Protein Science Facility (PSF)

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Page BDG, Valerie NCK, ..., Beato M, Helleday T

Nat Commun 9 (1) - [2018-12-00; online 2018-01-17]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

Karlberg T, Hornyak P, ..., Björkegren C, Schüler H

Nat Commun 9 (1) - [2018-12-00; online 2018-09-17]

STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions

Desroses M, Busker S, ..., Grandér D, Page BDG

Journal of Pharmaceutical and Biomedical Analysis 160 (-) 80-88 [2018-10-00; online 2018-10-00]

A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant.

Rozman Grinberg I, Lundin D, ..., Hofer A, Sjöberg BM

J. Biol. Chem. - (-) - [2018-08-30; online 2018-08-30]

Structural basis of cross-reactivity of anti-citrullinated protein antibodies

Ge C, Xu B, ..., Dobritzsch D, Holmdahl R

Arthritis Rheumatol - (-) - [2018-08-27; online 2018-08-27]

Autoimmunity Profiling [Service] Protein Science Facility (PSF) [Service]

BtsCI and BseGI display sequence preference in the nucleotides flanking the recognition sequence

Rosa J, Fernandez-Gonzalez E, Ducani C, Högberg B

PLoS ONE 13 (8) e0202057 [2018-08-17; online 2018-08-17]

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Haapaniemi E, Botla S, ..., Schmierer B, Taipale J

Nat Med - (-) - [2018-06-11; online 2018-06-11]

High-throughput Genome Engineering (HTGE) [Collaborative] Protein Science Facility (PSF) [Service]

Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14

Holechek J, Lease R, ..., Schüler H, Ferraris D

Bioorganic & Medicinal Chemistry Letters 28 (11) 2050-2054 [2018-06-00; online 2018-06-00]

The structure of the N-terminal module of the cell wall hydrolase RipA and its role in regulating catalytic activity.

Steiner EM, Lyngsø J, ..., Schneider G, Schnell R

Proteins - (-) - [2018-05-02; online 2018-05-02]

Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.

Gustafsson R, Zhang S, ..., Dong M, Stenmark P

Toxins (Basel) 10 (4) - [2018-04-12; online 2018-04-12]

Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.

Morgunova E, Yin Y, ..., Nilsson L, Taipale J

Elife 7 (-) - [2018-04-11; online 2018-04-11]

Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol

Ekblad T, Verheugd P, ..., Elofsson M, Schüler H

SLAS DISCOVERY: Advancing Life Sciences R&D 23 (4) 353-362 [2018-04-00; online 2018-01-09]

Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF) [Collaborative]

Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in

Han X, Sun R, Sandalova T, Achour A

Open Biol 8 (4) - [2018-04-00; online 2018-04-20]

The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.

Hafstrand I, Doorduijn EM, ..., van Hall T, Achour A

J. Immunol. - (-) - [2018-03-05; online 2018-03-05]

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

Stafford WC, Peng X, ..., Linder S, Arnér ESJ

Sci Transl Med 10 (428) - [2018-02-14; online 2018-02-16]

Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.

Rozman Grinberg I, Lundin D, ..., Logan DT, Sjöberg BM

Elife 7 (-) - [2018-02-01; online 2018-02-01]

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold

Carter M, Jemth AS, ..., Helleday T, Stenmark P

Structure 26 (2) 295-303.e6 [2018-02-00; online 2018-02-00]

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

Narwal M, Jemth AS, ..., Helleday T, Stenmark P

Biochemistry - (-) - [2018-01-16; online 2018-01-16]

Year 2017

Structural basis for dolichylphosphate mannose biosynthesis

Gandini R, Reichenbach T, Tan TC, Divne C

Nat Commun 8 (1) - [2017-12-00; online 2017-07-25]

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

Carreras-Puigvert J, Zitnik M, ..., Zupan B, Helleday T

Nat Commun 8 (1) - [2017-12-00; online 2017-11-16]

Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Lehmann LC, Hewitt G, ..., Boulton SJ, Deindl S

Molecular Cell 68 (5) 847-859.e7 [2017-12-00; online 2017-12-00]

Cryo-EM [Service] Protein Science Facility (PSF) [Service]

Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance

Petrus P, Bialesova L, ..., Gao H, Rydén M

- - (-) - [2017-11-07; online 2017-11-07]

Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.

Kumar R, Moche M, Winblad B, Pavlov PF

Sci Rep 7 (1) 14288 [2017-10-27; online 2017-10-27]

Protein Science Facility (PSF) [Collaborative]

Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX type gene cluster.

Gustafsson R, Berntsson RP, ..., Johnson EA, Stenmark P

FEBS Lett. - (-) - [2017-10-25; online 2017-10-25]

Entirely enzymatic nanofabrication of DNA–protein conjugates

Bernardinelli G, Högberg B

Nucleic Acids Res 45 (18) e160-e160 [2017-10-13; online 2017-08-16]

Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis

Brunner K, Steiner EM, ..., Schnell R, Schneider G

Bioorganic & Medicinal Chemistry Letters 27 (19) 4582-4587 [2017-10-00; online 2017-10-00]

Capturing LTA4hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4synthesis

Stsiapanava A, Samuelsson B, Haeggström JZ

Proc Natl Acad Sci USA 114 (36) 9689-9694 [2017-09-05; online 2017-08-21]

Mucin-Inspired Lubrication on Hydrophobic Surfaces

Käsdorf BT, Weber F, ..., Crouzier T, Lieleg O

Biomacromolecules 18 (8) 2454-2462 [2017-08-14; online 2017-07-03]

Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase

Mittal M, Hasan M, ..., Haeggström JZ, Rinaldo-Matthis A

Biochimica et Biophysica Acta (BBA) - General Subjects 1861 (8) 2099-2111 [2017-08-00; online 2017-08-00]

Biophysical characterization of the calmodulin-like domain of Plasmodium falciparum calcium dependent protein kinase 3

Andresen C, Niklasson M, ..., Wallner B, Lundström P

PLoS ONE 12 (7) e0181721 [2017-07-26; online 2017-07-26]

Protein Science Facility (PSF) [Service] Swedish NMR Centre (SNC) [Service]

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.

Ge C, Tong D, ..., Dobritzsch D, Holmdahl R

JCI Insight 2 (13) - [2017-07-06; online 2017-07-06]

Autoimmunity Profiling [Service] Protein Science Facility (PSF) [Service]

Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14

Upton K, Meyers M, ..., Schüler H, Ferraris D

Bioorganic & Medicinal Chemistry Letters 27 (13) 2907-2911 [2017-07-00; online 2017-07-00]

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yin Y, Morgunova E, ..., Vinson C, Taipale J

Science 356 (6337) eaaj2239 [2017-05-05; online 2017-05-04]

SnoN Stabilizes the SMAD3/SMAD4 Protein Complex

Walldén K, Nyman T, Hällberg BM

Sci Rep 7 (-) 46370 [2017-04-11; online 2017-04-11]

Protein Science Facility (PSF) [Collaborative]

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

B. Kumar R, Zhu L, Hebert H, Jegerschöld C

J Vis Exp - (121) - [2017-03-05; online 2017-03-05]

Binding and processing of β-lactam antibiotics by the transpeptidase LdtMt2fromMycobacterium tuberculosis

Steiner EM, Schneider G, Schnell R

FEBS J 284 (5) 725-741 [2017-03-00; online 2017-02-08]

Characterization of the Ruler Protein Interaction Interface on the Substrate Specificity Switch Protein in theYersiniaType III Secretion System

Ho O, Rogne P, ..., Login FH, Wolf-Watz M

J. Biol. Chem. 292 (8) 3299-3311 [2017-02-24; online 2016-12-30]

Protein Science Facility (PSF) [Service] Swedish NMR Centre (SNC) [Service]

Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors

Thorsell AG, Ekblad T, ..., Cohen MS, Schüler H

J. Med. Chem. 60 (4) 1262-1271 [2017-02-23; online 2016-12-21]

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

Herold N, Rudd SG, ..., Helleday T, Schaller T

Nat Med 23 (2) 256-263 [2017-01-09; online 2017-01-09]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

Small Molecule Microarray Based Discovery of PARP14 Inhibitors

Peng B, Thorsell AG, ..., Schüler H, Yao SQ

Angew. Chem. Int. Ed. 56 (1) 248-253 [2017-01-02; online 2016-12-05]

Year 2016

A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.

Crona M, Codó P, ..., Fernandes AP, Tholander F

Mol Oncol 10 (9) 1375-1386 [2016-11-00; online 2016-07-26]

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice.

Lundbäck P, Lea JD, ..., Antoine DJ, Erlandsson Harris H

Hepatology 64 (5) 1699-1710 [2016-11-00; online 2016-09-01]

Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.

Säll A, Walle M, ..., Borrebaeck CAK, Persson H

Protein Eng. Des. Sel. 29 (10) 427-437 [2016-10-00; online 2016-09-01]

Drug Discovery and Development (DDD) [Technology development] Protein Science Facility (PSF) [Collaborative]

Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.

Quistgaard EM, Weininger U, ..., Akke M, Löw C

BMC Biol. 14 (1) 82 [2016-09-23; online 2016-09-23]

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.

Valerie NC, Hagenkort A, ..., Jemth AS, Helleday T

Cancer Res. 76 (18) 5501-5511 [2016-09-15; online 2016-08-16]

The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.

Schulte T, Mikaelsson C, ..., Nygren PÅ, Achour A

Sci Rep 6 (-) 32371 [2016-09-01; online 2016-09-01]

The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.

Sandalova T, Lee M, ..., Mellroth P, Achour A

Mol. Microbiol. 101 (6) 954-967 [2016-09-00; online 2016-07-05]

Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression.

Anandapadamanaban M, Pilstål R, ..., Wallner B, Sunnerhagen M

Structure 24 (8) 1311-1321 [2016-08-02; online 2016-07-14]

Protein Science Facility (PSF) [Collaborative]

Kinetic investigation of human 5-lipoxygenase with arachidonic acid.

Mittal M, Kumar RB, ..., Haeggström JZ, Rinaldo-Matthis A

Bioorg. Med. Chem. Lett. 26 (15) 3547-3551 [2016-08-01; online 2016-06-11]

Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.

Brunner K, Maric S, ..., Schnell R, Schneider G

J. Med. Chem. 59 (14) 6848-6859 [2016-07-28; online 2016-07-13]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.

Schulte T, Liu L, ..., Achour A, McInerney GM

Open Biol 6 (7) - [2016-07-00; online 2016-07-08]

Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.

Pinto AF, Ebrahimi M, ..., Elofsson M, Schüler H

J Biomol Screen 21 (6) 590-595 [2016-07-00; online 2016-02-05]

Coxsackievirus counters the host innate immune response by blocking type III interferon expression.

Lind K, Svedin E, ..., Moll M, Flodström-Tullberg M

J. Gen. Virol. 97 (6) 1-12 [2016-06-00; online 2016-03-02]

Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.

Siitonen V, Selvaraj B, ..., Schneider G, Metsä-Ketelä M

Proc. Natl. Acad. Sci. U.S.A. 113 (19) 5251-5256 [2016-05-10; online 2016-04-25]

Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.

Kouznetsova E, Kanno T, ..., Sjögren C, Schüler H

Structure 24 (5) 789-796 [2016-05-03; online 2016-04-21]

A saposin-lipoprotein nanoparticle system for membrane proteins.

Frauenfeld J, Löving R, ..., Cheng Y, Nordlund P

Nat. Methods 13 (4) 345-351 [2016-04-00; online 2016-03-07]

Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants.

Stellmacher L, Sandalova T, ..., Sprenger GA, Samland AK

Acta Crystallogr D Struct Biol 72 (Pt 4) 467-476 [2016-04-00; online 2016-03-24]

Engineering a thermostable Halothermothrix orenii β-glucosidase for improved galacto-oligosaccharide synthesis.

Hassan N, Geiger B, ..., Divne C, Tan TC

Appl. Microbiol. Biotechnol. 100 (8) 3533-3543 [2016-04-00; online 2015-12-02]

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.

Almqvist H, Axelsson H, ..., Lundbäck T, Nordlund P

Nat Commun 7 (-) 11040 [2016-03-24; online 2016-03-24]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.

Mills SJ, Silvander C, ..., Nordlund P, Potter BV

Biochemistry 55 (9) 1384-1397 [2016-03-08; online 2016-02-29]

The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.

Hafstrand I, Doorduijn EM, ..., van Hall T, Achour A

J. Immunol. 196 (5) 2327-2334 [2016-03-01; online 2016-01-22]

The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.

Lim SM, Yeung K, ..., Ling TH, Nordlund P

FEBS J. 283 (6) 1107-1123 [2016-03-00; online 2016-02-05]

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Llona-Minguez S, Höglund A, ..., Scobie M, Helleday T

J. Med. Chem. 59 (3) 1140-1148 [2016-02-11; online 2016-02-11]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]

Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa.

Jacewicz A, Schnell R, Lindqvist Y, Schneider G

Acta Crystallogr F Struct Biol Commun 72 (Pt 2) 105-111 [2016-02-00; online 2016-01-22]

A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.

Brock JS, Hamberg M, ..., Rinaldo-Matthis A, Haeggström JZ

Proc. Natl. Acad. Sci. U.S.A. 113 (4) 972-977 [2016-01-26; online 2016-01-11]

Year 2015

Exploring water as building bricks in enzyme engineering.

Hendil-Forssell P, Martinelle M, Syrén PO

Chem. Commun. (Camb.) 51 (97) 17221-17224 [2015-12-18; online 2015-10-02]

Structural insights into the DNA-binding specificity of E2F family transcription factors.

Morgunova E, Yin Y, ..., Nilsson L, Taipale J

Nat Commun 6 (-) 10050 [2015-12-03; online 2015-12-03]

Karolinska High Throughput Center (KHTC) Protein Science Facility (PSF)

DNA-dependent formation of transcription factor pairs alters their binding specificity.

Jolma A, Yin Y, ..., Morgunova E, Taipale J

Nature 527 (7578) 384-388 [2015-11-19; online 2015-11-10]

Karolinska High Throughput Center (KHTC) Protein Science Facility (PSF)

Acid-Base Catalyst Discriminates between a Fructose 6-Phosphate Aldolase and a Transaldolase

Stellmacher L, Sandalova T, ..., Sprenger GA, Samland AK

ChemCatChem 7 (19) 3140-3151 [2015-10-00; online 2015-08-06]

Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.

Ahmad S, Thulasingam M, ..., Haeggström JZ, Rinaldo-Matthis A

Biochim. Biophys. Acta 1854 (10 Pt A) 1365-1371 [2015-10-00; online 2015-06-13]

Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase.

Liu Q, Chai J, ..., Lindqvist Y, Shanklin J

Plant Physiol. 169 (1) 432-441 [2015-09-00; online 2015-08-01]

Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.

Possner DD, Claesson M, Guy JE

PLoS ONE 10 (8) e0136239 [2015-08-21; online 2015-08-21]

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.

Carter M, Jemth AS, ..., Helleday T, Stenmark P

Nat Commun 6 (-) 7871 [2015-08-04; online 2015-08-04]

Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.

Tan TC, Kracher D, ..., Ludwig R, Divne C

Nat Commun 6 (-) 7542 [2015-07-07; online 2015-07-07]

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

Trésaugues L, Lundbäck T, ..., Gräslund S, Nordlund P

PLoS ONE 10 (6) e0131507 [2015-06-29; online 2015-06-29]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF)

Structure of the nuclease subunit of human mitochondrial RNase P.

Reinhard L, Sridhara S, Hällberg BM

Nucleic Acids Res. 43 (11) 5664-5672 [2015-06-23; online 2015-05-09]

Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis

Poyraz Ö, Brunner K, ..., Schnell R, Schneider G

PLoS ONE 10 (3) e0121494 [2015-03-25; online 2015-03-25]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF)

Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.

Karlberg T, Klepsch M, ..., Linusson A, Schüler H

J. Biol. Chem. 290 (12) 7336-7344 [2015-03-20; online 2015-01-31]

High-resolution crystal structure of a polyextreme GH43 glycosidase from Halothermothrix orenii with α-L-arabinofuranosidase activity.

Hassan N, Kori LD, ..., Divne C, Tan TC

Acta Crystallogr F Struct Biol Commun 71 (Pt 3) 338-345 [2015-03-00; online 2015-02-19]

Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.

Schmidberger JW, Schnell R, Schneider G

Acta Crystallogr. D Biol. Crystallogr. 71 (Pt 3) 721-731 [2015-03-00; online 2015-02-26]

Biochemical and structural characterization of a thermostable β-glucosidase from Halothermothrix orenii for galacto-oligosaccharide synthesis.

Hassan N, Nguyen TH, ..., Divne C, Tan TC

Appl. Microbiol. Biotechnol. 99 (4) 1731-1744 [2015-02-00; online 2014-09-01]

Year 2014

A novel cytosolic NADH:quinone oxidoreductase fromMethanothermobacter marburgensis

Ullmann E, Tan TC, ..., Divne C, Spadiut O

Biosci. Rep. 34 (6) 893-904 [2014-12-23; online 2014-12-23]

Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.

Dobritzsch D, Wang H, Schneider G, Yu S

Biochem. J. 462 (3) 441-452 [2014-09-15; online 2014-06-21]

Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain.

Swarbrick CM, Roman N, ..., Lehtiö L, Forwood JK

J. Biol. Chem. 289 (35) 24263-24274 [2014-08-29; online 2014-07-09]

Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.

Guettou F, Quistgaard EM, ..., Löw C, Nordlund P

Nat. Struct. Mol. Biol. 21 (8) 728-731 [2014-08-00; online 2014-07-30]

Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family.

Pinto AF, Schüler H

Curr. Top. Microbiol. Immunol. 384 (-) 153-166 [2014-07-13; online 2014-07-13]

Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A.

Dovega R, Tsutakawa S, ..., Löw C, Nordlund P

PLoS ONE 9 (7) e101846 [2014-07-09; online 2014-07-09]

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.

Löw C, Quistgaard EM, ..., Balbach J, Nordlund P

Biol. Chem. 395 (7-8) 881-889 [2014-07-00; online 2014-07-09]

Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder

Ponnusamy R, Lebedev AA, Pahlow S, Lohkamp B

Acta Crystallogr. D Biol. Crystallogr. 70 (6) 1680-1694 [2014-06-01; online 2014-05-30]

Structure and inhibition of mouse leukotriene C4 synthase.

Niegowski D, Kleinschmidt T, ..., Rinaldo-Matthis A, Haeggström JZ

PLoS ONE 9 (5) e96763 [2014-05-08; online 2014-05-08]

Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF)

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

Trésaugues L, Silvander C, ..., Berglund H, Nordlund P

Structure 22 (5) 744-755 [2014-05-06; online 2014-04-08]

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H, Koolmeister T, ..., Berglund UW, Helleday T

Nature 508 (7495) 215-221 [2014-04-10; online 2014-04-02]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF)

Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.

Liscio P, Carotti A, ..., Pellicciari R, Camaioni E

J. Med. Chem. 57 (6) 2807-2812 [2014-03-27; online 2014-02-18]

Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.

Stsiapanava A, Olsson U, ..., Rinaldo-Matthis A, Haeggström JZ

Proc. Natl. Acad. Sci. U.S.A. 111 (11) 4227-4232 [2014-03-18; online 2014-03-05]

Advanced Mass Spectrometry Proteomics Protein Science Facility (PSF)

Epitope-specific antibody response is controlled by immunoglobulin V(H) polymorphisms.

Raposo B, Dobritzsch D, ..., Schneider G, Holmdahl R

J. Exp. Med. 211 (3) 405-411 [2014-03-10; online 2014-02-19]

ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.

Marteyn BS, Karimova G, ..., Sansonetti PJ, Tang CM

MBio 5 (2) e00022-e00014 [2014-03-04; online 2014-03-04]

Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.

Niegowski D, Kleinschmidt T, ..., Rinaldo-Matthis A, Haeggström JZ

J. Biol. Chem. 289 (8) 5199-5207 [2014-02-21; online 2013-12-25]

Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.

Mellroth P, Sandalova T, ..., Henriques-Normark B, Achour A

MBio 5 (1) e01120-e01113 [2014-02-11; online 2014-02-11]

Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.

Stsiapanava A, Tholander F, ..., Haeggström JZ, Rinaldo-Matthis A

Biochim. Biophys. Acta 1844 (2) 439-446 [2014-02-00; online 2013-12-18]

Structural basis for binding of fluorinated glucose and galactose to Trametes multicolor pyranose 2-oxidase variants with improved galactose conversion.

Tan TC, Spadiut O, ..., Haltrich D, Divne C

PLoS ONE 9 (1) e86736 [2014-01-21; online 2014-01-21]

The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.

Schulte T, Löfling J, ..., Henriques-Normark B, Achour A

Open Biol 4 (-) 130090 [2014-01-15; online 2014-01-15]

RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function.

Böth D, Steiner EM, ..., Schneider G, Schnell R

Biochem. J. 457 (1) 33-41 [2014-01-01; online 2013-10-11]

Year 2013

Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.

Lindgren AE, Karlberg T, ..., Schüler H, Elofsson M

J. Med. Chem. 56 (23) 9556-9568 [2013-12-12; online 2013-11-06]

Substrate specificity and oligomerization of human GMP synthetase.

Welin M, Lehtiö L, ..., Gräslund S, Nordlund P

J. Mol. Biol. 425 (22) 4323-4333 [2013-11-15; online 2013-07-03]

Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa.

Cukier CD, Hope AG, ..., Gray DW, Schneider G

ACS Chem. Biol. 8 (11) 2518-2527 [2013-11-15; online 2013-09-11]

Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms.

Quistgaard EM, Löw C, Moberg P, Nordlund P

J. Struct. Biol. 184 (2) 375-378 [2013-11-00; online 2013-09-26]

Nanobody mediated crystallization of an archeal mechanosensitive channel.

Löw C, Yau YH, ..., Steyaert J, Nordlund P

PLoS ONE 8 (10) e77984 [2013-10-21; online 2013-10-21]

Structural insights into substrate recognition in proton-dependent oligopeptide transporters.

Guettou F, Quistgaard EM, ..., Nordlund P, Löw C

EMBO Rep. 14 (9) 804-810 [2013-09-00; online 2013-07-23]

PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.

Lindgren AE, Karlberg T, ..., Elofsson M, Schüler H

ACS Chem. Biol. 8 (8) 1698-1703 [2013-08-16; online 2013-06-08]

Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31.

Quistgaard EM, Löw C, ..., Maddi K, Nordlund P

PLoS ONE 8 (8) e71111 [2013-08-13; online 2013-08-13]

Advanced Mass Spectrometry Proteomics Protein Science Facility (PSF)

High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation.

Anandapadamanaban M, Andresen C, ..., Moche M, Sunnerhagen M

Nat. Struct. Mol. Biol. 20 (8) 1008-1014 [2013-08-00; online 2013-07-16]

Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides.

Ducani C, Kaul C, ..., Shih WM, Högberg B

Nat. Methods 10 (7) 647-652 [2013-07-00; online 2013-06-04]

The crystal structure of the lumenal domain of Erv41p, a protein involved in transport between the endoplasmic reticulum and Golgi apparatus.

Biterova EI, Svärd M, Possner DD, Guy JE

J. Mol. Biol. 425 (12) 2208-2218 [2013-06-26; online 2013-03-26]

Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.

Chen MW, Lohkamp B, ..., Lescar J, Schneider G

PLoS ONE 8 (6) e66936 [2013-06-21; online 2013-06-21]

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.

Lim SM, Chen D, ..., Pervushin K, Nordlund P

J. Lipid Res. 54 (6) 1630-1643 [2013-06-00; online 2013-03-26]

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.

Quistgaard EM, Löw C, ..., Trésaugues L, Nordlund P

Nat. Struct. Mol. Biol. 20 (6) 766-768 [2013-06-00; online 2013-04-30]

Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.

Forst AH, Karlberg T, ..., Schüler H, Lüscher B

Structure 21 (3) 462-475 [2013-03-05; online 2013-03-12]

Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.

Böth D, Steiner EM, ..., Schnell R, Schneider G

Acta Crystallogr. D Biol. Crystallogr. 69 (Pt 3) 432-441 [2013-03-00; online 2013-02-16]

Year 2012

Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics.

Allerbring EB, Duru AD, ..., Nygren PÅ, Achour A

Eur. J. Immunol. 42 (11) 2990-3000 [2012-11-00; online 2012-07-28]

High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA.

Quistgaard EM, Nordlund P, Löw C

FASEB J. 26 (10) 4003-4013 [2012-10-00; online 2012-06-28]

Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening

Andersson CD, Karlberg T, ..., Schüler H, Linusson A

J. Med. Chem. 55 (17) 7706-7718 [2012-09-13; online 2012-09-13]

Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF)

Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex.

Madhurantakam C, Duru AD, ..., Webb JR, Achour A

PLoS ONE 7 (3) e32805 [2012-03-14; online 2012-03-14]

Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion.

Schnell R, Oehlmann W, ..., Singh M, Schneider G

PLoS ONE 7 (2) e31133 [2012-02-16; online 2012-02-16]

High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.

Willander H, Askarieh G, ..., Knight SD, Johansson J

Proc. Natl. Acad. Sci. U.S.A. 109 (7) 2325-2329 [2012-02-14; online 2012-02-07]