5072 publications

Subcellular proteomics
Christopher JA, Stadler C, Martin CE, ..., Emili A, Lilley KS
Nat Rev Methods Primers 1 (1) - [2021-12-00; online 2021-04-29]
Cell Profiling
Structure of a full-length bacterial polysaccharide co-polymerase
Wiseman B, Nitharwal RG, Widmalm G, Högbom M
Nat Commun 12 (1) - [2021-12-00; online 2021-01-14]
Cryo-EM [Service]
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Sancho-Shimizu V, Brodin P, Cobat A, ..., Zhang SY, None
J. Exp. Med. 218 (6) - [2021-06-07; online 2021-04-27]
Mass Cytometry [Collaborative]
High diagnostic yield in skeletal ciliopathies using massively parallel genome sequencing, structural variant screening and RNA analyses.
Hammarsjö A, Pettersson M, Chitayat D, ..., Lindstrand A, Grigelioniene G
pii: 10.1038/s10038-021-00925-x
J. Hum. Genet. - (-) - [2021-04-20; online 2021-04-20]
Clinical Genomics Stockholm [Service]
Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies.
Cotugno N, Ruggiero A, Bonfante F, ..., De Rossi A, Palma P
pii: S2211-1247(21)00166-2
Cell Rep 34 (11) 108852 [2021-03-16; online 2021-03-18]
Mass Cytometry [Collaborative]
Antibodies to SARS-CoV-2 and risk of past or future sick leave.
Dillner J, Elfström KM, Blomqvist J, ..., Mühr LSA, Conneryd Lundgren K
pii: 10.1038/s41598-021-84356-w NCT04411576
Sci Rep 11 (1) 5160 [2021-03-04; online 2021-03-04]
Autoimmunity and Serology Profiling [Service]
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics
Mahdessian D, Cesnik AJ, Gnann C, ..., Sullivan DP, Lundberg E
Nature 590 (7847) 649-654 [2021-02-25; online 2021-02-24]
Cell Profiling Eukaryotic Single Cell Genomics (ESCG)
Mechanism of membrane-tethered mitochondrial protein synthesis
Itoh Y, Andréll J, Choi A, ..., Battersby BJ, Amunts A
Science 371 (6531) 846-849 [2021-02-19; online 2021-02-18]
Cryo-EM [Service] Proteogenomics [Service]
Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy
Strunz B, Bister J, Jönsson H, ..., Ivarsson MA, Björkström NK
Sci Immunol 6 (56) eabb7800 [2021-02-19; online 2021-02-19]
Mass Cytometry [Service]
Million-year-old DNA sheds light on the genomic history of mammoths
van der Valk T, Pečnerová P, Díez-del-Molino D, ..., Götherström A, Dalén L
Nature - (-) - [2021-02-17; online 2021-02-17]
NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit
Tobiasson V, Gahura O, Aibara S, ..., Zíková A, Amunts A
EMBO J - (-) - [2021-02-12; online 2021-02-12]
Cryo-EM [Service]
A spinal organ of proprioception for integrated motor action feedback.
Picton LD, Bertuzzi M, Pallucchi I, ..., Shearing PR, El Manira A
pii: S0896-6273(21)00040-4
Neuron - (-) - [2021-02-03; online 2021-02-03]
Eukaryotic Single Cell Genomics (ESCG)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou V, Mägi R, Hottenga JJ, ..., Prokopenko I, Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
pii: 10.1038/s41467-020-19366-9
Nat Commun 12 (1) 24 [2021-01-05; online 2021-01-05]
NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure
ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria.
Mühleip A, Kock Flygaard R, Ovciarikova J, ..., Sheiner L, Amunts A
pii: 10.1038/s41467-020-20381-z
Nat Commun 12 (1) 120 [2021-01-05; online 2021-01-05]
Cryo-EM [Service] Proteogenomics [Service]
Heparan Sulfate Biosynthesis in Zebrafish
Filipek-Górniok B, Habicher J, Ledin J, Kjellén L
J. Histochem. Cytochem. 69 (1) 49-60 [2021-01-00; online 2020-11-20]
Genome Engineering Zebrafish [Collaborative]
The structure of enteric human adenovirus 41—A leading cause of diarrhea in children
Rafie K, Lenman A, Fuchs J, ..., Arnberg N, Carlson LA
Sci Adv 7 (2) eabe0974 [2021-01-00; online 2021-01-08]
Cryo-EM [Service]
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
Becker K, Aranzana-Climent V, Cao S, ..., Hobbie SN, ENABLE consortium
pii: S1198-743X(20)30754-0
Clin. Microbiol. Infect. - (-) - [2020-12-11; online 2020-12-11]
National Resource for Mass Spectrometry Imaging [Service]
Association between inflammasome-related polymorphisms and psoriatic arthritis.
Juneblad K, Kastbom A, Johansson L, ..., Söderkvist P, Alenius GM
Scand. J. Rheumatol. - (-) 1-7 [2020-12-10; online 2020-12-10]
Clinical Genomics Linköping
Reaction Wood Anatomical Traits and Hormonal Profiles in Poplar Bent Stem and Root
De Zio E, Montagnoli A, Karady M, ..., Chiatante D, Trupiano D
Front Plant Sci 11 (-) - [2020-12-07; online 2020-12-07]
Swedish Metabolomics Centre (SMC) [Service]
Longitudinal plasma protein profiling of newly diagnosed type 2 diabetes.
Gummesson A, Björnson E, Fagerberg L, ..., Uhlén M, Bergström G
pii: S2352-3964(20)30523-5
EBioMedicine 63 (-) 103147 [2020-12-03; online 2020-12-03]
Bioinformatics Compute and Storage [Service] Translational Plasma Profiling [Collaborative]
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study.
Gudmundsdottir V, Pedersen HK, Mazzoni G, ..., Pedersen O, Brunak S
pii: 10.1186/s13073-020-00806-6 pmc: PMC7708171
Genome Med 12 (1) 109 [2020-12-01; online 2020-12-01]
Translational Plasma Profiling [Collaborative]
α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice
Mucibabic M, Steneberg P, Lidh E, ..., Lindahl E, Edlund H
Sci Rep 10 (1) - [2020-12-00; online 2020-11-24]
Cryo-EM [Service]
Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish
Banote RK, Chebli J, Şatır TM, ..., Abramsson A, Zetterberg H
Sci Rep 10 (1) - [2020-12-00; online 2020-06-23]
Genome Engineering Zebrafish [Collaborative]
Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation
Zhang Q, Bastard P, Bolze A, ..., Abel L, Casanova JL
Med 1 (1) 14-20 [2020-12-00; online 2020-12-00]
Mass Cytometry [Collaborative]
Cell-surface receptors enable perception of extracellular cytokinins
Antoniadi I, Novák O, Gelová Z, ..., Ljung K, Turnbull C
Nat Commun 11 (1) - [2020-12-00; online 2020-08-27]
Swedish Metabolomics Centre (SMC) [Service]
Primary cell wall inspired micro containers as a step towards a synthetic plant cell
Paulraj T, Wennmalm S, Wieland DCF, ..., Cárdenas M, Svagan AJ
Nat Commun 11 (1) - [2020-12-00; online 2020-02-19]
Advanced Light Microscopy (ALM) [Collaborative]
Distinct pre-initiation steps in human mitochondrial translation
Khawaja A, Itoh Y, Remes C, ..., Amunts A, Rorbach J
Nat Commun 11 (1) 1-10 [2020-12-00; online 2020-06-10]
Cryo-EM [Service]
Clonal competition within complex evolutionary hierarchies shapes AML over time
Sandén C, Lilljebjörn H, Orsmark Pietras C, ..., Ågerstam H, Fioretos T
Nat Commun 11 (1) - [2020-12-00; online 2020-02-05]
Clinical Genomics Lund
Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch
Lehmann LC, Bacic L, Hewitt G, ..., Boulton SJ, Deindl S
Cell Rep 33 (12) 108529 [2020-12-00; online 2020-12-00]
Cryo-EM [Service]
TrackMate: My favorite image analysis tool, by Neubias members
Klemm A
Wiley Analytical Science (-) - [2020-11-30; online 2020-05-26]
BioImage Informatics [Service]
A workflow for high-throughput screening, data analysis, processing, and hit identification
Hansel CS, Yousefian S, Klemm AH, Carreras-Puigvert J
KNIME blog (-) - [2020-11-30; online 2020-06-19]
BioImage Informatics [Technology development]
A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1.
Pontén E, Frisk S, Taylan F, ..., Lagerstedt-Robinson K, Nordgren A
pii: jmedgenet-2020-107385
J. Med. Genet. - (-) - [2020-11-18; online 2020-11-18]
Clinical Genomics Stockholm [Service]
Cryo‐EM structure of native human uromodulin, a zona pellucida module polymer
Stsiapanava A, Xu C, Brunati M, ..., Wu B, Jovine L
EMBO J - (-) e106807 [2020-11-16; online 2020-11-16]
Cryo-EM [Collaborative]
Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer.
Mehmeti-Ajradini M, Bergenfelz C, Larsson AM, ..., Bexell D, Leandersson K
pii: 3/11/e202000893
Life Sci. Alliance 3 (11) - [2020-11-00; online 2020-09-21]
Mass Cytometry [Service]
Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP
Crowe-McAuliffe C, Takada H, Murina V, ..., Wilson DN, Hauryliuk V
Molecular Cell - (-) - [2020-11-00; online 2020-11-00]
Cryo-EM [Service]
Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome
Ehrenbolger K, Jespersen N, Sharma H, ..., Vossbrinck CR, Barandun J
PLoS Biol. 18 (10) e3000958 [2020-10-30; online 2020-10-30]
Cryo-EM [Service]
Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9
Winkelmann I, Matsuoka R, Meier PF, ..., Beckstein O, Drew D
EMBO J - (-) - [2020-10-29; online 2020-10-29]
Cryo-EM [Service]
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
Zhang Q, Bastard P, Liu Z, ..., Su HC, Casanova JL
pii: science.abd4570 Dryad: 10.5061/dryad.8pk0p2nkk
Science 370 (6515) - [2020-10-23; online 2020-09-24]
Mass Cytometry [Collaborative]
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Bastard P, Rosen LB, Zhang Q, ..., Su HC, Casanova JL
pii: science.abd4585
Science 370 (6515) - [2020-10-23; online 2020-09-24]
Mass Cytometry [Collaborative]
Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.
Flygaard RK, Mühleip A, Tobiasson V, Amunts A
pii: 10.1038/s41467-020-18993-6
Nat Commun 11 (1) 5342 [2020-10-22; online 2020-10-22]
Cryo-EM [Service] Proteogenomics [Service]
A high-stringency blueprint of the human proteome.
Adhikari S, Nice EC, Deutsch EW, ..., Aebersold R, Baker MS
pii: 10.1038/s41467-020-19045-9 pmc: PMC7568584
Nat Commun 11 (1) 5301 [2020-10-16; online 2020-10-16]
Translational Plasma Profiling [Collaborative]
Optotracing for selective fluorescence-based detection, visualization and quantification of live S. aureus in real-time.
Butina K, Tomac A, Choong FX, ..., Löffler S, Richter-Dahlfors A
pii: 10.1038/s41522-020-00150-y
NPJ Biofilms Microbiomes 6 (1) 35 [2020-10-09; online 2020-10-09]
Advanced Light Microscopy (ALM) [Service]
SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.
Rudberg AS, Havervall S, Månberg A, ..., Hober S, Thålin C
pii: 10.1038/s41467-020-18848-0
Nat Commun 11 (1) 5064 [2020-10-08; online 2020-10-08]
Autoimmunity and Serology Profiling [Collaborative]
A latent lineage potential in resident neural stem cells enables spinal cord repair.
Llorens-Bobadilla E, Chell JM, Le Merre P, ..., Carlén M, Frisén J
pii: 370/6512/eabb8795
Science 370 (6512) eabb8795 [2020-10-02; online 2020-10-03]
Advanced Light Microscopy (ALM) [Service] Eukaryotic Single Cell Genomics (ESCG)
Exploring the bacterial nano-universe
Söderholm N, Singh B, Uhlin BE, Sandblad L
Current Opinion in Structural Biology 64 (-) 166-173 [2020-10-00; online 2020-10-00]
Cryo-EM [Collaborative]
Discovery of USP7 small-molecule allosteric inhibitors
Engström O, Belda O, Kullman-Magnusson M, ..., Parkes KEB, Zhao H
Bioorganic & Medicinal Chemistry Letters 30 (20) 127471 [2020-10-00; online 2020-10-00]
Swedish NMR Centre (SNC) [Service]
Geographically widespread invasive meningococcal disease caused by a ciprofloxacin resistant non-groupable strain of the ST-175 clonal complex.
Willerton L, Lucidarme J, Campbell H, ..., Vogel U, Borrow R
pii: S0163-4453(20)30570-3
J Infect 81 (4) 575-584 [2020-10-00; online 2020-08-25]
Clinical Genomics Örebro
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.
Bernard E, Nannya Y, Hasserjian RP, ..., Ogawa S, Papaemmanuil E
pii: 10.1038/s41591-020-1008-z
Nat. Med. 26 (10) 1549-1556 [2020-10-00; online 2020-08-03]
Clinical Genomics Uppsala [Service]
Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3
Rogne P, Dulko-Smith B, Goodman J, ..., Sauer-Eriksson AE, Wolf-Watz M
Biochemistry 59 (38) 3570-3581 [2020-09-29; online 2020-08-21]
Swedish NMR Centre (SNC) [Service]
MAIT cell activation and dynamics associated with COVID-19 disease severity.
Parrot T, Gorin JB, Ponzetta A, ..., Strålin K, Sandberg JK
pii: 5/51/eabe1670
Sci Immunol 5 (51) - [2020-09-28; online 2020-09-30]
Translational Plasma Profiling [Service]
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Bailey MH, Meyerson WU, Dursi LJ, ..., Ding L, PCAWG Consortium
pii: 10.1038/s41467-020-18151-y pmc: PMC7505971
Nat Commun 11 (1) 4748 [2020-09-21; online 2020-09-21]
Clinical Genomics Uppsala [Service]
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, ..., Murrell B, McInerney GM
pii: 10.1038/s41467-020-18174-5 PDB: 6ZXN
Nat Commun 11 (1) 4420 [2020-09-04; online 2020-09-04]
Bioinformatics Compute and Storage [Service] Protein Science Facility (PSF) [Service]
NMR Structure and Dynamics Studies of Yeast Respiratory Supercomplex Factor 2
Zhou S, Pettersson P, Huang J, ..., Mäler L, Ädelroth P
Structure - (-) - [2020-09-00; online 2020-09-00]
Swedish NMR Centre (SNC)
Sex differences in oncogenic mutational processes.
Li CH, Prokopec SD, Sun RX, ..., Boutros PC, PCAWG Consortium
pii: 10.1038/s41467-020-17359-2 pmc: PMC7455744
Nat Commun 11 (1) 4330 [2020-08-28; online 2020-08-28]
Clinical Genomics Uppsala [Service]
Prenylated Flavonoids from the Roots of Tephrosia rhodesica
Atilaw Y, Muiva-Mutisya L, Bogaerts J, ..., Erdélyi M, Yenesew A
J. Nat. Prod. 83 (8) 2390-2398 [2020-08-28; online 2020-08-13]
Swedish NMR Centre (SNC) [Service]
µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease.
Bezard E, Li Q, Hulme H, ..., Andren PE, Crossman AR
pii: JNEUROSCI.0610-20.2020 pmc: PMC7455220
J. Neurosci. 40 (35) 6812-6819 [2020-08-26; online 2020-07-20]
National Resource for Mass Spectrometry Imaging [Service]
Natural killer cell immunotypes related to COVID-19 disease severity.
Maucourant C, Filipovic I, Ponzetta A, ..., Björkström NK, Karolinska COVID-19 Study Group
pii: 5/50/eabd6832 pmc: PMC7665314
Sci Immunol 5 (50) eabd6832 [2020-08-21; online 2020-08-23]
Bioinformatics Compute and Storage [Service] Translational Plasma Profiling [Service]
13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking.
Yang M, Safavi S, Woodward EL, ..., Nord KH, Paulsson K
pii: 454973 pmc: PMC7498303
Blood 136 (8) 946-956 [2020-08-20; online 2020-05-10]
Clinical Genomics Lund
Structural basis of mitochondrial translation
Aibara S, Singh V, Modelska A, Amunts A
Elife 9 (-) 1-17 [2020-08-19; online 2020-08-19]
Cryo-EM [Service] Proteogenomics [Service]
Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
Zhang Y, Cedervall J, Hamidi A, ..., Dimberg A, Olsson AK
Cancer Res 80 (16) 3345-3358 [2020-08-15; online 2020-06-25]
PLA and Single Cell Proteomics [Service]
Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area
Nagaeva E, Zubarev I, Bengtsson Gonzales C, ..., Augustine GJ, Korpi ER
Elife 9 (-) - [2020-08-04; online 2020-08-04]
Eukaryotic Single Cell Genomics (ESCG)
Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway.
Andersson CR, Selvin T, Blom K, ..., Nygren P, Larsson R
pii: 10.1038/s41598-020-68986-0 pmc: PMC7403428
Sci Rep 10 (1) 13124 [2020-08-04; online 2020-08-04]
Drug Discovery and Development (DDD) [Service]
SLC12A2 mutations cause NKCC1 deficiency with encephalopathy and impaired secretory epithelia.
Stödberg T, Magnusson M, Lesko N, ..., Stranneheim H, Wedell A
pii: NG2020013649 pmc: PMC7357422
Neurol Genet 6 (4) e478 [2020-08-00; online 2020-07-02]
Clinical Genomics Stockholm [Service]
Immunocyte single cell analysis of vaccine‐induced narcolepsy
Lind A, Salami F, Landtblom A, ..., Adolfsson J, Elding Larsson H
Eur. J. Immunol. - (-) - [2020-07-30; online 2020-07-30]
Mass Cytometry [Service]
Detection of leukemia gene fusions by targeted RNA-sequencing in routine diagnostics.
Engvall M, Cahill N, Jonsson BI, ..., Hallböök H, Cavelier L
pii: 10.1186/s12920-020-00739-4 pmc: PMC7388219
BMC Med Genomics 13 (1) 106 [2020-07-29; online 2020-07-29]
Clinical Genomics Uppsala [Technology development]
A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.
Johansson P, Krona C, Kundu S, ..., Marino S, Nelander S
pii: S2211-1247(20)30878-0
Cell Rep 32 (2) 107897 [2020-07-14; online 2020-07-16]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Service]
SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS.
Malcovati L, Stevenson K, Papaemmanuil E, ..., Hellstrom-Lindberg E, Cazzola M
pii: 454668 pmc: PMC7362582
Blood 136 (2) 157-170 [2020-07-09; online 2020-04-30]
Clinical Genomics Uppsala [Service]
Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor
Köhler C, Carlström G, Gunnarsson A, ..., Edman K, Akke M
Sci Adv 6 (29) eabb5277 [2020-07-00; online 2020-07-17]
Swedish NMR Centre (SNC) [Service]
Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA.
Baronti L, Guzzetti I, Ebrahimi P, ..., Chen AA, Petzold K
pii: 10.1038/s41586-020-2336-3
Nature 583 (7814) 139-144 [2020-07-00; online 2020-05-27]
Protein Science Facility (PSF) [Service]
Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling.
Dodig-Crnković T, Hong M, Thomas CE, ..., Uhlén M, Schwenk JM
pii: S2352-3964(20)30229-2 pmc: PMC7334812
EBioMedicine 57 (-) 102854 [2020-07-00; online 2020-07-03]
Translational Plasma Profiling [Collaborative]
Serum Metabolites in Hand-Arm Vibration Exposed Workers
Vihlborg P, Graff P, Hagenbjörk A, ..., Bryngelsson IL, Eriksson K
- 62 (7) 460-465 [2020-07-00; online 2020-04-06]
Swedish Metabolomics Centre (SMC) [Service]
High content drug screening for Fanconi anemia therapeutics.
Montanuy H, Camps-Fajol C, Carreras-Puigvert J, ..., Minguillón J, Surrallés J
pii: 10.1186/s13023-020-01437-1 pmc: PMC7325660
Orphanet J Rare Dis 15 (1) 170 [2020-06-30; online 2020-06-30]
Drug Discovery and Development (DDD)
Serum choline in extremely preterm infants declines with increasing parenteral nutrition
Nilsson AK, Pedersen A, Malmodin D, ..., Pupp IH, Hellström A
Eur J Nutr - (-) - [2020-06-25; online 2020-06-25]
Swedish NMR Centre (SNC) [Collaborative]
Chanjo: Clincal grade sequence coverage analysis
Andeer R, Magnusson M, Wedell A, Stranneheim H
F1000Res 9 (-) 615 [2020-06-16; online 2020-06-16]
Clinical Genomics Stockholm [Technology development]
Auxin export from proximal fruits drives arrest in temporally competent inflorescences
Ware A, Walker CH, Šimura J, ..., Wilson ZA, Bennett T
NPLANTS 6 (6) 699-707 [2020-06-00; online 2020-05-25]
Swedish Metabolomics Centre (SMC) [Service]
GPSeq reveals the radial organization of chromatin in the cell nucleus
Girelli G, Custodio J, Kallas T, ..., Crosetto N, Bienko M
Nat Biotechnol - (-) - [2020-05-25; online 2020-05-25]
Advanced Light Microscopy (ALM) [Service]
A chemical screen identifies a link between lipid metabolism and mRNA translation
Corman A, Kanellis DC, Häggblad M, ..., Carreras-Puigvert J, Fernandez-Capetillo O
- - (-) - [2020-05-11; online 2020-05-11]
Chemical Biology Consortium Sweden (CBCS) [Service]
A molecular mechanism explaining albuminuria in kidney disease
Butt L, Unnersjö-Jess D, Höhne M, ..., Schermer B, Benzing T
Nat Metab 2 (5) 461-474 [2020-05-00; online 2020-05-11]
Advanced Light Microscopy (ALM) [Collaborative]
Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin.
Saei AA, Gullberg H, Sabatier P, ..., Arnér ESJ, Zubarev RA
pii: S2213-2317(20)30243-3 pmc: PMC7082630
Redox Biol 32 (-) 101491 [2020-05-00; online 2020-03-03]
Drug Discovery and Development (DDD)
Solution Conformations Explain the Chameleonic Behaviour of Macrocyclic Drugs
Danelius E, Poongavanam V, Peintner S, ..., Erdélyi M, Kihlberg J
Chem. Eur. J. 26 (23) 5231-5244 [2020-04-21; online 2020-04-06]
Swedish NMR Centre (SNC) [Service]
Fungi and Oomycetes in the Irrigation Water of Forest Nurseries
Marčiulynas A, Marčiulynienė D, Lynikienė J, ..., Vaičiukynė M, Menkis A
Forests 11 (4) 459 [2020-04-18; online 2020-04-18]
NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]
Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-Analysis.
Akingbuwa WA, Hammerschlag AR, Jami ES, ..., Middeldorp CM, and the Bipolar Disorder and Major Depressive Disorder Working Groups of the Psychiatric Genomics Consortium
pii: 2763801 pmc: PMC7160753
JAMA Psychiatry - (-) - [2020-04-15; online 2020-04-15]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
Difference in virulence between Neisseria meningitidis serogroups W and Y in transgenic mice.
Eriksson L, Stenmark B, Deghmane AE, ..., Mölling P, Taha MK
pii: 10.1186/s12866-020-01760-4 pmc: PMC7160935
BMC Microbiol. 20 (1) 92 [2020-04-15; online 2020-04-15]
Clinical Genomics Örebro
Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study.
Sutton L, Ljungström V, Enjuanes A, ..., Rosenquist R, European Research Initiative on CLL (ERIC)
pii: haematol.2019.234716
Haematologica - (-) - [2020-04-09; online 2020-04-09]
Clinical Genomics Uppsala [Service]
Genomic characterization and outcome of prosthetic joint infections caused by Staphylococcus aureus.
Wildeman P, Tevell S, Eriksson C, ..., Söderquist B, Stenmark B
pii: 10.1038/s41598-020-62751-z pmc: PMC7125104
Sci Rep 10 (1) 5938 [2020-04-03; online 2020-04-03]
Clinical Genomics Örebro
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS
pii: RA120.012636 PDB: 6QVO
J. Biol. Chem. - (-) - [2020-03-06; online 2020-03-06]
Protein Science Facility (PSF) [Service]
Structure of a minimal photosystem I from the green alga Dunaliella salina
Perez-Boerema A, Klaiman D, Caspy I, ..., Amunts A, Nelson N
NPLANTS 6 (3) 321-327 [2020-03-02; online 2020-03-02]
Cryo-EM [Service]
Heritability of Caries Scores, Trajectories, and Disease Subtypes
Haworth S, Esberg A, Lif Holgerson P, ..., Franks PW, Johansson I
J Dent Res 99 (3) 264-270 [2020-03-00; online 2020-01-06]
NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure
Complete genome and methylome analysis of Neisseria meningitidis associated with increased serogroup Y disease.
Stenmark B, Harrison OB, Eriksson L, ..., Maiden MCJ, Mölling P
pii: 10.1038/s41598-020-59509-y pmc: PMC7046676
Sci Rep 10 (1) 3644 [2020-02-27; online 2020-02-27]
Clinical Genomics Örebro
Capsid Structure of a Marine Algal Virus of the Order Picornavirales
Munke A, Kimura K, Tomaru Y, Okamoto K
J Virol 94 (9) - [2020-02-05; online 2020-04-16]
Cryo-EM [Service]
Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces.
Wang X, Shah FA, Vazirisani F, ..., Ekström K, Thomsen P
pii: S0142-9612(19)30670-2
Biomaterials 230 (-) 119571 [2020-02-00; online 2019-10-24]
Glycoproteomics [Service]
Molecular mechanisms of collateral sensitivity to the antibiotic nitrofurantoin.
Roemhild R, Linkevicius M, Andersson DI
pii: PBIOLOGY-D-19-02723
PLoS Biol. 18 (1) e3000612 [2020-01-27; online 2020-01-27]
Glycoproteomics [Service]
Proteomic analysis of follicular fluid during human ovulation.
Zakerkish F, Brännström M, Carlsohn E, ..., van der Post S, Thoroddsen A
Acta Obstet Gynecol Scand - (-) - [2020-01-16; online 2020-01-16]
Glycoproteomics [Service]
Evolution of a new function by fusion between phage DNA and a bacterial gene.
Warsi O, Knopp M, Surkov S, Hultqvist JJ, Andersson DI
pii: 5707441
Mol. Biol. Evol. - (-) - [2020-01-16; online 2020-01-16]
Glycoproteomics [Service]
Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study.
Bonomi A, Veglia F, Baldassarre D, ..., Gigante B, on behalf of the IMPROVE study group
pii: 10.1038/s41435-019-0090-z
Genes Immun. - (-) - [2020-01-14; online 2020-01-14]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
Integrative discovery of treatments for high-risk neuroblastoma.
Almstedt E, Elgendy R, Hekmati N, ..., Krona C, Nelander S
pii: 10.1038/s41467-019-13817-8 pmc: PMC6941971
Nat Commun 11 (1) 71 [2020-01-03; online 2020-01-03]
Bioinformatics Compute and Storage [Service] Genome Engineering Zebrafish [Service]
A dual-action peptide-containing hydrogel targets wound infection and inflammation
Puthia M, Butrym M, Petrlova J, ..., Kjellström S, Schmidtchen A
Sci. Transl. Med. 12 (524) eaax6601 [2020-01-01; online 2020-01-01]
Targeted and Structural Proteomics [Collaborative]
Regulation of α-synuclein by chaperones in mammalian cells
Burmann BM, Gerez JA, Matečko-Burmann I, ..., Riek R, Hiller S
Nature 577 (7788) 127-132 [2020-01-00; online 2019-12-04]
Swedish NMR Centre (SNC) [Service]
Identification of novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm
Memon AA, Zarrouk M, Ågren-Witteschus S, ..., Gottsäter A, Sundquist K
Eur J Prev Cardiolog 27 (2) 132-142 [2020-01-00; online 2019-08-29]
Clinical Biomarkers [Service]
Resolution enhancement in NMR spectra by deconvolution with compressed sensing reconstruction
Kazimierczuk K, Kasprzak P, Georgoulia PS, ..., Westenhoff S, Orekhov VY
Chem. Commun. 56 (93) 14585-14588 [2020-00-00; online 2020-00-00]
Swedish NMR Centre (SNC) [Collaborative]
Regeneration of water-deactivated Cu/SAPO-34(MO) with acids
Woo J, Bernin D, Ahari H, ..., Zammit M, Olsson L
Catal. Sci. Technol. 10 (5) 1539-1550 [2020-00-00; online 2020-00-00]
Swedish NMR Centre (SNC)
An integrative toolbox to unlock the structure and dynamics of protein–surfactant complexes
Sanchez-Fernandez A, Diehl C, Houston JE, ..., Sjögren H, Wahlgren M
Nanoscale Adv. 2 (9) 4011-4023 [2020-00-00; online 2020-00-00]
Swedish NMR Centre (SNC) [Service]
Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
Bhandage AK, Cunningham JL, Jin Z, ..., Ekselius L, Birnir B
Int J Mol Sci 20 (24) 6172 [2019-12-06; online 2019-12-06]
PLA and Single Cell Proteomics [Collaborative]
DNA methylation profiles in chronic lymphocytic leukemia patients treated with chemoimmunotherapy.
Tsagiopoulou M, Papakonstantinou N, Moysiadis T, ..., Rosenquist R, Stamatopoulos K
pii: 10.1186/s13148-019-0783-1
Clin Epigenetics 11 (1) 177 [2019-12-02; online 2019-12-02]
NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
Impact of Q-Griffithsin anti-HIV microbicide gel in non-human primates: In situ analyses of epithelial and immune cell markers in rectal mucosa.
Günaydın G, Edfeldt G, Garber DA, ..., Tjernlund A, Broliden K
pii: 10.1038/s41598-019-54493-4
Sci Rep 9 (1) 18120 [2019-12-02; online 2019-12-02]
BioImage Informatics [Service]