Ezerskyte M, Paredes JA, Malvezzi S, Burns JA, Margison GP, Olsson M, Scicchitano DA, Dreij K

Proc. Natl. Acad. Sci. U.S.A. - (-) - [2018-04-17; online 2018-04-17]
PubMed: 29666243 DOI: 10.1073/pnas.1721764115 Crossref: 10.1073/pnas.1721764115

Altered protein function due to mutagenesis plays an important role in disease development. This is perhaps most evident in tumorigenesis and the associated loss or gain of function of tumor-suppressor genes and oncogenes. The extent to which lesion-induced transcriptional mutagenesis (TM) influences protein function and its contribution to the development of disease is not well understood. In this study, the impact of

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