Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells.

Karlsson IK, Ploner A, Wang Y, Gatz M, Pedersen NL, Hägg S

Epigenetics - (-) 1-5 [2022-12-26; online 2022-12-26]

Differences in gene-wide DNA methylation of the Alzheimer's disease (AD)-associated genes BIN1, HLA-DRB5, SORL1, SLC24A4, and ABCA7 are reported to be associated with AD in post-mortem brain samples. We investigated whether the same associations could be found in leukocytes collected pre-mortem. Using cohort data of 544 Swedish twins (204 dementia diagnoses), we replicated the findings in HLA-DRB5 and SLC24A4 at P < 0.05. However, co-twin control analyses indicated that the associations were partly explained by familial confounding. Thus, DNA methylation differences in HLA-DRB5 and SLC24A4 are present in both neuronal cells and leukocytes, and not fully explained familial factors.

NGI SNP genotyping [Service]

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

National Genomics Infrastructure [Service]

PubMed 36573011

DOI 10.1080/15592294.2022.2158285

Crossref 10.1080/15592294.2022.2158285

Publications 9.5.0