Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery.

Varghese OP, Liu J, Sundaram K, Hilborn J, Oommen OP

Biomater Sci 4 (9) 1310-1313 [2016-08-16; online 2016-07-20]

Glycosaminoglycan derived nanoparticles are a promising delivery system owing to their unique tumour targeting ability. Exploiting fluorescein for inducing amphiphilicity in these biopolymers provides inherent imaging and drug stabilization capabilities by π-π stacking interactions with aromatic antineoplastic agents. This offers a versatile and highly customizable nanocarrier with narrow size distribution and high drug loading efficiency (80%) with sustained drug release.

Karolinska High Throughput Center (KHTC) [Service]

PubMed 27431007

DOI 10.1039/c6bm00335d

Crossref 10.1039/c6bm00335d

Publications 9.5.0