The genomics of major psychiatric disorders in a large pedigree from Northern Sweden.

Szatkiewicz J, Crowley JJ, Adolfsson AN, Ã…berg KA, Alaerts M, Genovese G, McCarroll S, Del-Favero J, Adolfsson R, Sullivan PF

Transl Psychiatry 9 (1) 60 [2019-02-04; online 2019-02-04]

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.

Bioinformatics Compute and Storage [Service]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

National Genomics Infrastructure [Service]

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PubMed 30718465

DOI 10.1038/s41398-019-0414-9

Crossref 10.1038/s41398-019-0414-9

pii: 10.1038/s41398-019-0414-9
pmc: PMC6362018