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Alaçamlı E, Naidoo T, Güler MN, Sağlıcan E, Aktürk Ş, Mapelli I, Vural KB, Somel M, Malmström H, Günther T
Genome Biol. 25 (1) 216 [2024-08-12; online 2024-08-12]
The advent of genome-wide ancient DNA analysis has revolutionized our understanding of prehistoric societies. However, studying biological relatedness in these groups requires tailored approaches due to the challenges of analyzing ancient DNA. READv2, an optimized Python3 implementation of the most widely used tool for this purpose, addresses these challenges while surpassing its predecessor in speed and accuracy. For sufficient amounts of data, it can classify up to third-degree relatedness and differentiate between the two types of first-degree relatedness, full siblings and parent-offspring. READv2 enables user-friendly, efficient, and nuanced analysis of biological relatedness, facilitating a deeper understanding of past social structures.
Ancient DNA [Technology development]
Bioinformatics Support for Computational Resources [Service]
PubMed 39135108
DOI 10.1186/s13059-024-03350-3
Crossref 10.1186/s13059-024-03350-3
pmc: PMC11318251
pii: 10.1186/s13059-024-03350-3