Nordenfelt P

Antisense-mediated regulation of exon usage in the elastic spring region of Titin modulates sarcomere function.

Celik S, Hyrefelt L, Czuba T, ..., Smith JG, Gidlöf O

Cardiovasc. Res. - (-) - [2025-03-05; online 2025-03-05]

Bioinformatics (NBIS) [Collaborative] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative]

Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow

Gomez Toledo A, Chowdhury S, Hjortswang E, ..., Rasmussen M, Malmström J

Nat Commun 16 (1) - [2025-02-24; online 2025-02-24]

Structural Proteomics [Collaborative]

Protective Non-neutralizing anti-N-terminal Domain mAb Maintains Fc-mediated Function against SARS-COV-2 Variants up to BA.2.86-JN.1 with Superfluous In Vivo Protection against JN.1 Due to Attenuated Virulence.

Izadi A, Godzwon M, Söderlund Strand A, ..., Ohlin M, Nordenfelt P

J. Immunol. 213 (5) 678-689 [2024-09-01; online 2024-07-17]

Drug Discovery and Development (DDD) [Service]

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.

Izadi A, Karami Y, Bratanis E, ..., Malmström L, Nordenfelt P

Nat Commun 15 (1) 3600 [2024-04-27; online 2024-04-27]

Drug Discovery and Development (DDD) [Service]

Reply to Pandey: IgG3 allotypes, modulation of antigen binding by constant domain changes, and therapeutic applications of Fc engineering.

Izadi A, Bahnan W, Ohlin M, Nordenfelt P

Proc. Natl. Acad. Sci. U.S.A. 120 (22) e2306562120 [2023-05-30; online 2023-05-22]

Drug Discovery and Development (DDD) [Service]

Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization.

Izadi A, Hailu A, Godzwon M, ..., Bahnan W, Nordenfelt P

Proc. Natl. Acad. Sci. U.S.A. 120 (15) e2217590120 [2023-04-11; online 2023-04-03]

Drug Discovery and Development (DDD) [Service]

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function.

Bahnan W, Happonen L, Khakzad H, ..., Malmström J, Nordenfelt P

EMBO Mol Med 15 (2) e16208 [2023-02-08; online 2022-12-12]

Structural Proteomics [Collaborative]

Developmental cues license megakaryocyte priming in murine hematopoietic stem cells.

Kristiansen TA, Zhang Q, Vergani S, ..., Ungerbäck J, Yuan J

Blood Adv 6 (24) 6228-6241 [2022-12-27; online 2022-05-19]

Clinical Genomics [Service] Clinical Genomics Lund [Service]