Liin SI

Two-step voltage-sensor activation of the human KV7.4 channel and effect of a deafness-associated mutation.

Nappi M, Frampton DJA, Kusay AS, ..., Taglialatela M, Pantazis A

Nat Commun 17 (1) - [2026-02-05; online 2026-02-05]

Clinical Genomics [Service] Clinical Genomics Linköping [Service]

Inhibitory effect of oestradiol on the cardiac KV7.1/KCNE1 channel is species dependent.

Linhart VA, Dauga L, Liin SI

Exp. Physiol. 111 (1) 54-68 [2026-01-00; online 2025-05-05]

Clinical Genomics [Service] Clinical Genomics Linköping [Service]

Synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG

Ottosson NE, Frampton DJA, Pipatpolkai T, ..., Gréen H, Liin SI

- - (-) - [2025-12-06; online 2025-12-06]

Chemical Biology Consortium Sweden [Collaborative]

Rescue of loss-of-function long QT syndrome-associated mutations in KV7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S).

Hiniesto-Iñigo I, Sridhar A, Louradour J, ..., Ottosson NE, Liin SI

British Journal of Pharmacology 182 (13) 2861-2877 [2025-07-00; online 2025-03-14]

Chemical Biology Consortium Sweden [Collaborative] Clinical Genomics [Service] Clinical Genomics Linköping [Service]

Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism.

Li P, Liu S, Wallerstein J, ..., Liin SI, Gourdon P

Nat. Struct. Mol. Biol. 32 (3) 491-501 [2025-03-00; online 2024-11-28]

Cryo-EM [Service]