Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5

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Rossi Sebastiano M, Doak BC, Backlund M, Poongavanam V, Over B, Ermondi G, Caron G, Matsson P, Kihlberg J

J. Med. Chem. 61 (9) 4189-4202 [2018-05-10; online 2018-04-02]

Chemical Biology Consortium Sweden (CBCS) [Service]

Drug Discovery and Development (DDD) [Service]

PubMed 29608068

DOI 10.1021/acs.jmedchem.8b00347

Crossref 10.1021/acs.jmedchem.8b00347