Clinical Genomics Lund

Multiplex profiling of serum proteins in solution using barcoded antibody fragments and next generation sequencing

Brofelth M, Ekstrand AI, Gour S, ..., Axelsson U, Borrebaeck CAK

Commun Biol 3 (1) - [2020-12-00; online 2020-07-03]

Clonal competition within complex evolutionary hierarchies shapes AML over time

Sandén C, Lilljebjörn H, Orsmark Pietras C, ..., Ågerstam H, Fioretos T

Nat Commun 11 (1) - [2020-12-00; online 2020-02-05]

A dynamic mutational landscape associated with an inter‐regionally diverse immune response in malignant rhabdoid tumour

Yasui H, Valind A, Karlsson J, ..., Backman T, Gisselsson D

J. Pathol 252 (1) 22-28 [2020-09-00; online 2020-07-22]

13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking.

Yang M, Safavi S, Woodward EL, ..., Nord KH, Paulsson K

pii: 454973 pmc: PMC7498303

Blood 136 (8) 946-956 [2020-08-20; online 2020-05-10]

Recurrent Fusions Between YAP1 and KMT2A in Morphologically Distinct Neoplasms Within the Spectrum of Low-grade Fibromyxoid Sarcoma and Sclerosing Epithelioid Fibrosarcoma

Puls F, Agaimy A, Flucke U, ..., Arbajian E, Mertens F

Am. J. Surg. Pathol. 44 (5) 594-606 [2020-05-00; online 2020-05-00]

Bioinformatics Compute and Storage [Service] Clinical Genomics Lund [Service]

Genomic and transcriptomic features of dermatofibrosarcoma protuberans: Unusual chromosomal origin of the COL1A1-PDGFB fusion gene and synergistic effects of amplified regions in tumor development

Köster J, Arbajian E, Viklund B, ..., Mandahl N, Mertens F

Cancer Genet 241 (-) 34-41 [2020-02-00; online 2020-02-00]

Bioinformatics Compute and Storage [Service] Clinical Genomics Lund

Year 2019

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia

Yang M, Vesterlund M, Siavelis I, ..., Lehtiö J, Paulsson K

Nat Commun 10 (1) - [2019-12-00; online 2019-04-03]

Bioinformatics Compute and Storage [Service] Clinical Genomics Lund [Service] Proteogenomics [Technology development]

Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a distinct gene expression profile

Hofvander J, Puls F, Pillay N, ..., Nilsson J, Mertens F

J. Pathol 249 (4) 425-434 [2019-12-00; online 2019-08-27]

Bioinformatics Compute and Storage [Service] Clinical Genomics Lund [Service]

FLT3N676K drives acute myeloid leukemia in a xenograft model of KMT2A-MLLT3 leukemogenesis

Hyrenius-Wittsten A, Pilheden M, Falqués-Costa A, ..., Järås M, Hagström-Andersson AK

Leukemia 33 (9) 2310-2314 [2019-09-00; online 2019-04-05]

Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells

Li H, Lim HC, Zacharaki D, ..., Hansson J, Scheding S

Haematologica - (-) haematol.2019.216648 [2019-08-01; online 2019-08-01]

Gene fusion involving the insulin-like growth factor 1 receptor in an ALK-negative inflammatory myofibroblastic tumour

Piarulli G, Puls F, Wängberg B, ..., Arbajian E, Mertens F

Histopathology 74 (7) 1098-1102 [2019-06-00; online 2019-04-24]

Bioinformatics Compute and Storage [Service] Clinical Genomics Lund [Service]

A urinary extracellular vesicle microRNA biomarker discovery pipeline; from automated extracellular vesicle enrichment by acoustic trapping to microRNA sequencing

Ku A, Ravi N, Yang M, ..., Lilja H, Ceder Y

PLoS ONE 14 (5) e0217507 [2019-05-29; online 2019-05-29]

Year 2018

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.

Li JF, Dai YT, Lilljebjörn H, ..., Chen SJ, Huang JY

pii: 1814397115 pmc: PMC6294900

Proc. Natl. Acad. Sci. U.S.A. 115 (50) E11711-E11720 [2018-12-11; online 2018-11-28]

Convergent evolution of 11p allelic loss in multifocal Wilms tumors arising in WT1 mutation carriers.

Valind A, Wessman S, Pal N, ..., Sandstedt B, Gisselsson D

Pediatr Blood Cancer 65 (11) e27301 [2018-11-00; online 2018-07-03]

Neuroblastoma with flat genomic profile: a question of representativity?

Valind A, Öra I, Mertens F, Gisselsson D

BMJ Case Reports - (-) bcr-2018-225568 [2018-09-08; online 2018-09-08]

Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury.

Kapur R, Kim M, Rebetz J, ..., Speck ER, Semple JW

pii: bloodadvances.2018018903 pmc: PMC6039664

Blood Adv 2 (13) 1651-1663 [2018-07-10; online 2018-07-12]

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.

Roswall P, Bocci M, Bartoschek M, ..., Eriksson U, Pietras K

pii: nm.4494 pmc: PMC5896729 mid: EMS75725

Nat. Med. 24 (4) 463-473 [2018-05-00; online 2018-03-12]

Clinical Value of RNA Sequencing–Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network—Breast Initiative

Brueffer C, Vallon-Christersson J, Grabau D, ..., Borg Å, Saal LH

JCO Precision Oncology - (2) 1-18 [2018-03-00; online 2018-03-00]

Minimizing inequality in access to precision medicine in breast cancer by real-time population-based molecular analysis in the SCAN-B initiative.

Rydén L, Loman N, Larsson C, ..., Saal LH, Borg Å

Br J Surg 105 (2) e158-e168 [2018-01-00; online 2018-01-18]

Bioinformatics Compute and Storage [Service] Clinical Genomics Lund [Collaborative]

Year 2017

Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow.

Lazarevic V, Orsmark-Pietras C, Lilljebjörn H, ..., Juliusson G, Fioretos T

pii: blood-2017-07-793620

Blood - (-) - [2017-11-30; online 2017-11-30]

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia.

Lilljebjörn H, Fioretos T

pii: blood-2017-05-742643

Blood 130 (12) 1395-1401 [2017-09-21; online 2017-08-04]

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification

Karlsson A, Brunnström H, Micke P, ..., Planck M, Staaf J

Journal of Thoracic Oncology 12 (8) 1257-1267 [2017-08-00; online 2017-08-00]

Clinical Genomics Lund [Service] Clinical Genomics Uppsala [Collaborative]

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.

Davies H, Glodzik D, Morganella S, ..., Stratton MR, Nik-Zainal S

pii: nm.4292

Nat. Med. 23 (4) 517-525 [2017-04-00; online 2017-03-13]

Identification of two distinct mesenchymal stromal cell populations in human malignant glioma.

Svensson A, Ramos-Moreno T, Eberstål S, Scheding S, Bengzon J

pii: 10.1007/s11060-016-2302-y pmc: PMC5306185

J. Neurooncol. 131 (2) 245-254 [2017-01-00; online 2016-10-18]

Year 2016

Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.

Lilljebjörn H, Henningsson R, Hyrenius-Wittsten A, ..., Fontes M, Fioretos T

pii: ncomms11790 pmc: PMC4897744

Nat Commun 7 (-) 11790 [2016-06-06; online 2016-06-06]