Schmierer B

Family name	Schmierer
Given name	Bernhard
Initials	B
ORCID	ORCID 0000-0002-9082-7022
Affiliations	Karolinska Institutet, Stockholm, Sweden. Science for Life Laboratory, Stockholm, Sweden.

13 publications

DOI Crossref

CRISPR-Cas9 Knockout Screens Identify DNA Damage Response Pathways and BTK as Essential for Cisplatin Response in Diffuse Large B-Cell Lymphoma

Issa II, Due H, Brøndum RF, ..., Schmierer B, Dybkær K

Cancers (Basel) 16 (13) 2437 [2024-07-02; online 2024-07-02]

CRISPR Functional Genomics [Service]

DOI Crossref

A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype

Söderqvist S, Viljamaa A, Geyer N, ..., Moro CF, Gerling M

- - (-) - [2024-03-15; online 2024-03-15]

CRISPR Functional Genomics [Service]

PubMed DOI Crossref

An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.

Fernández Moro C, Geyer N, Harrizi S, ..., Bozóky B, Gerling M

Nat Commun 14 (1) 5024 [2023-08-18; online 2023-08-18]

CRISPR Functional Genomics [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Rapid genome editing by CRISPR-Cas9-POLD3 fusion

Reint G, Li Z, Labun K, ..., Taipale J, Haapaniemi E

Elife 10 (-) - [2021-12-13; online 2021-12-13] Open Access

CRISPR Functional Genomics [Collaborative]

DOI Crossref

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

Laise P, Turunen M, Garcia AC, ..., Olive KP, Califano A

- - (-) - [2020-10-27; online 2020-10-27]

CRISPR Functional Genomics [Service]

PubMed DOI Crossref

Designing custom CRISPR libraries for hypothesis-driven drug target discovery.

Iyer VS, Jiang L, Shen Y, ..., Schmierer B, Wermeling F

Computational and Structural Biotechnology Journal 18 (-) 2237-2246 [2020-08-18; online 2020-08-18]

Bioinformatics Support for Computational Resources [Service] CRISPR Functional Genomics [Collaborative]

PubMed DOI Crossref

Reply to "CRISPR screens are feasible in TP53 wild-type cells".

Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J

Mol. Syst. Biol. 15 (8) e9059 [2019-08-00; online 2019-08-30]

CRISPR Functional Genomics [Collaborative]

PubMed DOI Crossref

TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation.

Miller DSJ, Schmierer B, Hill CS

J. Cell. Sci. 132 (14) - [2019-07-15; online 2019-07-15]

CRISPR Functional Genomics [Collaborative]

PubMed DOI Crossref

Contribution of allelic imbalance to colorectal cancer.

Palin K, Pitkänen E, Turunen M, ..., Taipale J, Aaltonen LA

Nat Commun 9 (1) 3664 [2018-09-10; online 2018-09-10]

Bioinformatics Support for Computational Resources [Service] CRISPR Functional Genomics [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response.

Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J

Nat. Med. 24 (7) 927-930 [2018-07-00; online 2018-06-11]

CRISPR Functional Genomics [Collaborative] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Protein Science Facility (PSF) [Service]

PubMed DOI Crossref

CRISPR/Cas9 screening using unique molecular identifiers.

Schmierer B, Botla SK, Zhang J, ..., Kivioja T, Taipale J

Mol. Syst. Biol. 13 (10) 945 [2017-10-09; online 2017-10-09]

CRISPR Functional Genomics [Technology development]

PubMed DOI Crossref

Structural insights into the DNA-binding specificity of E2F family transcription factors.

Morgunova E, Yin Y, Jolma A, ..., Nilsson L, Taipale J

Nat Commun 6 (1) 10050 [2015-12-03; online 2015-12-03]

Karolinska High Throughput Center (KHTC) Protein Science Facility (PSF)

PubMed DOI Crossref

Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites.

Yan J, Enge M, Whitington T, ..., Taipale M, Taipale J

Cell 154 (4) 801-813 [2013-08-15; online 2013-08-21]

Bioinformatics and Expression Analysis (BEA) Karolinska High Throughput Center (KHTC)