Illuminating Non-genetic Cellular Heterogeneity with Imaging-Based Spatial Proteomics.

Gnann C, Cesnik AJ, Lundberg E

Trends Cancer 7 (4) 278-282 [2021-04-00; online 2021-01-10]

Cellular heterogeneity is an important biological phenomenon observed across space and time in human tissues. Imaging-based spatial proteomic technologies can provide fruitful new readouts of phenotypic states for individual cells at subcellular resolution, which may help unravel the roles of non-genetic cellular heterogeneity in tumorigenesis and drug resistance.

Spatial Proteomics [Technology development]

PubMed 33436349

DOI 10.1016/j.trecan.2020.12.006

Crossref 10.1016/j.trecan.2020.12.006

pii: S2405-8033(20)30333-2

Publications 9.5.0