Varghese OP, Liu J, Sundaram K, Hilborn J, Oommen OP
Biomater Sci 4 (9) 1310-1313 [2016-08-16; online 2016-07-20]
Glycosaminoglycan derived nanoparticles are a promising delivery system owing to their unique tumour targeting ability. Exploiting fluorescein for inducing amphiphilicity in these biopolymers provides inherent imaging and drug stabilization capabilities by π-π stacking interactions with aromatic antineoplastic agents. This offers a versatile and highly customizable nanocarrier with narrow size distribution and high drug loading efficiency (80%) with sustained drug release.