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Jemth AS

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Family name Jemth
Given name Ann Sofie
Initials AS
ORCID

ORCID 0000-0002-7550-1833
Affiliations Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm S-171 21, Sweden

6 publications

PubMed DOI Crossref
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Green AC, Marttila P, Kiweler N, ..., Henriksson M, Meiser J
Nat Metab 5 (4) 642-659 [2023-04-00; online 2023-04-03]
Drug Discovery and Development (DDD) [Collaborative] Swedish Metabolomics Centre (SMC) [Collaborative]
PubMed DOI Crossref
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Bonagas N, Gustafsson NMS, Henriksson M, ..., Homan EJ, Helleday T
Nat Cancer 3 (2) 156-172 [2022-02-00; online 2022-02-28]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Škerlová J, Unterlass J, Göttmann M, ..., Jemth AS, Stenmark P
J. Biol. Chem. 295 (33) 11656-11668 [2020-08-14; online 2020-06-22]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS
J. Biol. Chem. 295 (15) 4761-4772 [2020-04-10; online 2020-03-06]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P
Biochemistry 58 (7) 887-899 [2019-02-19; online 2019-01-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Narwal M, Jemth AS, Gustafsson R, ..., Helleday T, Stenmark P
Biochemistry 57 (5) 593-603 [2018-02-06; online 2018-01-16]
Protein Science Facility (PSF) [Service]
SciLifeLab Data Centre
Publications 9.5.1