Drug Discovery and Development (DDD)

SciLifeLab National platform since 2013. Includes facilities ADME of Therapeautics, Biochemical and cellular screening, Biophysical Screening and Characterization, Human Antibody Therapeutics, In Vitro and Systems Pharmacology, Medicinal Chemistry – Hit2lead, Medicinal Chemistry – Lead Identification, Protein Expression and Characterization.

83 publications

Year 2018

PubMed DOI Crossref
In Vitro Evolution of Antibodies Inspired by In Vivo Evolution
Persson H, Kirik U, Thörnqvist L, ..., Levander F, Ohlin M
Front Immunol 9 (-) - [2018-06-21; online 2018-06-21]
Drug Discovery and Development (DDD) [Collaborative]

Year 2017

PubMed DOI Crossref
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth AS, ..., Scobie M, Ulrika Warpman Berglund &Thomas Helleday
Nature 544 (7651) 508 [2017-04-26; online 2017-04-28]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Sulfonimidamides in Medicinal and Agricultural Chemistry
Chinthakindi PK, Naicker T, Thota N, ..., Kruger HG, Arvidsson PI
Angew. Chem. Int. Ed. 56 (15) 4100-4109 [2017-04-03; online 2017-02-23]
Drug Discovery and Development (DDD) [Technology development]

Year 2016

PubMed DOI Crossref
Case-specific potentiation of glioblastoma drugs by pterostilbene.
Schmidt L, Baskaran S, Johansson P, ..., Krona C, Nelander S
pmc
Oncotarget 7 (45) 73200-73215 [2016-11-08; online 2016-10-01]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Enantioselective Organocatalyzed Transformations of β-Ketoesters.
Govender T, Arvidsson PI, Maguire GE, Kruger HG, Naicker T
Chem. Rev. 116 (16) 9375-9437 [2016-08-24; online 2016-07-28]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
A Facile Synthesis of NODASA-Functionalized Peptide
Naicker T, Albericio F, Dutta J, ..., Kruger H, Govender T
Synlett 27 (11) 1685-1688 [2016-03-30; online 2016-03-30]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
On-Water Synthesis of Biaryl Sulfonyl Fluorides.
Chinthakindi PK, Kruger HG, Govender T, Naicker T, Arvidsson PI
J. Org. Chem. 81 (6) 2618-2623 [2016-03-18; online 2016-02-24]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Stereoselective synthesis towards unnatural proline based amino acids
Makhathini SS, Das SK, Singh T, ..., Govender T, Naicker T
ARKIVOC 2016 (3) 134 [2016-02-07; online 2016-02-07]
Drug Discovery and Development (DDD) [Collaborative]

Year 2015

DOI Crossref
Synthesis of enantiopure angiotensin II type 2 receptor [AT2R] antagonist EMA401
Wakchaure PB, Bremberg U, Wannberg J, Larhed M
Tetrahedron 71 (38) 6881-6887 [2015-09-00; online 2015-09-00]
Drug Discovery and Development (DDD)
DOI Crossref
NOTA: a potent metallo-β-lactamase inhibitor
Somboro AM, Tiwari D, Bester LA, ..., Naicker T, Essack SY
J. Antimicrob. Chemother. 70 (5) 1594-1596 [2015-05-00; online 2015-01-06]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study
Md. Abdur Rauf S, Arvidsson PI, Albericio F, ..., Kruger HG, Honarparvar B
Org. Biomol. Chem. 13 (39) 9993-10006 [2015-00-00; online 2015-00-00]
Drug Discovery and Development (DDD) [Collaborative]

Year 2014

Year 2013