The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO.

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Jacobsson JA, Schiöth HB, Fredriksson R

Obes Rev 13 (12) 1096-1109 [2012-12-00; online 2012-08-31]

In 2007, the first common genetic variants were identified, which undoubtedly affect our susceptibility to obesity. These variants are located in the fat mass and obesity-associated gene FTO. Since then, over 50 loci for common obesity have been identified. As the research on these loci is still at an early stage, there is a great need to review, for clarification purposes, the current research on FTO, as this is likely to influence future studies. Based on the current knowledge, FTO seems to be directly involved in the regulation of energy intake, but there is an urgent need for the identification of regulatory polymorphisms. Thus, herein, we discuss current knowledge and highlight putative functional regions in FTO based on published data and computer-based analysis.

NGI Uppsala (SNP&SEQ Technology Platform)

National Genomics Infrastructure

PubMed 22931202

DOI 10.1111/j.1467-789X.2012.01025.x

Crossref 10.1111/j.1467-789X.2012.01025.x