The association between genetically determined ABO blood types and major depressive disorder.

Garvert L, Baune BT, Berger K, Boomsma DI, Breen G, Greinacher A, Hamilton SP, Levinson DF, Lewis CM, Lucae S, Magnusson PKE, Martin NG, McIntosh AM, Mors O, Müller-Myhsok B, Penninx BWJH, Perlis RH, Pistis G, Potash JB, Preisig M, Rietschel M, Shi J, Smoller JW, Tiemeier H, Uher R, Völker U, Völzke H, Weissman MM, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium , Grabe HJ, Van der Auwera S

Psychiatry Res 299 (-) 113837 [2021-05-00; online 2021-02-24]

ABO blood types and their corresponding antigens have long been assumed to be related to different human diseases. So far, smaller studies on the relationship between mental disorders and blood types yielded contradicting results. In this study we analyzed the association between ABO blood types and lifetime major depressive disorder (MDD). We performed a pooled analysis with data from 26 cohorts that are part of the MDD working group of the Psychiatric Genomics Consortium (PGC). The dataset included 37,208 individuals of largely European ancestry of which 41.6% were diagnosed with lifetime MDD. ABO blood types were identified using three single nucleotide polymorphisms in the ABO gene: rs505922, rs8176746 and rs8176747. Regression analyses were performed to assess associations between the individual ABO blood types and MDD diagnosis as well as putative interaction effects with sex. The models were adjusted for sex, cohort and the first ten genetic principal components. The percentage of blood type A was slightly lower in cases than controls while blood type O was more prominent in cases. However, these differences were not statistically significant. Our analyses found no evidence of an association between ABO blood types and major depressive disorder.

NGI Uppsala (SNP&SEQ Technology Platform)

National Genomics Infrastructure

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PubMed 33721783

DOI 10.1016/j.psychres.2021.113837

Crossref 10.1016/j.psychres.2021.113837

pii: S0165-1781(21)00134-7
pmc: PMC8071927
mid: NIHMS1683126