranneheim H, Wedell A
pii: NG2020013649 pmc: PMC7357422
Neurol Genet 6 (4) e478 [2020-08-00; online 2020-07-02]
Clinical Genomics Stockholm [Service]
Systems-level immunomonitoring from acute to recovery phase of severe COVID-19
Rodriguez L, Pekkarinen PT, Lakshmikanth T, ..., Kekäläinen E, Brodin P
Cell Reports Medicine - (-) 100078 [2020-08-00; online 2020-08-00]
Mass Cytometry [Collaborative]
Immunocyte single cell analysis of vaccine‐induced narcolepsy
Lind A, Salami F, Landtblom A, ..., Adolfsson J, Elding Larsson H
Eur. J. Immunol. - (-) - [2020-07-30; online 2020-07-30]
Mass Cytometry [Service]
Detection of leukemia gene fusions by targeted RNA-sequencing in routine diagnostics.
Engvall M, Cahill N, Jonsson BI, ..., Hallböök H, Cavelier L
pii: 10.1186/s12920-020-00739-4 pmc: PMC7388219
BMC Med Genomics 13 (1) 106 [2020-07-29; online 2020-07-29]
Clinical Genomics Uppsala [Technology development]
Loqusdb: added value of an observations database of local genomic variation.
Magnusson M, Eisfeldt J, Nilsson D, ..., Wedell A, Stranneheim H
pii: 10.1186/s12859-020-03609-z pmc: PMC7329469
BMC Bioinformatics 21 (1) 273 [2020-07-01; online 2020-07-01]
Clinical Genomics Stockholm [Service]
Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal.
Tamborero D, Dienstmann R, Rachid MH, ..., Rodon J, Lehtiö J
pii: 10.1038/s41591-020-0969-2
Nat. Med. 26 (7) 992-994 [2020-07-00; online 2020-07-08]
Clinical Genomics Stockholm [Service]
Human Immune System Variation during 1 Year
Lakshmikanth T, Muhammad SA, Olin A, ..., Uhlen M, Brodin P
Cell Rep 32 (3) 107923 [2020-07-00; online 2020-07-00]
Mass Cytometry [Collaborative]
Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA.
Baronti L, Guzzetti I, Ebrahimi P, ..., Chen AA, Petzold K
pii: 10.1038/s41586-020-2336-3
Nature 583 (7814) 139-144 [2020-07-00; online 2020-05-27]
Protein Science Facility (PSF) [Service]
Lysine-specific demethylase 1A (LSD1) restricts ex vivo propagation of human HSCs and is a target of UM171
Subramaniam A, Žemaitis K, Safaee Talkhoncheh M, ..., Zubarev RA, Larsson J
- - (-) - [2020-06-24; online 2020-06-24]
Chemical Proteomics [Collaborative]
A sample preparation protocol for high throughput immunofluorescence of suspension cells
Backstrom A, Kugel L, Gnann C, ..., Lundberg E, Stadler C
JHC - (-) - [2020-06-20; online 2020-01-20]
Cell Profiling [Technology development]
Chanjo: Clincal grade sequence coverage analysis
Andeer R, Magnusson M, Wedell A, Stranneheim H
F1000Res 9 (-) 615 [2020-06-16; online 2020-06-16]
Clinical Genomics Stockholm [Technology development]
GPSeq reveals the radial organization of chromatin in the cell nucleus
Girelli G, Custodio J, Kallas T, ..., Crosetto N, Bienko M
Nat Biotechnol - (-) - [2020-05-25; online 2020-05-25]
Advanced Light Microscopy (ALM) [Service]
A chemical screen identifies a link between lipid metabolism and mRNA translation
Corman A, Kanellis DC, Häggblad M, ..., Carreras-Puigvert J, Fernandez-Capetillo O
- - (-) - [2020-05-11; online 2020-05-11]
Chemical Biology Consortium Sweden (CBCS) [Service]
A molecular mechanism explaining albuminuria in kidney disease
Butt L, Unnersjö-Jess D, Höhne M, ..., Schermer B, Benzing T
Nat Metab 2 (5) 461-474 [2020-05-00; online 2020-05-11]
Advanced Light Microscopy (ALM) [Collaborative]
Fungi and Oomycetes in the Irrigation Water of Forest Nurseries
Marčiulynas A, Marčiulynienė D, Lynikienė J, ..., Vaičiukynė M, Menkis A
Forests 11 (4) 459 [2020-04-18; online 2020-04-18]
NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]
Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-Analysis.
Akingbuwa WA, Hammerschlag AR, Jami ES, ..., Middeldorp CM, and the Bipolar Disorder and Major Depressive Disorder Working Groups of the Psychiatric Genomics Consortium
pii: 2763801 pmc: PMC7160753
JAMA Psychiatry - (-) - [2020-04-15; online 2020-04-15]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS
pii: RA120.012636 PDB: 6QVO
J. Biol. Chem. - (-) - [2020-03-06; online 2020-03-06]
Protein Science Facility (PSF) [Service]
Structure of a minimal photosystem I from the green alga Dunaliella salina
Perez-Boerema A, Klaiman D, Caspy I, ..., Amunts A, Nelson N
NPLANTS 6 (3) 321-327 [2020-03-02; online 2020-03-02]
Cryo-EM [Service]
Stressful Beginnings with Long-Term Consequences
Consiglio CR, Brodin P
Cell 180 (5) 820-821 [2020-03-00; online 2020-03-00]
Mass Cytometry [Collaborative]
Patterns of African and Asian admixture in the Afrikaner population of South Africa.
Hollfelder N, Erasmus JC, Hammaren R, ..., Greeff JM, Schlebusch CM
pii: 10.1186/s12915-020-0746-1
BMC Biol. 18 (1) 16 [2020-02-24; online 2020-02-24]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
Screening for autoantibody targets in post-vaccination narcolepsy using proteome arrays.
Lind A, Eriksson D, Akel O, ..., Elding Larsson H, Landegren N
Scand. J. Immunol. - (-) e12864 [2020-02-13; online 2020-02-13]
Autoimmunity Profiling [Service]
Capsid Structure of a Marine Algal Virus of the Order Picornavirales
Munke A, Kimura K, Tomaru Y, Okamoto K
J Virol 94 (9) - [2020-02-05; online 2020-04-16]
Cryo-EM [Service]
Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces.
Wang X, Shah FA, Vazirisani F, ..., Ekström K, Thomsen P
pii: S0142-9612(19)30670-2
Biomaterials 230 (-) 119571 [2020-02-00; online 2019-10-24]
Glycoproteomics [Service]
Molecular mechanisms of collateral sensitivity to the antibiotic nitrofurantoin.
Roemhild R, Linkevicius M, Andersson DI
pii: PBIOLOGY-D-19-02723
PLoS Biol. 18 (1) e3000612 [2020-01-27; online 2020-01-27]
Glycoproteomics [Service]
Proteomic analysis of follicular fluid during human ovulation.
Zakerkish F, Brännström M, Carlsohn E, ..., van der Post S, Thoroddsen A
Acta Obstet Gynecol Scand - (-) - [2020-01-16; online 2020-01-16]
Glycoproteomics [Service]
Evolution of a new function by fusion between phage DNA and a bacterial gene.
Warsi O, Knopp M, Surkov S, Hultqvist JJ, Andersson DI
pii: 5707441
Mol. Biol. Evol. - (-) - [2020-01-16; online 2020-01-16]
Glycoproteomics [Service]
Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study.
Bonomi A, Veglia F, Baldassarre D, ..., Gigante B, on behalf of the IMPROVE study group
pii: 10.1038/s41435-019-0090-z
Genes Immun. - (-) - [2020-01-14; online 2020-01-14]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes.
Sen I, Zhou X, Chernobrovkin A, ..., Zubarev RA, Riedel CG
pii: 10.1038/s41467-019-13931-7 pmc: PMC6952425
Nat Commun 11 (1) 138 [2020-01-09; online 2020-01-09]
Chemical Proteomics [Service]
Integrative discovery of treatments for high-risk neuroblastoma.
Almstedt E, Elgendy R, Hekmati N, ..., Krona C, Nelander S
pii: 10.1038/s41467-019-13817-8 pmc: PMC6941971
Nat Commun 11 (1) 71 [2020-01-03; online 2020-01-03]
Genome Engineering Zebrafish [Service]
A dual-action peptide-containing hydrogel targets wound infection and inflammation
Puthia M, Butrym M, Petrlova J, ..., Kjellström S, Schmidtchen A
Sci. Transl. Med. 12 (524) eaax6601 [2020-01-01; online 2020-01-01]
Targeted and Structural Proteomics [Collaborative]
Probabilistic cell typing enables fine mapping of closely related cell types in situ
Qian X, Harris KD, Hauling T, ..., Hjerling-Leffler J, Nilsson M
Nat Methods 17 (1) 101-106 [2020-01-00; online 2019-11-18]
In Situ Sequencing (ISS) [Technology development]
Regulation of α-synuclein by chaperones in mammalian cells
Burmann BM, Gerez JA, Matečko-Burmann I, ..., Riek R, Hiller S
Nature 577 (7788) 127-132 [2020-01-00; online 2019-12-04]
Swedish NMR Centre (SNC) [Service]
Copper nanoparticles have negligible direct antibacterial impact
Bastos CAP, Faria N, Wills J, ..., Rees P, Powell JJ
NanoImpact 17 (-) 100192 [2020-01-00; online 2020-01-00]
Gothenburg Imaging Mass Spectrometry [Collaborative]
The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease.
Haytural H, Mermelekas G, Emre C, ..., Tjernberg LO, Frykman S
pii: RA119.001737
Mol. Cell Proteomics 19 (1) 128-141 [2020-01-00; online 2019-11-07]
Proteogenomics [Collaborative]
Identification of novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm
Memon AA, Zarrouk M, Ågren-Witteschus S, ..., Gottsäter A, Sundquist K
Eur J Prev Cardiolog 27 (2) 132-142 [2020-01-00; online 2019-08-29]
Clinical Biomarkers [Service]
In-plate toxicometabolomics of single zebrafish embryos
Ribbenstedt A, Posselt M, Brunius C, Benskin JP
Mol Omics - (-) - [2020-00-00; online 2020-00-00]
Genome Engineering Zebrafish [Service]
Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis.
Brink M, Lundquist A, Alexeyenko A, Lejon K, Rantapää-Dahlqvist S
pii: 10.1186/s13075-019-2066-9 pmc: PMC6915963
Arthritis Res. Ther. 21 (1) 288 [2019-12-16; online 2019-12-16]
Plasma Profiling [Service]
Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
Bhandage AK, Cunningham JL, Jin Z, ..., Ekselius L, Birnir B
Int J Mol Sci 20 (24) 6172 [2019-12-06; online 2019-12-06]
PLA and Single Cell Proteomics [Collaborative]
DNA methylation profiles in chronic lymphocytic leukemia patients treated with chemoimmunotherapy.
Tsagiopoulou M, Papakonstantinou N, Moysiadis T, ..., Rosenquist R, Stamatopoulos K
pii: 10.1186/s13148-019-0783-1
Clin Epigenetics 11 (1) 177 [2019-12-02; online 2019-12-02]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
Impact of Q-Griffithsin anti-HIV microbicide gel in non-human primates: In situ analyses of epithelial and immune cell markers in rectal mucosa.
Günaydın G, Edfeldt G, Garber DA, ..., Tjernlund A, Broliden K
pii: 10.1038/s41598-019-54493-4
Sci Rep 9 (1) 18120 [2019-12-02; online 2019-12-02]
BioImage Informatics [Service]
Cardiovascular organ damage in type 2 diabetes mellitus: the role of lipids and inflammation
Kozakova M, Morizzo C, Goncalves I, ..., Nilsson J, Palombo C
Cardiovasc Diabetol 18 (1) - [2019-12-00; online 2019-05-10]
Clinical Biomarkers [Service]
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis
van der Post S, Jabbar KS, Birchenough G, ..., Johansson MEV, Hansson GC
Gut 68 (12) 2142-2151 [2019-12-00; online 2019-03-26]
Centre for Cellular Imaging [Service]
A microfluidic platform towards automated multiplexed in situ sequencing
Maïno N, Hauling T, Cappi G, ..., Dupouy DG, Nilsson M
Sci Rep 9 (1) - [2019-12-00; online 2019-03-05]
In Situ Sequencing (ISS) [Technology development]
A bacterial assay for rapid screening of IAA catabolic enzymes
Brunoni F, Collani S, Šimura J, ..., Bellini C, Ljung K
Plant Methods 15 (1) - [2019-12-00; online 2019-11-04]
Swedish Metabolomics Centre (SMC) [Service]
Wnt5a is a TLR2/4-ligand that induces tolerance in human myeloid cells
Mehmeti M, Bergenfelz C, Källberg E, ..., André I, Leandersson K
Commun Biol 2 (1) - [2019-12-00; online 2019-05-09]
Targeted and Structural Proteomics [Service]
A Mitochondrial LYR Protein Is Required for Complex I Assembly.
Ivanova A, Gill-Hille M, Huang S, ..., Whelan J, Murcha MW
pii: pp.19.00822 pmc: PMC6878026
Plant Physiol. 181 (4) 1632-1650 [2019-12-00; online 2019-10-10]
Proteogenomics [Collaborative]
Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC
Nirwan N, Itoh Y, Singh P, ..., Amunts A, Saikrishnan K
Nat Commun 10 (1) 1-9 [2019-12-00; online 2019-07-11]
Cryo-EM [Service]
MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma.
Oliynyk G, Ruiz-Pérez MV, Sainero-Alcolado L, ..., Lehtiö J, Arsenian-Henriksson M
pii: S2589-0042(19)30399-2 pmc: PMC6889365
iScience 21 (-) 188-204 [2019-11-22; online 2019-10-11]
Bioinformatics Compute and Storage [Service] Proteogenomics [Collaborative]
Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3
Ceballos J, Schwalfenberg M, Karageorgis G, ..., Ziegler S, Waldmann H
Angew. Chem. Int. Ed. 58 (47) 17016-17025 [2019-11-18; online 2019-10-07]
Swedish Metabolomics Centre (SMC) [Service]
Counting the Number of Glutamate Molecules in Single Synaptic Vesicles
Wang Y, Fathali H, Mishra D, ..., Skibicka KP, Cans AS
J. Am. Chem. Soc. 141 (44) 17507-17511 [2019-11-06; online 2019-10-23]
Gothenburg Imaging Mass Spectrometry [Service]
Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2
Testini C, Smith RO, Jin Y, ..., Hellström M, Claesson‐Welsh L
EMBO rep 20 (11) - [2019-11-05; online 2019-09-23]
Proteogenomics [Service]
The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function
Volk JK, Nyström EEL, van der Post S, ..., Hansson GC, Birchenough GMH
- 216 (11) 2602-2618 [2019-11-04; online 2019-08-16]
Centre for Cellular Imaging [Service]
Diagnostic pitfalls in vitamin B6-dependent epilepsy caused by mutations in the PLPBP gene.
Jensen KV, Frid M, Stödberg T, ..., Darin N, Grønborg S
pii: JMD212063 pmc: PMC6850975
JIMD Rep 50 (1) 1-8 [2019-11-00; online 2019-09-30]
Clinical Genomics Stockholm [Service]
PIN-driven auxin transport emerged early in streptophyte evolution
Skokan R, Medvecká E, Viaene T, ..., Petrášek J, Friml J
NPLANTS 5 (11) 1114-1119 [2019-11-00; online 2019-11-11]
Swedish Metabolomics Centre (SMC) [Service]
Protein Paucimannosylation Is an Enriched N-Glycosylation Signature of Human Cancers.
Chatterjee S, Lee LY, Kawahara R, ..., Palmisano G, Thaysen-Andersen M
Proteomics 19 (21-22) e1900010 [2019-11-00; online 2019-10-16]
Glycoproteomics [Collaborative]
Modulation of Structural Heterogeneity Controls Phytochrome Photoswitching
Gustavsson E, Isaksson L, Persson C, ..., Orekhov V, Westenhoff S
Biophysical Journal - (-) - [2019-11-00; online 2019-11-00]
Swedish NMR Centre (SNC) [Collaborative]
Challenges in the Multivariate Analysis of Mass Cytometry Data: The Effect of Randomization.
Papoutsoglou G, Lagani V, Schmidt A, ..., Tegnér J, Tsamardinos I
Cytometry A 95 (11) 1178-1190 [2019-11-00; online 2019-11-06]
Mass Cytometry [Service]
Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis
Dobie R, Wilson-Kanamori JR, Henderson BEP, ..., Marioni JC, Henderson NC
Cell Rep 29 (7) 1832-1847.e8 [2019-11-00; online 2019-11-00]
Eukaryotic Single Cell Genomics (ESCG) [Service]
Identification of two abundant Aerococcus urinae cell wall-anchored proteins.
Senneby E, Sunnerhagen T, Hallström B, ..., Karlsson C, Rasmussen M
pii: S1438-4221(18)30350-3
Int. J. Med. Microbiol. 309 (7) 151325 [2019-11-00; online 2019-06-24]
Targeted and Structural Proteomics [Collaborative]
Association of PTHrP levels in CSF with Alzheimer’s disease biomarkers
Kushnir MM, Michno W, Rockwood AL, ..., Strathmann FG, Hanrieder J
Clinical Mass Spectrometry 14 (-) 124-129 [2019-11-00; online 2019-11-00]
Gothenburg Imaging Mass Spectrometry [Service]
A revised solid-state NMR method to assess the crystallinity of cellulose
Sparrman T, Svenningsson L, Sahlin-Sjövold K, ..., Westman G, Bernin D
Cellulose 26 (17) 8993-9003 [2019-11-00; online 2019-09-03]
Swedish NMR Centre (SNC) [Collaborative]
Tuning drug release from polyoxazoline-drug conjugates
Harris JM, Bentley MD, Moreadith RW, ..., Dizman B, Nordstierna L
European Polymer Journal 120 (-) 109241 [2019-11-00; online 2019-11-00]
Swedish NMR Centre (SNC) [Service]
Viral antigens elicit augmented immune responses in primary Sjögren’s syndrome
Björk A, Thorlacius GE, Mofors J, ..., Kvarnström M, Wahren-Herlenius M
- - (-) - [2019-10-30; online 2019-10-30]
Clinical Biomarkers [Service]
Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging.
Sugiyama E, Guerrini MM, Honda K, ..., Suematsu M, Sugiura Y
pii: S2589-0042(19)30375-X pmc: PMC6818351
iScience 20 (-) 359-372 [2019-10-25; online 2019-09-27]
National Resource for Mass Spectrometry Imaging [Service]
DPI Selectively Inhibits Intracellular NADPH Oxidase Activity in Human Neutrophils.
Buck A, Sanchez Klose FP, Venkatakrishnan V, ..., Christenson K, Bylund J
pii: 3/10/488
Immunohorizons 3 (10) 488-497 [2019-10-18; online 2019-10-18]
Glycoproteomics [Service]
The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell–specific adapter protein
Andersen TCB, Kristiansen PE, Huszenicza Z, ..., Andreotti AH, Spurkland A
J. Biol. Chem. 294 (42) 15480-15494 [2019-10-18; online 2019-09-04]
Swedish NMR Centre (SNC) [Collaborative]
A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding
Fleming CL, Sandoz PA, Inghardt T, ..., Grøtli M, Andréasson J
Angew. Chem. Int. Ed. 58 (42) 15000-15004 [2019-10-14; online 2019-09-05]
Centre for Cellular Imaging [Service]
Novel functional proteins coded by the human genome discovered in metastases of melanoma patients.
Sanchez A, Kuras M, Murillo JR, ..., Betancourt LH, Marko-Varga G
pii: 10.1007/s10565-019-09494-4
Cell Biol. Toxicol. - (-) - [2019-10-10; online 2019-10-10]
Targeted and Structural Proteomics [Service]
Apolipoprotein E impairs amyloid‐β fibril elongation and maturation
Islam T, Gharibyan AL, Golchin SA, ..., Olofsson L, Olofsson A
FEBS J - (-) - [2019-10-09; online 2019-10-09]
Cryo-EM [Service]
SynQuant: an automatic tool to quantify synapses from microscopy images
Wang Y, Wang C, Ranefall P, ..., Tian L, Yu G
- - (-) - [2019-10-09; online 2019-10-09]
BioImage Informatics [Collaborative]
Proteomic Analysis of Longitudinal Changes in Blood Pressure
Lin YT, Fall T, Hammar U, ..., Engström G, Sundström J
J Clin Med 8 (10) 1585 [2019-10-02; online 2019-10-02]
Clinical Biomarkers [Service]
Real time MRI to elucidate the functionality of coating films intended for modified release
Bernin D, Marucci M, Boissier C, ..., Olsson U, Abrahmsén-Alami S
Journal of Controlled Release 311-312 (-) 117-124 [2019-10-00; online 2019-10-00]
Swedish NMR Centre (SNC) [Collaborative]
Cell generation dynamics underlying naive T-cell homeostasis in adult humans.
Mold JE, Réu P, Olin A, ..., Brodin P, Frisén J
pii: PBIOLOGY-D-19-01355
PLoS Biol. 17 (10) e3000383 [2019-10-00; online 2019-10-29]
Bioinformatics Compute and Storage [Service] Mass Cytometry [Collaborative]
Isolation and characterization of microvesicles from mesenchymal stem cells
Mohammadi MR, Riazifar M, Pone EJ, ..., Lotvall J, Zhao W
Methods - (-) - [2019-10-00; online 2019-10-00]
Centre for Cellular Imaging [Service]
Implantable Organic Electronic Ion Pump Enables ABA Hormone Delivery for Control of Stomata in an Intact Tobacco Plant
Bernacka‐Wojcik I, Huerta M, Tybrandt K, ..., Berggren M, Stavrinidou E
Small 15 (43) 1902189 [2019-10-00; online 2019-09-12]
Swedish Metabolomics Centre (SMC) [Service]
Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging.
Shariatgorji M, Nilsson A, Fridjonsdottir E, ..., Odell LR, Andrén PE
pii: 10.1038/s41592-019-0551-3
Nat. Methods 16 (10) 1021-1028 [2019-10-00; online 2019-09-23]
National Resource for Mass Spectrometry Imaging [Technology development]
A clonal expression biomarker associates with lung cancer mortality.
Biswas D, Birkbak NJ, Rosenthal R, ..., Swanton C, TRACERx Consortium
pii: 10.1038/s41591-019-0595-z
Nat. Med. 25 (10) 1540-1548 [2019-10-00; online 2019-10-07]
Clinical Genomics Uppsala [Collaborative]
Fam83F induces p53 stabilisation and promotes its activity.
Salama M, Benitez-Riquelme D, Elabd S, ..., Davidson G, Blattner C
pii: 10.1038/s41418-019-0281-1 pmc: PMC6748130
Cell Death Differ. 26 (10) 2125-2138 [2019-10-00; online 2019-01-28]
NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]
The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity.
Papoutsoglou P, Tsubakihara Y, Caja L, ..., Heldin CH, Moustakas A
pii: S2211-1247(19)31062-9
Cell Rep 28 (12) 3182-3198.e11 [2019-09-17; online 2019-09-19]
NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]
Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells
Wilhelmsson U, Lebkuechner I, Leke R, ..., Pekna M, Pekny M
- 29 (10) 4050-4066 [2019-09-13; online 2019-01-03]
Centre for Cellular Imaging [Service]
Chemical screening pipeline for identification of specific plant autophagy modulators
Dauphinee AN, Cardoso C, Dalman K, ..., Bozhkov P, Minina EA
Plant Physiol. 181 (3) pp.00647.2019 [2019-09-05; online 2019-09-05]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
Akula MK, Ibrahim MX, Ivarsson EG, ..., Sayin VI, Bergo MO
pii: 10.1038/s41467-019-11606-x pmc: PMC6726657
Nat Commun 10 (1) 3975 [2019-09-04; online 2019-09-04]
Glycoproteomics [Service]
Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes
Pablo , Marasek , Pozo-Rodrigálvarez , ..., Pekna , Pekny
Cells 8 (9) 1016 [2019-09-01; online 2019-09-01]
Centre for Cellular Imaging [Service]
Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics.
Indira Chandran V, Welinder C, Gonçalves de Oliveira K, ..., Marko-Varga G, Belting M
pii: 10.1007/s11060-019-03262-4 pmc: PMC6764937
J. Neurooncol. 144 (3) 477-488 [2019-09-00; online 2019-08-14]
Targeted and Structural Proteomics [Service]
Multiplexed analysis of the secretin-like GPCR-RAMP interactome.
Lorenzen E, Dodig-Crnković T, Kotliar IB, ..., Schwenk JM, Sakmar TP
pii: aaw2778 pmc: PMC6750928
Sci Adv 5 (9) eaaw2778 [2019-09-00; online 2019-09-18]
Plasma Profiling [Collaborative]
FLT3N676K drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis
Hyrenius-Wittsten A, Pilheden M, Falqués-Costa A, ..., Järås M, Hagström-Andersson AK
Leukemia 33 (9) 2310-2314 [2019-09-00; online 2019-04-05]
Clinical Genomics Lund [Service]
Dimerization of 9,10-anthraquinone-2,7-Disulfonic acid (AQDS)
Wiberg C, Carney TJ, Brushett F, Ahlberg E, Wang E
Electrochimica Acta 317 (-) 478-485 [2019-09-00; online 2019-09-00]
Swedish NMR Centre (SNC) [Service]
Array-Based Profiling of Proteins and Autoantibody Repertoires in CSF.
Pin E, Sjöberg R, Andersson E, ..., Nilsson P, Månberg A
Methods Mol. Biol. 2044 (-) 303-318 [2019-08-23; online 2019-08-23]
Autoimmunity Profiling [Technology development]
Yeast Volatomes Differentially Affect Larval Feeding in an Insect Herbivore
Ljunggren J, Borrero-Echeverry F, Chakraborty A, ..., Witzgall P, Bengtsson M
Appl Environ Microbiol 85 (21) - [2019-08-23; online 2019-10-16]
Swedish Metabolomics Centre (SMC) [Service]
Molecular Basis and Ecological Relevance of Caulobacter Cell Filamentation in Freshwater Habitats
Heinrich K, Leslie DJ, Morlock M, Bertilsson S, Jonas K
MBio 10 (4) - [2019-08-20; online 2019-08-20]
Proteogenomics [Service]
Matrisome Properties of Scaffolds Direct Fibroblasts in Idiopathic Pulmonary Fibrosis.
Elowsson Rendin L, Löfdahl A, Åhrman E, ..., Malmström J, Westergren-Thorsson G
pii: ijms20164013 pmc: PMC6719040
Int J Mol Sci 20 (16) - [2019-08-17; online 2019-08-17]
Targeted and Structural Proteomics [Collaborative]
Nucleation of an Activating Conformational Change by a Cation−π Interaction
Rogne P, Andersson D, Grundström C, ..., Linusson A, Wolf-Watz M
Biochemistry 58 (32) 3408-3412 [2019-08-13; online 2019-07-24]
Swedish NMR Centre (SNC) [Service]
Glycosylation influences activity, stability and immobilization of the feruloyl esterase 1a from Myceliophthora thermophila.
Bonzom C, Hüttner S, Mirgorodskaya E, ..., Verhaert RMD, Olsson L
pii: 10.1186/s13568-019-0852-z pmc: PMC6691016
AMB Express 9 (1) 126 [2019-08-12; online 2019-08-12]
Glycoproteomics [Collaborative]
The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer.
Liu N, Cui W, Jiang X, ..., Wang X, Sun XF
pii: S0360-3016(19)30653-4
Int. J. Radiat. Oncol. Biol. Phys. 104 (5) 1153-1164 [2019-08-01; online 2019-04-27]
Mass Cytometry [Service]
Role of apolipoprotein C-III overproduction in diabetic dyslipidaemia.
Adiels M, Taskinen MR, Björnson E, ..., Packard C, Borén J
Diabetes Obes Metab 21 (8) 1861-1870 [2019-08-00; online 2019-05-08]
Glycoproteomics [Service]
Clinical protein science in translational medicine targeting malignant melanoma.
Gil J, Betancourt LH, Pla I, ..., Malm J, Marko-Varga G
pii: 10.1007/s10565-019-09468-6 pmc: PMC6757020
Cell Biol. Toxicol. 35 (4) 293-332 [2019-08-00; online 2019-03-21]
Targeted and Structural Proteomics [Service]
Systematic Development of Sandwich Immunoassays for the Plasma Secretome.
Häussler RS, Bendes A, Iglesias M, ..., Qundos U, Schwenk JM
Proteomics 19 (15) e1900008 [2019-08-00; online 2019-07-22]
Plasma Profiling [Technology development]
Estrogen deprivation triggers an immunosuppressive phenotype in breast cancer cells
Hühn D, Martí-Rodrigo P, Mouron S, ..., Carreras-Puigvert J, Fernandez-Capetillo O
- - (-) - [2019-07-25; online 2019-07-25]
Chemical Biology Consortium Sweden (CBCS) [Service]
Annotations, Ontologies, and Whole Slide Images - Development of an Annotated Ontology-Driven Whole Slide Image Library of Normal and Abnormal Human Tissue.
Lindman K, Rose JF, Lindvall M, Lundström C, Treanor D
pii: JPI-10-22 pmc: PMC6669998 AIDA Data Hub: AIDA Data Hub:
J Pathol Inform 10 (-) 22 [2019-07-23; online 2019-07-23]
AIDA Data Hub [Collaborative]
Vitamin D and Phenylbutyrate Supplementation Does Not Modulate Gut Derived Immune Activation in HIV-1
Missailidis C, Sørensen N, Ashenafi S, ..., Brighenti S, Bergman P
Nutrients 11 (7) 1675 [2019-07-21; online 2019-07-21]
Swedish Metabolomics Centre (SMC) [Service]
Systems-level immunomonitoring using self-sampled capillary blood
Josyula VS, Lakshmikanth T, Mikes J, Chen Y, Brodin P
- - (-) - [2019-07-08; online 2019-07-08]
Mass Cytometry [Technology development]
Screening a Resource of Recombinant Protein Fragments for Targeted Proteomics.
Edfors F, Forsström B, Vunk H, ..., Schwenk JM, Uhlen M
J. Proteome Res. 18 (7) 2706-2718 [2019-07-05; online 2019-06-07]
Plasma Profiling [Technology development]
Serum metabolite profiles of habitual diet: evaluation by 1H-nuclear magnetic resonance analysis
Lindqvist HM, Rådjursöga M, Malmodin D, Winkvist A, Ellegård L
Am J Clin Nutr 110 (1) 53-62 [2019-07-01; online 2019-05-25]
Swedish NMR Centre (SNC) [Collaborative]
Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis.
Naegeli A, Bratanis E, Karlsson C, ..., Malmström J, Collin M
pii: jem.20190293 pmc: PMC6605743
J. Exp. Med. 216 (7) 1615-1629 [2019-07-01; online 2019-05-15]
Targeted and Structural Proteomics [Collaborative]
Androgen Receptor Burden and Poor Response to Abiraterone or Enzalutamide in TP53 Wild-Type Metastatic Castration-Resistant Prostate Cancer.
De Laere B, Rajan P, Grönberg H, ..., Lindberg J, CORE-ARV-CTC and ProBIO Investigators
pii: 2732501 pmc: PMC6499126
JAMA Oncol 5 (7) 1060-1062 [2019-07-01; online 2019-05-03]
Clinical Genomics Stockholm [Service]
Development of parallel reaction monitoring assays for cerebrospinal fluid proteins associated with Alzheimer's disease.
Andersson A, Remnestål J, Nellgård B, ..., Nilsson P, Fredolini C
pii: S0009-8981(19)30348-1
Clin. Chim. Acta 494 (-) 79-93 [2019-07-00; online 2019-03-09]
Plasma Profiling [Technology development]
The autoimmune targets in IPEX are dominated by gut epithelial proteins
Eriksson D, Bacchetta R, Gunnarsson HI, ..., Kämpe O, Landegren N
Journal of Allergy and Clinical Immunology 144 (1) 327-330.e8 [2019-07-00; online 2019-07-00]
Autoimmunity Profiling [Service]