Schmierer B

An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.

Fernández Moro C, Geyer N, Harrizi S, ..., Bozóky B, Gerling M

Nat Commun 14 (1) 5024 [2023-08-18; online 2023-08-18]

CRISPR Functional Genomics [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Rapid genome editing by CRISPR-Cas9-POLD3 fusion

Reint G, Li Z, Labun K, ..., Taipale J, Haapaniemi E

Elife 10 (-) - [2021-12-13; online 2021-12-13]

CRISPR Functional Genomics [Collaborative]

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

Laise P, Turunen M, Garcia AC, ..., Olive KP, Califano A

- - (-) - [2020-10-27; online 2020-10-27]

CRISPR Functional Genomics [Service]

Designing custom CRISPR libraries for hypothesis-driven drug target discovery.

Iyer VS, Jiang L, Shen Y, ..., Schmierer B, Wermeling F

Computational and Structural Biotechnology Journal 18 (-) 2237-2246 [2020-08-18; online 2020-08-18]

Bioinformatics Support for Computational Resources [Service] CRISPR Functional Genomics [Collaborative]

Reply to "CRISPR screens are feasible in TP53 wild-type cells".

Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J

Mol. Syst. Biol. 15 (8) e9059 [2019-08-00; online 2019-08-30]

CRISPR Functional Genomics [Collaborative]

TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation.

Miller DSJ, Schmierer B, Hill CS

J. Cell. Sci. 132 (14) - [2019-07-15; online 2019-07-15]

CRISPR Functional Genomics [Collaborative]

Contribution of allelic imbalance to colorectal cancer.

Palin K, Pitkänen E, Turunen M, ..., Taipale J, Aaltonen LA

Nat Commun 9 (1) 3664 [2018-09-10; online 2018-09-10]

Bioinformatics Support for Computational Resources [Service] CRISPR Functional Genomics [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.

Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J

Nat. Med. 24 (7) 927-930 [2018-07-00; online 2018-06-11]

CRISPR Functional Genomics [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Protein Science Facility (PSF) [Service]

CRISPR/Cas9 screening using unique molecular identifiers.

Schmierer B, Botla SK, Zhang J, ..., Kivioja T, Taipale J

Mol. Syst. Biol. 13 (10) 945 [2017-10-09; online 2017-10-09]

CRISPR Functional Genomics [Technology development]

Structural insights into the DNA-binding specificity of E2F family transcription factors.

Morgunova E, Yin Y, Jolma A, ..., Nilsson L, Taipale J

Nat Commun 6 (1) 10050 [2015-12-03; online 2015-12-03]

Karolinska High Throughput Center (KHTC) Protein Science Facility (PSF)

Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites.

Yan J, Enge M, Whitington T, ..., Taipale M, Taipale J

Cell 154 (4) 801-813 [2013-08-15; online 2013-08-21]

Bioinformatics and Expression Analysis (BEA) Karolinska High Throughput Center (KHTC)