Protein Science Facility (PSF)

SciLifeLab Infrastructure Unit 2013–2020.

Started: 2013

Ended: 2020

146 publications

Year 2020

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, ..., Murrell B, McInerney GM
pii: 10.1038/s41467-020-18174-5 PDB: 6ZXN
Nat Commun 11 (1) 4420 [2020-09-04; online 2020-09-04]
Bioinformatics Compute and Storage [Service] Protein Science Facility (PSF) [Service]
Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA.
Baronti L, Guzzetti I, Ebrahimi P, ..., Chen AA, Petzold K
pii: 10.1038/s41586-020-2336-3
Nature 583 (7814) 139-144 [2020-07-00; online 2020-05-27]
Protein Science Facility (PSF) [Service]
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS
pii: RA120.012636 PDB: 6QVO
J. Biol. Chem. - (-) - [2020-03-06; online 2020-03-06]
Protein Science Facility (PSF) [Service]

Year 2019

Year 2018

Cotranslational Folding of a Pentarepeat β-Helix Protein.
Notari L, Martínez-Carranza M, Farías-Rico JA, Stenmark P, von Heijne G
pii: S0022-2836(18)30737-X PDB: 6FLS
J. Mol. Biol. 430 (24) 5196-5206 [2018-12-07; online 2018-10-27]
Protein Science Facility (PSF) [Service]
Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
Spåhr H, Chia T, Lingford JP, ..., Filipovska A, Rackham O
Nat Commun 9 (1) - [2018-12-00; online 2018-06-07]
Protein Science Facility (PSF) [Service]
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
Stafford WC, Peng X, Olofsson MH, ..., Linder S, Arnér ESJ
pii: 10/428/eaaf7444
Sci Transl Med 10 (428) - [2018-02-14; online 2018-02-16]
Protein Science Facility (PSF) [Service]
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold
Carter M, Jemth AS, Carreras-Puigvert J, ..., Helleday T, Stenmark P
Structure 26 (2) 295-303.e6 [2018-02-00; online 2018-02-00]
Protein Science Facility (PSF) [Service]

Year 2017

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
Lehmann LC, Hewitt G, Aibara S, ..., Boulton SJ, Deindl S
Molecular Cell 68 (5) 847-859.e7 [2017-12-00; online 2017-12-00]
Cryo-EM [Service] Protein Science Facility (PSF) [Service]
Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX type gene cluster.
Gustafsson R, Berntsson RP, Martínez-Carranza M, ..., Johnson EA, Stenmark P
FEBS Lett. - (-) - [2017-10-25; online 2017-10-25]
Protein Science Facility (PSF) [Service]
Mucin-Inspired Lubrication on Hydrophobic Surfaces
Käsdorf BT, Weber F, Petrou G, ..., Crouzier T, Lieleg O
Biomacromolecules 18 (8) 2454-2462 [2017-08-14; online 2017-07-03]
Protein Science Facility (PSF) [Service]
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yin Y, Morgunova E, Jolma A, ..., Vinson C, Taipale J
Science 356 (6337) eaaj2239 [2017-05-05; online 2017-05-04]
Protein Science Facility (PSF) [Service]
Small Molecule Microarray Based Discovery of PARP14 Inhibitors
Peng B, Thorsell AG, Karlberg T, Schüler H, Yao SQ
Angew. Chem. Int. Ed. 56 (1) 248-253 [2017-01-02; online 2016-12-05]
Protein Science Facility (PSF) [Service]

Year 2016

A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity.
Crona M, Codó P, Jonna VR, ..., Fernandes AP, Tholander F
pii: S1574-7891(16)30068-0
Mol Oncol 10 (9) 1375-1386 [2016-11-00; online 2016-07-26]
Protein Science Facility (PSF) [Service]
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Valerie NC, Hagenkort A, Page BD, ..., Jemth AS, Helleday T
pii: 0008-5472.CAN-16-0584
Cancer Res. 76 (18) 5501-5511 [2016-09-15; online 2016-08-16]
Protein Science Facility (PSF) [Service]
Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression.
Anandapadamanaban M, Pilstål R, Andresen C, ..., Wallner B, Sunnerhagen M
pii: S0969-2126(16)30133-2
Structure 24 (8) 1311-1321 [2016-08-02; online 2016-07-14]
Protein Science Facility (PSF) [Collaborative]
Kinetic investigation of human 5-lipoxygenase with arachidonic acid.
Mittal M, Kumar RB, Balagunaseelan N, ..., Haeggström JZ, Rinaldo-Matthis A
pii: S0960-894X(16)30636-9
Bioorg. Med. Chem. Lett. 26 (15) 3547-3551 [2016-08-01; online 2016-06-11]
Protein Science Facility (PSF) [Service]
Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity.
Pinto AF, Ebrahimi M, Saleeb M, ..., Elofsson M, Schüler H
pii: 1087057116629923
J Biomol Screen 21 (6) 590-595 [2016-07-00; online 2016-02-05]
Protein Science Facility (PSF) [Service]
Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.
Kouznetsova E, Kanno T, Karlberg T, ..., Sjögren C, Schüler H
pii: S0969-2126(16)30032-6
Structure 24 (5) 789-796 [2016-05-03; online 2016-04-21]
Protein Science Facility (PSF) [Service]
A saposin-lipoprotein nanoparticle system for membrane proteins.
Frauenfeld J, Löving R, Armache JP, ..., Cheng Y, Nordlund P
Nat. Methods 13 (4) 345-351 [2016-04-00; online 2016-03-07]
Protein Science Facility (PSF) [Service]
A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.
Brock JS, Hamberg M, Balagunaseelan N, ..., Rinaldo-Matthis A, Haeggström JZ
pii: 1522891113 pmc: PMC4743789
Proc. Natl. Acad. Sci. U.S.A. 113 (4) 972-977 [2016-01-26; online 2016-01-11]
Protein Science Facility (PSF) [Service]

Year 2015

Exploring water as building bricks in enzyme engineering.
Hendil-Forssell P, Martinelle M, Syrén PO
Chem. Commun. (Camb.) 51 (97) 17221-17224 [2015-12-18; online 2015-10-02]
Protein Science Facility (PSF)
Acid-Base Catalyst Discriminates between a Fructose 6-Phosphate Aldolase and a Transaldolase
Stellmacher L, Sandalova T, Leptihn S, ..., Sprenger GA, Samland AK
ChemCatChem 7 (19) 3140-3151 [2015-10-00; online 2015-08-06]
Protein Science Facility (PSF)
Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.
Ahmad S, Thulasingam M, Palombo I, ..., Haeggström JZ, Rinaldo-Matthis A
pii: S1570-9639(15)00169-7
Biochim. Biophys. Acta 1854 (10 Pt A) 1365-1371 [2015-10-00; online 2015-06-13]
Protein Science Facility (PSF)
Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase.
Liu Q, Chai J, Moche M, ..., Lindqvist Y, Shanklin J
pii: pp.15.00622 pmc: PMC4577402
Plant Physiol. 169 (1) 432-441 [2015-09-00; online 2015-08-01]
Protein Science Facility (PSF)
Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae.
Possner DD, Claesson M, Guy JE
pii: PONE-D-15-23020 pmc: PMC4546622
PLoS ONE 10 (8) e0136239 [2015-08-21; online 2015-08-21]
Protein Science Facility (PSF)

Year 2014

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
Löw C, Quistgaard EM, Kovermann M, ..., Balbach J, Nordlund P
pii: /j/bchm.2014.395.issue-7-8/hsz-2014-0106/hsz-2014-0106.xml PDB: 4NY3
Biol. Chem. 395 (7-8) 881-889 [2014-07-00; online 2014-07-09]
Protein Science Facility (PSF)
Structure and inhibition of mouse leukotriene C4 synthase.
Niegowski D, Kleinschmidt T, Ahmad S, ..., Rinaldo-Matthis A, Haeggström JZ
pii: PONE-D-14-10371 pmc: PMC4014545
PLoS ONE 9 (5) e96763 [2014-05-08; online 2014-05-08]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF)
Epitope-specific antibody response is controlled by immunoglobulin V(H) polymorphisms.
Raposo B, Dobritzsch D, Ge C, ..., Schneider G, Holmdahl R
pii: jem.20130968 pmc: PMC3949579
J. Exp. Med. 211 (3) 405-411 [2014-03-10; online 2014-02-19]
Protein Science Facility (PSF)
ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.
Marteyn BS, Karimova G, Fenton AK, ..., Sansonetti PJ, Tang CM
pii: mBio.00022-14 pmc: PMC3958796
MBio 5 (2) e00022-e00014 [2014-03-04; online 2014-03-04]
Protein Science Facility (PSF)
Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.
Mellroth P, Sandalova T, Kikhney A, ..., Henriques-Normark B, Achour A
pii: mBio.01120-13 pmc: PMC3950521
MBio 5 (1) e01120-e01113 [2014-02-11; online 2014-02-11]
Protein Science Facility (PSF)
Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.
Stsiapanava A, Tholander F, Kumar RB, ..., Haeggström JZ, Rinaldo-Matthis A
pii: S1570-9639(13)00425-1
Biochim. Biophys. Acta 1844 (2) 439-446 [2014-02-00; online 2013-12-18]
Protein Science Facility (PSF)

Year 2013

Substrate specificity and oligomerization of human GMP synthetase.
Welin M, Lehtiö L, Johansson A, ..., Gräslund S, Nordlund P
pii: S0022-2836(13)00427-0 PDB: 2VXO
J. Mol. Biol. 425 (22) 4323-4333 [2013-11-15; online 2013-07-03]
Protein Science Facility (PSF)
Nanobody mediated crystallization of an archeal mechanosensitive channel.
Löw C, Yau YH, Pardon E, ..., Steyaert J, Nordlund P
pii: PONE-D-13-33201 pmc: PMC3804602
PLoS ONE 8 (10) e77984 [2013-10-21; online 2013-10-21]
Protein Science Facility (PSF)
Structural insights into substrate recognition in proton-dependent oligopeptide transporters.
Guettou F, Quistgaard EM, Trésaugues L, ..., Nordlund P, Löw C
pii: embor2013107 pmc: PMC3790050 PDB: 4LEP
EMBO Rep. 14 (9) 804-810 [2013-09-00; online 2013-07-23]
Protein Science Facility (PSF)
Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates.
Chen MW, Lohkamp B, Schnell R, Lescar J, Schneider G
pii: PONE-D-13-09972 pmc: PMC3689657
PLoS ONE 8 (6) e66936 [2013-06-21; online 2013-06-21]
Protein Science Facility (PSF)

Year 2012