Ledin J

Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development.

Habicher J, Varshney GK, Waldmann L, ..., Burgess SM, Ledin J

PLoS Genet. 18 (2) e1010067 [2022-02-00; online 2022-02-22]

BioImage Informatics [Collaborative]

Heparan Sulfate Biosynthesis in Zebrafish.

Filipek-Górniok B, Habicher J, Ledin J, Kjellén L

J. Histochem. Cytochem. 69 (1) 49-60 [2021-01-00; online 2020-11-20]

Genome Engineering Zebrafish [Collaborative]

Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish.

Banote RK, Chebli J, Şatır TM, ..., Abramsson A, Zetterberg H

Sci Rep 10 (1) 10127 [2020-06-23; online 2020-06-23]

Genome Engineering Zebrafish [Collaborative] Integrated Microscopy Technologies Gothenburg [Service]

Zebrafish embryo as a replacement model for initial biocompatibility studies of biomaterials and drug delivery systems.

Rothenbücher TSP, Ledin J, Gibbs D, ..., Persson C, Hulsart-Billström G

Acta Biomater 100 (-) 235-243 [2019-12-00; online 2019-10-01]

Genome Engineering Zebrafish

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.

Morikawa M, Mitani Y, Holmborn K, ..., Heldin CH, Miyazono K

Sci Signal 12 (607) eaay4430 [2019-11-12; online 2019-11-12]

Genome Engineering Zebrafish [Collaborative]

TAF1, associated with intellectual disability in humans, is essential for embryogenesis and regulates neurodevelopmental processes in zebrafish.

Gudmundsson S, Wilbe M, Filipek-Górniok B, ..., Annerén G, Bondeson M

Sci Rep 9 (1) 10730 [2019-07-24; online 2019-07-24]

BioImage Informatics [Collaborative] Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service] Clinical Genomics Uppsala [Collaborative] Genome Engineering Zebrafish [Collaborative] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Zebrafish larvae as a model system for systematic characterization of drugs and genes in dyslipidemia and atherosclerosis

Bandaru MK, Emmanouilidou A, Ranefall P, ..., Ingelsson E, den Hoed M

- - (-) - [2018-12-20; online 2018-12-20]

Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service]

Large-scale validation of zebrafish larvae as a model system for genetic screens in dyslipidaemia, atherosclerosis and coronary artery disease

Bandaru M, Emmanouilidou A, Ranefall P, ..., Ingelsson E, den Hoed M

ASHG 2017 Annual Meeting - The American Society of Human Genetics - (-) - [2017-10-17; online 2017-10-17]

BioImage Informatics [Collaborative]

A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish.

Varshney GK, Carrington B, Pei W, ..., Sood R, Burgess SM

Nat Protoc 11 (12) 2357-2375 [2016-12-00; online 2016-10-27]

Genome Engineering Zebrafish [Technology development]

Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo.

Griffiths G, Müller F, Ledin J, ..., Press CM, Aleström P

Zebrafish 13 (2) 132-137 [2016-04-00; online 2016-02-09]

Genome Engineering Zebrafish [Collaborative]

CRISPRz: a database of zebrafish validated sgRNAs.

Varshney GK, Zhang S, Pei W, ..., Sood R, Burgess SM

Nucleic Acids Res. 44 (D1) D822-D826 [2016-01-04; online 2015-10-04]

Genome Engineering Zebrafish [Technology development]

Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis.

Hayes AJ, Reynolds S, Nowell MA, ..., Caterson B, Hammond CL

PLoS ONE 8 (9) e75787 [2013-09-24; online 2013-09-24]

Genome Engineering Zebrafish

Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development.

Filipek-Górniok B, Holmborn K, Haitina T, ..., Kreuger J, Ledin J

Dev. Dyn. 242 (8) 964-975 [2013-08-00; online 2013-06-18]

Genome Engineering Zebrafish

On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis.

Holmborn K, Habicher J, Kasza Z, ..., Kreuger J, Ledin J

J. Biol. Chem. 287 (40) 33905-33916 [2012-09-28; online 2012-08-06]

Genome Engineering Zebrafish