Cellular Immunomonitoring

Gut bacteria at 6 months of age are associated with immune cell status in 1‐year‐old children

Nilsen M, Nygaard UC, Brodin P, ..., Vettukattil R, Rudi K

Scand J Immunol - (-) - [2023-12-07; online 2023-12-07]

In-depth immune profiling reveals advanced B- and T-cell differentiation to be associated with Th1-driven immune dysregulation in common variable immunodeficiency.

Hultberg J, Blixt E, Göransson R, ..., Ernerudh J, Nyström S

Clin. Immunol. 257 (-) 109816 [2023-12-00; online 2023-10-31]

Affinity Proteomics Uppsala [Service] Cellular Immunomonitoring [Service]

Scalablein-vitroimmunostimulation of human blood for in-depth profiling of acute immune response effects

Reitzner SM, Brodin P, Mikeš J

- - (-) - [2023-06-11; online 2023-06-11]

Molecular Pixelation: Single cell spatial proteomics by sequencing

Karlsson F, Kallas T, Thiagarajan D, ..., Barrio AM, Fredriksson S

- - (-) - [2023-06-08; online 2023-06-08]

Achieving symptom relief in patients with myalgic encephalomyelitis by targeting the neuro-immune interface and optimizing disease tolerance.

Rodriguez L, Pou C, Lakshmikanth T, ..., Julin P, Brodin P

Oxf Open Immunol 4 (1) iqad003 [2023-04-17; online 2023-04-17]

Affinity Proteomics Stockholm [Service] Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Three Adult Cases of STAT1 Gain-of-Function with Chronic Mucocutaneous Candidiasis Treated with JAK Inhibitors.

Borgström EW, Edvinsson M, Pérez LP, ..., Brodin P, Bergman P

J Clin Immunol 43 (1) 136-150 [2023-01-00; online 2022-09-02]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Collaborative] Clinical Genomics [Service] Clinical Genomics Stockholm [Service]

Year 2022

Longitudinal analyses of development of the immune system during the first five years of life in relation to lifestyle.

Olin A, Acevedo N, Lakshmikanth T, ..., Scheynius A, Brodin P

Allergy - (-) - [2022-01-29; online 2022-01-29]

Year 2021

Multiplexed single‐cell mass cytometry reveals distinct inhibitory effects on intracellular phosphoproteins by midostaurin in combination with chemotherapy in AML cells

Rörby E, Adolfsson J, Hultin E, ..., Cammenga J, Jönsson JI

Exp Hematol Oncol 10 (1) 7 [2021-12-00; online 2021-02-02]

High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids.

Silva CS, Sundling C, Folkesson E, ..., Correia-Neves M, Källenius G

Front Immunol 12 (-) 727300 [2021-11-23; online 2021-11-23]

Affinity Proteomics Stockholm [Service] Cellular Immunomonitoring [Collaborative]

Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity.

Zhou X, Singh M, Sanz Santos G, ..., Johnsen JI, Selivanova G

Cancer Discov - (-) - [2021-07-06; online 2021-07-06]

Bifidobacteria-mediated immune system imprinting early in life

Henrick BM, Rodriguez L, Lakshmikanth T, ..., Frese SA, Brodin P

Cell 184 (15) 3884-3898.e11 [2021-07-00; online 2021-07-00]

Affinity Proteomics Stockholm [Service] Bioinformatics (NBIS) [Service] Bioinformatics Support and Infrastructure [Service] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Service] Cellular Immunomonitoring [Technology development] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy.

Strunz B, Bister J, Jönsson H, ..., Ivarsson MA, Björkström NK

Sci Immunol 6 (56) eabb7800 [2021-02-19; online 2021-02-19]

Aging and CMV discordance are associated with increased immune diversity between monozygotic twins.

Yan Z, Maecker HT, Brodin P, ..., Nadeau KC, Andorf S

Immun Ageing 18 (1) 5 [2021-01-18; online 2021-01-18]

Immunocyte single cell analysis of vaccine‐induced narcolepsy

Lind A, Salami F, Landtblom A, ..., Adolfsson J, Elding Larsson H

Eur. J. Immunol. 51 (1) 247-249 [2021-01-00; online 2020-07-30]

Immune determinants of COVID-19 disease presentation and severity.

Nat. Med. 27 (1) 28-33 [2021-01-00; online 2021-01-13]

Year 2020

High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood.

Petkov S, Bekele Y, Lakshmikanth T, ..., Brodin P, Chiodi F

Sci Rep 10 (1) 20425 [2020-11-24; online 2020-11-24]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Collaborative]

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.

Consiglio CR, Cotugno N, Sardh F, ..., Palma P, Brodin P

Cell 183 (4) 968-981.e7 [2020-11-12; online 2020-09-06]

Affinity Proteomics Stockholm [Service] Autoimmunity and Serology Profiling [Service] Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer

Mehmeti-Ajradini M, Bergenfelz C, Larsson AM, ..., Bexell D, Leandersson K

Life Sci. Alliance 3 (11) e202000893 [2020-11-00; online 2020-09-21]

Bioinformatics (NBIS) [Service] Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service] Cellular Immunomonitoring [Service]

Unraveling the Immune Response in Severe COVID-19.

Rodriguez L, Brodin P

J Clin Immunol 40 (7) 958-959 [2020-10-00; online 2020-08-22]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Integration of molecular profiles in a longitudinal wellness profiling cohort.

Tebani A, Gummesson A, Zhong W, ..., Uhlen M, Fagerberg L

Nat Commun 11 (1) 4487 [2020-09-08; online 2020-09-08]

Affinity Proteomics Stockholm [Collaborative] Autoimmunity and Serology Profiling [Collaborative] Bioinformatics (NBIS) [Collaborative] Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Collaborative] Cellular Immunomonitoring [Collaborative] Swedish Metabolomics Centre [Collaborative]

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.

Rodriguez L, Pekkarinen PT, Lakshmikanth T, ..., Kekäläinen E, Brodin P

Cell Reports Medicine 1 (5) 100078 [2020-08-25; online 2020-08-05]

Affinity Proteomics Stockholm [Service] Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Technologies for assessing vaccine responses in the very young.

Current Opinion in Immunology 65 (-) 28-31 [2020-08-00; online 2020-04-24]

Human Immune System Variation during 1 Year.

Lakshmikanth T, Muhammad SA, Olin A, ..., Uhlen M, Brodin P

Cell Rep 32 (3) 107923 [2020-07-21; online 2020-07-23]

Affinity Proteomics Stockholm [Service] Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

New approaches to the study of immune responses in humans.

Hum. Genet. 139 (6-7) 795-799 [2020-06-00; online 2020-02-10]

Stressful Beginnings with Long-Term Consequences.

Consiglio CR, Brodin P

Cell 180 (5) 820-821 [2020-03-05; online 2020-03-07]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Year 2019

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.

Uhlen M, Karlsson MJ, Zhong W, ..., Fagerberg L, Brodin P

Science 366 (6472) - [2019-12-20; online 2019-12-21]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Challenges in the Multivariate Analysis of Mass Cytometry Data: The Effect of Randomization.

Papoutsoglou G, Lagani V, Schmidt A, ..., Tegnér J, Tsamardinos I

Cytometry A 95 (11) 1178-1190 [2019-11-00; online 2019-11-06]

Cell generation dynamics underlying naive T-cell homeostasis in adult humans.

Mold JE, Réu P, Olin A, ..., Brodin P, Frisén J

PLoS Biol. 17 (10) e3000383 [2019-10-00; online 2019-10-29]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Collaborative]

The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer.

Liu N, Cui W, Jiang X, ..., Wang X, Sun XF

Int. J. Radiat. Oncol. Biol. Phys. 104 (5) 1153-1164 [2019-08-01; online 2019-04-27]

Systems-level immunomonitoring using self-sampled capillary blood

Josyula VS, Lakshmikanth T, Mikes J, Chen Y, Brodin P

- - (-) - [2019-07-08; online 2019-07-08]

A Call for Blood—In Human Immunology

Brodin P, Duffy D, Quintana-Murci L

Immunity 50 (6) 1335-1336 [2019-06-00; online 2019-06-00]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Automated Cell Processing for Mass Cytometry Experiments.

Mikes J, Olin A, Lakshmikanth T, Chen Y, Brodin P

Methods Mol. Biol. 1989 (-) 111-123 [2019-05-12; online 2019-05-12]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Mass Cytometry Identifies Distinct Subsets of Regulatory T Cells and Natural Killer Cells Associated With High Risk for Type 1 Diabetes.

Barcenilla H, Åkerman L, Pihl M, Ludvigsson J, Casas R

Front Immunol 10 (-) 982 [2019-05-03; online 2019-05-03]

B cell profiling in malaria reveals expansion and remodelling of CD11c+ B cell subsets.

Sundling C, Rönnberg C, Yman V, ..., Persson KE, Färnert A

JCI Insight 5 (-) - [2019-04-02; online 2019-04-02]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Collaborative]

The biology of the cell - insights from mass cytometry.

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

FEBS J. 286 (8) 1514-1522 [2019-04-00; online 2018-11-26]

Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1-infected patients according to antiretroviral therapy initiation.

Bekele Y, Lakshmikanth T, Chen Y, ..., Brodin P, Chiodi F

JCI Insight 4 (3) - [2019-02-07; online 2019-02-07]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Collaborative]

Systems-level patterns emerge.

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Nat. Rev. Immunol. 19 (2) 87-88 [2019-02-00; online 2019-01-04]

B cell alterations during BAFF inhibition with belimumab in SLE.

Ramsköld D, Parodis I, Lakshmikanth T, ..., Gunnarsson I, Malmström V

EBioMedicine 40 (-) 517-527 [2019-02-00; online 2018-12-26]

Systems-Level Immune Monitoring by Mass Cytometry.

Lakshmikanth T, Brodin P

Methods Mol. Biol. 1913 (-) 33-48 [2019-01-23; online 2019-01-23]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis.

Tang Q, Ramsköld D, Krystufkova O, ..., Lundberg IE, Malmström V

Scand. J. Immunol. 89 (1) e12732 [2019-01-00; online 2018-12-09]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Collaborative]

Year 2018

Continuous Immune Cell Differentiation Inferred From Single-Cell Measurements Following Allogeneic Stem Cell Transplantation.

Chen Y, Lakshmikanth T, Olin A, ..., Remberger M, Brodin P

Front Mol Biosci 5 (-) 81 [2018-09-12; online 2018-09-12]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development]

Stereotypic Immune System Development in Newborn Children

Olin A, Henckel E, Chen Y, ..., Bohlin K, Brodin P

Cell 174 (5) 1277-1292.e14 [2018-08-00; online 2018-08-00]

Affinity Proteomics Stockholm [Service] Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Technology development] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Rebooting Human Immunology.

Davis MM, Brodin P

Annu. Rev. Immunol. 36 (-) 843-864 [2018-04-26; online 2018-02-28]

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.

Agudelo LZ, Ferreira DMS, Cervenka I, ..., Berggren PO, Ruas JL

Cell Metab. 27 (2) 378-392.e5 [2018-02-06; online 2018-02-08]

Bioinformatics Support for Computational Resources [Service] Cellular Immunomonitoring [Collaborative]

Year 2017

STRT-seq-2i: dual-index 5' single cell and nucleus RNA-seq on an addressable microwell array.

Hochgerner H, Lönnerberg P, Hodge R, ..., Zeisel A, Linnarsson S

Sci Rep 7 (1) 16327 [2017-11-27; online 2017-11-27]

Cellular Immunomonitoring [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Mass Cytometry Identifies Distinct Lung CD4+ T Cell Patterns in Löfgren's Syndrome and Non-Löfgren's Syndrome Sarcoidosis.

Kaiser Y, Lakshmikanth T, Chen Y, ..., Achour A, Grunewald J

Front Immunol 8 (-) 1130 [2017-09-12; online 2017-09-12]

The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.

Ganesan S, Luu TT, Chambers BJ, ..., Kadri N, Höglund P

Scand. J. Immunol. 86 (3) 135-142 [2017-09-00; online 2017-06-13]

Mass Cytometry and Topological Data Analysis Reveal Immune Parameters Associated with Complications after Allogeneic Stem Cell Transplantation.

Lakshmikanth T, Olin A, Chen Y, ..., Omazic B, Brodin P

Cell Rep 20 (9) 2238-2250 [2017-08-29; online 2017-08-31]

Continuous immunotypes describe human immune variation and predict diverse responses.

Kaczorowski KJ, Shekhar K, Nkulikiyimfura D, ..., Chakraborty AK, Brodin P

Proc. Natl. Acad. Sci. U.S.A. 114 (30) E6097-E6106 [2017-07-25; online 2017-07-10]

Combining Flow and Mass Cytometry in the Search for Biomarkers in Chronic Graft-versus-Host Disease.

Stikvoort A, Chen Y, Rådestad E, ..., Brodin P, Uhlin M

Front Immunol 8 (-) 717 [2017-06-19; online 2017-06-19]

Expression of CD226 is associated to but not required for NK cell education.

Wagner AK, Kadri N, Snäll J, ..., Kärre K, Chambers BJ

Nat Commun 8 (-) 15627 [2017-05-31; online 2017-05-31]

Life-Saving Degeneracy in the Human Immune System.

Cell Host Microbe 21 (3) 309-310 [2017-03-08; online 2017-03-11]

Human immune system variation.

Brodin P, Davis MM

Nat. Rev. Immunol. 17 (1) 21-29 [2017-01-00; online 2016-12-05]

Year 2016

Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMV.

Rölle A, Brodin P

Trends Immunol. 37 (3) 233-243 [2016-03-00; online 2016-02-09]

Year 2015

Powerful Populations Respond to Viruses and Vaccines.

Immunity 43 (6) 1035-1037 [2015-12-15; online 2015-12-20]

Drug-induced mRNA signatures are enriched for the minority of genes that are highly heritable.

Gao T, Brodin P, Davis MM, Jojic V

Pac Symp Biocomput - (-) 395-406 [2015-01-17; online 2015-01-17]

Variation in the human immune system is largely driven by non-heritable influences.

Brodin P, Jojic V, Gao T, ..., Maecker HT, Davis MM

Cell 160 (1-2) 37-47 [2015-01-15; online 2015-01-17]