Protein Science Facility (PSF)

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Publications

2020 (246)

2019 (742)

2018 (663)

2017 (698)

2016 (671)

2015 (431)

2014 (376)

2013 (320)

2012 (243)

2011 (163)

2010 (139)

All (4692)


Facilities

Journals

SciLifeLab National facility since 2013.

142 publications

Year 2020

PubMed DOI Crossref
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, ..., Murrell B, McInerney GM
Nat Commun 11 (1) 4420 [2020-09-04; online 2020-09-04]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA.
Baronti L, Guzzetti I, Ebrahimi P, ..., Chen AA, Petzold K
Nature 583 (7814) 139-144 [2020-07-00; online 2020-05-27]
Protein Science Facility (PSF) [Service]
DOI Crossref
In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization
Michel M, Homan EJ, Wiita E, ..., Helleday T, Warpman Berglund U
Front. Chem. 8 (-) - [2020-05-29; online 2020-05-29]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS
J. Biol. Chem. - (-) - [2020-03-06; online 2020-03-06]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
Scaletti E, Claesson M, Helleday T, Jemth AS, Stenmark P
J. Mol. Biol. 432 (4) 1126-1142 [2020-02-14; online 2020-01-15]
Protein Science Facility (PSF) [Service]

Year 2019

PubMed DOI Crossref
Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease.
Akaberi D, Chinthakindi PK, Båhlström A, ..., Lundkvist Å, Lennerstrand J
J. Biomol. Struct. Dyn. - (-) 1-11 [2019-12-27; online 2019-12-27]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Nicholls TJ, Spåhr H, Jiang S, ..., Larsson NG, Gustafsson CM
Mol. Cell 76 (5) 784-796.e6 [2019-12-05; online 2019-10-03]
Bioinformatics Compute and Storage [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.
Anandapadamanaban M, Kyriakidis NC, Csizmók V, ..., Wahren-Herlenius M, Sunnerhagen M
J. Biol. Chem. - (-) - [2019-06-03; online 2019-06-03]
Protein Science Facility (PSF) [Collaborative]
DOI Crossref
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
Scaletti E, Jemth A, Helleday T, Stenmark P
FEBS Lett - (-) - [2019-05-25; online 2019-05-25]
Protein Science Facility (PSF) [Service]
DOI Crossref
Crystal structure of the catalytic domain of the Weissela oryzae botulinum-like toxin
Košenina S, Masuyer G, Zhang S, Dong M, Stenmark P
FEBS Lett - (-) - [2019-05-20; online 2019-05-20]
Bioinformatics Compute and Storage [Service] Protein Science Facility (PSF) [Service]
DOI Crossref
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana
Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P
Biochemistry 58 (7) 887-899 [2019-02-19; online 2019-01-07]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural Basis of Cross‐Reactivity of Anti–Citrullinated Protein Antibodies
Ge C, Xu B, Liang B, ..., Dobritzsch D, Holmdahl R
Arthritis Rheumatol 71 (2) 210-221 [2019-02-00; online 2019-01-04]
Chemical Proteomics [Collaborative] Protein Science Facility (PSF) [Service]

Year 2018

PubMed DOI Crossref
Cotranslational Folding of a Pentarepeat β-Helix Protein.
Notari L, Martínez-Carranza M, Farías-Rico JA, Stenmark P, von Heijne G
J. Mol. Biol. 430 (24) 5196-5206 [2018-12-07; online 2018-10-27]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds MJGW, van Leeuwen IMM, Drummond CJ, ..., McCormack E, Laín S
PDB GEO
Nat Commun 9 (1) - [2018-12-00; online 2018-03-16]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
DOI Crossref
Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
Spåhr H, Chia T, Lingford JP, ..., Filipovska A, Rackham O
Nat Commun 9 (1) - [2018-12-00; online 2018-06-07]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page BDG, Valerie NCK, Wright RHG, ..., Beato M, Helleday T
PDB PDB
Nat Commun 9 (1) - [2018-12-00; online 2018-01-17]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface
Karlberg T, Hornyak P, Pinto AF, ..., Björkegren C, Schüler H
PDB PDB PDB PDB PDB
Nat Commun 9 (1) - [2018-12-00; online 2018-09-17]
Bioinformatics Compute and Storage [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Visnes T, Cázares-Körner A, Hao W, ..., Boldogh I, Helleday T
Science 362 (6416) 834-839 [2018-11-16; online 2018-11-15]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Chemical Proteomics [Collaborative] Drug Discovery and Development (DDD) [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP
Jemth AS, Gustafsson R, Bräutigam L, ..., Stenmark P, Helleday T
PDB PDB
Nucleic Acids Res - (-) - [2018-10-10; online 2018-10-10]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions
Desroses M, Busker S, Astorga-Wells J, ..., Grandér D, Page BDG
Journal of Pharmaceutical and Biomedical Analysis 160 (-) 80-88 [2018-10-00; online 2018-10-00]
Chemical Proteomics [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural and biochemical characterization of the Cutibacterium acnes exo-β-1,4-mannosidase that targets the N-glycan core of host glycoproteins
Reichenbach T, Kalyani D, Gandini R, ..., Aspeborg H, Divne C
PLoS ONE 13 (9) e0204703 [2018-09-27; online 2018-09-27]
Bioinformatics Compute and Storage [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium.
Sun L, Vella P, Schnell R, ..., Schneider G, Römling U
PDB PDB
J. Mol. Biol. 430 (18 Pt B) 3170-3189 [2018-09-14; online 2018-07-12]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant.
Rozman Grinberg I, Lundin D, Sahlin M, ..., Hofer A, Sjöberg BM
J. Biol. Chem. - (-) - [2018-08-30; online 2018-08-30]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
BtsCI and BseGI display sequence preference in the nucleotides flanking the recognition sequence
Rosa J, Fernandez-Gonzalez E, Ducani C, Högberg B
PLoS ONE 13 (8) e0202057 [2018-08-17; online 2018-08-17]
NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J
Nat Med - (-) - [2018-06-11; online 2018-06-11]
Bioinformatics Compute and Storage [Service] High-throughput Genome Engineering (HTGE) [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14
Holechek J, Lease R, Thorsell AG, ..., Schüler H, Ferraris D
Bioorganic & Medicinal Chemistry Letters 28 (11) 2050-2054 [2018-06-00; online 2018-06-00]
Bioinformatics Compute and Storage [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity.
Steiner EM, Lyngsø J, Guy JE, ..., Schneider G, Schnell R
PDB
Proteins - (-) - [2018-05-02; online 2018-05-02]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark P
pmc PDB
Toxins (Basel) 10 (4) - [2018-04-12; online 2018-04-12]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Morgunova E, Yin Y, Das PK, ..., Nilsson L, Taipale J
pmc
Elife 7 (-) - [2018-04-11; online 2018-04-11]
Bioinformatics Compute and Storage [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol
Ekblad T, Verheugd P, Lindgren AE, ..., Elofsson M, Schüler H
SLAS DISCOVERY: Advancing Life Sciences R&D 23 (4) 353-362 [2018-04-00; online 2018-01-09]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in
Han X, Sun R, Sandalova T, Achour A
pmc
Open Biol 8 (4) - [2018-04-00; online 2018-04-20]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.
Hafstrand I, Doorduijn EM, Sun R, ..., van Hall T, Achour A
J. Immunol. - (-) - [2018-03-05; online 2018-03-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
Stafford WC, Peng X, Olofsson MH, ..., Linder S, Arnér ESJ
Sci Transl Med 10 (428) - [2018-02-14; online 2018-02-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.
Rozman Grinberg I, Lundin D, Hasan M, ..., Logan DT, Sjöberg BM
pmc
Elife 7 (-) - [2018-02-01; online 2018-02-01]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold
Carter M, Jemth AS, Carreras-Puigvert J, ..., Helleday T, Stenmark P
PDB PDB
Structure 26 (2) 295-303.e6 [2018-02-00; online 2018-02-00]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity
Narwal M, Jemth AS, Gustafsson R, ..., Helleday T, Stenmark P
PDB PDB PDB PDB
Biochemistry - (-) - [2018-01-16; online 2018-01-16]
Protein Science Facility (PSF) [Service]

Year 2017

PubMed DOI Crossref
Structural basis for dolichylphosphate mannose biosynthesis
Gandini R, Reichenbach T, Tan TC, Divne C
Nat Commun 8 (1) - [2017-12-00; online 2017-07-25]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Carreras-Puigvert J, Zitnik M, Jemth AS, ..., Zupan B, Helleday T
Nat Commun 8 (1) - [2017-12-00; online 2017-11-16]
BioImage Informatics [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
Lehmann LC, Hewitt G, Aibara S, ..., Boulton SJ, Deindl S
Molecular Cell 68 (5) 847-859.e7 [2017-12-00; online 2017-12-00]
Cryo-EM [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance
Petrus P, Bialesova L, Checa A, ..., Gao H, Rydén M
- - (-) - [2017-11-07; online 2017-11-07]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.
Kumar R, Moche M, Winblad B, Pavlov PF
Sci Rep 7 (1) 14288 [2017-10-27; online 2017-10-27]
Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX type gene cluster.
Gustafsson R, Berntsson RP, Martínez-Carranza M, ..., Johnson EA, Stenmark P
FEBS Lett. - (-) - [2017-10-25; online 2017-10-25]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Entirely enzymatic nanofabrication of DNA–protein conjugates
Bernardinelli G, Högberg B
Nucleic Acids Res 45 (18) e160-e160 [2017-10-13; online 2017-08-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis
Brunner K, Steiner EM, Reshma RS, ..., Schnell R, Schneider G
Bioorganic & Medicinal Chemistry Letters 27 (19) 4582-4587 [2017-10-00; online 2017-10-00]
Protein Science Facility (PSF) [Service]
DOI Crossref
Capturing LTA4hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4synthesis
Stsiapanava A, Samuelsson B, Haeggström JZ
Proc Natl Acad Sci USA 114 (36) 9689-9694 [2017-09-05; online 2017-08-21]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Mucin-Inspired Lubrication on Hydrophobic Surfaces
Käsdorf BT, Weber F, Petrou G, ..., Crouzier T, Lieleg O
Biomacromolecules 18 (8) 2454-2462 [2017-08-14; online 2017-07-03]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase
Mittal M, Hasan M, Balagunaseelan N, ..., Haeggström JZ, Rinaldo-Matthis A
Biochimica et Biophysica Acta (BBA) - General Subjects 1861 (8) 2099-2111 [2017-08-00; online 2017-08-00]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Biophysical characterization of the calmodulin-like domain of Plasmodium falciparum calcium dependent protein kinase 3
Andresen C, Niklasson M, Cassman Eklöf S, Wallner B, Lundström P
PLoS ONE 12 (7) e0181721 [2017-07-26; online 2017-07-26]
Protein Science Facility (PSF) [Service] Swedish NMR Centre (SNC) [Service]
PubMed DOI Crossref
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
Ge C, Tong D, Liang B, ..., Dobritzsch D, Holmdahl R
pmc
JCI Insight 2 (13) - [2017-07-06; online 2017-07-06]
Autoimmunity Profiling [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14
Upton K, Meyers M, Thorsell AG, ..., Schüler H, Ferraris D
Bioorganic & Medicinal Chemistry Letters 27 (13) 2907-2911 [2017-07-00; online 2017-07-00]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yin Y, Morgunova E, Jolma A, ..., Vinson C, Taipale J
Science 356 (6337) eaaj2239 [2017-05-05; online 2017-05-04]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
SnoN Stabilizes the SMAD3/SMAD4 Protein Complex
Walldén K, Nyman T, Hällberg BM
Sci Rep 7 (-) 46370 [2017-04-11; online 2017-04-11]
Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
B. Kumar R, Zhu L, Hebert H, Jegerschöld C
J Vis Exp - (121) - [2017-03-05; online 2017-03-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Binding and processing of β-lactam antibiotics by the transpeptidase LdtMt2fromMycobacterium tuberculosis
Steiner EM, Schneider G, Schnell R
FEBS J 284 (5) 725-741 [2017-03-00; online 2017-02-08]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Characterization of the Ruler Protein Interaction Interface on the Substrate Specificity Switch Protein in theYersiniaType III Secretion System
Ho O, Rogne P, Edgren T, ..., Login FH, Wolf-Watz M
J. Biol. Chem. 292 (8) 3299-3311 [2017-02-24; online 2016-12-30]
Protein Science Facility (PSF) [Service] Swedish NMR Centre (SNC) [Service]
PubMed DOI Crossref
Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors
Thorsell AG, Ekblad T, Karlberg T, ..., Cohen MS, Schüler H
J. Med. Chem. 60 (4) 1262-1271 [2017-02-23; online 2016-12-21]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold N, Rudd SG, Ljungblad L, ..., Helleday T, Schaller T
Nat Med 23 (2) 256-263 [2017-01-09; online 2017-01-09]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Small Molecule Microarray Based Discovery of PARP14 Inhibitors
Peng B, Thorsell AG, Karlberg T, Schüler H, Yao SQ
Angew. Chem. Int. Ed. 56 (1) 248-253 [2017-01-02; online 2016-12-05]
Protein Science Facility (PSF) [Service]

Year 2016

PubMed DOI Crossref
A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.
Crona M, Codó P, Jonna VR, ..., Fernandes AP, Tholander F
Mol Oncol 10 (9) 1375-1386 [2016-11-00; online 2016-07-26]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.
Lundbäck P, Lea JD, Sowinska A, ..., Antoine DJ, Erlandsson Harris H
pmc
Hepatology 64 (5) 1699-1710 [2016-11-00; online 2016-09-01]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.
Säll A, Walle M, Wingren C, ..., Borrebaeck CAK, Persson H
Protein Eng. Des. Sel. 29 (10) 427-437 [2016-10-00; online 2016-09-01]
Drug Discovery and Development (DDD) [Technology development] Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
Quistgaard EM, Weininger U, Ural-Blimke Y, ..., Akke M, Löw C
pmc
BMC Biol. 14 (1) 82 [2016-09-23; online 2016-09-23]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Valerie NC, Hagenkort A, Page BD, ..., Jemth AS, Helleday T
Cancer Res. 76 (18) 5501-5511 [2016-09-15; online 2016-08-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.
Schulte T, Mikaelsson C, Beaussart A, ..., Nygren PÅ, Achour A
pmc
Sci Rep 6 (-) 32371 [2016-09-01; online 2016-09-01]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.
Sandalova T, Lee M, Henriques-Normark B, ..., Mellroth P, Achour A
pmc mid
Mol. Microbiol. 101 (6) 954-967 [2016-09-00; online 2016-07-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression.
Anandapadamanaban M, Pilstål R, Andresen C, ..., Wallner B, Sunnerhagen M
Structure 24 (8) 1311-1321 [2016-08-02; online 2016-07-14]
Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Kinetic investigation of human 5-lipoxygenase with arachidonic acid.
Mittal M, Kumar RB, Balagunaseelan N, ..., Haeggström JZ, Rinaldo-Matthis A
Bioorg. Med. Chem. Lett. 26 (15) 3547-3551 [2016-08-01; online 2016-06-11]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
Brunner K, Maric S, Reshma RS, ..., Schnell R, Schneider G
J. Med. Chem. 59 (14) 6848-6859 [2016-07-28; online 2016-07-13]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.
Schulte T, Liu L, Panas MD, ..., Achour A, McInerney GM
pmc
Open Biol 6 (7) - [2016-07-00; online 2016-07-08]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.
Pinto AF, Ebrahimi M, Saleeb M, ..., Elofsson M, Schüler H
J Biomol Screen 21 (6) 590-595 [2016-07-00; online 2016-02-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Coxsackievirus counters the host innate immune response by blocking type III interferon expression.
Lind K, Svedin E, Domsgen E, ..., Moll M, Flodström-Tullberg M
J. Gen. Virol. 97 (6) 1-12 [2016-06-00; online 2016-03-02]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Siitonen V, Selvaraj B, Niiranen L, ..., Schneider G, Metsä-Ketelä M
pmc GENBANK PDB PDB PDB PDB
Proc. Natl. Acad. Sci. U.S.A. 113 (19) 5251-5256 [2016-05-10; online 2016-04-25]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
Kouznetsova E, Kanno T, Karlberg T, ..., Sjögren C, Schüler H
Structure 24 (5) 789-796 [2016-05-03; online 2016-04-21]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A saposin-lipoprotein nanoparticle system for membrane proteins.
Frauenfeld J, Löving R, Armache JP, ..., Cheng Y, Nordlund P
pmc mid
Nat. Methods 13 (4) 345-351 [2016-04-00; online 2016-03-07]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants.
Stellmacher L, Sandalova T, Schneider S, ..., Sprenger GA, Samland AK
Acta Crystallogr D Struct Biol 72 (Pt 4) 467-476 [2016-04-00; online 2016-03-24]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Engineering a thermostable Halothermothrix orenii β-glucosidase for improved galacto-oligosaccharide synthesis.
Hassan N, Geiger B, Gandini R, ..., Divne C, Tan TC
pmc mid
Appl. Microbiol. Biotechnol. 100 (8) 3533-3543 [2016-04-00; online 2015-12-02]
Protein Science Facility (PSF)
PubMed DOI Crossref
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
Almqvist H, Axelsson H, Jafari R, ..., Lundbäck T, Nordlund P
pmc
Nat Commun 7 (-) 11040 [2016-03-24; online 2016-03-24]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Mills SJ, Silvander C, Cozier G, ..., Nordlund P, Potter BV
pmc mid
Biochemistry 55 (9) 1384-1397 [2016-03-08; online 2016-02-29]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
Hafstrand I, Doorduijn EM, Duru AD, ..., van Hall T, Achour A
J. Immunol. 196 (5) 2327-2334 [2016-03-01; online 2016-01-22]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
Lim SM, Yeung K, Trésaugues L, Ling TH, Nordlund P
FEBS J. 283 (6) 1107-1123 [2016-03-00; online 2016-02-05]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Llona-Minguez S, Höglund A, Jacques SA, ..., Scobie M, Helleday T
J. Med. Chem. 59 (3) 1140-1148 [2016-02-11; online 2016-02-11]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa.
Jacewicz A, Schnell R, Lindqvist Y, Schneider G
pmc
Acta Crystallogr F Struct Biol Commun 72 (Pt 2) 105-111 [2016-02-00; online 2016-01-22]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.
Brock JS, Hamberg M, Balagunaseelan N, ..., Rinaldo-Matthis A, Haeggström JZ
pmc
Proc. Natl. Acad. Sci. U.S.A. 113 (4) 972-977 [2016-01-26; online 2016-01-11]
Protein Science Facility (PSF) [Service]

Year 2015

PubMed DOI Crossref
Exploring water as building bricks in enzyme engineering.
Hendil-Forssell P, Martinelle M, Syrén PO
Chem. Commun. (Camb.) 51 (97) 17221-17224 [2015-12-18; online 2015-10-02]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural insights into the DNA-binding specificity of E2F family transcription factors.
Morgunova E, Yin Y, Jolma A, ..., Nilsson L, Taipale J
pmc BioProject PDB
Nat Commun 6 (-) 10050 [2015-12-03; online 2015-12-03]
Karolinska High Throughput Center (KHTC) Protein Science Facility (PSF)
PubMed DOI Crossref
DNA-dependent formation of transcription factor pairs alters their binding specificity.
Jolma A, Yin Y, Nitta KR, ..., Morgunova E, Taipale J
BioProject PDB PDB PDB
Nature 527 (7578) 384-388 [2015-11-19; online 2015-11-10]
Karolinska High Throughput Center (KHTC) Protein Science Facility (PSF)
DOI Crossref
Acid-Base Catalyst Discriminates between a Fructose 6-Phosphate Aldolase and a Transaldolase
Stellmacher L, Sandalova T, Leptihn S, ..., Sprenger GA, Samland AK
ChemCatChem 7 (19) 3140-3151 [2015-10-00; online 2015-08-06]
Protein Science Facility (PSF)
PubMed DOI Crossref
Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.
Ahmad S, Thulasingam M, Palombo I, ..., Haeggström JZ, Rinaldo-Matthis A
Biochim. Biophys. Acta 1854 (10 Pt A) 1365-1371 [2015-10-00; online 2015-06-13]
Protein Science Facility (PSF)
PubMed DOI Crossref
Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase.
Liu Q, Chai J, Moche M, ..., Lindqvist Y, Shanklin J
pmc
Plant Physiol. 169 (1) 432-441 [2015-09-00; online 2015-08-01]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.
Possner DD, Claesson M, Guy JE
pmc
PLoS ONE 10 (8) e0136239 [2015-08-21; online 2015-08-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Carter M, Jemth AS, Hagenkort A, ..., Helleday T, Stenmark P
pmc
Nat Commun 6 (-) 7871 [2015-08-04; online 2015-08-04]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
Tan TC, Kracher D, Gandini R, ..., Ludwig R, Divne C
pmc PDB PDB PDB PDB PDB PDB
Nat Commun 6 (-) 7542 [2015-07-07; online 2015-07-07]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate
Trésaugues L, Lundbäck T, Welin M, ..., Gräslund S, Nordlund P
PDB PDB
PLoS ONE 10 (6) e0131507 [2015-06-29; online 2015-06-29]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF)
PubMed DOI Crossref
Structure of the nuclease subunit of human mitochondrial RNase P.
Reinhard L, Sridhara S, Hällberg BM
pmc PDB PDB
Nucleic Acids Res. 43 (11) 5664-5672 [2015-06-23; online 2015-05-09]
Protein Science Facility (PSF)
DOI Crossref
Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis
Poyraz Ö, Brunner K, Lohkamp B, ..., Schnell R, Schneider G
PDB PDB PDB PDB
PLoS ONE 10 (3) e0121494 [2015-03-25; online 2015-03-25]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
Karlberg T, Klepsch M, Thorsell AG, ..., Linusson A, Schüler H
pmc
J. Biol. Chem. 290 (12) 7336-7344 [2015-03-20; online 2015-01-31]
Protein Science Facility (PSF)
PubMed DOI Crossref
High-resolution crystal structure of a polyextreme GH43 glycosidase from Halothermothrix orenii with α-L-arabinofuranosidase activity.
Hassan N, Kori LD, Gandini R, ..., Divne C, Tan TC
pmc PDB
Acta Crystallogr F Struct Biol Commun 71 (Pt 3) 338-345 [2015-03-00; online 2015-02-19]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.
Schmidberger JW, Schnell R, Schneider G
pmc PDB PDB PDB PDB PDB
Acta Crystallogr. D Biol. Crystallogr. 71 (Pt 3) 721-731 [2015-03-00; online 2015-02-26]
Protein Science Facility (PSF)
PubMed DOI Crossref
Biochemical and structural characterization of a thermostable β-glucosidase from Halothermothrix orenii for galacto-oligosaccharide synthesis.
Hassan N, Nguyen TH, Intanon M, ..., Divne C, Tan TC
pmc PDB PDB PDB
Appl. Microbiol. Biotechnol. 99 (4) 1731-1744 [2015-02-00; online 2014-09-01]
Protein Science Facility (PSF)

Year 2014

PubMed DOI Crossref
A novel cytosolic NADH:quinone oxidoreductase fromMethanothermobacter marburgensis
Ullmann E, Tan TC, Gundinger T, ..., Divne C, Spadiut O
PDB
Biosci. Rep. 34 (6) 893-904 [2014-12-23; online 2014-12-23]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.
Dobritzsch D, Wang H, Schneider G, Yu S
PDB PDB PDB PDB
Biochem. J. 462 (3) 441-452 [2014-09-15; online 2014-06-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain.
Swarbrick CM, Roman N, Cowieson N, ..., Lehtiö L, Forwood JK
pmc PDB PDB PDB PDB PDB PDB PDB PDB
J. Biol. Chem. 289 (35) 24263-24274 [2014-08-29; online 2014-07-09]
Protein Science Facility (PSF)
PubMed DOI Crossref
Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Guettou F, Quistgaard EM, Raba M, ..., Löw C, Nordlund P
PDB PDB PDB
Nat. Struct. Mol. Biol. 21 (8) 728-731 [2014-08-00; online 2014-07-30]
Protein Science Facility (PSF)
PubMed DOI Crossref
Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family.
Pinto AF, Schüler H
Curr. Top. Microbiol. Immunol. 384 (-) 153-166 [2014-07-13; online 2014-07-13]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A.
Dovega R, Tsutakawa S, Quistgaard EM, ..., Löw C, Nordlund P
pmc PDB
PLoS ONE 9 (7) e101846 [2014-07-09; online 2014-07-09]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
Löw C, Quistgaard EM, Kovermann M, ..., Balbach J, Nordlund P
PDB
Biol. Chem. 395 (7-8) 881-889 [2014-07-00; online 2014-07-09]
Protein Science Facility (PSF)
PubMed DOI Crossref
Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder
Ponnusamy R, Lebedev AA, Pahlow S, Lohkamp B
PDB PDB PDB
Acta Crystallogr. D Biol. Crystallogr. 70 (6) 1680-1694 [2014-06-01; online 2014-05-30]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Structure and inhibition of mouse leukotriene C4 synthase.
Niegowski D, Kleinschmidt T, Ahmad S, ..., Rinaldo-Matthis A, Haeggström JZ
pmc
PLoS ONE 9 (5) e96763 [2014-05-08; online 2014-05-08]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.
Trésaugues L, Silvander C, Flodin S, ..., Berglund H, Nordlund P
PDB PDB PDB PDB PDB
Structure 22 (5) 744-755 [2014-05-06; online 2014-04-08]
Protein Science Facility (PSF)
PubMed DOI Crossref
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth A, ..., Berglund UW, Helleday T
Nature 508 (7495) 215-221 [2014-04-10; online 2014-04-02]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF)
PubMed DOI Crossref
Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.
Liscio P, Carotti A, Asciutti S, ..., Pellicciari R, Camaioni E
pmc mid PDB
J. Med. Chem. 57 (6) 2807-2812 [2014-03-27; online 2014-02-18]
Protein Science Facility (PSF)
PubMed DOI Crossref
Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Stsiapanava A, Olsson U, Wan M, ..., Rinaldo-Matthis A, Haeggström JZ
pmc PDB PDB PDB
Proc. Natl. Acad. Sci. U.S.A. 111 (11) 4227-4232 [2014-03-18; online 2014-03-05]
Advanced Mass Spectrometry Proteomics Protein Science Facility (PSF)
PubMed DOI Crossref
Epitope-specific antibody response is controlled by immunoglobulin V(H) polymorphisms.
Raposo B, Dobritzsch D, Ge C, ..., Schneider G, Holmdahl R
pmc
J. Exp. Med. 211 (3) 405-411 [2014-03-10; online 2014-02-19]
Protein Science Facility (PSF)
PubMed DOI Crossref
ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.
Marteyn BS, Karimova G, Fenton AK, ..., Sansonetti PJ, Tang CM
pmc
MBio 5 (2) e00022-e00014 [2014-03-04; online 2014-03-04]
Protein Science Facility (PSF)
PubMed DOI Crossref
Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.
Niegowski D, Kleinschmidt T, Olsson U, ..., Rinaldo-Matthis A, Haeggström JZ
pmc PDB PDB PDB PDB PDB
J. Biol. Chem. 289 (8) 5199-5207 [2014-02-21; online 2013-12-25]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.
Mellroth P, Sandalova T, Kikhney A, ..., Henriques-Normark B, Achour A
pmc
MBio 5 (1) e01120-e01113 [2014-02-11; online 2014-02-11]
Protein Science Facility (PSF)
PubMed DOI Crossref
Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Stsiapanava A, Tholander F, Kumar RB, ..., Haeggström JZ, Rinaldo-Matthis A
Biochim. Biophys. Acta 1844 (2) 439-446 [2014-02-00; online 2013-12-18]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for binding of fluorinated glucose and galactose to Trametes multicolor pyranose 2-oxidase variants with improved galactose conversion.
Tan TC, Spadiut O, Gandini R, Haltrich D, Divne C
pmc
PLoS ONE 9 (1) e86736 [2014-01-21; online 2014-01-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.
Schulte T, Löfling J, Mikaelsson C, ..., Henriques-Normark B, Achour A
pmc PDB PDB
Open Biol 4 (-) 130090 [2014-01-15; online 2014-01-15]
Protein Science Facility (PSF)
PubMed DOI Crossref
RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function.
Böth D, Steiner EM, Izumi A, Schneider G, Schnell R
Biochem. J. 457 (1) 33-41 [2014-01-01; online 2013-10-11]
Protein Science Facility (PSF)

Year 2013

PubMed DOI Crossref
Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.
Lindgren AE, Karlberg T, Ekblad T, ..., Schüler H, Elofsson M
PDB PDB PDB PDB PDB PDB PDB PDB
J. Med. Chem. 56 (23) 9556-9568 [2013-12-12; online 2013-11-06]
Protein Science Facility (PSF)
PubMed DOI Crossref
Substrate specificity and oligomerization of human GMP synthetase.
Welin M, Lehtiö L, Johansson A, ..., Gräslund S, Nordlund P
PDB
J. Mol. Biol. 425 (22) 4323-4333 [2013-11-15; online 2013-07-03]
Protein Science Facility (PSF)
PubMed DOI Crossref
Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa.
Cukier CD, Hope AG, Elamin AA, ..., Gray DW, Schneider G
pmc
ACS Chem. Biol. 8 (11) 2518-2527 [2013-11-15; online 2013-09-11]
Protein Science Facility (PSF)
PubMed DOI Crossref
Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms.
Quistgaard EM, Löw C, Moberg P, Nordlund P
J. Struct. Biol. 184 (2) 375-378 [2013-11-00; online 2013-09-26]
Protein Science Facility (PSF)
PubMed DOI Crossref
Nanobody mediated crystallization of an archeal mechanosensitive channel.
Löw C, Yau YH, Pardon E, ..., Steyaert J, Nordlund P
pmc
PLoS ONE 8 (10) e77984 [2013-10-21; online 2013-10-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural insights into substrate recognition in proton-dependent oligopeptide transporters.
Guettou F, Quistgaard EM, Trésaugues L, ..., Nordlund P, Löw C
pmc PDB
EMBO Rep. 14 (9) 804-810 [2013-09-00; online 2013-07-23]
Protein Science Facility (PSF)
PubMed DOI Crossref
PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
Lindgren AE, Karlberg T, Thorsell AG, ..., Elofsson M, Schüler H
PDB PDB PDB PDB
ACS Chem. Biol. 8 (8) 1698-1703 [2013-08-16; online 2013-06-08]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31.
Quistgaard EM, Löw C, Moberg P, ..., Maddi K, Nordlund P
pmc PDB PDB
PLoS ONE 8 (8) e71111 [2013-08-13; online 2013-08-13]
Advanced Mass Spectrometry Proteomics Protein Science Facility (PSF)
PubMed DOI Crossref
High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation.
Anandapadamanaban M, Andresen C, Helander S, ..., Moche M, Sunnerhagen M
pmc mid PDB
Nat. Struct. Mol. Biol. 20 (8) 1008-1014 [2013-08-00; online 2013-07-16]
Protein Science Facility (PSF)
PubMed DOI Crossref
Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides.
Ducani C, Kaul C, Moche M, Shih WM, Högberg B
pmc mid PDB
Nat. Methods 10 (7) 647-652 [2013-07-00; online 2013-06-04]
Protein Science Facility (PSF)
PubMed DOI Crossref
The crystal structure of the lumenal domain of Erv41p, a protein involved in transport between the endoplasmic reticulum and Golgi apparatus.
Biterova EI, Svärd M, Possner DD, Guy JE
PDB
J. Mol. Biol. 425 (12) 2208-2218 [2013-06-26; online 2013-03-26]
Protein Science Facility (PSF)
PubMed DOI Crossref
Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.
Chen MW, Lohkamp B, Schnell R, Lescar J, Schneider G
pmc
PLoS ONE 8 (6) e66936 [2013-06-21; online 2013-06-21]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.
Lim SM, Chen D, Teo H, ..., Pervushin K, Nordlund P
pmc
J. Lipid Res. 54 (6) 1630-1643 [2013-06-00; online 2013-03-26]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Quistgaard EM, Löw C, Moberg P, Trésaugues L, Nordlund P
PDB PDB
Nat. Struct. Mol. Biol. 20 (6) 766-768 [2013-06-00; online 2013-04-30]
Protein Science Facility (PSF)
PubMed DOI Crossref
Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.
Forst AH, Karlberg T, Herzog N, ..., Schüler H, Lüscher B
PDB PDB PDB PDB PDB PDB PDB
Structure 21 (3) 462-475 [2013-03-05; online 2013-03-12]
Protein Science Facility (PSF)
PubMed DOI Crossref
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
Böth D, Steiner EM, Stadler D, ..., Schnell R, Schneider G
pmc PDB PDB
Acta Crystallogr. D Biol. Crystallogr. 69 (Pt 3) 432-441 [2013-03-00; online 2013-02-16]
Protein Science Facility (PSF)

Year 2012

PubMed DOI Crossref
Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.
Allerbring EB, Duru AD, Uchtenhagen H, ..., Nygren PÅ, Achour A
PDB PDB
Eur. J. Immunol. 42 (11) 2990-3000 [2012-11-00; online 2012-07-28]
Protein Science Facility (PSF)
PubMed DOI Crossref
High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA.
Quistgaard EM, Nordlund P, Löw C
PDB
FASEB J. 26 (10) 4003-4013 [2012-10-00; online 2012-06-28]
Protein Science Facility (PSF)
PubMed DOI Crossref
Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening
Andersson CD, Karlberg T, Ekblad T, ..., Schüler H, Linusson A
PDB PDB PDB
J. Med. Chem. 55 (17) 7706-7718 [2012-09-13; online 2012-09-13]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF)
PubMed DOI Crossref
Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex.
Madhurantakam C, Duru AD, Sandalova T, Webb JR, Achour A
pmc
PLoS ONE 7 (3) e32805 [2012-03-14; online 2012-03-14]
Protein Science Facility (PSF)
PubMed DOI Crossref
Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion.
Schnell R, Oehlmann W, Sandalova T, ..., Singh M, Schneider G
pmc PDB PDB PDB PDB
PLoS ONE 7 (2) e31133 [2012-02-16; online 2012-02-16]
Protein Science Facility (PSF)
PubMed DOI Crossref
High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.
Willander H, Askarieh G, Landreh M, ..., Knight SD, Johansson J
pmc PDB
Proc. Natl. Acad. Sci. U.S.A. 109 (7) 2325-2329 [2012-02-14; online 2012-02-07]
Protein Science Facility (PSF)
Software 3.3.5