Affinity Proteomics Uppsala

Development and validation of a quantitative Proximity Extension Assay instrument with 21 proteins associated with cardiovascular risk (CVD-21).

Siegbahn A, Eriksson N, Assarsson E, ..., Åberg M, Wallentin L

PLoS ONE 18 (11) e0293465 [2023-11-14; online 2023-11-14]

Comprehensive analyses of circulating cardiometabolic proteins and objective measures of fat mass.

Titova OE, Brunius C, Warensjö Lemming E, ..., Michaëlsson K, Larsson SC

Int J Obes (Lond) 47 (11) 1043-1049 [2023-11-00; online 2023-08-07]

In-depth immune profiling reveals advanced B- and T-cell differentiation to be associated with Th1-driven immune dysregulation in common variable immunodeficiency.

Hultberg J, Blixt E, Göransson R, ..., Ernerudh J, Nyström S

Clin. Immunol. 257 (-) 109816 [2023-10-31; online 2023-10-31]

Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis.

Åkesson J, Hojjati S, Hellberg S, ..., Ernerudh J, Gustafsson M

Nat Commun 14 (1) 6903 [2023-10-30; online 2023-10-30]

Affinity Proteomics Uppsala [Service] NGI Proteomics [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Mucosal and Serum Antibodies 3 Weeks after Symptomatic BA.2.86 Infection.

Bladh O, Greilert-Norin N, Havervall S, ..., Klingström J, Thålin C

N. Engl. J. Med. 389 (17) 1626-1628 [2023-10-26; online 2023-10-27]

Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients.

Sarén T, Ramachandran M, Gammelgård G, ..., Enblad G, Essand M

Clin. Cancer Res. 29 (20) 4139-4152 [2023-10-13; online 2023-08-04]

Affinity Proteomics Uppsala [Service] Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] NGI Short read [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome.

Angerfors A, Brännmark C, Lagging C, ..., Jern C, Stanne TM

J Neuroinflammation 20 (1) 224 [2023-10-04; online 2023-10-04]

Blom K, Fjällström P, Molnár C, ..., Forsell MNE, Johansson AF

Lancet Infect Dis 23 (10) e393-e394 [2023-10-00; online 2023-09-13]

Circulating soluble IL-6 receptor associates with plaque inflammation but not with atherosclerosis severity and cardiovascular risk.

Edsfeldt A, Gonçalves I, Vigren I, ..., Khan F, Nilsson J

Vascul Pharmacol 152 (-) 107214 [2023-10-00; online 2023-08-25]

Alterations in the Serum Proteome Following Electroconvulsive Therapy for a Major Depressive Episode: A Longitudinal Multicenter Study.

Göteson A, Clements CC, Juréus A, ..., Pålsson E, Landén M

Biol Psychiatry Glob Open Sci 3 (4) 884-892 [2023-10-00; online 2022-12-12]

Plasma type I collagen α1 chain in relation to coronary artery disease: findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden.

Hammaréus F, Nilsson L, Ong KL, ..., Holm Nielsen S, Jonasson L

BMJ Open 13 (9) e073561 [2023-09-15; online 2023-09-15]

Transforming growth factor-β2 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events.

Edsfeldt A, Singh P, Matthes F, ..., Sun J, Gonçalves I

Cardiovasc. Res. 119 (11) 2061-2073 [2023-09-05; online 2023-05-18]

The role of NLRP3 in regulating gingival epithelial cell responses evoked by Aggregatibacter actinomycetemcomitans.

Jayaprakash Demirel K, Wu R, Neves Guimaraes A, Demirel I

Cytokine 169 (-) 156316 [2023-09-00; online 2023-08-02]

Increased plasma levels of soluble programmed death ligand 1 (sPD-L1) and fibroblast growth factor 23 (FGF-23) in patients with Graves' ophthalmopathy in comparison to hyperthyroid patients without Graves' ophthalmopathy.

Khamisi S, Anders Karlsson F, Ljunggren Ö, Thulin M, Larsson A

Cytokine 169 (-) 156269 [2023-09-00; online 2023-06-10]

Systemic and mucosal adaptive immunity to SARS-CoV-2 during the Omicron wave in patients with chronic lymphocytic leukemia.

Ingelman-Sundberg HM, Blixt L, Wullimann D, ..., Buggert M, Österborg A

Haematologica - (-) - [2023-08-31; online 2023-08-31]

SARS-CoV-2 Antibodies in Commercial Immunoglobulin Products Show Markedly Reduced Cross-reactivities Against Omicron Variants.

Lindahl H, Chen P, Åberg M, ..., Smith CIE, Bergman P

J Clin Immunol 43 (6) 1075-1082 [2023-08-00; online 2023-04-14]

Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a one-year follow-up of the prospective clinical trial COVAXID.

Chen P, Bergman P, Blennow O, ..., Aleman S, Ljunggren H

EBioMedicine 94 (-) 104700 [2023-08-00; online 2023-07-13]

Mucosal IgA protects against BQ.1 and BQ.1.1 infection.

Marking U, Bladh O, Havervall S, ..., Klingström J, Thålin C

Lancet Infect Dis 23 (8) e272-e273 [2023-08-00; online 2023-07-12]

Local and Systemic Immunity During Five Vaccinations Against SARS-CoV-2 in Zanubrutinib-Treated Patients With Chronic Lymphocytic Leukemia.

Andersson M, Wu J, Wullimann D, ..., Ingelman-Sundberg HM, Osterborg A

J Hematol 12 (4) 170-175 [2023-08-00; online 2023-08-08]

A machine learning based approach to identify carotid subclinical atherosclerosis endotypes.

Chen QS, Bergman O, Ziegler L, ..., Gigante B, IMPROVE study group

Cardiovasc. Res. - (-) - [2023-07-21; online 2023-07-21]

Next generation pan-cancer blood proteome profiling using proximity extension assay.

Álvez MB, Edfors F, von Feilitzen K, ..., Fagerberg L, Uhlén M

Nat Commun 14 (1) 4308 [2023-07-18; online 2023-07-18]

Affinity Proteomics Uppsala [Collaborative] NGI Proteomics [Collaborative] NGI Uppsala (SNP&SEQ Technology Platform) [Collaborative] National Genomics Infrastructure [Collaborative]

Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease.

Davidsson P, Eketjäll S, Eriksson N, ..., White H, Wallentin L

Cardiovasc. Res. 119 (7) 1596-1605 [2023-07-04; online 2023-03-05]

Affinity Proteomics Uppsala [Service] NGI SNP genotyping [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis.

Yuan S, Li X, Liu Q, ..., Burgess S, Larsson SC

J Endocr Soc 7 (8) bvad090 [2023-07-03; online 2023-06-26]

Plasma levels of per- and polyfluoroalkyl substances (PFAS) are associated with altered levels of proteins previously linked to inflammation, metabolism and cardiovascular disease.

Dunder L, Salihovic S, Lind PM, Elmståhl S, Lind L

Environ Int 177 (-) 107979 [2023-07-00; online 2023-05-24]

Multiplex protein analysis and ensemble machine learning methods of fine needle aspirates from prostate cancer patients reveal potential diagnostic signatures associated with tumour grade.

Röbeck P, Franzén B, Cantera-Ahlman R, ..., Häggman M, Ladjevardi S

Cytopathology 34 (4) 286-294 [2023-07-00; online 2023-03-20]

Mucosal immune responses following a fourth SARS-CoV-2 vaccine dose.

Bladh O, Marking U, Havervall S, ..., Klingström J, Thålin C

Lancet Microbe 4 (7) e488 [2023-07-00; online 2023-04-20]

Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer.

Kerzeli IK, Kostakis A, Türker P, ..., Lord M, Mangsbo SM

BMC Cancer 23 (1) 605 [2023-06-30; online 2023-06-30]

Identification of potential biomarkers in active Lyme borreliosis.

Tjernberg I, Lager M, Furset Jensen G, ..., Brudin L, Henningsson AJ

PLoS ONE 18 (6) e0287586 [2023-06-26; online 2023-06-26]

Dysregulated peripheral proteome reveals NASH-specific signatures identifying patient subgroups with distinct liver biology.

Stiglund N, Hagström H, Stål P, Cornillet M, Björkström NK

Front Immunol 14 (-) 1186097 [2023-06-05; online 2023-06-05]

Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study.

Vikström L, Fjällström P, Gwon YD, ..., Johansson AF, Forsell MNE

Lancet Reg Health Eur 30 (-) 100646 [2023-05-06; online 2023-05-06]

Plasma protein and venous thromboembolism: prospective cohort and mendelian randomisation analyses.

Yuan S, Titova OE, Zhang K, ..., Damrauer SM, Larsson SC

Br. J. Haematol. 201 (4) 783-792 [2023-05-00; online 2023-02-02]

Extracellular Vesicle-Associated TWEAK Contributes to Vascular Inflammation and Remodeling During Acute Cellular Rejection.

Celik S, Sadrian J, Grossi M, ..., Smith JG, Gidlöf O

JACC Basic Transl Sci 8 (5) 439-456 [2023-05-00; online 2023-01-11]

Circulating proteins and peripheral artery disease risk: observational and Mendelian randomization analyses.

Yuan S, Titova OE, Zhang K, ..., VA Million Veteran Program , Larsson SC

Eur Heart J Open 3 (3) oead056 [2023-05-00; online 2023-05-30]

Characterization of the Mitochondrial Genetic Landscape in Abdominal Aortic Aneurysm.

Vats S, Sundquist K, Li Y, ..., Gottsäter A, Memon AA

J Am Heart Assoc 12 (8) e029248 [2023-04-18; online 2023-04-07]

Affinity Proteomics Uppsala [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative]

Trimethylamine N-Oxide (TMAO) Mediates Increased Inflammation and Colonization of Bladder Epithelial Cells during a Uropathogenic E. coli Infection In Vitro.

Wu R, Kumawat AK, Demirel I

Pathogens 12 (4) - [2023-03-27; online 2023-03-27]

Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers.

Marking U, Havervall S, Norin NG, ..., Klingström J, Thålin C

Nat Commun 14 (1) 1577 [2023-03-22; online 2023-03-22]

Affinity Proteomics Uppsala [Collaborative] Autoimmunity and Serology Profiling [Collaborative]

Cardiovascular disease-linked plasma proteins are mainly associated with lung volume.

Rydell A, Nerpin E, Zhou X, ..., Ärnlöv J, Malinovschi A

ERJ Open Res 9 (2) - [2023-03-00; online 2023-03-27]

Prognostic importance of biomarkers associated with haemostatic, vascular and endothelial disturbances in acute coronary syndrome patients in relation to kidney function.

Mörtberg J, Salzinger B, Lundwall K, ..., Lindahl B, Spaak J

Int. J. Cardiol. 373 (-) 64-71 [2023-02-15; online 2022-12-05]

Plasma levels of CCL21, but not CCL19, independently predict future coronary events in a prospective population-based cohort.

Katra P, Hennings V, Nilsson J, ..., Bengtsson E, Björkbacka H

Atherosclerosis 366 (-) 1-7 [2023-02-00; online 2023-01-12]

7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection.

Marking U, Bladh O, Havervall S, ..., Klingström J, Thålin C

Lancet Infect Dis 23 (2) 150-152 [2023-02-00; online 2023-01-11]

Starch intake, amylase gene copy number variation, plasma proteins, and risk of cardiovascular disease and mortality.

Li H, Borné Y, Wang Y, Sonestedt E

BMC Med 21 (1) 27 [2023-01-24; online 2023-01-24]

Exhaled phospholipid transfer protein and hepatocyte growth factor receptor in lung adenocarcinoma.

Andreasson J, Bodén E, Fakhro M, ..., Hallgren O, Lindstedt S

Respir. Res. 23 (1) 369 [2022-12-21; online 2022-12-21]

A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses.

Lenart K, Hellgren F, Ols S, ..., Petsch B, Loré K

Mol Ther Methods Clin Dev 27 (-) 309-323 [2022-12-08; online 2022-10-06]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service]

Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH.

Larsson SC, Michaëlsson K, Mola-Caminal M, Höijer J, Mantzoros CS

Metabolism 137 (-) 155329 [2022-12-00; online 2022-10-05]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] NGI SNP genotyping [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Plasma protein biomarker profiling reveals major differences between acute leukaemia, lymphoma patients and controls.

Abu Sabaa A, Shen Q, Lennmyr EB, ..., Enblad G, Eriksson A

N Biotechnol 71 (-) 21-29 [2022-11-25; online 2022-06-29]

Affinity Proteomics Uppsala [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative]

Mucosal IgA against SARS-CoV-2 Omicron Infection. Reply.

Åberg M, Smed-Sörensen A, Thålin C

N. Engl. J. Med. 387 (21) e55 [2022-11-24; online 2022-11-24]

Short and long-term associations between serum proteins linked to cardiovascular disease and particle exposure among constructions workers.

Gliga AR, Grahn K, Gustavsson P, ..., Selander J, Broberg K

Scand J Work Environ Health - (-) - [2022-11-21; online 2022-11-21]

Detection of SARS-CoV-2 antibodies in serum and dried blood spot samples of vaccinated individuals using a sensitive homogeneous proximity extension assay.

Zhao H, Wang M, Muthelo P, ..., Mei YF, Landegren U

N Biotechnol 72 (-) 139-148 [2022-11-21; online 2022-11-21]

Affinity Proteomics Uppsala [Technology development]

Plasma proteins from several components of the immune system differentiate chronic widespread pain patients from healthy controls - an exploratory case-control study combining targeted and non-targeted protein identification.

Gerdle B, Wåhlén K, Gordh T, ..., Carlsson A, Ghafouri B

Medicine 101 (46) e31013 [2022-11-18; online 2022-11-20]

Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.

Havervall S, Marking U, Svensson J, ..., Smed-Sörensen A, Thålin C

N. Engl. J. Med. 387 (14) 1333-1336 [2022-10-06; online 2022-09-14]

Affinity Proteomics Uppsala [Collaborative] Autoimmunity and Serology Profiling [Collaborative]

Biomarkers of demyelination and axonal damage are decreased after autologous hematopoietic stem cell transplantation for multiple sclerosis.

Zjukovskaja C, Larsson A, Cherif H, Kultima K, Burman J

Mult Scler Relat Disord 68 (-) 104210 [2022-10-03; online 2022-10-03]

Parvimonas micra is associated with tumour immune profiles in molecular subtypes of colorectal cancer.

Löwenmark T, Li X, Löfgren-Burström A, ..., Edin S, Palmqvist R

Cancer Immunol. Immunother. 71 (10) 2565-2575 [2022-10-00; online 2022-03-17]

Affinity Proteomics Uppsala [Service] Clinical Genomics Umeå [Service]

Generation of Human iPSC-Derived Astrocytes with a mature star-shaped phenotype for CNS modeling.

Voulgaris D, Nikolakopoulou P, Herland A

Stem Cell Rev Rep 18 (7) 2494-2512 [2022-10-00; online 2022-04-30]

Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air-liquid interface.

Rahman M, Irmler M, Introna M, ..., Upadhyay S, Ganguly K

Sci Rep 12 (1) 16396 [2022-09-30; online 2022-09-30]

Early Mid-pregnancy Blood-Based Proteins as Possible Biomarkers of Increased Infant Birth Size in Sex-Stratified Analyses.

Lindberger E, Ahlsson F, Junus K, ..., Wikström AK, Sundström Poromaa I

Reprod Sci - (-) 1-11 [2022-09-30; online 2022-09-30]

Proteins associated with future suicide attempts in bipolar disorder: A large-scale biomarker discovery study.

Sandberg JV, Hansson C, Göteson A, ..., Pålsson E, Landén M

Mol. Psychiatry 27 (9) 3857-3863 [2022-09-00; online 2022-06-13]

Effects of denosumab treatment on the expression of receptor activator of nuclear kappa-B ligand (RANKL) and TNF-receptor TNFRSF9 after total hip arthroplasty-results from a randomized placebo-controlled clinical trial.

Sköld C, Kultima K, Freyhult E, ..., Hailer NP, Mallmin H

Osteoporos Int 33 (9) 1-8 [2022-09-00; online 2022-05-24]

Cerebrospinal fluid proteomic study of two bipolar disorder cohorts.

Isgren A, Göteson A, Holmén-Larsson J, ..., Jakobsson J, Landén M

Mol. Psychiatry - (-) - [2022-08-19; online 2022-08-19]

Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity.

Ambikan AT, Yang H, Krishnan S, ..., Benfeitas R, Neogi U

Cell Syst 13 (8) 665-681.e4 [2022-08-17; online 2022-07-08]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Swedish Metabolomics Centre (SMC) [Service]

Plasma protein profiling reveals dynamic immunomodulatory changes in multiple sclerosis patients during pregnancy.

Papapavlou Lingehed G, Hellberg S, Huang J, ..., Olsson T, Ernerudh J

Front Immunol 13 (-) 930947 [2022-07-29; online 2022-07-29]

Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation.

Pol T, Hijazi Z, Lindbäck J, ..., Siegbahn A, Wallentin L

Cardiovasc. Res. 118 (9) 2112-2123 [2022-07-20; online 2021-08-07]

Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis.

Khan F, Gonçalves I, Shore AC, ..., Kozakova M, Nilsson J

Cell Reports Medicine 3 (7) 100676 [2022-07-19; online 2022-07-21]

Galectin-4 levels in hospitalized versus non-hospitalized subjects with obesity: the Malmö Preventive Project.

Korduner J, Holm H, Jujic A, ..., Olsen MH, Magnusson M

Cardiovasc Diabetol 21 (1) 125 [2022-07-02; online 2022-07-02]

Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection.

Blom K, Marking U, Havervall S, ..., Klingström J, Thålin C

Lancet Infect Dis 22 (7) 943-945 [2022-07-00; online 2022-06-09]

Affinity Proteomics Uppsala [Collaborative] Autoimmunity and Serology Profiling [Collaborative]

Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections.

Rosendal E, Mihai IS, Becker M, ..., Överby AK, Lenman A

MBio 13 (3) e0089222 [2022-06-28; online 2022-05-09]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Microbial Single Cell Genomics [Service]

Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome.

Christersson C, Baron T, Flachskampf F, ..., Lindahl B, Siegbahn A

J. of Cardiovasc. Trans. Res. - (-) - [2022-06-21; online 2022-06-21]

Applicability of polygenic risk scores in endometriosis clinical presentation.

Svensson A, Garcia-Etxebarria K, Åkesson A, ..., D'Amato M, Ohlsson B

BMC Womens Health 22 (1) 208 [2022-06-03; online 2022-06-03]

A breathing mask attenuates acute airway responses to exercise in sub-zero environment in healthy subjects.

Stenfors N, Persson H, Tutt A, ..., Ainegren M, Hanstock HG

Eur J Appl Physiol 122 (6) 1473-1484 [2022-06-00; online 2022-04-07]

Association between systemic inflammation and experimental pain sensitivity in subjects with pain and painless neuropathy after traumatic nerve injuries.

Miclescu AA, Granlund P, Butler S, Gordh T

Scand J Pain - (-) - [2022-05-09; online 2022-05-09]

Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab.

Tolf A, Wiberg A, Müller M, ..., Mangsbo S, Burman J

JAMA Netw Open 5 (5) e2211497 [2022-05-02; online 2022-05-02]

Hepatocyte growth factor, colony-stimulating factor 1, CD40, and 11 other inflammation-related proteins are associated with pain in diabetic neuropathy: exploration and replication serum data from the Pain in Neuropathy Study.

Bäckryd E, Themistocleous A, Larsson A, ..., Bennett DL, Gerdle B

Pain 163 (5) 897-909 [2022-05-01; online 2021-08-27]

Advances in the development of new biomarkers for Alzheimer's disease.

Klyucherev TO, Olszewski P, Shalimova AA, ..., Syvänen S, Schiöth HB

Transl Neurodegener 11 (1) 25 [2022-04-21; online 2022-04-21]

Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time.

Havervall S, Marking U, Greilert-Norin N, ..., Åberg M, Thålin C

Clin Transl Immunology 11 (4) e1388 [2022-04-18; online 2022-04-18]

Affinity Proteomics Uppsala [Collaborative] Autoimmunity and Serology Profiling [Collaborative]

Peripheral blood CD4+CCR6+ compartment differentiates HIV-1 infected or seropositive elite controllers from long-term successfully treated individuals.

Svensson Akusjärvi S, Krishnan S, Jütte BB, ..., Sönnerborg A, Neogi U

Commun Biol 5 (1) 357 [2022-04-13; online 2022-04-13]

Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.

Gyllensten U, Hedlund-Lindberg J, Svensson J, ..., Åberg M, Enroth S

Cancers (Basel) 14 (7) - [2022-03-30; online 2022-03-30]

Affinity Proteomics Uppsala [Collaborative] NGI Proteomics [Collaborative] NGI Uppsala (SNP&SEQ Technology Platform) [Collaborative] National Genomics Infrastructure [Collaborative]

Temporal patterns of inflammation-related proteins measured in the cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage using multiplex Proximity Extension Assay technology.

Vlachogiannis P, Hillered L, Enblad P, Ronne-Engström E

PLoS ONE 17 (3) e0263460 [2022-03-24; online 2022-03-24]

Periodontal Disease Augments Cardiovascular Disease Risk Biomarkers in Rheumatoid Arthritis.

Panezai J, Ghaffar A, Altamash M, ..., Larsson A, Engström PE

Biomedicines 10 (3) - [2022-03-19; online 2022-03-19]

Elevated mid-pregnancy plasma levels of angiotensin-converting enzyme 2 in women prior to the development of preeclampsia.

Junus K, Björk Ragnarsdóttir I, Nordlöf Callbo P, ..., Lager S, Wikström AK

Sci Rep 12 (1) 4109 [2022-03-08; online 2022-03-08]

Associations between biomarkers of multimorbidity burden and mortality risk among patients with acute dyspnea.

Wessman T, Tofik R, Ruge T, Melander O

Intern Emerg Med 17 (2) 559-567 [2022-03-00; online 2021-08-20]

Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines.

Marking U, Havervall S, Greilert-Norin N, ..., Åberg M, Thålin C

Vaccines (Basel) 10 (3) - [2022-02-24; online 2022-02-24]

Affinity Proteomics Uppsala [Collaborative] Autoimmunity and Serology Profiling [Collaborative]

A serum proteomic study of two case-control cohorts identifies novel biomarkers for bipolar disorder.

Göteson A, Isgren A, Sparding T, ..., Pålsson E, Landén M

Transl Psychiatry 12 (1) 55 [2022-02-08; online 2022-02-08]

The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli.

Lindblad A, Johansson C, Persson K, Demirel I

Sci Rep 12 (1) 2005 [2022-02-07; online 2022-02-07]

Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.

Havervall S, Ng H, Jernbom Falk A, ..., Hober S, Thålin C

J. Intern. Med. 291 (1) 72-80 [2022-01-00; online 2021-09-27]

Affinity Proteomics Uppsala [Service] Autoimmunity and Serology Profiling [Collaborative]

Fibroblast growth factor 23 is associated with risk of intracerebral hemorrhage.

Svensson EH, Söderholm M

Eur. J. Neurol. 29 (1) 114-120 [2022-01-00; online 2021-08-31]

Causal effects of inflammatory protein biomarkers on inflammatory diseases.

Ek WE, Karlsson T, Höglund J, Rask-Andersen M, Johansson Å

Sci Adv 7 (50) eabl4359 [2021-12-10; online 2021-12-08]

Differences in biomarker concentrations and predictions of long-term outcome in patients with ST-elevation and non-ST-elevation myocardial infarction.

Hjort M, Eggers KM, Lindhagen L, ..., Spaak J, Lindahl B

Clin. Biochem. 98 (-) 17-23 [2021-12-00; online 2021-09-05]

Cerebrospinal fluid proteomics targeted for central nervous system processes in bipolar disorder.

Göteson A, Isgren A, Jonsson L, ..., Holmén-Larsson J, Landén M

Mol. Psychiatry 26 (12) 7446-7453 [2021-12-00; online 2021-08-04]

Proteins associated with incident metabolic syndrome in population-based cohorts.

Lind L, Sundström J, Ärnlöv J

Diabetol Metab Syndr 13 (1) 131 [2021-11-10; online 2021-11-10]

Elevated circulating follistatin associates with an increased risk of type 2 diabetes.

Wu C, Borné Y, Gao R, ..., Groop L, De Marinis Y

Nat Commun 12 (1) 6486 [2021-11-10; online 2021-11-10]

Affinity Proteomics Stockholm [Collaborative] Affinity Proteomics Uppsala [Service]

The role of circulating galectin-1 in type 2 diabetes and chronic kidney disease: evidence from cross-sectional, longitudinal and Mendelian randomisation analyses.

Drake I, Fryk E, Strindberg L, ..., Orho-Melander M, Jansson PA

Diabetologia - (-) - [2021-11-07; online 2021-11-07]

Systemic Inflammation in Preclinical Ulcerative Colitis.

Bergemalm D, Andersson E, Hultdin J, ..., Karling P, Halfvarson J

Gastroenterology 161 (5) 1526-1539.e9 [2021-11-00; online 2021-07-21]

Multiplex protein screening of biomarkers associated with major bleeding in patients with atrial fibrillation treated with oral anticoagulation.

Siegbahn A, Lindbäck J, Hijazi Z, ..., Yusuf S, Wallentin L

J. Thromb. Haemost. 19 (11) 2726-2737 [2021-11-00; online 2021-08-24]

Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort.

Korduner J, Nilsson PM, Melander O, ..., Magnusson M, Ottosson F

J Obes 2021 (-) 6616983 [2021-10-06; online 2021-10-06]

Metabolic Perturbation Associated With COVID-19 Disease Severity and SARS-CoV-2 Replication.

Krishnan S, Nordqvist H, Ambikan AT, ..., Treutiger CJ, Neogi U

Mol. Cell Proteomics 20 (-) 100159 [2021-10-05; online 2021-10-05]

Predicting outcome in acute myocardial infarction: an analysis investigating 175 circulating biomarkers.

Eggers KM, Lindhagen L, Baron T, ..., Spaak J, Lindahl B

Eur Heart J Acute Cardiovasc Care 10 (7) 806-812 [2021-10-01; online 2021-06-09]

Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients.

Gradin A, Andersson H, Luther T, ..., Frithiof R, Hultström M

Cytokine 146 (-) 155589 [2021-10-00; online 2021-05-24]

Sleep duration is associated with protein biomarkers for cardiometabolic health: A large-scale population study.

Theorell-Haglöw J, Hammar U, Lind L, ..., Lindberg E, Fall T

J Sleep Res 30 (5) e13284 [2021-10-00; online 2021-03-09]

Inflammatory proteins and miRNA-144-5p in patients with depression, anxiety, or stress- and adjustment disorders after psychological treatment.

Sundquist K, Memon AA, Palmér K, Sundquist J, Wang X

Cytokine 146 (-) 155646 [2021-10-00; online 2021-07-27]

Immune responses against oxidized LDL as possible targets for prevention of atherosclerosis in systemic lupus erythematosus.

Yao Mattisson I, Rattik S, Björkbacka H, ..., Nilsson J, Wigren M

Vascul Pharmacol 140 (-) 106863 [2021-10-00; online 2021-04-15]

Hyperglycaemia-associated Caspase-3 predicts diabetes and coronary artery disease events.

Sun J, Singh P, Österlund J, ..., Engström G, Edsfeldt A

J. Intern. Med. 290 (4) 855-865 [2021-10-00; online 2021-07-26]

Differential effects of estradiol and progesterone on human T cell activation in vitro.

Papapavlou G, Hellberg S, Raffetseder J, ..., Jenmalm MC, Ernerudh J

Eur. J. Immunol. 51 (10) 2430-2440 [2021-10-00; online 2021-07-26]

Carotid atherosclerosis, changes in tissue remodeling and repair in patients with aortic coarctation.

Hlebowicz J, Holm J, Lindstedt S, Goncalves I, Nilsson J

Atherosclerosis 335 (-) 47-52 [2021-10-00; online 2021-09-21]

Association between cardiovascular disease- and inflammation-related serum biomarkers and poor lung function in elderly.

Egervall K, Rosso A, Elmståhl S

Clin Proteomics 18 (1) 23 [2021-09-28; online 2021-09-28]

Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals.

Tserel L, Jõgi P, Naaber P, ..., Lutsar I, Peterson P

Front Immunol 12 (-) 709759 [2021-09-17; online 2021-09-17]

Screening of biomarkers for prediction of multisite artery disease in patients with recent myocardial infarction.

Jönelid B, Christersson C, Hedberg P, ..., Oldgren J, Siegbahn A

Scand J Clin Lab Invest 81 (5) 353-360 [2021-09-00; online 2021-08-04]

Evaluation of 92 cardiovascular proteins in dried blood spots collected under field-conditions: Off-the-shelf affinity-based multiplexed assays work well, allowing for simplified sample collection.

Broberg K, Svensson J, Grahn K, ..., Selander J, Enroth S

Bioessays 43 (9) e2000299 [2021-09-00; online 2021-02-15]

Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis.

Gülen T, Teufelberger A, Ekoff M, ..., Dahlén B, Nilsson G

J. Allergy Clin. Immunol. 148 (3) 889-894 [2021-09-00; online 2021-03-02]

Interleukin 6 and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Chronic Coronary Syndrome.

Batra G, Ghukasyan Lakic T, Lindbäck J, ..., Wallentin L, STABILITY Investigators

JAMA Cardiol - (-) - [2021-08-25; online 2021-08-25]

Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout.

Al-Amin RA, Gallant CJ, Muthelo PM, Landegren U

Anal. Chem. 93 (31) 10999-11009 [2021-08-10; online 2021-07-28]

Single-cell multimodal analysis in a case with reduced penetrance of Progranulin-Frontotemporal Dementia.

Natarajan K, Eisfeldt J, Hammond M, ..., Öijerstedt L, Graff C

Acta Neuropathol Commun 9 (1) 132 [2021-08-03; online 2021-08-03]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Strong Associations Between Early Tubular Damage and Urinary Cytokine, Chemokine, and Growth Factor Levels in Elderly Males and Females.

Fellström B, Helmersson-Karlqvist J, Lind L, ..., Kultima K, Larsson A

Journal of Interferon & Cytokine Research 41 (8) 283-290 [2021-08-00; online 2021-08-20]

Plasma proteome alterations by MAPK inhibitors in BRAFV600-mutated metastatic cutaneous melanoma.

Babačić H, Eriksson H, Pernemalm M

Neoplasia 23 (8) 783-791 [2021-08-00; online 2021-07-08]

Decidual stromal cells support tolerance at the human foetal-maternal interface by inducing regulatory M2 macrophages and regulatory T-cells.

Lindau R, Vondra S, Spreckels J, ..., Jenmalm MC, Ernerudh J

J Reprod Immunol 146 (-) 103330 [2021-08-00; online 2021-05-12]

Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2.

Havervall S, Marking U, Greilert-Norin N, ..., Åberg M, Thålin C

EBioMedicine 70 (-) 103523 [2021-08-00; online 2021-08-12]

Affinity Proteomics Uppsala [Collaborative] Autoimmunity and Serology Profiling [Collaborative]

Neuroinflammation and Alzheimer's Disease: A Machine Learning Approach to CSF Proteomics.

Gaetani L, Bellomo G, Parnetti L, ..., Zetterberg H, Di Filippo M

Cells 10 (8) - [2021-07-29; online 2021-07-29]

Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors.

Larsson A, Helmersson-Karlqvist J, Lind L, Ärnlöv J, Feldreich TR

Biomedicines 9 (8) - [2021-07-28; online 2021-07-28]

Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99.

Mattisson J, Danielsson M, Hammond M, ..., Halvardson J, Forsberg LA

Sci Rep 11 (1) 15160 [2021-07-26; online 2021-07-26]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Compute and Storage [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Collaborative] National Genomics Infrastructure [Collaborative]

Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women: a Cross-Sectional Study.

Enarsson M, Feldreich T, Byberg L, ..., Lind L, Ärnlöv J

Sports Med Open 7 (1) 52 [2021-07-26; online 2021-07-26]

Large-scale serum analysis identifies unique systemic biomarkers in psoriasis and hidradenitis suppurativa.

Navrazhina K, Renert-Yuval Y, Frew JW, ..., Garcet S, Krueger JG

Br J Dermatol - (-) - [2021-07-13; online 2021-07-13]

Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations.

Kerzeli IK, Lord M, Doroszko M, ..., Segersten U, Mangsbo SM

PLoS ONE 16 (7) e0253178 [2021-07-07; online 2021-07-07]

Affinity Proteomics Uppsala [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Real-world effectiveness of vedolizumab in inflammatory bowel disease: week 52 results from the Swedish prospective multicentre SVEAH study.

Eriksson C, Rundquist S, Lykiardopoulos V, ..., Halfvarson J, SWIBREG SVEAH Study Group

Therap Adv Gastroenterol 14 (-) 17562848211023386 [2021-07-03; online 2021-07-03]

Plasma S1P (Sphingosine-1-Phosphate) Links to Hypertension and Biomarkers of Inflammation and Cardiovascular Disease: Findings From a Translational Investigation.

Jujic A, Matthes F, Vanherle L, ..., Magnusson M, Meissner A

Hypertension 78 (1) 195-209 [2021-07-00; online 2021-05-17]

Toll-like receptor 4 methylation grade is linked to depressive symptom severity.

Rasmusson AJ, Gallwitz M, Soltanabadi B, ..., Schiöth HB, Cunningham JL

Transl Psychiatry 11 (1) 371 [2021-06-24; online 2021-06-24]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Osteoprotegerin predicts cardiovascular events in patients treated with hemodialysis.

Wu PH, Glerup RI, Svensson MHS, ..., Ljunggren Ö, Fellström B

Nephrol Dial Transplant - (-) - [2021-06-04; online 2021-06-04]

Urokinase, CX3CL1, CCL2, TRAIL and IL-18 induced by interferon-β treatment.

Zhukovsky C, Herman S, Wiberg A, ..., Kultima K, Burman J

Acta Neurol. Scand. 143 (6) 602-607 [2021-06-00; online 2021-02-24]

Cancer diagnostics based on plasma protein biomarkers: hard times but great expectations.

Landegren U, Hammond M

Mol Oncol 15 (6) 1715-1726 [2021-06-00; online 2020-11-17]

Klevebro S, Björkander S, Ekström S, ..., Bergström A, Melén E

Sci Rep 11 (1) 11391 [2021-05-31; online 2021-05-31]

A combined approach for single-cell mRNA and intracellular protein expression analysis.

Reimegård J, Tarbier M, Danielsson M, ..., Friedländer MR, Gallant CJ

Commun Biol 4 (1) 624 [2021-05-25; online 2021-05-25]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Compute and Storage [Service] Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Progesterone Dampens Immune Responses in In Vitro Activated CD4+ T Cells and Affects Genes Associated With Autoimmune Diseases That Improve During Pregnancy.

Hellberg S, Raffetseder J, Rundquist O, ..., Ernerudh J, Gustafsson M

Front Immunol 12 (-) 672168 [2021-05-12; online 2021-05-12]

Affinity Proteomics Uppsala [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Plasma Protein Profile of Carotid Artery Atherosclerosis and Atherosclerotic Outcomes: Meta-Analyses and Mendelian Randomization Analyses.

Lind L, Gigante B, Borné Y, ..., Engström G, Mälarstig A

Arterioscler. Thromb. Vasc. Biol. 41 (5) 1777-1788 [2021-05-05; online 2021-03-04]

Association of Epicardial Fat Volume With the Extent of Coronary Atherosclerosis and Cardiovascular Adverse Events in Asymptomatic Patients With Diabetes.

Venuraju SM, Lahiri A, Jeevarethinam A, ..., Shah PK, Nilsson J

Angiology 72 (5) 442-450 [2021-05-00; online 2021-01-20]

Sex-differences in circulating biomarkers during acute myocardial infarction: An analysis from the SWEDEHEART registry.

Eggers KM, Lindhagen L, Baron T, ..., Spaak J, Lindahl B

PLoS ONE 16 (4) e0249830 [2021-04-08; online 2021-04-08]

Serum proteins associated with periodontitis relapse post-surgery: A pilot study.

Esberg A, Isehed C, Holmlund A, Lindquist S, Lundberg P

J Periodontol - (-) - [2021-04-04; online 2021-04-04]

Autoantibodies against the C-terminus of Lipopolysaccharide binding protein are elevated in young adults with psychiatric disease.

Just D, Rasmusson AJ, Nilsson P, ..., Månberg A, Cunningham JL

Psychoneuroendocrinology 126 (-) 105162 [2021-04-00; online 2021-02-04]

The associations between red cell distribution width and plasma proteins in a general population.

Pan J, Borné Y, Orho-Melander M, ..., Melander O, Engström G

Clin Proteomics 18 (1) 12 [2021-03-30; online 2021-03-30]

Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort.

Drake I, Hindy G, Almgren P, ..., Melander O, Orho-Melander M

Sci Rep 11 (1) 6734 [2021-03-24; online 2021-03-24]

Proteomic blood profiling in mild, severe and critical COVID-19 patients.

Patel H, Ashton NJ, Dobson RJB, ..., Gisslen M, Zetterberg H

Sci Rep 11 (1) 6357 [2021-03-18; online 2021-03-18]

Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans.

Fellström B, Helmersson-Karlqvist J, Lind L, ..., Kultima K, Larsson A

Biomolecules 11 (3) - [2021-03-08; online 2021-03-08]

A two-tiered targeted proteomics approach to identify pre-diagnostic biomarkers of colorectal cancer risk.

Harlid S, Harbs J, Myte R, ..., Liu X, Van Guelpen B

Sci Rep 11 (1) 5151 [2021-03-04; online 2021-03-04]

Inflammatory bowel disease and risk of severe COVID-19: A nationwide population-based cohort study in Sweden.

Ludvigsson JF, Axelrad J, Halfvarson J, ..., Söderling J, Olén O

United European Gastroenterol J 9 (2) 177-192 [2021-03-00; online 2021-03-11]

Evaluation of the prognostic value of GDF-15, ABC-AF-bleeding score and ABC-AF-death score in patients with atrial fibrillation across different geographical areas.

Pol T, Hijazi Z, Lindbäck J, ..., Siegbahn A, Wallentin L

Open Heart 8 (1) - [2021-03-00; online 2021-03-21]

Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma.

Mörth C, Sabaa AA, Freyhult E, ..., Eriksson A, Enblad G

Cardiooncology 7 (1) 6 [2021-02-03; online 2021-02-03]

Affinity Proteomics Uppsala [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative]

Plasma proteins associated with cardiovascular death in patients with chronic coronary heart disease: A retrospective study.

Wallentin L, Eriksson N, Olszowka M, ..., Åberg M, Siegbahn A

PLoS Med. 18 (1) e1003513 [2021-01-00; online 2021-01-13]

Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation.

Hijazi Z, Wallentin L, Lindbäck J, ..., Oldgren J, Siegbahn A

J Am Heart Assoc 9 (24) e018984 [2020-12-15; online 2020-12-09]

Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation.

Wallentin L, Lindbäck J, Eriksson N, ..., Oldgren J, Siegbahn A

Eur. Heart J. 41 (41) 4037-4046 [2020-11-01; online 2020-09-29]

Affinity Proteomics Uppsala [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis.

Zhang Y, Cedervall J, Hamidi A, ..., Dimberg A, Olsson AK

Cancer Res. 80 (16) 3345-3358 [2020-08-15; online 2020-06-25]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

Viral antigens elicit augmented immune responses in primary Sjögren's syndrome.

Björk A, Thorlacius GE, Mofors J, ..., Kvarnström M, Wahren-Herlenius M

Rheumatology (Oxford) 59 (7) 1651-1661 [2020-07-01; online 2019-10-31]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Inflammatory markers in women with postpartum depressive symptoms.

Bränn E, Fransson E, White RA, ..., Sundström-Poromaa I, Skalkidou A

J Neuro Res 98 (7) 1309-1321 [2020-07-00; online 2018-09-05]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years.

Schulz CA, Engström G, Nilsson J, ..., Melander O, Orho-Melander M

Nephrol Dial Transplant 35 (2) 265-273 [2020-02-01; online 2019-01-11]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Associations Between Apolipoprotein A1, High-Density Lipoprotein Cholesterol, and Urinary Cytokine Levels in Elderly Males and Females.

Fellström B, Helmersson-Karlqvist J, Lind L, ..., Ärnlöv J, Larsson A

Journal of Interferon & Cytokine Research 40 (2) 71-74 [2020-02-00; online 2019-10-10]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Protein and DNA methylation-based scores as surrogate markers for interferon system activation in patients with primary Sjögren's syndrome.

Björk A, Richardsdotter Andersson E, Imgenberg-Kreuz J, ..., Nordmark G, Wahren-Herlenius M

RMD Open 6 (1) e000995 [2020-01-00; online 2020-01-21]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service] PLA and Single Cell Proteomics [Service]

Identification of novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm.

Memon AA, Zarrouk M, Ågren-Witteschus S, ..., Gottsäter A, Sundquist K

Eur J Prev Cardiol 27 (2) 132-142 [2020-01-00; online 2019-08-29]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Levels of caspase-3 and histidine-rich glycoprotein in the embryo secretome as biomarkers of good-quality day-2 embryos and high-quality blastocysts

Kaihola H, Yaldir FG, Bohlin T, ..., Hreinsson J, Åkerud H

PLoS ONE 14 (12) e0226419 [2019-12-19; online 2019-12-19]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers.

Bhandage AK, Cunningham JL, Jin Z, ..., Ekselius L, Birnir B

Int J Mol Sci 20 (24) 6172 [2019-12-06; online 2019-12-06]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Collaborative]

The associations of self-rated health with cardiovascular risk proteins: a proteomics approach.

Bao X, Borné Y, Yin S, ..., Melander O, Engström G

Clin Proteomics 16 (1) 40 [2019-11-18; online 2019-11-18]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders.

Sundberg I, Rasmusson AJ, Ramklint M, ..., Ekselius L, Cunningham JL

Psychoneuroendocrinology 112 (-) 104514 [2019-11-14; online 2019-11-14]

Affinity Proteomics Uppsala [Service] Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts.

Stattin K, Lind L, Elmståhl S, ..., Michaëlsson K, Byberg L

Eur J Prev Cardiol 26 (17) 1865-1873 [2019-11-00; online 2019-08-14]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

In search of causal pathways in diabetes: a study using proteomics and genotyping data from a cross-sectional study.

Beijer K, Nowak C, Sundström J, ..., Fall T, Lind L

Diabetologia 62 (11) 1998-2006 [2019-11-00; online 2019-08-24]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service] PLA and Single Cell Proteomics [Service]

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum.

Rajan MR, Sotak M, Barrenäs F, ..., Lange S, Börgeson E

Sci Rep 9 (1) 15385 [2019-10-28; online 2019-10-28]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care.

Dyhrfort P, Shen Q, Clausen F, ..., Lewén A, Hillered L

J. Neurotrauma 36 (20) 2872-2885 [2019-10-15; online 2019-06-17]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Reduced sialyl-Lewisx on salivary MUC7 from patients with burning mouth syndrome.

Acharya S, Jin C, Bylund J, ..., Carlén A, Karlsson NG

Mol Omics 15 (5) 331-339 [2019-10-07; online 2019-08-16]

Affinity Proteomics Uppsala [Collaborative] Glycoproteomics [Collaborative] PLA and Single Cell Proteomics [Collaborative]

Proteomic Analysis of Longitudinal Changes in Blood Pressure.

Lin YT, Fall T, Hammar U, ..., Engström G, Sundström J

J Clin Med 8 (10) 1585 [2019-10-02; online 2019-10-02]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death.

Grufman H, Yndigegn T, Gonçalves I, Nilsson J, Schiopu A

Cytokine 122 (-) 154208 [2019-10-00; online 2018-02-07]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation.

Olsson KW, Larsson A, Jonzon A, Sindelar R

Pediatr. Res. 86 (3) 333-338 [2019-09-00; online 2018-09-18]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Profiling surface proteins on individual exosomes using a proximity barcoding assay.

Wu D, Yan J, Shen X, ..., Landegren U, Kamali-Moghaddam M

Nat Commun 10 (1) 3854 [2019-08-26; online 2019-08-26]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Compute and Storage [Service] PLA and Single Cell Proteomics [Technology development]

sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events.

Gonçalves I, Singh P, Tengryd C, ..., Nilsson J, Edsfeldt A

Stroke 50 (8) 1989-1996 [2019-08-00; online 2019-07-05]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Circulating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes: A Population-Based Cohort Study.

Muhammad IF, Borné Y, Bao X, ..., Nilsson J, Engström G

Diabetes Care 42 (8) 1582-1588 [2019-08-00; online 2019-06-14]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung.

Djureinovic D, Pontén V, Landelius P, ..., Micke P, Ståhle E

BMC Cancer 19 (1) 741 [2019-07-29; online 2019-07-29]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer

Aripaka K, Gudey SK, Zang G, ..., von Hofsten J, Landström M

EBioMedicine 45 (-) 192-207 [2019-07-00; online 2019-07-00]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

Proteomic profiling of extracellular vesicles reveals additional diagnostic biomarkers for myocardial infarction compared to plasma alone.

Gidlöf O, Evander M, Rezeli M, ..., Laurell T, Erlinge D

Sci Rep 9 (1) 8991 [2019-06-20; online 2019-06-20]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Dietary Pattern Specific Protein Biomarkers for Cardiovascular Disease: A Cross-Sectional Study in 2 Independent Cohorts.

Warensjö Lemming E, Byberg L, Stattin K, ..., Wolk A, Michaëlsson K

J Am Heart Assoc 8 (11) e011860 [2019-06-04; online 2019-06-01]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Circulating mast cell progenitors correlate with reduced lung function in allergic asthma.

Salomonsson M, Malinovschi A, Kalm-Stephens P, ..., Alving K, Hallgren J

Clin Exp Allergy 49 (6) 874-882 [2019-06-00; online 2019-03-21]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

A targeted proteomics approach reveals a serum protein signature as diagnostic biomarker for resectable gastric cancer.

Shen Q, Polom K, Williams C, ..., Roviello F, Kamali-Moghaddam M

EBioMedicine 44 (-) 322-333 [2019-06-00; online 2019-05-28]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] Glycoproteomics [Collaborative] PLA and Single Cell Proteomics [Technology development]

Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study.

Borné Y, Fagerberg B, Sallsten G, ..., Barregard L, Engström G

Clin Proteomics 16 (1) 21 [2019-05-15; online 2019-05-15]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Cardiovascular organ damage in type 2 diabetes mellitus: the role of lipids and inflammation.

Kozakova M, Morizzo C, Goncalves I, ..., Nilsson J, Palombo C

Cardiovasc Diabetol 18 (1) 61 [2019-05-10; online 2019-05-10]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Elevated circulating effector memory T cells but similar levels of regulatory T cells in patients with type 2 diabetes mellitus and cardiovascular disease.

Rattik S, Engelbertsen D, Wigren M, ..., Nilsson J, Björkbacka H

Diabetes and Vascular Disease Research 16 (3) 270-280 [2019-05-00; online 2018-12-21]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Increased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke.

Berntsson J, Smith JG, Johnson LSB, ..., Nilsson J, Engström G

Heart 105 (7) 553-558 [2019-04-00; online 2018-10-16]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

High Serum sCD40 and a Distinct Colonic T Cell Profile in Ulcerative Colitis Associated With Primary Sclerosing Cholangitis.

Lampinen M, Vessby J, Fredricsson A, ..., Rorsman F, Carlson M

J Crohns Colitis 13 (3) 341-350 [2019-03-26; online 2018-11-02]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Longitudinal effects of aging on plasma proteins levels in older adults - associations with kidney function and hemoglobin levels.

Lind L, Sundström J, Larsson A, ..., Ärnlöv J, Ingelsson E

PLoS ONE 14 (2) e0212060 [2019-02-25; online 2019-02-25]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke.

Markstad H, Edsfeldt A, Yao Mattison I, ..., Engström G, Gonçalves I

J Am Heart Assoc 8 (4) e009874 [2019-02-19; online 2019-02-13]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Protein measurements in venous plasma, earlobe capillary plasma and in plasma stored on filter paper.

Siart B, de Oliveira FMS, Shen Q, ..., Kamali-Moghaddam M, Wallner B

Anal. Biochem. 566 (-) 146-150 [2019-02-01; online 2018-11-22]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Protein profiling of fine-needle aspirates reveals subtype-associated immune signatures and involvement of chemokines in breast cancer.

Franzén B, Alexeyenko A, Kamali-Moghaddam M, ..., Landegren U, Lewensohn R

Mol Oncol 13 (2) 376-391 [2019-02-00; online 2019-01-07]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Technology development]

Metformin is the key factor in elevated plasma growth differentiation factor-15 levels in type 2 diabetes: A nested, case-control study.

Natali A, Nesti L, Venturi E, ..., Nilsson J, SUMMIT consortium

Diabetes Obes Metab 21 (2) 412-416 [2019-02-00; online 2018-10-02]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease.

Feldreich T, Nowak C, Fall T, ..., Green D, Ärnlöv J

J Nephrol 32 (1) 111-119 [2019-02-00; online 2018-11-29]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis.

Ek M, Roth B, Engström G, Ohlsson B

Int J Mol Sci 20 (1) 189 [2019-01-07; online 2019-01-07]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins.

Almén MS, Björk J, Nyman U, ..., Christensson A, Grubb A

Kidney International Reports 4 (1) 67-79 [2019-01-00; online 2018-09-13]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmö Diet and Cancer-Cardiovascular Cohort.

Bao X, Borné Y, Muhammad IF, ..., Orho-Melander M, Engström G

Diabetologia 62 (1) 78-86 [2019-01-00; online 2018-10-22]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury.

Lindblom RPF, Shen Q, Axén S, ..., Kamali-Moghaddam M, Thelin S

J. of Cardiovasc. Trans. Res. 11 (6) 503-516 [2018-12-00; online 2018-10-26]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Compute and Storage [Service] PLA and Single Cell Proteomics [Collaborative]

Markers of Basement Membrane Remodeling Are Associated With Higher Mortality in Patients With Known Atherosclerosis.

Holm Nielsen S, Tengryd C, Edsfeldt A, ..., Nilsson J, Goncalves I

J Am Heart Assoc 7 (21) e009193 [2018-11-06; online 2019-01-05]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival

Morin E, Sjöberg E, Tjomsland V, ..., Sjöblom T, Claesson-Welsh L

J. Pathol 246 (3) 311-322 [2018-11-00; online 2018-09-04]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] PLA and Single Cell Proteomics [Service]

Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells

Batool T, Fang J, Jansson V, ..., Moustakas A, Li JP

Cellular Signalling - (-) - [2018-11-00; online 2018-11-00]

Affinity Proteomics Uppsala [Collaborative] PLA and Single Cell Proteomics [Collaborative]

Detection of post-translational modifications using solid-phase proximity ligation assay.

Oliveira FMS, Mereiter S, Lönn P, ..., Reis CA, Kamali-Moghaddam M

N Biotechnol 45 (-) 51-59 [2018-10-25; online 2017-10-31]

Affinity Proteomics Uppsala [Technology development] Glycoproteomics [Technology development] PLA and Single Cell Proteomics [Technology development]

Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study.

Shore AC, Colhoun HM, Natali A, ..., Nilsson J, SUMMIT Consortium

Diabetes Care 41 (10) 2212-2219 [2018-10-00; online 2018-07-30]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality.

Fernandez C, Rysä J, Almgren P, ..., Ruskoaho H, Melander O

J. Intern. Med. 284 (4) 377-387 [2018-10-00; online 2018-07-02]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Ibrutinib induces rapid down-regulation of inflammatory markers and altered transcription of chronic lymphocytic leukaemia-related genes in blood and lymph nodes.

Palma M, Krstic A, Peña Perez L, ..., Månsson R, Smith CIE

Br. J. Haematol. 183 (2) 212-224 [2018-10-00; online 2018-08-20]

Affinity Proteomics Uppsala [Collaborative] PLA and Single Cell Proteomics [Collaborative]

Associations of Circulating Protein Levels With Lipid Fractions in the General Population.

Figarska SM, Gustafsson S, Sundström J, ..., Lind L, Ingelsson E

Arterioscler. Thromb. Vasc. Biol. 38 (10) 2505-2518 [2018-10-00; online 2018-10-26]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.

Lovric A, Granér M, Bjornson E, ..., Mardinoglu A, Boren J

Sci Rep 8 (1) 14200 [2018-09-21; online 2018-09-21]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke.

Muhammad IF, Borné Y, Melander O, ..., Söderholm M, Engström G

Stroke 49 (9) 2224-2226 [2018-09-00; online 2018-10-26]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

A fine-needle aspiration-based protein signature discriminates benign from malignant breast lesions

Franzén B, Kamali-Moghaddam M, Alexeyenko A, ..., Landegren U, Lewensohn R

Mol Oncol 12 (9) 1415-1428 [2018-09-00; online 2018-08-09]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Technology development]

The endoplasmic reticulum-resident collagen chaperone Hsp47 interacts with and promotes the secretion of decorin, fibromodulin, and lumican.

Ishikawa Y, Rubin K, Bächinger HP, Kalamajski S

J. Biol. Chem. 293 (35) 13707-13716 [2018-08-31; online 2018-07-12]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

Proteomic Biomarkers for Incident Aortic Stenosis Requiring Valvular Replacement.

Ljungberg J, Janiec M, Bergdahl IA, ..., Fall T, Söderberg S

Circulation 138 (6) 590-599 [2018-08-07; online 2018-03-01]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis.

Lugano R, Vemuri K, Yu D, ..., Dejana E, Dimberg A

J. Clin. Invest. 128 (8) 3280-3297 [2018-08-01; online 2018-06-25]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] PLA and Single Cell Proteomics [Service]

Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer

Birgisson H, Tsimogiannis K, Freyhult E, Kamali-Moghaddam M

Transl Oncol 11 (4) 1034-1043 [2018-08-00; online 2018-08-00]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing

Aqrawi LA, Ivanchenko M, Björk A, ..., Skarstein K, Wahren-Herlenius M

Clin Exp Immunol 192 (3) 259-270 [2018-05-25; online 2018-03-24]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Inflammatory biomarker profiling in classical orthostatic hypotension: Insights from the SYSTEMA cohort.

Johansson M, Ricci F, Aung N, ..., Melander O, Fedorowski A

Int. J. Cardiol. 259 (-) 192-197 [2018-05-15; online 2018-03-27]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Identification of novel diagnostic biomarkers for deep venous thrombosis.

Memon AA, Sundquist K, PirouziFard M, ..., Sundquist J, Zöller B

Br. J. Haematol. 181 (3) 378-385 [2018-05-00; online 2018-04-19]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

DOI Crossref

Human erythrocyte-derived nanovesicles can readily be loaded with doxorubicin and act as anticancer agents.

Dubois L, None , Löf L, ..., Ronquist G, Ronquist KG

Cancer Res Front 4 (1) 13-26 [2018-04-20; online 2018-04-20]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4 + T Cells and Is Immunosuppressive in Type 1 Diabetes

Bhandage AK, Jin Z, Korol SV, ..., Kamali-Moghaddam M, Birnir B

EBioMedicine 30 (-) 283-294 [2018-04-00; online 2018-04-00]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes.

Klaesson A, Grannas K, Ebai T, ..., Söderberg O, Landegren U

Sci Rep 8 (1) 5400 [2018-03-29; online 2018-03-29]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Strong impact on plasma protein profiles by precentrifugation delay but not by repeated freeze-thaw cycles, as analyzed using multiplex proximity extension assays.

Shen Q, Björkesten J, Galli J, ..., Tybring G, Landegren U

Clin. Chem. Lab. Med. 56 (4) 582-594 [2018-03-28; online 2017-10-19]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome.

Ramqvist T, Näsman A, Franzén B, ..., Dalianis T, Munck-Wikland E

Int J Mol Sci 19 (4) 978 [2018-03-25; online 2018-03-25]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

Mardinoglu A, Wu H, Bjornson E, ..., Taskinen MR, Borén J

Cell Metab. 27 (3) 559-571.e5 [2018-03-06; online 2018-02-15]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Proteomic Profiling for Cardiovascular Biomarker Discovery in Orthostatic Hypotension.

Johansson M, Ricci F, Aung N, ..., Melander O, Fedorowski A

Hypertension 71 (3) 465-472 [2018-03-00; online 2018-01-02]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Galectin-3 levels relate in children to total body fat, abdominal fat, body fat distribution, and cardiac size.

Dencker M, Arvidsson D, Karlsson MK, ..., Andersen LB, Thorsson O

Eur J Pediatr 177 (3) 461-467 [2018-03-00; online 2018-01-11]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Cardiovascular disease in systemic lupus erythematosus is associated with increased levels of biomarkers reflecting receptor-activated apoptosis.

Wigren M, Svenungsson E, Mattisson IY, ..., Fredrikson GN, Nilsson J

Atherosclerosis 270 (-) 1-7 [2018-03-00; online 2018-01-17]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Vascular Endothelial Growth Factor D, Pulmonary Congestion, and Incidence of Heart Failure.

Borné Y, Gränsbo K, Nilsson J, ..., Smith JG, Engström G

J. Am. Coll. Cardiol. 71 (5) 580-582 [2018-02-06; online 2018-02-07]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.

Inturi R, Mun K, Singethan K, Schreiner S, Punga T

J. Virol. 92 (3) - [2018-02-01; online 2018-01-17]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

Targeted proteomic analysis of habitual coffee consumption.

Cornelis MC, Gustafsson S, Ärnlöv J, ..., Lind L, Ingelsson E

J. Intern. Med. 283 (2) 200-211 [2018-02-00; online 2017-11-16]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

In situ protein detection with enhanced specificity using DNA-conjugated antibodies and proximity ligation.

Zieba A, Ponten F, Uhlén M, Landegren U

Mod. Pathol. 31 (2) 253-263 [2018-02-00; online 2017-09-22]

Affinity Proteomics Uppsala [Technology development] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] PLA and Single Cell Proteomics [Technology development] Tissue Profiling [Collaborative]

Spotty Carotid Plaques Are Associated with Inflammation and the Occurrence of Cerebrovascular Symptoms.

Halak S, Östling G, Edsfeldt A, ..., Gonçalves I, Asciutto G

Cerebrovasc Dis Extra 8 (1) 16-25 [2018-01-15; online 2018-01-15]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Circulating proteins as predictors of incident heart failure in the elderly.

Stenemo M, Nowak C, Byberg L, ..., Fall T, Ärnlöv J

Eur. J. Heart Fail. 20 (1) 55-62 [2018-01-00; online 2017-10-02]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Plasma stem cell factor levels are associated with risk of cardiovascular disease and death.

Björkbacka H, Yao Mattisson I, Wigren M, ..., Engström G, Nilsson J

J. Intern. Med. 282 (6) 508-521 [2017-12-00; online 2017-09-21]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Highly sensitive and specific protein detection via combined capillary isoelectric focusing and proximity ligation

Padhan N, Yan J, Boge A, ..., Claesson-Welsh L, Landegren U

Sci Rep 7 (1) - [2017-12-00; online 2017-05-04]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

High levels of cerebrospinal fluid chemokines point to the presence of neuroinflammation in peripheral neuropathic pain: a cross-sectional study of 2 cohorts of patients compared with healthy controls.

Bäckryd E, Lind AL, Thulin M, ..., Gerdle B, Gordh T

Pain 158 (12) 2487-2495 [2017-12-00; online 2017-09-21]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Elevated Markers of Death Receptor-Activated Apoptosis are Associated with Increased Risk for Development of Diabetes and Cardiovascular Disease.

Mattisson IY, Björkbacka H, Wigren M, ..., Almgren P, Nilsson J

EBioMedicine 26 (-) 187-197 [2017-12-00; online 2017-11-24]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Autoantibodies against aldehyde-modified collagen type IV are associated with risk of development of myocardial infarction.

Vallejo J, Dunér P, Fredrikson GN, Nilsson J, Bengtsson E

J. Intern. Med. 282 (6) 496-507 [2017-12-00; online 2017-09-25]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue.

Boldrup L, Troiano G, Gu X, ..., Wang L, Nylander K

Oncotarget 8 (61) 103437-103448 [2017-11-28; online 2017-09-30]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface.

Flowers SA, Zieba A, Örnros J, ..., Kamali-Moghaddam M, Karlsson NG

Sci Rep 7 (1) 13149 [2017-10-13; online 2017-10-13]

Affinity Proteomics Uppsala [Collaborative] Glycoproteomics [Collaborative] PLA and Single Cell Proteomics [Collaborative]

Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles.

Andersson E, Bergemalm D, Kruse R, ..., Repsilber D, Halfvarson J

PLoS ONE 12 (10) e0186142 [2017-10-05; online 2017-10-05]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Tumor Necrosis Factor Receptor 1 and 2 Are Associated With Risk of Intracerebral Hemorrhage.

Svensson EH, Söderholm M, Abul-Kasim K, Engström G

Stroke 48 (10) 2710-2715 [2017-10-00; online 2017-08-22]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

GDF-15 and TRAIL-R2 are powerful predictors of long-term mortality in patients with acute myocardial infarction.

Skau E, Henriksen E, Wagner P, ..., Siegbahn A, Leppert J

Eur J Prev Cardiol 24 (15) 1576-1583 [2017-10-00; online 2017-08-01]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke.

Sundström J, Söderholm M, Borné Y, ..., Orho-Melander M, Engström G

Stroke 48 (10) 2686-2692 [2017-10-00; online 2017-09-13]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Proteomics in Hypothermia as Adjunctive Therapy in Patients with ST-Segment Elevation Myocardial Infarction: A CHILL-MI Substudy.

Mohammad MA, Noc M, Lang I, ..., Metzler B, Erlinge D

Ther Hypothermia Temp Manag 7 (3) 152-161 [2017-09-00; online 2017-03-02]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Effect of food intake on 92 neurological biomarkers in plasma.

Dencker M, Björgell O, Hlebowicz J

Brain Behav 7 (9) e00747 [2017-09-00; online 2017-08-01]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Analytically Sensitive Protein Detection in Microtiter Plates by Proximity Ligation with Rolling Circle Amplification

Ebai T, Souza de Oliveira FM, Löf L, ..., Landegren U, Kamali-Moghaddam M

Clinical Chemistry 63 (9) 1497-1505 [2017-09-00; online 2017-06-30]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Circulating GDF-15 levels predict future secondary manifestations of cardiovascular disease explicitly in women but not men with atherosclerosis.

Gohar A, Gonçalves I, Vrijenhoek J, ..., Björkbacka H, de Jager SCA

Int. J. Cardiol. 241 (-) 430-436 [2017-08-15; online 2017-03-22]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Use of Proteomics To Investigate Kidney Function Decline over 5 Years.

Carlsson AC, Ingelsson E, Sundström J, ..., Lind L, Ärnlöv J

Clin J Am Soc Nephrol 12 (8) 1226-1235 [2017-08-07; online 2017-07-21]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Detection of Extracellular Vesicles Using Proximity Ligation Assay with Flow Cytometry Readout-ExoPLA.

Löf L, Arngården L, Ebai T, ..., Söderberg O, Kamali-Moghaddam M

Curr Protoc Cytom 81 (-) 4.8.1-4.8.10 [2017-07-05; online 2017-07-05]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Stability of Proteins in Dried Blood Spot Biobanks

Björkesten J, Enroth S, Shen Q, ..., Kamali-Moghaddam M, Landegren U

Mol Cell Proteomics 16 (7) 1286-1296 [2017-07-00; online 2017-05-13]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Close Encounters – Probing Proximal Proteins in Live or Fixed Cells

Lönn P, Landegren U

Trends in Biochemical Sciences 42 (7) 504-515 [2017-07-00; online 2017-07-00]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Alterations of anti-inflammatory lipids in plasma from women with chronic widespread pain - a case control study.

Stensson N, Ghafouri B, Gerdle B, Ghafouri N

Lipids Health Dis 16 (1) 112 [2017-06-12; online 2017-06-12]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Effect of food intake on 92 biomarkers for cardiovascular disease.

Dencker M, Gårdinger Y, Björgell O, Hlebowicz J

PLoS ONE 12 (6) e0178656 [2017-06-06; online 2017-06-06]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Lower inflammatory markers in women with antenatal depression brings the M1/M2 balance into focus from a new direction

Edvinsson Å, Bränn E, Hellgren C, ..., Cunningham JL, Sundström-Poromaa I

Psychoneuroendocrinology 80 (-) 15-25 [2017-06-00; online 2017-06-00]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Structural Diversity of Human Gastric Mucin Glycans.

Jin C, Kenny DT, Skoog EC, ..., Lindén SK, Karlsson NG

Mol. Cell Proteomics 16 (5) 743-758 [2017-05-00; online 2017-05-04]

Affinity Proteomics Uppsala [Service] Glycoproteomics [Service] PLA and Single Cell Proteomics [Service]

Inflammatory markers in late pregnancy in association with postpartum depression-A nested case-control study.

Bränn E, Papadopoulos F, Fransson E, ..., Sundström-Poromaa I, Skalkidou A

Psychoneuroendocrinology 79 (-) 146-159 [2017-05-00; online 2017-02-28]

Affinity Proteomics Uppsala [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

FADD, Caspase-3, and Caspase-8 and Incidence of Coronary Events.

Xue L, Borné Y, Mattisson IY, ..., Nilsson J, Engström G

Arterioscler. Thromb. Vasc. Biol. 37 (5) 983-989 [2017-05-00; online 2017-03-16]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients.

Schiza A, Wenthe J, Mangsbo S, ..., Loskog A, Ullenhag G

J Transl Med 15 (1) 79 [2017-04-20; online 2017-04-20]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia.

Löf L, Arngården L, Olsson-Strömberg U, ..., Landegren U, Kamali-Moghaddam M

Sci Rep 7 (1) 623 [2017-04-04; online 2017-04-04]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children.

Dencker M, Danielson A, Karlsson MK, ..., Andersen LB, Thorsson O

J Pediatr Endocrinol Metab 30 (4) 375-382 [2017-04-01; online 2017-01-14]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.

Folkersen L, Fauman E, Sabater-Lleal M, ..., Hamsten A, Mälarstig A

PLoS Genet. 13 (4) e1006706 [2017-04-00; online 2017-04-03]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service] PLA and Single Cell Proteomics [Service]

Cardiometabolic biomarkers are predictors of readmission and death in patients hospitalized for acute dyspnea.

Lund N, Gränsbo K, Wernersson C, Melander O

The American Journal of Emergency Medicine 35 (4) 610-614 [2017-04-00; online 2016-12-22]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26.

Gudmundsson S, Wilbe M, Ekvall S, ..., Törmä H, Bondeson ML

Hum. Mol. Genet. 26 (6) 1070-1077 [2017-03-15; online 2017-02-06]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Compute and Storage [Service] Clinical Genomics Uppsala [Collaborative] NGI Uppsala (Uppsala Genome Center) [Collaborative] National Genomics Infrastructure [Collaborative] PLA and Single Cell Proteomics [Service]

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma.

Bäckryd E, Tanum L, Lind AL, Larsson A, Gordh T

J Pain Res 10 (-) 515-525 [2017-03-03; online 2017-03-03]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Use of a proximity extension assay proteomics chip to discover new biomarkers associated with albuminuria.

Carlsson AC, Sundström J, Carrero JJ, ..., Lind L, Ärnlöv J

Eur J Prev Cardiol 24 (4) 340-348 [2017-03-00; online 2016-10-28]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays

Larssen P, Wik L, Czarnewski P, ..., Gabrielsson S, Kamali-Moghaddam M

Mol Cell Proteomics 16 (3) 502-511 [2017-03-00; online 2017-01-22]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] PLA and Single Cell Proteomics [Technology development]

Signs of ongoing inflammation in female patients with chronic widespread pain: A multivariate, explorative, cross-sectional study of blood samples.

Gerdle B, Ghafouri B, Ghafouri N, Bäckryd E, Gordh T

Medicine 96 (9) e6130 [2017-03-00; online 2017-03-02]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip.

Lind L, Sundström J, Stenemo M, Hagström E, Ärnlöv J

Heart 103 (5) 377-382 [2017-03-00; online 2016-09-08]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation.

Jónsdóttir B, Jaworowski Å, San Miguel C, Melander O

BMC Pulm Med 17 (1) 35 [2017-02-08; online 2017-02-08]

Affinity Proteomics Stockholm [Service] Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service]

Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.

Molin CJ, Westerberg E, Punga AR

Sci Rep 7 (1) 39716 [2017-01-03; online 2017-01-03]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake.

Cheng Q, Wållberg H, Grafström J, ..., Ståhl S, Sel-tag imaging project

EJNMMI Res 6 (1) 58 [2016-12-00; online 2016-07-07]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

DcR3, TFF3, and Midkine Are Novel Serum Biomarkers in Small Intestinal Neuroendocrine Tumors.

Edfeldt K, Daskalakis K, Bäcklin C, ..., Hellman P, Stålberg P

Neuroendocrinology 105 (2) 170-181 [2016-11-09; online 2016-11-09]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Effects of cigarette smoking on cardiovascular-related protein profiles in two community-based cohort studies.

Huang B, Svensson P, Ärnlöv J, ..., Lind L, Ingelsson E

Atherosclerosis 254 (-) 52-58 [2016-11-00; online 2016-09-15]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Scaffolding protein IQGAP1: an insulin-dependent link between caveolae and the cytoskeleton in primary human adipocytes?

Jufvas A, Rajan MR, Jo nsson C, Stralfors P, Turkina MV

Biochemical Journal 473 (19) 3177-3188 [2016-10-01; online 2016-07-25]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study.

Nowak C, Salihovic S, Ganna A, ..., Ingelsson E, Fall T

PLoS Genet. 12 (10) e1006379 [2016-10-00; online 2016-10-21]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service] PLA and Single Cell Proteomics [Service]

Autoantibodies Targeting a Collecting Duct–Specific Water Channel in Tubulointerstitial Nephritis

Landegren N, Pourmousa Lindberg M, Skov J, ..., Fenton RA, Kämpe O

J. Am. Soc. Nephrol. 27 (10) 3220-3228 [2016-10-00; online 2016-03-16]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout.

Löf L, Ebai T, Dubois L, ..., Landegren U, Kamali-Moghaddam M

Sci Rep 6 (1) 34358 [2016-09-29; online 2016-09-29]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction.

Genshaft AS, Li S, Gallant CJ, ..., Landegren U, Shalek AK

Genome Biol. 17 (1) 188 [2016-09-19; online 2016-09-19]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Associations Between Macrophage Colony-Stimulating Factor and Monocyte Chemotactic Protein 1 in Plasma and First-Time Coronary Events: A Nested Case-Control Study.

Schiopu A, Bengtsson E, Gonçalves I, ..., Fredrikson GN, Björkbacka H

J Am Heart Assoc 5 (9) e002851 [2016-09-13; online 2016-09-13]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes.

Gonçalves I, Edsfeldt A, Colhoun HM, ..., Nilsson J, SUMMIT consortium

BMC Cardiovasc Disord 16 (1) 171 [2016-09-05; online 2016-09-05]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up.

Grönberg C, Asciutto G, Persson A, ..., Gonçalves I, Björkbacka H

Cytokine 85 (-) 137-139 [2016-09-00; online 2016-06-22]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation

Watanabe Y, Papoutsoglou P, Maturi V, ..., Heldin CH, Moustakas A

J. Biol. Chem. 291 (24) 12706-12723 [2016-06-10; online 2016-04-21]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

Single Chain Antibodies as Tools to Study transforming growth factor-β-Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens.

Blokzijl A, Zieba A, Hust M, ..., Dübel S, Landegren U

Mol. Cell Proteomics 15 (6) 1848-1856 [2016-06-00; online 2016-03-02]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Detection of Biomarkers with Solid-Phase Proximity Ligation Assay in Patients with Colorectal Cancer

Ghanipour L, Darmanis S, Landegren U, ..., Påhlman L, Birgisson H

Transl Oncol 9 (3) 251-255 [2016-06-00; online 2016-06-00]

Affinity Proteomics Uppsala [Collaborative] PLA and Single Cell Proteomics [Collaborative] Tissue Profiling [Service]

Inflammatory Serum Protein Profiling of Patients with Lumbar Radicular Pain One Year after Disc Herniation.

Moen A, Lind AL, Thulin M, ..., Gjerstad J, Gordh T

Int J Inflam 2016 (-) 3874964 [2016-05-11; online 2016-05-11]

Affinity Proteomics Uppsala [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay

Blokzijl A, Chen LE, Gustafsdottir SM, ..., Kamali-Moghaddam M, Hedstrand H

PLoS ONE 11 (4) e0154214 [2016-04-25; online 2016-04-25]

Affinity Proteomics Uppsala [Collaborative] PLA and Single Cell Proteomics [Collaborative]

Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients.

Loskog A, Maleka A, Mangsbo S, ..., Tötterman TH, Ullenhag G

Br. J. Cancer 114 (8) 872-880 [2016-04-12; online 2016-03-31]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients

Lind AL, Wu D, Freyhult E, ..., Landegren U, Kamali-Moghaddam M

PLoS ONE 11 (2) e0149821 [2016-02-25; online 2016-02-25]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] PLA and Single Cell Proteomics [Technology development]

Decreased levels of stem cell factor in subjects with incident coronary events.

Wigren M, Rattik S, Hultman K, ..., Gonçalves I, Nilsson J

J. Intern. Med. 279 (2) 180-191 [2016-02-00; online 2015-10-14]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.

Gonçalves I, Hultman K, Dunér P, ..., Nilsson J, Bengtsson E

Open Heart 3 (1) e000353 [2016-01-27; online 2016-01-27]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy.

Edsfeldt A, Bengtsson E, Asciutto G, ..., Nilsson J, Goncalves I

Cerebrovasc Dis 41 (3-4) 199-203 [2016-01-27; online 2016-01-27]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells.

Darmanis S, Gallant CJ, Marinescu VD, ..., Westermark B, Landegren U

Cell Rep 14 (2) 380-389 [2016-01-12; online 2016-01-11]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Protein Detection Using the Multiplexed Proximity Extension Assay (PEA) from Plasma and Vaginal Fluid Applied to the Indicating FTA Elute Micro Card™.

Berggrund M, Ekman D, Gustavsson I, ..., Enroth S, Gyllensten U

Journal of Circulating Biomarkers 5 (-) 9 [2016-01-01; online 2016-01-01]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts.

Nowak C, Sundström J, Gustafsson S, ..., Ingelsson E, Fall T

Diabetes 65 (1) 276-284 [2016-01-00; online 2015-09-29]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Clinical Biomarkers NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service] PLA and Single Cell Proteomics [Service]

Protein profiling reveals consequences of lifestyle choices on predicted biological aging.

Enroth S, Enroth SB, Johansson Å, Gyllensten U

Sci Rep 5 (1) 17282 [2015-12-01; online 2015-12-01]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics [Service]

The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid.

Larsson A, Carlsson L, Lind AL, ..., Kamali-Moghaddam M, Thulin M

Cytokine 76 (2) 514-518 [2015-12-00; online 2015-07-15]

Affinity Proteomics Uppsala [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip.

Lind L, Siegbahn A, Lindahl B, ..., Sundström J, Ärnlöv J

Stroke 46 (12) 3340-3347 [2015-12-00; online 2015-11-05]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics [Service]

Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction.

Helseth R, Weiss TW, Opstad TB, ..., Arnesen H, Seljeflot S

Thromb. Res. 136 (6) 1240-1244 [2015-12-00; online 2015-10-08]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP).

Enroth S, Bosdotter Enroth S, Johansson Å, Gyllensten U

Biomarkers 20 (6-7) 355-364 [2015-11-09; online 2015-11-09]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure PLA and Single Cell Proteomics [Service]

Fibroblast Growth Factor 23 and Incidence of Subarachnoid Hemorrhage: Nested Case-Control Study.

Söderholm M, Engström G

Stroke 46 (11) 3260-3262 [2015-11-00; online 2015-09-22]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

The effects of age and gender on plasma levels of 63 cytokines.

Larsson A, Carlsson L, Gordh T, ..., Thulin M, Kamali-Moghaddam M

J. Immunol. Methods 425 (-) 58-61 [2015-10-00; online 2015-06-14]

Affinity Proteomics Uppsala [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis.

Lind L, Ärnlöv J, Lindahl B, ..., Sundström J, Ingelsson E

Atherosclerosis 242 (1) 205-210 [2015-09-00; online 2015-07-14]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics [Service]

Evaluation of the protein biomarkers and the analgesic response to systemic methylene blue in patients with refractory neuropathic pain: a double-blind, controlled study.

Miclescu AA, Svahn M, Gordh TE

J Pain Res 8 (-) 387-397 [2015-07-15; online 2015-07-15]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics [Service]

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Goncalves I, Bengtsson E, Colhoun HM, ..., Nilsson J, SUMMIT Consortium

Arterioscler. Thromb. Vasc. Biol. 35 (7) 1723-1731 [2015-07-00; online 2015-05-07]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Transglutaminase 4 as a prostate autoantigen in male subfertility

Landegren N, Sharon D, Shum AK, ..., Snyder M, Kämpe O

Sci. Transl. Med. 7 (292) 292ra101 [2015-06-17; online 2015-06-17]

Affinity Proteomics Uppsala [Service] Autoimmunity and Serology Profiling [Service] Bioinformatics Support and Infrastructure Bioinformatics Support, Infrastructure and Training PLA and Single Cell Proteomics

Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.

Gu Urban GJ, Friedman M, Ren P, ..., Landegren U, Kamali-Moghaddam M

Sci Rep 5 (1) 11196 [2015-06-16; online 2015-06-16]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

Proximity-dependent initiation of hybridization chain reaction.

Koos B, Cane G, Grannas K, ..., Kamali-Moghaddam M, Söderberg O

Nat Commun 6 (-) 7294 [2015-06-12; online 2015-06-12]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]

Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke.

Asciutto G, Dias NV, Edsfeldt A, ..., Nilsson J, Gonçalves I

PLoS ONE 10 (3) e0121086 [2015-03-24; online 2015-03-24]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Parallel protein detection by solid-phase proximity ligation assay with real-time PCR or sequencing.

Ebai T, Kamali-Moghaddam M, Landegren U

Curr Protoc Mol Biol 109 (-) 20.10.1-20.1025 [2015-01-05; online 2015-01-05]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics [Technology development]

The Biobanking Analysis Resource Catalogue (BARCdb): a new research tool for the analysis of biobank samples.

Galli J, Oelrich J, Taussig MJ, ..., Ortega-Paino E, Landegren U

Nucleic Acids Res. 43 (Database issue) D1158-D1162 [2015-01-00; online 2014-10-23]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

High plasma levels of heparin-binding epidermal growth factor are associated with a more stable plaque phenotype and reduced incidence of coronary events.

Rattik S, Wigren M, Björkbacka H, ..., Gonçalves I, Nilsson J

Arterioscler. Thromb. Vasc. Biol. 35 (1) 222-228 [2015-01-00; online 2014-10-30]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Sensitive detection of aggregated prion protein via proximity ligation.

Hammond M, Wik L, Deslys JP, ..., Landegren U, Kamali-Moghaddam M

Prion 8 (3) 261-265 [2014-12-09; online 2014-12-09]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics [Technology development]

Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease.

Ganna A, Salihovic S, Sundström J, ..., Fall T, Ingelsson E

PLoS Genet. 10 (12) e1004801 [2014-12-00; online 2014-12-11]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service] PLA and Single Cell Proteomics [Service]

The Eph tyrosine kinase receptors EphB2 and EphA2 are novel proteolytic substrates of tissue factor/coagulation factor VIIa.

Eriksson O, Ramström M, Hörnaeus K, ..., Mokhtari D, Siegbahn A

J. Biol. Chem. 289 (47) 32379-32391 [2014-11-21; online 2014-10-05]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Growth differentiation factor 15, a marker of oxidative stress and inflammation, for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.

Wallentin L, Hijazi Z, Andersson U, ..., Siegbahn A, ARISTOTLE Investigators

Circulation 130 (21) 1847-1858 [2014-11-18; online 2014-10-07]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics [Service]

A universal approach to prepare reagents for DNA-assisted protein analysis.

Yan J, Gu GJ, Jost C, ..., Landegren U, Kamali-Moghaddam M

PLoS ONE 9 (9) e108061 [2014-09-18; online 2014-09-18]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics [Technology development]

Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs.

Enroth S, Johansson A, Enroth SB, Gyllensten U

Nat Commun 5 (1) 4684 [2014-08-22; online 2014-08-22]

Affinity Proteomics Uppsala [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Tyrosine phosphorylation profiling via in situ proximity ligation assay.

Elfineh L, Classon C, Asplund A, ..., Kamali-Moghaddam M, Lind SB

BMC Cancer 14 (-) 435 [2014-06-13; online 2014-06-13]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Protein biomarker validation via proximity ligation assays.

Blokzijl A, Nong R, Darmanis S, ..., Landegren U, Kamali-Moghaddam M

Biochim. Biophys. Acta 1844 (5) 933-939 [2014-05-00; online 2013-08-13]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Identification of novel downstream molecules of tissue factor activation by comparative proteomic analysis.

Kask L, Jorsback A, Winkvist M, ..., Bergquist J, Siegbahn A

J. Proteome Res. 13 (2) 477-488 [2014-02-07; online 2013-12-11]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics [Service]

A tosyl-activated magnetic bead cellulose as solid support for sensitive protein detection.

Yan J, Horák D, Lenfeld J, Hammond M, Kamali-Moghaddam M

J. Biotechnol. 167 (3) 235-240 [2013-09-10; online 2013-07-03]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.

Gu GJ, Lund H, Wu D, ..., Sunnemark D, Kamali-Moghaddam M

Neuromolecular Med. 15 (3) 458-469 [2013-09-00; online 2013-05-12]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics

Solid-phase proximity ligation assays for individual or parallel protein analyses with readout via real-time PCR or sequencing.

Nong RY, Wu D, Yan J, ..., Landegren U, Darmanis S

Nat Protoc 8 (6) 1234-1248 [2013-06-00; online 2013-05-30]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Parallel visualization of multiple protein complexes in individual cells in tumor tissue.

Leuchowius KJ, Clausson CM, Grannas K, ..., Landegren U, Söderberg O

Mol. Cell Proteomics 12 (6) 1563-1571 [2013-06-00; online 2013-02-26]

Affinity Proteomics Uppsala [Technology development] NGI Uppsala (Uppsala Genome Center) National Genomics Infrastructure PLA and Single Cell Proteomics

Dynamic gradients of an intermediate filament-like cytoskeleton are recruited by a polarity landmark during apical growth.

Fuchino K, Bagchi S, Cantlay S, ..., Flärdh K, Ausmees N

Proc. Natl. Acad. Sci. U.S.A. 110 (21) E1889-E1897 [2013-05-21; online 2013-05-04]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Offshoots of the ESF functional genomics programme.

Landegren U

N Biotechnol 30 (3) 296-298 [2013-03-25; online 2013-01-09]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Workshop on laboratory protocol standards for the Molecular Methods Database.

Klingström T, Soldatova L, Stevens R, ..., Landegren U, Bongcam-Rudloff E

N Biotechnol 30 (2) 109-113 [2013-01-25; online 2012-06-02]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation.

Gu GJ, Friedman M, Jost C, ..., Landegren U, Söderberg O

N Biotechnol 30 (2) 144-152 [2013-01-25; online 2012-06-06]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Multiplex protein detection with DNA readout via mass spectrometry.

Flanigon J, Kamali-Moghaddam M, Burbulis I, ..., Landegren U, Cantor C

N Biotechnol 30 (2) 153-158 [2013-01-25; online 2012-12-04]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

PCR-based multiparametric assays in single cells.

Darmanis S, Gallant C, Landegren U

Clin. Chem. 58 (12) 1618-1619 [2012-12-00; online 2012-10-17]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease.

Gu GJ, Wu D, Lund H, ..., Landegren U, Kamali-Moghaddam M

J. Alzheimers Dis. 33 (3) 699-713 [2012-09-25; online 2012-09-25]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics

Molecular tools for companion diagnostics.

Zieba A, Grannas K, Söderberg O, ..., Nilsson M, Landegren U

N Biotechnol 29 (6) 634-640 [2012-09-15; online 2012-05-24]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.

Teranishi Y, Hur JY, Gu GJ, ..., Frykman S, Tjernberg LO

Biochem. Biophys. Res. Commun. 424 (3) 476-481 [2012-08-03; online 2012-07-10]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Profiling cellular protein complexes by proximity ligation with dual tag microarray readout.

Hammond M, Nong RY, Ericsson O, Pardali K, Landegren U

PLoS ONE 7 (7) e40405 [2012-07-10; online 2012-07-10]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase.

Zieba A, Pardali K, Söderberg O, ..., Heldin CH, Landegren U

Mol. Cell Proteomics 11 (7) M111.013482 [2012-07-00; online 2012-03-24]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Visualising individual sequence-specific protein-DNA interactions in situ.

Weibrecht I, Gavrilovic M, Lindbom L, ..., Wählby C, Söderberg O

N Biotechnol 29 (5) 589-598 [2012-06-15; online 2011-09-13]

Affinity Proteomics Uppsala [Collaborative] BioImage Informatics [Collaborative] PLA and Single Cell Proteomics

Western blotting via proximity ligation for high performance protein analysis.

Liu Y, Gu J, Hagner-McWhirter Å, ..., Ivansson D, Landegren U

Mol. Cell Proteomics 10 (11) O111.011031 [2011-11-00; online 2011-08-02]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Increasing the dynamic range of in situ PLA.

Clausson C, Allalou A, Weibrecht I, ..., Wählby C, Söderberg O

Nat. Methods 8 (11) 892-893 [2011-10-28; online 2011-10-28]

Affinity Proteomics Uppsala [Collaborative] BioImage Informatics [Collaborative] PLA and Single Cell Proteomics

ProteinSeq: high-performance proteomic analyses by proximity ligation and next generation sequencing.

Darmanis S, Nong RY, Vänelid J, ..., Kamali-Moghaddam M, Landegren U

PLoS ONE 6 (9) e25583 [2011-09-29; online 2011-09-29]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer.

Tavoosidana G, Ronquist G, Darmanis S, ..., Landegren UD, Kamali-Moghaddam M

Proc. Natl. Acad. Sci. U.S.A. 108 (21) 8809-8814 [2011-05-24; online 2011-05-11]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers PLA and Single Cell Proteomics

Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease.

Kamali-Moghaddam M, Pettersson FE, Wu D, ..., Lannfelt L, Landegren U

BMC Neurosci 11 (-) 124 [2010-10-05; online 2010-10-05]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics

Profiling protein expression and interactions: proximity ligation as a tool for personalized medicine.

Blokzijl A, Friedman M, Pontén F, Landegren U

J. Intern. Med. 268 (3) 232-245 [2010-09-00; online 2010-08-11]

Affinity Proteomics Uppsala [Technology development] PLA and Single Cell Proteomics