Transcriptomics resources of human tissues and organs.

Uhlén M, Hallström BM, Lindskog C, Mardinoglu A, Pontén F, Nielsen J

Mol. Syst. Biol. 12 (4) 862 [2016-04-04; online 2016-04-04]

Quantifying the differential expression of genes in various human organs, tissues, and cell types is vital to understand human physiology and disease. Recently, several large-scale transcriptomics studies have analyzed the expression of protein-coding genes across tissues. These datasets provide a framework for defining the molecular constituents of the human body as well as for generating comprehensive lists of proteins expressed across tissues or in a tissue-restricted manner. Here, we review publicly available human transcriptome resources and discuss body-wide data from independent genome-wide transcriptome analyses of different tissues. Gene expression measurements from these independent datasets, generated using samples from fresh frozen surgical specimens and postmortem tissues, are consistent. Overall, the different genome-wide analyses support a distribution in which many proteins are found in all tissues and relatively few in a tissue-restricted manner. Moreover, we discuss the applications of publicly available omics data for building genome-scale metabolic models, used for analyzing cell and tissue functions both in physiological and in disease contexts.

Bioinformatics Support, Infrastructure and Training [Technology development]

NGI Stockholm (Genomics Production) [Service]

National Genomics Infrastructure [Service]

Systems Biology [Technology development]

Tissue Profiling [Collaborative]

PubMed 27044256

DOI 10.15252/msb.20155865

Crossref 10.15252/msb.20155865

pmc: PMC4848759

Publications 9.5.0