Spierings DCJ

Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma.

Karlsson J, Yasui H, Mañas A, ..., Bexell D, Gisselsson D

Nat Commun 15 (1) 8992 [2024-10-18; online 2024-10-18]

Clinical Genomics [Service] Clinical Genomics Lund [Service]

CDK4 is co-amplified with either TP53 promoter gene fusions or MDM2 through distinct mechanisms in osteosarcoma.

Saba KH, Difilippo V, Styring E, ..., Baumhoer D, Nord KH

npj Genom. Med. 9 (1) 42 [2024-09-25; online 2024-09-25]

Bioinformatics Support for Computational Resources [Service] NGI Long read [Service] NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]

MDM2 amplification in rod-shaped chromosomes provides clues to early stages of circularized gene amplification in liposarcoma.

Sydow S, Piccinelli P, Mitra S, ..., Spierings D, Mertens F

Commun Biol 7 (1) 606 [2024-05-20; online 2024-05-20]

Clinical Genomics [Service] Clinical Genomics Lund [Service] NGI Long read [Collaborative] NGI Uppsala (Uppsala Genome Center) [Collaborative] National Genomics Infrastructure [Collaborative]

Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia.

Woodward EL, Yang M, Moura-Castro LH, ..., Foijer F, Paulsson K

Nat Commun 14 (1) 1658 [2023-03-25; online 2023-03-25]

Clinical Genomics [Service] Clinical Genomics Lund [Service]

Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance.

Mañas A, Aaltonen K, Andersson N, ..., Gisselsson D, Bexell D

Sci Adv 8 (43) eabq4617 [2022-10-28; online 2022-10-28]

Clinical Genomics [Service] Clinical Genomics Lund [Service]

Extensive Clonal Branching Shapes the Evolutionary History of High-Risk Pediatric Cancers.

Andersson N, Bakker B, Karlsson J, ..., Foijer F, Gisselsson D

Cancer Res. 80 (7) 1512-1523 [2020-04-01; online 2020-02-10]

NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]