Happonen L

Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O

Tang D, Gueto-Tettay C, Hjortswang E, ..., Malmström L, Malmström J

Anal. Chem. 96 (22) 9060-9068 [2024-06-04; online 2024-05-03]

Structural Proteomics [Technology development]

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.

Izadi A, Karami Y, Bratanis E, ..., Malmström L, Nordenfelt P

Nat Commun 15 (1) 3600 [2024-04-27; online 2024-04-27]

Drug Discovery and Development (DDD) [Service]

Molecular view of ER membrane remodeling by the Sec61/TRAP translocon.

Karki S, Javanainen M, Rehan S, ..., Happonen L, Paavilainen V

EMBO Rep. - (-) e57910 [2023-11-20; online 2023-11-20]

Structural Proteomics [Collaborative]

Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation.

Chernyaeva L, Ratti G, Teirilä L, ..., Nissilä E, Haapasalo K

EMBO Rep. - (-) e56467 [2023-05-08; online 2023-05-08]

Structural Proteomics [Collaborative]

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function.

Bahnan W, Happonen L, Khakzad H, ..., Malmström J, Nordenfelt P

EMBO Mol Med 15 (2) e16208 [2023-02-08; online 2022-12-12]

Structural Proteomics [Collaborative]

Snapshots of actin and tubulin folding inside the TRiC chaperonin.

Kelly JJ, Tranter D, Pardon E, ..., Huiskonen JT, Yue WW

Nat. Struct. Mol. Biol. - (-) - [2022-04-21; online 2022-04-21]

Structural Proteomics [Collaborative]

The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.

Hasan M, Khakzad H, Happonen L, ..., Malmström A, Tykesson E

Chem. Sci. 12 (5) 1869-1885 [2021-02-07; online 2020-12-08]

Structural Proteomics [Collaborative]

Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology.

Khakzad H, Happonen L, Karami Y, ..., Malmström J, Malmström L

PLoS Comput. Biol. 17 (1) e1008169 [2021-01-00; online 2021-01-07]

Structural Proteomics [Collaborative]