Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

Welinder C, Jirström K, Lehn S, Nodin B, Marko-Varga G, Blixt O, Danielsson L, Jansson B

Heliyon 2 (8) e00143 [2016-08-00; online 2016-08-16]

A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.

Structural Proteomics [Service]

PubMed 27579449

DOI 10.1016/j.heliyon.2016.e00143

Crossref 10.1016/j.heliyon.2016.e00143

pii: S2405-8440(16)30369-3
pii: e00143
pmc: PMC4992093

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