Drug Discovery and Development (DDD)

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SciLifeLab National platform Since 2013.

Primary: Shown in the list of current labels, if end date is not specified.

Started: 2013

Ended: Current

Year 2023

PubMed DOI Crossref
New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
Durcik M, Cotman AE, Toplak Ž, ..., Tomašič T, Peterlin Mašič L
J. Med. Chem. 66 (6) 3968-3994 [2023-03-23; online 2023-03-06]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
In Vitro and In Vivo Development of a β-Lactam-Metallo-β-Lactamase Inhibitor: Targeting Carbapenem-Resistant Enterobacterales.
Peters BK, Reddy N, Shungube M, ..., Naicker T, Govender T
ACS Infect Dis 9 (3) 486-496 [2023-03-10; online 2023-02-14]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
Cotman AE, Durcik M, Benedetto Tiz D, ..., Sterk GJ, Kikelj D
J. Med. Chem. 66 (2) 1380-1425 [2023-01-26; online 2023-01-12]
Drug Discovery and Development (DDD) [Service]

Year 2022

PubMed DOI Crossref
Monitoring drug-target interactions through target engagement-mediated amplification on arrays and in situ.
Al-Amin RA, Johansson L, Abdurakhmanov E, ..., Lundbäck T, Landegren U
Nucleic Acids Res. 50 (22) e129 [2022-12-09; online 2022-10-04]
Autoimmunity and Serology Profiling [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies.
Preger C, Notarnicola A, Hellström C, ..., Gräslund S, Jakobsson PJ
J. Autoimmun. 134 (-) 102951 [2022-12-02; online 2022-12-02]
Autoimmunity and Serology Profiling [Service] Drug Discovery and Development (DDD) [Service]
DOI Crossref
Organic Base-Mediated Carboxylation of (Hetero)aromatic Compounds Using Supercritical Carbon Dioxide (scCO2)
Govender T, Chetty LC, Kruger HG, Arvidsson PI, Naicker T
Synthesis 54 (21) 4827-4833 [2022-11-00; online 2022-08-16]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS
Wegler C, Saleh A, Lindqvist A, ..., Smeraglia J, Baranczewski P
Journal of Chromatography B 1205 (-) 123340 [2022-08-00; online 2022-08-00]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Sensitive Protein Detection Using Site-Specifically Oligonucleotide-Conjugated Nanobodies.
Al-Amin RA, Muthelo PM, Abdurakhmanov E, ..., Danielson UH, Landegren U
Anal. Chem. 94 (28) 10054-10061 [2022-07-19; online 2022-07-05]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
An Adaptable Antibody‐Based Platform for Flexible Synthetic Peptide Delivery Built on Agonistic CD40 Antibodies
Eltahir M, Laurén I, Lord M, ..., Persson H, Mangsbo SM
Advanced Therapeutics 5 (7) 2200008 [2022-07-00; online 2022-06-14]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Broad-spectrum antidote discovery by untangling the reactivation mechanism of nerve agent inhibited acetylcholinesterase.
Lindgren C, Forsgren N, Hoster N, ..., Ekström F, Linusson A
Chemistry - (-) - [2022-04-14; online 2022-04-14]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
Luttens A, Gullberg H, Abdurakhmanov E, ..., Danielson UH, Carlsson J
J. Am. Chem. Soc. 144 (7) 2905-2920 [2022-02-23; online 2022-02-10]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Bonagas N, Gustafsson NMS, Henriksson M, ..., Homan EJ, Helleday T
Nat Cancer 3 (2) 156-172 [2022-02-00; online 2022-02-28]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Sequence specificity in DNA binding is mainly governed by association.
Marklund E, Mao G, Yuan J, ..., Deindl S, Elf J
Science 375 (6579) 442-445 [2022-01-28; online 2022-01-27]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Brem J, Panduwawala T, Hansen JU, ..., Walsh TR, Schofield CJ
Nat Chem 14 (1) 15-24 [2022-01-00; online 2021-12-13]
Drug Discovery and Development (DDD) [Service]

Year 2021

PubMed DOI Crossref
Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes.
Byrgazov K, Lind T, Rasmusson AJ, ..., Larsson R, Fryknäs M
Bone Rep 15 (-) 101098 [2021-12-00; online 2021-06-07]
Drug Discovery and Development (DDD)
PubMed DOI Crossref
Fed-batch production assessment of a tetravalent bispecific antibody: A case study on piggyBac stably transfected HEK293 cells.
Napoleone A, Laurén I, Linkgreim T, ..., Lord M, Mangsbo S
N Biotechnol 65 (-) 9-19 [2021-11-25; online 2021-07-15]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain.
Szykowska A, Chen Y, Smith TB, ..., Burgess-Brown NA, Bullock AN
Structure 29 (11) 1241-1252.e5 [2021-11-04; online 2021-07-06]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
ENABLE: an engine for European antibacterial drug discovery and development.
Olliver M, Griestop L, Hughes D, ..., Vingsbo Lundberg C, Karlén A
Nat Rev Drug Discov 20 (6) 407-408 [2021-06-00; online 2021-05-06]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase.
Talibov VO, Fabini E, FitzGerald EA, ..., Del Rio A, Danielson UH
ChemBioChem 22 (9) 1597-1608 [2021-05-04; online 2021-02-11]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.
Wannberg J, Gising J, Lindman J, ..., Hallberg M, Larhed M
Bioorg. Med. Chem. 29 (-) 115859 [2021-01-01; online 2020-11-07]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research.
Matsson P, Baranczewski P, Giacomini KM, ..., Charman WN, Bergström CAS
J Pharm Sci 110 (1) 2-11 [2021-01-00; online 2020-10-21]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
FitzGerald EA, Butko MT, Boronat P, ..., Young T, Danielson UH
RSC Adv. 11 (13) 7527-7537 [2021-00-00; online 2021-00-00]
Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD)

Year 2020

PubMed DOI Crossref
Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.
Hartmann RW, Fahrner R, Shevshenko D, ..., Lehmann F, Odell LR
ChemMedChem 15 (24) 2500-2512 [2020-12-15; online 2020-10-16]
Drug Discovery and Development (DDD)
PubMed DOI Crossref
Generation and validation of recombinant antibodies to study human aminoacyl-tRNA synthetases.
Preger C, Wigren E, Ossipova E, ..., Gräslund S, Persson H
J. Biol. Chem. 295 (41) 13981-13993 [2020-10-09; online 2020-08-14]
Autoimmunity and Serology Profiling [Service] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro.
Akaberi D, Krambrich J, Ling J, ..., Lennerstrand J, Lundkvist Å
Redox Biol 37 (-) 101734 [2020-10-00; online 2020-09-21]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway.
Andersson CR, Selvin T, Blom K, ..., Nygren P, Larsson R
Sci Rep 10 (1) 13124 [2020-08-04; online 2020-08-04]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids.
Steinmetz J, Senkowski W, Lengqvist J, ..., Fryknäs M, Kultima K
ACS Omega 5 (28) 17242-17254 [2020-07-21; online 2020-07-06]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.
Johansson P, Krona C, Kundu S, ..., Marino S, Nelander S
Cell Rep 32 (2) 107897 [2020-07-14; online 2020-07-16]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
High content drug screening for Fanconi anemia therapeutics.
Montanuy H, Camps-Fajol C, Carreras-Puigvert J, ..., Minguillón J, Surrallés J
Orphanet J Rare Dis 15 (1) 170 [2020-06-30; online 2020-06-30]
Drug Discovery and Development (DDD)
PubMed DOI Crossref
Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin.
Saei AA, Gullberg H, Sabatier P, ..., Arnér ESJ, Zubarev RA
Redox Biol 32 (-) 101491 [2020-05-00; online 2020-03-03]
Drug Discovery and Development (DDD)
PubMed DOI Crossref
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.
Popova G, Ladds MJGW, Johansson L, ..., Yngve U, Lain S
J. Med. Chem. 63 (8) 3915-3934 [2020-04-23; online 2020-04-08]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Establishing Trypanosoma cruzi farnesyl pyrophosphate synthase as a viable target for biosensor driven fragment-based lead discovery.
Opassi G, Nordström H, Lundin A, ..., Klebe G, Danielson UH
Protein Sci. 29 (4) 991-1003 [2020-04-00; online 2020-02-07]
Drug Discovery and Development (DDD)
PubMed DOI Crossref
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy.
Rendo V, Stoimenov I, Mateus A, ..., Cheong I, Sjöblom T
Nat Commun 11 (1) 1308 [2020-03-11; online 2020-03-11]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Tumor localized agonistic anti-CD40 therapy and beyond.
Eltahir M, Persson H, Mangsbo S
Expert Opin Biol Ther 20 (3) 215-217 [2020-03-00; online 2020-01-10]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Estimating Detection Limits of Potentiometric DNA Sensors Using Surface Plasmon Resonance Analyses.
Xu X, Makaraviciute A, Abdurakhmanov E, ..., Nyholm L, Zhang Z
ACS Sens. 5 (1) 217-224 [2020-01-24; online 2019-12-23]
Drug Discovery and Development (DDD) [Technology development]

Year 2019

PubMed DOI Crossref
Structural Changes of Mercaptohexanol Self-Assembled Monolayers on Gold and Their Influence on Impedimetric Aptamer Sensors.
Xu X, Makaraviciute A, Kumar S, ..., Nyholm L, Zhang Z
Anal. Chem. 91 (22) 14697-14704 [2019-11-19; online 2019-11-07]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f u,cell).
Treyer A, Walday S, Boriss H, Matsson P, Artursson P
Pharm. Res. 36 (12) 178 [2019-11-07; online 2019-11-07]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors.
Kulén M, Núñez-Otero C, Cairns AG, ..., Gylfe Å, Almqvist F
Med. Chem. Commun. 10 (11) 1966-1987 [2019-11-01; online 2019-10-17]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity.
Niklasson M, Bergström T, Jarvius M, ..., Segerman B, Segerman A
J. Pathol. 249 (3) 295-307 [2019-11-00; online 2019-08-31]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Inhibition of translation termination by small molecules targeting ribosomal release factors.
Ge X, Oliveira A, Hjort K, ..., Sanyal S, Åqvist J
Sci Rep 9 (1) 15424 [2019-10-28; online 2019-10-28]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
N-Trifluoromethylthiolated Sulfonimidamides and Sulfoximines: Anti-microbial, Anti-mycobacterial, and Cytotoxic Activity.
Thota N, Makam P, Rajbongshi KK, ..., Naicker T, Arvidsson PI
ACS Med Chem Lett 10 (10) 1457-1461 [2019-10-10; online 2019-09-11]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation.
Karlsson H, Senkowski W, Fryknäs M, ..., Larsson R, Nygren P
Oncotarget 10 (51) 5372-5382 [2019-09-03; online 2019-09-03]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
Idborg H, Zandian A, Ossipova E, ..., Svenungsson E, Jakobsson PJ
Front Immunol 10 (-) 1029 [2019-05-17; online 2019-05-17]
Affinity Proteomics Stockholm [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition.
Blom K, Rubin J, Berglund M, ..., Nygren P, Larsson R
BMC Res Notes 12 (1) 234 [2019-04-22; online 2019-04-22]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations.
Filppula AM, Parvizi R, Mateus A, Baranczewski P, Artursson P
Sci Rep 9 (1) 5850 [2019-04-10; online 2019-04-10]
Drug Discovery and Development (DDD) [Technology development]
DOI Crossref
Synthesis of Sulfonimidamide-Based Amino Acid Building Blocks with Orthogonal Protecting Groups
Chinthakindi PK, Benediktsdottir A, Ibrahim A, ..., Chen Y, Sandström A
Eur. J. Org. Chem. 2019 (5) 1045-1057 [2019-02-07; online 2019-01-02]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci.
Drobin K, Assadi G, Hong MG, ..., D'Amato M, Halfvarson J
Inflamm Bowel Dis 25 (2) 306-316 [2019-01-10; online 2018-10-26]
Affinity Proteomics Stockholm [Collaborative] Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
A Series of Analogues to the AT 2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode.
Isaksson R, Lindman J, Wannberg J, ..., Gising J, Larhed M
ChemistryOpen 8 (1) 114-125 [2019-01-00; online 2019-01-24]
Drug Discovery and Development (DDD) [Collaborative]

Year 2018

PubMed DOI Crossref
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
Gustafsson NMS, Färnegårdh K, Bonagas N, ..., Olin T, Helleday T
Nat Commun 9 (1) - [2018-12-00; online 2018-09-24]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds MJGW, van Leeuwen IMM, Drummond CJ, ..., McCormack E, Laín S
Nat Commun 9 (1) - [2018-12-00; online 2018-05-22]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
Islam MK, Strand M, Saleeb M, ..., Elofsson M, Evander M
Sci Rep 8 (1) - [2018-12-00; online 2018-01-31]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Visnes T, Cázares-Körner A, Hao W, ..., Boldogh I, Helleday T
Science 362 (6416) 834-839 [2018-11-16; online 2018-11-18]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Chemical Proteomics [Collaborative] Drug Discovery and Development (DDD) [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Combination of phage and Gram-positive bacterial display of human antibody repertoires enables isolation of functional high affinity binders.
Hu FJ, Volk AL, Persson H, ..., Uhlen M, Rockberg J
N Biotechnol 45 (-) 80-88 [2018-10-25; online 2017-08-01]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
The downfall of TBA-354 - a possible explanation for its neurotoxicity via mass spectrometric imaging.
Ntshangase S, Shobo A, Kruger HG, ..., Govender T, Baijnath S
Xenobiotica 48 (9) 938-944 [2018-09-00; online 2017-10-13]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Sulfonimidamides: Synthesis and Applications in Preparative Organic Chemistry
Nandi GC, Arvidsson PI
Adv. Synth. Catal. 360 (16) 2976-3001 [2018-08-17; online 2018-05-25]
Drug Discovery and Development (DDD) [Technology development]
DOI Crossref
Sulfonyl Fluorides (SFs): More Than Click Reagents?
Chinthakindi PK, Arvidsson PI
Eur. J. Org. Chem. 2018 (27-28) 3648-3666 [2018-08-01; online 2018-07-06]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
Sundell GN, Arnold R, Ali M, ..., Chi CN, Ivarsson Y
Mol. Syst. Biol. 14 (8) e8129 [2018-08-00; online 2018-08-20]
Drug Discovery and Development (DDD) [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
An imidazole based H-Phe-Phe-NH 2 peptidomimetic with anti-allodynic effect in spared nerve injury mice
Skogh A, Lesniak A, Sköld C, ..., Hallberg M, Sandström A
Bioorganic & Medicinal Chemistry Letters 28 (14) 2446-2450 [2018-08-00; online 2018-08-00]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Mebendazole stimulates CD14+ myeloid cells to enhance T-cell activation and tumour cell killing.
Rubin J, Mansoori S, Blom K, ..., Nygren P, Larsson R
Oncotarget 9 (56) 30805-30813 [2018-07-20; online 2018-07-20]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
In Vitro Evolution of Antibodies Inspired by In Vivo Evolution
Persson H, Kirik U, Thörnqvist L, ..., Levander F, Ohlin M
Front Immunol 9 (-) - [2018-06-21; online 2018-06-21]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5
Rossi Sebastiano M, Doak BC, Backlund M, ..., Matsson P, Kihlberg J
J. Med. Chem. 61 (9) 4189-4202 [2018-05-10; online 2018-04-02]
Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
Ladds MJGW, Pastor-Fernández A, Popova G, ..., Bhatia R, Laín S
PLoS ONE 13 (4) e0195956 [2018-04-23; online 2018-04-23]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.
Linkuvienė V, Talibov VO, Danielson UH, Matulis D
J. Med. Chem. 61 (6) 2292-2302 [2018-03-22; online 2018-03-02]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, ..., McCormack E, Laín S
Nat Commun 9 (1) 1107 [2018-03-16; online 2018-03-16]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase
Costeira-Paulo J, Gault J, Popova G, ..., Marklund EG, Landreh M
Cell Chem Biol 25 (3) 309-317.e4 [2018-03-00; online 2018-03-00]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Advancing the immunoaffinity platform AFFIRM to targeted measurements of proteins in serum in the pg/ml range.
Säll A, Corbee D, Vikström S, ..., Persson H, Waldemarson S
PLoS ONE 13 (2) e0189116 [2018-02-13; online 2018-02-13]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration
Pettersson-Klein AT, Izadi M, Ferreira DMS, ..., Griffin PR, Ruas JL
Mol Metab - (-) - [2018-02-00; online 2018-02-00]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes
Wannberg J, Isaksson R, Bremberg U, ..., Hallberg M, Larhed M
Bioorganic & Medicinal Chemistry Letters 28 (3) 519-522 [2018-02-00; online 2018-02-00]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page BDG, Valerie NCK, Wright RHG, ..., Beato M, Helleday T
Nat Commun 9 (1) 250 [2018-01-17; online 2018-01-17]
Bioinformatics Compute and Storage [Service] Drug Discovery and Development (DDD) [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Clofazimine protects against Mycobacterium tuberculosis dissemination in the central nervous system following aerosol challenge in a murine model.
Baijnath S, Moodley C, Ngcobo B, ..., Pym A, Govender T
International Journal of Antimicrobial Agents 51 (1) 77-81 [2018-01-00; online 2017-08-24]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction
Khumalo MF, Akpan ED, Chinthakindi PK, ..., Naicker T, Arvidsson PI
RSC Adv. 8 (65) 37503-37507 [2018-00-00; online 2018-00-00]
Drug Discovery and Development (DDD) [Technology development]
DOI Crossref
An unexpected re-arrangement of the antibiotic carbapenem core to new 1,4-diazepin-5-one scaffolds
Peters BK, Razuwika R, Samipillai M, ..., Govender T, Naicker T
RSC Adv. 8 (1) 190-193 [2018-00-00; online 2018-00-00]
Drug Discovery and Development (DDD) [Collaborative]

Year 2017

PubMed DOI Crossref
Targeting tumor cells based on Phosphodiesterase 3A expression.
Nazir M, Senkowski W, Nyberg F, ..., Larsson R, Fryknäs M
Exp. Cell Res. 361 (2) 308-315 [2017-12-15; online 2017-10-26]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.
Eriksson A, Chantzi E, Fryknäs M, ..., Höglund M, Larsson R
Leuk Res 63 (-) 41-46 [2017-12-00; online 2017-10-28]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Carreras-Puigvert J, Zitnik M, Jemth AS, ..., Zupan B, Helleday T
Nat Commun 8 (1) - [2017-12-00; online 2017-11-16]
BioImage Informatics [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism.
Kashif M, Andersson C, Mansoori S, ..., Nygren P, Gustafsson MG
Oncotarget 8 (61) 103952-103967 [2017-11-28; online 2017-10-19]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Antibody Heavy Chain Variable Domains of Different Germline Gene Origins Diversify through Different Paths
Kirik U, Persson H, Levander F, Greiff L, Ohlin M
Front Immunol 8 (-) - [2017-11-13; online 2017-11-13]
Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Institutional profile: the national Swedish academic drug discovery & development platform at SciLifeLab.
Arvidsson PI, Sandberg K, Sakariassen KS
Future Sci. OA 3(2), FSO176 (2) - [2017-10-30; online 2017-04-07]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration.
Skogh A, Lesniak A, Gaugaz FZ, ..., Hallberg M, Sandström A
Eur J Pharm Sci 109 (-) 533-540 [2017-09-05; online 2017-09-05]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.
Karlgren M, Simoff I, Backlund M, ..., Oswald S, Artursson P
J Pharm Sci 106 (9) 2909-2913 [2017-09-00; online 2017-04-24]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Technology development] Drug Discovery and Development (DDD) [Technology development] NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
Importance of N- and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration.
Skogh A, Lesniak A, Gaugaz FZ, ..., Hallberg M, Sandström A
Eur J Pharm Sci 106 (-) 345-351 [2017-08-30; online 2017-06-03]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.
Llona-Minguez S, Häggblad M, Martens U, ..., Scobie M, Helleday T
Bioorg. Med. Chem. Lett. 27 (16) 3897-3904 [2017-08-15; online 2017-06-16]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.
Llona-Minguez S, Häggblad M, Martens U, ..., Scobie M, Helleday T
Bioorg. Med. Chem. Lett. 27 (15) 3219-3225 [2017-08-01; online 2017-06-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation.
Blom K, Senkowski W, Jarvius M, ..., Nygren P, Larsson R
Immunopharmacol Immunotoxicol 39 (4) 199-210 [2017-08-00; online 2017-05-04]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent
Mdanda S, Baijnath S, Shobo A, ..., Naicker T, Govender T
Biomedical Chromatography - (-) e4035 [2017-07-13; online 2017-07-13]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines.
Llona-Minguez S, Ghassemian A, Baranczewski P, ..., Scobie M, Helleday T
Med. Chem. Commun. 8 (7) 1553-1560 [2017-07-01; online 2017-07-04]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation.
Spahiu L, Ålander J, Ottosson-Wadlund A, ..., Armstrong RN, Morgenstern R
Biochemistry 56 (24) 3089-3098 [2017-06-20; online 2017-06-09]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Synthetic approaches to radiochemical probes for imaging of bacterial infections
Dutta J, Naicker T, Ebenhan T, ..., Arvidsson PI, Govender T
European Journal of Medicinal Chemistry 133 (-) 287-308 [2017-06-00; online 2017-06-00]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
On the bridge over the translational valley of death: interview with Per I Arvidsson.
Arvidsson PI
Future Science OA 3 (2) FSO183 [2017-06-00; online 2017-04-10]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez S, Höglund A, Ghassemian A, ..., Scobie M, Helleday T
J. Med. Chem. 60 (10) 4279-4292 [2017-05-25; online 2017-05-16]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity.
Karlsson H, Fryknäs M, Strese S, ..., Larsson R, Nygren P
Oncotarget 8 (18) 30217-30234 [2017-05-02; online 2017-04-19]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.
Jiang Y, Marinescu VD, Xie Y, ..., Nelander S, Uhrbom L
Cell Rep 19 (5) 1080-1081 [2017-05-02; online 2017-05-04]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth AS, ..., Scobie M, Ulrika Warpman Berglund &Thomas Helleday
Nature 544 (7651) 508 [2017-04-26; online 2017-04-28]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Sulfonimidamides in Medicinal and Agricultural Chemistry
Chinthakindi PK, Naicker T, Thota N, ..., Kruger HG, Arvidsson PI
Angew. Chem. Int. Ed. 56 (15) 4100-4109 [2017-04-03; online 2017-02-23]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Wiita E, ..., Scobie M, Helleday T
J. Med. Chem. 60 (5) 2148-2154 [2017-03-09; online 2017-02-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Antibody Validation by Immunoprecipitation Followed by Mass Spectrometry Analysis.
Persson H, Preger C, Marcon E, Lengqvist J, Gräslund S
Methods Mol. Biol. 1575 (-) 175-187 [2017-03-04; online 2017-03-04]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Intracellular drug bioavailability: a new predictor of system dependent drug disposition.
Mateus A, Treyer A, Wegler C, ..., Matsson P, Artursson P
Sci Rep 7 (-) 43047 [2017-02-22; online 2017-02-22]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Gustafsson R, Jemth AS, Gustafsson NM, ..., Helleday T, Stenmark P
Cancer Res. 77 (4) 937-948 [2017-02-15; online 2016-11-29]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
A Synthesis of “Dual Warhead” β-Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β-Sultams
Chinthakindi PK, Govender KB, Kumar AS, ..., Naicker T, Arvidsson PI
Org. Lett. 19 (3) 480-483 [2017-02-03; online 2017-01-11]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia.
Strese S, Hassan SB, Velander E, ..., Larsson R, Gullbo J
Oncotarget 8 (4) 6341-6352 [2017-01-24; online 2016-12-16]
Drug Discovery and Development (DDD) [Service]

Year 2016

PubMed DOI Crossref
Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition.
Segerman A, Niklasson M, Haglund C, ..., Segerman B, Westermark B
Cell Rep 17 (11) 2994-3009 [2016-12-13; online 2016-12-16]
Drug Discovery and Development (DDD) [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
Iron chelators target both proliferating and quiescent cancer cells.
Fryknäs M, Zhang X, Bremberg U, ..., Linder S, Larsson R
Sci Rep 6 (-) 38343 [2016-12-07; online 2016-12-07]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Validation and development of MTH1 inhibitors for treatment of cancer.
Warpman Berglund U, Sanjiv K, Gad H, ..., Scobie M, Helleday T
Ann. Oncol. 27 (12) 2275-2283 [2016-12-00; online 2016-11-08]
Advanced Mass Spectrometry Proteomics [Collaborative] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Chemical Proteomics [Service] Clinical Proteomics Mass spectrometry [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids.
Senkowski W, Jarvius M, Rubin J, ..., Larsson R, Fryknäs M
Cell Chem Biol 23 (11) 1428-1438 [2016-11-17; online 2016-10-27]
Drug Discovery and Development (DDD) [Service] Tissue Profiling [Service]
PubMed DOI Crossref
Case-specific potentiation of glioblastoma drugs by pterostilbene.
Schmidt L, Baskaran S, Johansson P, ..., Krona C, Nelander S
Oncotarget 7 (45) 73200-73215 [2016-11-08; online 2016-10-01]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.
Orhan F, Bhat M, Sandberg K, ..., Erhardt S, Schwieler L
Scand. J. Immunol. 84 (5) 262-271 [2016-11-00; online 2016-10-27]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.
Diwakarla S, Nylander E, Grönbladh A, ..., Chai SY, Hallberg M
ACS Chem Neurosci 7 (10) 1383-1392 [2016-10-19; online 2016-08-08]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Open for collaboration: an academic platform for drug discovery and development at SciLifeLab.
Arvidsson PI, Sandberg K, Forsberg-Nilsson K
Drug Discov. Today 21 (10) 1690-1698 [2016-10-00; online 2016-07-05]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.
Säll A, Walle M, Wingren C, ..., Borrebaeck CAK, Persson H
Protein Eng. Des. Sel. 29 (10) 427-437 [2016-10-00; online 2016-09-01]
Drug Discovery and Development (DDD) [Technology development] Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
Biophysics in drug discovery: impact, challenges and opportunities.
Renaud JP, Chung CW, Danielson UH, ..., Hubbard RE, Nar H
Nat Rev Drug Discov 15 (10) 679-698 [2016-10-00; online 2016-08-16]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features.
Hammarström LG, Harmel RK, Granath M, ..., Lehmann F, Ernfors P
J. Med. Chem. 59 (18) 8577-8592 [2016-09-22; online 2016-09-09]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels.
Thulin P, Bamberg K, Buler M, Dahl B, Glinghammar B
Int. J. Mol. Med. 38 (3) 961-968 [2016-09-00; online 2016-07-20]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice.
Larsson MK, Faka A, Bhat M, ..., Schwieler L, Erhardt S
Neurochem. Res. 41 (9) 2243-2255 [2016-09-00; online 2016-05-10]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Enantioselective Organocatalyzed Transformations of β-Ketoesters.
Govender T, Arvidsson PI, Maguire GE, Kruger HG, Naicker T
Chem. Rev. 116 (16) 9375-9437 [2016-08-24; online 2016-07-28]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.
Baijnath S, Shobo A, Bester LA, ..., Naicker T, Govender T
J. Mol. Histol. 47 (4) 429-435 [2016-08-00; online 2016-06-22]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening.
Engen K, Rosenström U, Axelsson H, ..., Lundbäck T, Larhed M
Assay Drug Dev Technol 14 (3) 180-193 [2016-04-00; online 2016-04-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
DOI Crossref
A Facile Synthesis of NODASA-Functionalized Peptide
Naicker T, Albericio F, Dutta J, ..., Kruger H, Govender T
Synlett 27 (11) 1685-1688 [2016-03-30; online 2016-03-30]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
On-Water Synthesis of Biaryl Sulfonyl Fluorides.
Chinthakindi PK, Kruger HG, Govender T, Naicker T, Arvidsson PI
J. Org. Chem. 81 (6) 2618-2623 [2016-03-18; online 2016-02-24]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII.
Talibov VO, Linkuvienė V, Matulis D, Danielson UH
J. Med. Chem. 59 (5) 2083-2093 [2016-03-10; online 2016-01-26]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Rapid and straightforward transesterification of sulfonyl carbamates
Isaksson R, Kumpiņa I, Larhed M, Wannberg J
Tetrahedron Letters 57 (13) 1476-1478 [2016-03-00; online 2016-03-00]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
An Efficient Protecting-Group-Free Synthesis of Vinylic Sulfoximines via Horner–Wadsworth–Emmons Reaction
Naicker T, Arvidsson P, Chinthakindi P, ..., Govender T, Kruger H
Synlett 27 (09) 1423-1427 [2016-02-24; online 2016-02-24]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Microwave Promoted Transcarbamylation Reaction of Sulfonylcarbamates under Continuous-Flow Conditions
Kumpiņa I, Isaksson R, Sävmarker J, Wannberg J, Larhed M
Org. Process Res. Dev. 20 (2) 440-445 [2016-02-19; online 2016-01-05]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Jacques SA, ..., Scobie M, Helleday T
J. Med. Chem. 59 (3) 1140-1148 [2016-02-11; online 2016-01-27]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
DOI Crossref
Stereoselective synthesis towards unnatural proline based amino acids
S.Makhathini S, Das SK, Singh T, ..., Govender T, Naicker T
ARKIVOC 2016 (3) 134-144 [2016-02-07; online 2016-02-07]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy.
Blom K, Nygren P, Alvarsson J, Larsson R, Andersson CR
J Lab Autom 21 (1) 178-187 [2016-02-00; online 2015-08-05]
Drug Discovery and Development (DDD) [Service]
DOI Crossref
Organocatalyzed Mannich reactions on minocycline: Towards novel tetracycline antibiotics
CHIWUNZE TE, Azumah R, Ramtahal M, ..., Govender T, Naicker T
S.Afr.j.chem. 69 (-) - [2016-00-00; online 2016-00-00]
Drug Discovery and Development (DDD) [Collaborative]

Year 2015

PubMed DOI Crossref
Positive Modulation of the Glycine Receptor by Means of Glycine Receptor-Binding Aptamers.
Shalaly ND, Aneiros E, Blank M, ..., Andersson CV, Sandberg K
J Biomol Screen 20 (9) 1112-1123 [2015-10-00; online 2015-06-12]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Towards a stereoselective synthesis of α,α-disubstituted proline analogues
Das SK, Bhatt N, Mujahid M, ..., Naicker T, Govender T
Tetrahedron Letters 56 (37) 5172-5174 [2015-09-00; online 2015-09-00]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Synthesis of enantiopure angiotensin II type 2 receptor [AT2R] antagonist EMA401
Wakchaure PB, Bremberg U, Wannberg J, Larhed M
Tetrahedron 71 (38) 6881-6887 [2015-09-00; online 2015-09-00]
Drug Discovery and Development (DDD)
PubMed DOI Crossref
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer.
Senkowski W, Zhang X, Olofsson MH, ..., Larsson R, Fryknäs M
Mol Cancer Ther 14 (6) 1504-1516 [2015-06-00; online 2015-04-24]
Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
NOTA: a potent metallo-β-lactamase inhibitor.
Somboro AM, Tiwari D, Bester LA, ..., Naicker T, Essack SY
J. Antimicrob. Chemother. 70 (5) 1594-1596 [2015-05-00; online 2015-01-06]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Cu(OAc)2-Catalysed Oxidative Dual C-H/N-H Activation of Terminal Alkynes andN-Deprotected Sulfonimidamides: An Easy Access toN-Alkynylated Sulfonimidamides
Nandi GC, Kota SR, Naicker T, ..., Kruger HG, Arvidsson PI
Eur. J. Org. Chem. 2015 (13) 2861-2867 [2015-05-00; online 2015-03-17]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Detection of cell aggregation and altered cell viability by automated label-free video microscopy: a promising alternative to endpoint viability assays in high-throughput screening.
Aftab O, Fryknäs M, Hammerling U, Larsson R, Gustafsson MG
J Biomol Screen 20 (3) 372-381 [2015-03-00; online 2014-12-17]
Drug Discovery and Development (DDD)
DOI Crossref
Synthesis of Vinyl- and Aryl-Acyl Sulfonimidamides Through Pd-Catalyzed Carbonylation Using Mo(CO)6as ex situ CO Source
Wakchaure PB, Borhade SR, Sandström A, Arvidsson PI
Eur. J. Org. Chem. 2015 (1) 213-219 [2015-01-00; online 2014-11-19]
Drug Discovery and Development (DDD) [Technology development]
PubMed DOI Crossref
Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.
Strömberg K, Eketjäll S, Georgievska B, ..., Cowburn RF, Dabrowski M
FEBS J. 282 (1) 65-73 [2015-01-00; online 2014-11-07]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Applied Enantioselective Aminocatalysis: α-Heteroatom Functionalization Reactions on the Carbapenem (β-Lactam Antibiotic) Core
Cele ZED, Arvidsson PI, Kruger HG, Govender T, Naicker T
Eur. J. Org. Chem. 2015 (3) 638-646 [2015-01-00; online 2014-12-11]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study
Md. Abdur Rauf S, Arvidsson PI, Albericio F, ..., Kruger HG, Honarparvar B
Org. Biomol. Chem. 13 (39) 9993-10006 [2015-00-00; online 2015-00-00]
Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Pd-catalyzed C–N coupling of vinylbromides and sulfonimidamides: a facile synthesis of N′-vinylsulfonimidamides
Nandi GC, Kota SR, Wakchaure PB, ..., Naicker T, Arvidsson PI
RSC Adv. 5 (76) 62084-62090 [2015-00-00; online 2015-00-00]
Drug Discovery and Development (DDD) [Technology development]

Year 2014

PubMed DOI Crossref
Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides.
Borhade SR, Rosenström U, Sävmarker J, ..., Larhed M, Hallberg M
ChemistryOpen 3 (6) 256-263 [2014-12-00; online 2014-11-21]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Cu(OAc)2 promoted Chan–Evans–Lam C–N cross coupling reactions on the N- and N′-nitrogen atoms of sulfonimidamides with aryl boronic acids
Nandi GC, Kota SR, Govender T, Kruger HG, Arvidsson PI
Tetrahedron 70 (35) 5428-5433 [2014-09-00; online 2014-09-00]
Drug Discovery and Development (DDD) [Technology development]
DOI Crossref
l-Proline organocatalyzed Michael synthesis of monobactam and carbapenem β-lactam cores
Khanyase S, Naicker T, Maguire GEM, ..., Arvidsson PI, Govender T
Tetrahedron: Asymmetry 25 (13-14) 969-973 [2014-07-00; online 2014-07-00]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth A, ..., Berglund UW, Helleday T
Nature 508 (7495) 215-221 [2014-04-10; online 2014-04-02]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF)
DOI Crossref
Organocatalytic Mannich Reactions on a Carbapenem Core - Synthesis of Mannich Bases and Bicyclic Diazanonanes
Cele ZED, Pawar SA, Naicker T, ..., Kruger HG, Govender T
Eur. J. Org. Chem. 2014 (11) 2253-2260 [2014-04-00; online 2014-02-06]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Proline N-oxides: modulators of the 3D conformation of linear peptides through “NO-turns”
Farahani MD, Honarparvar B, Albericio F, ..., Arvidsson PI, Kruger HG
Org. Biomol. Chem. 12 (25) 4479 [2014-00-00; online 2014-00-00]
Drug Discovery and Development (DDD) [Collaborative]

Year 2013

PubMed DOI Crossref
Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions.
Schmidt L, Kling T, Monsefi N, ..., Gerlee P, Nelander S
Neuro-oncology 15 (11) 1469-1478 [2013-11-00; online 2013-10-06]
Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer.
Johansson HJ, Sanchez BC, Mundt F, ..., Linderholm BK, Lehtiö J
Nat Commun 4 (-) 2175 [2013-07-23; online 2013-07-23]
Drug Discovery and Development (DDD) [Collaborative]

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