Bergonzini G, Cassani C, Lorimer-Olsson H, Hörberg J, Wallentin CJ
Chemistry 22 (10) 3292-3295 [2016-03-01; online 2016-02-02]
A novel method for the mild photoredox-mediated tandem radical acylarylation and tandem acylation/semipinacol rearrangement has been developed. The synthesis of highly functionalized ketones bearing all-carbon α- or β-quaternary centers has been achieved using easily available symmetric aromatic carboxylic anhydrides as the acyl radical source. The method allows for a straightforward introduction of the keto functionality and concomitant construction of molecular complexity in a single operation.