Estimation of linkage disequilibrium and interspecific gene flow in Ficedula flycatchers by a newly developed 50k single-nucleotide polymorphism array.

Kawakami T, Backström N, Burri R, Husby A, Olason P, Rice AM, Ålund M, Qvarnström A, Ellegren H

Mol Ecol Resour 14 (6) 1248-1260 [2014-11-00; online 2014-05-03]

With the access to draft genome sequence assemblies and whole-genome resequencing data from population samples, molecular ecology studies will be able to take truly genome-wide approaches. This now applies to an avian model system in ecological and evolutionary research: Old World flycatchers of the genus Ficedula, for which we recently obtained a 1.1 Gb collared flycatcher genome assembly and identified 13 million single-nucleotide polymorphism (SNP)s in population resequencing of this species and its sister species, pied flycatcher. Here, we developed a custom 50K Illumina iSelect flycatcher SNP array with markers covering 30 autosomes and the Z chromosome. Using a number of selection criteria for inclusion in the array, both genotyping success rate and polymorphism information content (mean marker heterozygosity = 0.41) were high. We used the array to assess linkage disequilibrium (LD) and hybridization in flycatchers. Linkage disequilibrium declined quickly to the background level at an average distance of 17 kb, but the extent of LD varied markedly within the genome and was more than 10-fold higher in 'genomic islands' of differentiation than in the rest of the genome. Genetic ancestry analysis identified 33 F1 hybrids but no later-generation hybrids from sympatric populations of collared flycatchers and pied flycatchers, contradicting earlier reports of backcrosses identified from much fewer number of markers. With an estimated divergence time as recently as <1 Ma, this suggests strong selection against F1 hybrids and unusually rapid evolution of reproductive incompatibility in an avian system.

NGI Uppsala (SNP&SEQ Technology Platform)

National Genomics Infrastructure

PubMed 24784959

DOI 10.1111/1755-0998.12270

Crossref 10.1111/1755-0998.12270

pmc: PMC4368375
dbSNP: SS_974710772
dbSNP: SS_974710773
dbSNP: SS_974710774
dbSNP: SS_974710775
dbSNP: SS_974710776
dbSNP: SS_974710777
dbSNP: SS_974710778
dbSNP: SS_974710779
dbSNP: SS_974710780
dbSNP: SS_974710781
dbSNP: SS_974710782
dbSNP: SS_974710783
dbSNP: SS_974710784
dbSNP: SS_974710785
dbSNP: SS_974710786
dbSNP: SS_974710787
dbSNP: SS_974710788
dbSNP: SS_974710789
dbSNP: SS_974710790
dbSNP: SS_974710791
dbSNP: SS_974710792
dbSNP: SS_974710793
dbSNP: SS_974710794
dbSNP: SS_974710795
dbSNP: SS_974710796
dbSNP: SS_974710797
dbSNP: SS_974710798
dbSNP: SS_974710799
dbSNP: SS_974710800
dbSNP: SS_974710801
dbSNP: SS_974710802
dbSNP: SS_974710803
dbSNP: SS_974710804
dbSNP: SS_974710805
dbSNP: SS_974710806
dbSNP: SS_974710807
dbSNP: SS_974710808
dbSNP: SS_974710809
dbSNP: SS_974710810
dbSNP: SS_974710811
dbSNP: SS_974710812
dbSNP: SS_974710813
dbSNP: SS_974710814
dbSNP: SS_974710815
dbSNP: SS_974710816
dbSNP: SS_974710817
dbSNP: SS_974710818
dbSNP: SS_974710819
dbSNP: SS_974710820
dbSNP: SS_974710821
dbSNP: SS_974710822
dbSNP: SS_974710823
dbSNP: SS_974710824
dbSNP: SS_974710825
dbSNP: SS_974710826
dbSNP: SS_974710827
dbSNP: SS_974710828
dbSNP: SS_974710829
dbSNP: SS_974710830
dbSNP: SS_974710831
dbSNP: SS_974710832
dbSNP: SS_974710833
dbSNP: SS_974710834
dbSNP: SS_974710835
dbSNP: SS_974710836
dbSNP: SS_974710837
dbSNP: SS_974710838
dbSNP: SS_974710839
dbSNP: SS_974710840
dbSNP: SS_974710841
dbSNP: SS_974710842
dbSNP: SS_974710843
dbSNP: SS_974710844
dbSNP: SS_974710845
dbSNP: SS_974710846
dbSNP: SS_974710847
dbSNP: SS_974710848
dbSNP: SS_974710849
dbSNP: SS_974710850
dbSNP: SS_974710851
dbSNP: SS_974710852
dbSNP: SS_974710853
dbSNP: SS_974710854
dbSNP: SS_974710855
dbSNP: SS_974710856
dbSNP: SS_974710857
dbSNP: SS_974710858
dbSNP: SS_974710859
dbSNP: SS_974710860
dbSNP: SS_974710861
dbSNP: SS_974710862
dbSNP: SS_974710863
dbSNP: SS_974710864
dbSNP: SS_974710865
dbSNP: SS_974710866
dbSNP: SS_974710867
dbSNP: SS_974710868
dbSNP: SS_974710869
dbSNP: SS_974710870
dbSNP: SS_974710871
dbSNP: SS_974710872
dbSNP: SS_974710873
dbSNP: SS_974710874
dbSNP: SS_974710875
dbSNP: SS_974710876
dbSNP: SS_974710877
dbSNP: SS_974710878
dbSNP: SS_974710879
dbSNP: SS_974710880
dbSNP: SS_974710881
dbSNP: SS_974710882
dbSNP: SS_974710883
dbSNP: SS_974710884
dbSNP: SS_974710885
dbSNP: SS_974710886
dbSNP: SS_974710887
dbSNP: SS_974710888
dbSNP: SS_974710889
dbSNP: SS_974710890
dbSNP: SS_974710891
dbSNP: SS_974710892
dbSNP: SS_974710893
dbSNP: SS_974710894
dbSNP: SS_974710895
dbSNP: SS_974710896
dbSNP: SS_974710897
dbSNP: SS_974710898
dbSNP: SS_974710899
dbSNP: SS_974710900
dbSNP: SS_974710901
dbSNP: SS_974710902
dbSNP: SS_974710903
dbSNP: SS_974710904
dbSNP: SS_974710905
dbSNP: SS_974710906
dbSNP: SS_974710907
dbSNP: SS_974710908
dbSNP: SS_974710909
dbSNP: SS_974710910
dbSNP: SS_974710911
dbSNP: SS_974710912
dbSNP: SS_974710913
dbSNP: SS_974710914
dbSNP: SS_974710915
dbSNP: SS_974710916
dbSNP: SS_974710917
dbSNP: SS_974710918
dbSNP: SS_974710919
dbSNP: SS_974710920
dbSNP: SS_974710921
dbSNP: SS_974710922
dbSNP: SS_974710923
dbSNP: SS_974710924
dbSNP: SS_974710925
dbSNP: SS_974710926
dbSNP: SS_974710927
dbSNP: SS_974710928
dbSNP: SS_974710929
dbSNP: SS_974710930
dbSNP: SS_974710931
dbSNP: SS_974710932
dbSNP: SS_974710933
dbSNP: SS_974710934
dbSNP: SS_974710935
dbSNP: SS_974710936
dbSNP: SS_974710937
dbSNP: SS_974710938
dbSNP: SS_974710939
dbSNP: SS_974710940
dbSNP: SS_974710941
dbSNP: SS_974710942
dbSNP: SS_974710943
dbSNP: SS_974710944
dbSNP: SS_974710945
dbSNP: SS_974710946
dbSNP: SS_974710947
dbSNP: SS_974710948
dbSNP: SS_974710949
dbSNP: SS_974710950
dbSNP: SS_974710951
dbSNP: SS_974710952
dbSNP: SS_974710953
dbSNP: SS_974710954
dbSNP: SS_974710955
dbSNP: SS_974710956
dbSNP: SS_974710957
dbSNP: SS_974710958
dbSNP: SS_974710959
dbSNP: SS_974710960
dbSNP: SS_974710961
dbSNP: SS_974710962
dbSNP: SS_974710963
dbSNP: SS_974710964
dbSNP: SS_974710965
dbSNP: SS_974710966
dbSNP: SS_974710967
dbSNP: SS_974710968
dbSNP: SS_974710969
dbSNP: SS_974710970
dbSNP: SS_974710971
dbSNP: SS_974710972
dbSNP: SS_974710973
dbSNP: SS_974710974
dbSNP: SS_974710975
dbSNP: SS_974710976
dbSNP: SS_974710977
dbSNP: SS_974710978
dbSNP: SS_974710979
dbSNP: SS_974710980
dbSNP: SS_974710981
dbSNP: SS_974710982
dbSNP: SS_974710983
dbSNP: SS_974710984
dbSNP: SS_974710985
dbSNP: SS_974710986
dbSNP: SS_974710987
dbSNP: SS_974710988
dbSNP: SS_974710989
dbSNP: SS_974710990
dbSNP: SS_974710991
dbSNP: SS_974710992
dbSNP: SS_974710993
dbSNP: SS_974710994
dbSNP: SS_974710995
dbSNP: SS_974710996
dbSNP: SS_974710997
dbSNP: SS_974710998
dbSNP: SS_974710999
dbSNP: SS_974711000
dbSNP: SS_974711001
dbSNP: SS_974711002
dbSNP: SS_974711003
dbSNP: SS_974711004
dbSNP: SS_974711005
dbSNP: SS_974711006
dbSNP: SS_974711007
dbSNP: SS_974711008
dbSNP: SS_974711009
dbSNP: SS_974711010
dbSNP: SS_974711011
dbSNP: SS_974711012
dbSNP: SS_974711013
dbSNP: SS_974711014
dbSNP: SS_974711015
dbSNP: SS_974711016
dbSNP: SS_974711017
dbSNP: SS_974711018
dbSNP: SS_974711019
dbSNP: SS_974711020
dbSNP: SS_974711021
dbSNP: SS_974711022
dbSNP: SS_974711023
dbSNP: SS_974711024
dbSNP: SS_974711025
dbSNP: SS_974711026
dbSNP: SS_974711027
dbSNP: SS_974711028
dbSNP: SS_974711029
dbSNP: SS_974711030
dbSNP: SS_974711031
dbSNP: SS_974711032
dbSNP: SS_974711033
dbSNP: SS_974711034
dbSNP: SS_974711035
dbSNP: SS_974711036
dbSNP: SS_974711037
dbSNP: SS_974711038
dbSNP: SS_974711039
dbSNP: SS_974711040
dbSNP: SS_974711041
dbSNP: SS_974711042
dbSNP: SS_974711043
dbSNP: SS_974711044
dbSNP: SS_974711045
dbSNP: SS_974711046
dbSNP: SS_974711047
dbSNP: SS_974711048
dbSNP: SS_974711049
dbSNP: SS_974711050
dbSNP: SS_974711051
dbSNP: SS_974711052
dbSNP: SS_974711053
dbSNP: SS_974711054
dbSNP: SS_974711055
dbSNP: SS_974711056
dbSNP: SS_974711057
dbSNP: SS_974711058
dbSNP: SS_974711059
dbSNP: SS_974711060
dbSNP: SS_974711061
dbSNP: SS_974711062
dbSNP: SS_974711063
dbSNP: SS_974711064
dbSNP: SS_974711065
dbSNP: SS_974711066
dbSNP: SS_974711067
dbSNP: SS_974711068
dbSNP: SS_974711069
dbSNP: SS_974711070
dbSNP: SS_974711071
dbSNP: SS_974711072
dbSNP: SS_974711073
dbSNP: SS_974711074
dbSNP: SS_974711075
dbSNP: SS_974711076
dbSNP: SS_974711077
dbSNP: SS_974711078
dbSNP: SS_974711079
dbSNP: SS_974711080
dbSNP: SS_974711081
dbSNP: SS_974711082
dbSNP: SS_974711083
dbSNP: SS_974711084
dbSNP: SS_974711085
dbSNP: SS_974711086
dbSNP: SS_974711087
dbSNP: SS_974711088
dbSNP: SS_974711089
dbSNP: SS_974711090
dbSNP: SS_974711091
dbSNP: SS_974711092
dbSNP: SS_974711093
dbSNP: SS_974711094
dbSNP: SS_974711095
dbSNP: SS_974711096
dbSNP: SS_974711097
dbSNP: SS_974711098
dbSNP: SS_974711099
dbSNP: SS_974711100
dbSNP: SS_974711101
dbSNP: SS_974711102
dbSNP: SS_974711103
dbSNP: SS_974711104
dbSNP: SS_974711105
dbSNP: SS_974711106
dbSNP: SS_974711107
dbSNP: SS_974711108
dbSNP: SS_974711109
dbSNP: SS_974711110
dbSNP: SS_974711111
dbSNP: SS_974711112
dbSNP: SS_974711113
dbSNP: SS_974711114
dbSNP: SS_974711115
dbSNP: SS_974711116
dbSNP: SS_974711117
dbSNP: SS_974711118
dbSNP: SS_974711119
dbSNP: SS_974711120
dbSNP: SS_974711121
dbSNP: SS_974711122
dbSNP: SS_974711123
dbSNP: SS_974711124
dbSNP: SS_974711125
dbSNP: SS_974711126
dbSNP: SS_974711127
dbSNP: SS_974711128
dbSNP: SS_974711129
dbSNP: SS_974711130
dbSNP: SS_974711131
dbSNP: SS_974711132
dbSNP: SS_974711133
dbSNP: SS_974711134
dbSNP: SS_974711135
dbSNP: SS_974711136
dbSNP: SS_974711137
dbSNP: SS_974711138
dbSNP: SS_974711139
dbSNP: SS_974711140
dbSNP: SS_974711141
dbSNP: SS_974711142
dbSNP: SS_974711143
dbSNP: SS_974711144
dbSNP: SS_974711145
dbSNP: SS_974711146
dbSNP: SS_974711147
dbSNP: SS_974711148
dbSNP: SS_974711149
dbSNP: SS_974711150
dbSNP: SS_974711151
dbSNP: SS_974711152
dbSNP: SS_974711153
dbSNP: SS_974711154
dbSNP: SS_974711155
dbSNP: SS_974711156
dbSNP: SS_974711157
dbSNP: SS_974711158
dbSNP: SS_974711159
dbSNP: SS_974711160
dbSNP: SS_974711161
dbSNP: SS_974711162
dbSNP: SS_974711163
dbSNP: SS_974711164
dbSNP: SS_974711165
dbSNP: SS_974711166
dbSNP: SS_974711167
dbSNP: SS_974711168
dbSNP: SS_974711169
dbSNP: SS_974711170
dbSNP: SS_974711171
dbSNP: SS_974711172
dbSNP: SS_974711173
dbSNP: SS_974711174
dbSNP: SS_974711175
dbSNP: SS_974711176
dbSNP: SS_974711177
dbSNP: SS_974711178
dbSNP: SS_974711179
dbSNP: SS_974711180
dbSNP: SS_974711181
dbSNP: SS_974711182
dbSNP: SS_974711183
dbSNP: SS_974711184
dbSNP: SS_974711185
dbSNP: SS_974711186
dbSNP: SS_974711187
dbSNP: SS_974711188
dbSNP: SS_974711189
dbSNP: SS_974711190
dbSNP: SS_974711191
dbSNP: SS_974711192
dbSNP: SS_974711193
dbSNP: SS_974711194
dbSNP: SS_974711195
dbSNP: SS_974711196
dbSNP: SS_974711197
dbSNP: SS_974711198
dbSNP: SS_974711199
dbSNP: SS_974711200
dbSNP: SS_974711201
dbSNP: SS_974711202
dbSNP: SS_974711203
dbSNP: SS_974711204
dbSNP: SS_974711205
dbSNP: SS_974711206
dbSNP: SS_974711207
dbSNP: SS_974711208
dbSNP: SS_974711209
dbSNP: SS_974711210
dbSNP: SS_974711211
dbSNP: SS_974711212
dbSNP: SS_974711213
dbSNP: SS_974711214
dbSNP: SS_974711215
dbSNP: SS_974711216
dbSNP: SS_974711217
dbSNP: SS_974711218
dbSNP: SS_974711219
dbSNP: SS_974711220
dbSNP: SS_974711221
dbSNP: SS_974711222
dbSNP: SS_974711223
dbSNP: SS_974711224
dbSNP: SS_974711225
dbSNP: SS_974711226
dbSNP: SS_974711227
dbSNP: SS_974711228
dbSNP: SS_974711229
dbSNP: SS_974711230
dbSNP: SS_974711231
dbSNP: SS_974711232
dbSNP: SS_974711233
dbSNP: SS_974711234
dbSNP: SS_974711235
dbSNP: SS_974711236
dbSNP: SS_974711237
dbSNP: SS_974711238
dbSNP: SS_974711239
dbSNP: SS_974711240
dbSNP: SS_974711241
dbSNP: SS_974711242
dbSNP: SS_974711243
dbSNP: SS_974711244
dbSNP: SS_974711245
dbSNP: SS_974711246
dbSNP: SS_974711247
dbSNP: SS_974711248
dbSNP: SS_974711249
dbSNP: SS_974711250
dbSNP: SS_974711251
dbSNP: SS_974711252
dbSNP: SS_974711253
dbSNP: SS_974711254
dbSNP: SS_974711255
dbSNP: SS_974711256
dbSNP: SS_974711257
dbSNP: SS_974711258
dbSNP: SS_974711259
dbSNP: SS_974711260
dbSNP: SS_974711261
dbSNP: SS_974711262
dbSNP: SS_974711263
dbSNP: SS_974711264
dbSNP: SS_974711265
dbSNP: SS_974711266
dbSNP: SS_974711267
dbSNP: SS_974711268
dbSNP: SS_974711269
dbSNP: SS_974711270
dbSNP: SS_974711271
dbSNP: SS_974711272
dbSNP: SS_974711273
dbSNP: SS_974711274
dbSNP: SS_974711275
dbSNP: SS_974711276
dbSNP: SS_974711277
dbSNP: SS_974711278
dbSNP: SS_974711279
dbSNP: SS_974711280
dbSNP: SS_974711281
dbSNP: SS_974711282
dbSNP: SS_974711283
dbSNP: SS_974711284
dbSNP: SS_974711285
dbSNP: SS_974711286
dbSNP: SS_974711287
dbSNP: SS_974711288
dbSNP: SS_974711289
dbSNP: SS_974711290
dbSNP: SS_974711291
dbSNP: SS_974711292
dbSNP: SS_974711293
dbSNP: SS_974711294
dbSNP: SS_974711295
dbSNP: SS_974711296
dbSNP: SS_974711297
dbSNP: SS_974711298
dbSNP: SS_974711299
dbSNP: SS_974711300
dbSNP: SS_974711301
dbSNP: SS_974711302
dbSNP: SS_974711303
dbSNP: SS_974711304
dbSNP: SS_974711305
dbSNP: SS_974711306
dbSNP: SS_974711307
dbSNP: SS_974711308
dbSNP: SS_974711309
dbSNP: SS_974711310
dbSNP: SS_974711311
dbSNP: SS_974711312
dbSNP: SS_974711313
dbSNP: SS_974711314
dbSNP: SS_974711315
dbSNP: SS_974711316
dbSNP: SS_974711317
dbSNP: SS_974711318
dbSNP: SS_974711319
dbSNP: SS_974711320
dbSNP: SS_974711321
dbSNP: SS_974711322
dbSNP: SS_974711323
dbSNP: SS_974711324
dbSNP: SS_974711325
dbSNP: SS_974711326
dbSNP: SS_974711327
dbSNP: SS_974711328
dbSNP: SS_974711329
dbSNP: SS_974711330
dbSNP: SS_974711331
dbSNP: SS_974711332
dbSNP: SS_974711333
dbSNP: SS_974711334
dbSNP: SS_974711335
dbSNP: SS_974711336
dbSNP: SS_974711337
dbSNP: SS_974711338
dbSNP: SS_974711339
dbSNP: SS_974711340
dbSNP: SS_974711341
dbSNP: SS_974711342
dbSNP: SS_974711343
dbSNP: SS_974711344
dbSNP: SS_974711345
dbSNP: SS_974711346
dbSNP: SS_974711347
dbSNP: SS_974711348
dbSNP: SS_974711349
dbSNP: SS_974711350
dbSNP: SS_974711351
dbSNP: SS_974711352
dbSNP: SS_974711353
dbSNP: SS_974711354
dbSNP: SS_974711355
dbSNP: SS_974711356
dbSNP: SS_974711357
dbSNP: SS_974711358
dbSNP: SS_974711359
dbSNP: SS_974711360
dbSNP: SS_974711361
dbSNP: SS_974711362
dbSNP: SS_974711363
dbSNP: SS_974711364
dbSNP: SS_974711365
dbSNP: SS_974711366
dbSNP: SS_974711367
dbSNP: SS_974711368
dbSNP: SS_974711369
dbSNP: SS_974711370
dbSNP: SS_974711371
dbSNP: SS_974711372
dbSNP: SS_974711373
dbSNP: SS_974711374
dbSNP: SS_974711375
dbSNP: SS_974711376
dbSNP: SS_974711377
dbSNP: SS_974711378
dbSNP: SS_974711379
dbSNP: SS_974711380
dbSNP: SS_974711381
dbSNP: SS_974711382
dbSNP: SS_974711383
dbSNP: SS_974711384
dbSNP: SS_974711385
dbSNP: SS_974711386
dbSNP: SS_974711387
dbSNP: SS_974711388
dbSNP: SS_974711389
dbSNP: SS_974711390
dbSNP: SS_974711391
dbSNP: SS_974711392
dbSNP: SS_974711393
dbSNP: SS_974711394
dbSNP: SS_974711395
dbSNP: SS_974711396
dbSNP: SS_974711397
dbSNP: SS_974711398
dbSNP: SS_974711399
dbSNP: SS_974711400
dbSNP: SS_974711401
dbSNP: SS_974711402
dbSNP: SS_974711403
dbSNP: SS_974711404
dbSNP: SS_974711405
dbSNP: SS_974711406
dbSNP: SS_974711407
dbSNP: SS_974711408
dbSNP: SS_974711409
dbSNP: SS_974711410
dbSNP: SS_974711411
dbSNP: SS_974711412
dbSNP: SS_974711413
dbSNP: SS_974711414
dbSNP: SS_974711415
dbSNP: SS_974711416
dbSNP: SS_974711417
dbSNP: SS_974711418
dbSNP: SS_974711419
dbSNP: SS_974711420
dbSNP: SS_974711421
dbSNP: SS_974711422
dbSNP: SS_974711423
dbSNP: SS_974711424
dbSNP: SS_974711425
dbSNP: SS_974711426
dbSNP: SS_974711427
dbSNP: SS_974711428
dbSNP: SS_974711429
dbSNP: SS_974711430
dbSNP: SS_974711431
dbSNP: SS_974711432
dbSNP: SS_974711433
dbSNP: SS_974711434
dbSNP: SS_974711435
dbSNP: SS_974711436
dbSNP: SS_974711437
dbSNP: SS_974711438
dbSNP: SS_974711439
dbSNP: SS_974711440
dbSNP: SS_974711441
dbSNP: SS_974711442
dbSNP: SS_974711443
dbSNP: SS_974711444
dbSNP: SS_974711445
dbSNP: SS_974711446
dbSNP: SS_974711447
dbSNP: SS_974711448
dbSNP: SS_974711449
dbSNP: SS_974711450
dbSNP: SS_974711451
dbSNP: SS_974711452
dbSNP: SS_974711453
dbSNP: SS_974711454
dbSNP: SS_974711455
dbSNP: SS_974711456
dbSNP: SS_974711457
dbSNP: SS_974711458
dbSNP: SS_974711459
dbSNP: SS_974711460
dbSNP: SS_974711461
dbSNP: SS_974711462
dbSNP: SS_974711463
dbSNP: SS_974711464
dbSNP: SS_974711465
dbSNP: SS_974711466
dbSNP: SS_974711467
dbSNP: SS_974711468
dbSNP: SS_974711469
dbSNP: SS_974711470
dbSNP: SS_974711471
dbSNP: SS_974711472
dbSNP: SS_974711473
dbSNP: SS_974711474
dbSNP: SS_974711475
dbSNP: SS_974711476
dbSNP: SS_974711477
dbSNP: SS_974711478
dbSNP: SS_974711479
dbSNP: SS_974711480
dbSNP: SS_974711481
dbSNP: SS_974711482
dbSNP: SS_974711483
dbSNP: SS_974711484
dbSNP: SS_974711485
dbSNP: SS_974711486
dbSNP: SS_974711487
dbSNP: SS_974711488
dbSNP: SS_974711489
dbSNP: SS_974711490
dbSNP: SS_974711491
dbSNP: SS_974711492
dbSNP: SS_974711493
dbSNP: SS_974711494
dbSNP: SS_974711495
dbSNP: SS_974711496
dbSNP: SS_974711497
dbSNP: SS_974711498
dbSNP: SS_974711499
dbSNP: SS_974711500
dbSNP: SS_974711501
dbSNP: SS_974711502
dbSNP: SS_974711503
dbSNP: SS_974711504
dbSNP: SS_974711505
dbSNP: SS_974711506
dbSNP: SS_974711507
dbSNP: SS_974711508
dbSNP: SS_974711509
dbSNP: SS_974711510
dbSNP: SS_974711511
dbSNP: SS_974711512
dbSNP: SS_974711513
dbSNP: SS_974711514
dbSNP: SS_974711515
dbSNP: SS_974711516
dbSNP: SS_974711517
dbSNP: SS_974711518
dbSNP: SS_974711519
dbSNP: SS_974711520
dbSNP: SS_974711521
dbSNP: SS_974711522
dbSNP: SS_974711523
dbSNP: SS_974711524
dbSNP: SS_974711525
dbSNP: SS_974711526
dbSNP: SS_974711527
dbSNP: SS_974711528
dbSNP: SS_974711529
dbSNP: SS_974711530
dbSNP: SS_974711531
dbSNP: SS_974711532
dbSNP: SS_974711533
dbSNP: SS_974711534
dbSNP: SS_974711535
dbSNP: SS_974711536
dbSNP: SS_974711537
dbSNP: SS_974711538
dbSNP: SS_974711539
dbSNP: SS_974711540
dbSNP: SS_974711541
dbSNP: SS_974711542
dbSNP: SS_974711543
dbSNP: SS_974711544
dbSNP: SS_974711545
dbSNP: SS_974711546
dbSNP: SS_974711547
dbSNP: SS_974711548
dbSNP: SS_974711549
dbSNP: SS_974711550
dbSNP: SS_974711551
dbSNP: SS_974711552
dbSNP: SS_974711553
dbSNP: SS_974711554
dbSNP: SS_974711555
dbSNP: SS_974711556
dbSNP: SS_974711557
dbSNP: SS_974711558
dbSNP: SS_974711559
dbSNP: SS_974711560
dbSNP: SS_974711561
dbSNP: SS_974711562
dbSNP: SS_974711563
dbSNP: SS_974711564
dbSNP: SS_974711565
dbSNP: SS_974711566
dbSNP: SS_974711567
dbSNP: SS_974711568
dbSNP: SS_974711569
dbSNP: SS_974711570
dbSNP: SS_974711571
dbSNP: SS_974711572
dbSNP: SS_974711573
dbSNP: SS_974711574
dbSNP: SS_974711575
dbSNP: SS_974711576
dbSNP: SS_974711577
dbSNP: SS_974711578
dbSNP: SS_974711579
dbSNP: SS_974711580
dbSNP: SS_974711581
dbSNP: SS_974711582
dbSNP: SS_974711583
dbSNP: SS_974711584
dbSNP: SS_974711585
dbSNP: SS_974711586
dbSNP: SS_974711587
dbSNP: SS_974711588
dbSNP: SS_974711589
dbSNP: SS_974711590
dbSNP: SS_974711591
dbSNP: SS_974711592
dbSNP: SS_974711593
dbSNP: SS_974711594
dbSNP: SS_974711595
dbSNP: SS_974711596
dbSNP: SS_974711597
dbSNP: SS_974711598
dbSNP: SS_974711599
dbSNP: SS_974711600
dbSNP: SS_974711601
dbSNP: SS_974711602
dbSNP: SS_974711603
dbSNP: SS_974711604
dbSNP: SS_974711605
dbSNP: SS_974711606
dbSNP: SS_974711607
dbSNP: SS_974711608
dbSNP: SS_974711609
dbSNP: SS_974711610
dbSNP: SS_974711611
dbSNP: SS_974711612
dbSNP: SS_974711613
dbSNP: SS_974711614
dbSNP: SS_974711615
dbSNP: SS_974711616
dbSNP: SS_974711617
dbSNP: SS_974711618
dbSNP: SS_974711619
dbSNP: SS_974711620
dbSNP: SS_974711621
dbSNP: SS_974711622
dbSNP: SS_974711623
dbSNP: SS_974711624
dbSNP: SS_974711625
dbSNP: SS_974711626
dbSNP: SS_974711627
dbSNP: SS_974711628
dbSNP: SS_974711629
dbSNP: SS_974711630
dbSNP: SS_974711631
dbSNP: SS_974711632
dbSNP: SS_974711633
dbSNP: SS_974711634
dbSNP: SS_974711635
dbSNP: SS_974711636
dbSNP: SS_974711637
dbSNP: SS_974711638
dbSNP: SS_974711639
dbSNP: SS_974711640
dbSNP: SS_974711641
dbSNP: SS_974711642
dbSNP: SS_974711643
dbSNP: SS_974711644
dbSNP: SS_974711645
dbSNP: SS_974711646
dbSNP: SS_974711647
dbSNP: SS_974711648
dbSNP: SS_974711649
dbSNP: SS_974711650
dbSNP: SS_974711651
dbSNP: SS_974711652
dbSNP: SS_974711653
dbSNP: SS_974711654
dbSNP: SS_974711655
dbSNP: SS_974711656
dbSNP: SS_974711657
dbSNP: SS_974711658
dbSNP: SS_974711659
dbSNP: SS_974711660
dbSNP: SS_974711661
dbSNP: SS_974711662
dbSNP: SS_974711663
dbSNP: SS_974711664
dbSNP: SS_974711665
dbSNP: SS_974711666
dbSNP: SS_974711667
dbSNP: SS_974711668
dbSNP: SS_974711669
dbSNP: SS_974711670
dbSNP: SS_974711671
dbSNP: SS_974711672
dbSNP: SS_974711673
dbSNP: SS_974711674
dbSNP: SS_974711675
dbSNP: SS_974711676
dbSNP: SS_974711677
dbSNP: SS_974711678
dbSNP: SS_974711679
dbSNP: SS_974711680
dbSNP: SS_974711681
dbSNP: SS_974711682
dbSNP: SS_974711683
dbSNP: SS_974711684
dbSNP: SS_974711685
dbSNP: SS_974711686
dbSNP: SS_974711687
dbSNP: SS_974711688
dbSNP: SS_974711689
dbSNP: SS_974711690
dbSNP: SS_974711691
dbSNP: SS_974711692
dbSNP: SS_974711693
dbSNP: SS_974711694
dbSNP: SS_974711695
dbSNP: SS_974711696
dbSNP: SS_974711697
dbSNP: SS_974711698
dbSNP: SS_974711699
dbSNP: SS_974711700
dbSNP: SS_974711701
dbSNP: SS_974711702
dbSNP: SS_974711703
dbSNP: SS_974711704
dbSNP: SS_974711705
dbSNP: SS_974711706
dbSNP: SS_974711707
dbSNP: SS_974711708
dbSNP: SS_974711709
dbSNP: SS_974711710
dbSNP: SS_974711711
dbSNP: SS_974711712
dbSNP: SS_974711713
dbSNP: SS_974711714
dbSNP: SS_974711715
dbSNP: SS_974711716
dbSNP: SS_974711717
dbSNP: SS_974711718
dbSNP: SS_974711719
dbSNP: SS_974711720
dbSNP: SS_974711721
dbSNP: SS_974711722
dbSNP: SS_974711723
dbSNP: SS_974711724
dbSNP: SS_974711725
dbSNP: SS_974711726
dbSNP: SS_974711727
dbSNP: SS_974711728
dbSNP: SS_974711729
dbSNP: SS_974711730
dbSNP: SS_974711731
dbSNP: SS_974711732
dbSNP: SS_974711733
dbSNP: SS_974711734
dbSNP: SS_974711735
dbSNP: SS_974711736
dbSNP: SS_974711737
dbSNP: SS_974711738
dbSNP: SS_974711739
dbSNP: SS_974711740
dbSNP: SS_974711741
dbSNP: SS_974711742
dbSNP: SS_974711743
dbSNP: SS_974711744
dbSNP: SS_974711745
dbSNP: SS_974711746
dbSNP: SS_974711747
dbSNP: SS_974711748
dbSNP: SS_974711749
dbSNP: SS_974711750
dbSNP: SS_974711751
dbSNP: SS_974711752
dbSNP: SS_974711753
dbSNP: SS_974711754
dbSNP: SS_974711755
dbSNP: SS_974711756
dbSNP: SS_974711757
dbSNP: SS_974711758
dbSNP: SS_974711759
dbSNP: SS_974711760
dbSNP: SS_974711761
dbSNP: SS_974711762
dbSNP: SS_974711763
dbSNP: SS_974711764
dbSNP: SS_974711765
dbSNP: SS_974711766
dbSNP: SS_974711767
dbSNP: SS_974711768
dbSNP: SS_974711769
dbSNP: SS_974711770
dbSNP: SS_974711771