GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.

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Science 340 (6139) 1467-1471 [2013-06-21; online 2013-06-01]

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

NGI Uppsala (SNP&SEQ Technology Platform) [Service]

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PubMed 23722424

DOI 10.1126/science.1235488

Crossref 10.1126/science.1235488

mid NIHMS495960

science.1235488

pmc PMC3751588