N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.

Marwaha S, Uvell H, Salin O, Lindgren AEG, Silver J, Elofsson M, Gylfe A

Antimicrob. Agents Chemother. 58 (5) 2968-2971 [2014-05-00; online 2014-02-26]

Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distinct from that of sulfonamide antibiotics, as para-aminobenzoic acid did not reduce efficacy. Chemical inhibitors play an important role in Chlamydia research as probes of potential targets and as drug development starting points.

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed 24566180

DOI 10.1128/AAC.02015-13

Crossref 10.1128/AAC.02015-13

pii: AAC.02015-13
pmc: PMC3993265

Laboratories for Chemical Biology Umeå (LCBU)