PLA and Single Cell Proteomics

SciLifeLab National facility since 2013. In 2019, renamed from "PLA Proteomics" and merged with "Single Cell Proteomics" (facility since 2015).

87 publications

Year 2020

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
Zhang Y, Cedervall J, Hamidi A, ..., Dimberg A, Olsson AK
Cancer Res 80 (16) 3345-3358 [2020-08-15; online 2020-06-25]
PLA and Single Cell Proteomics [Service]

Year 2019

Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
Bhandage AK, Cunningham JL, Jin Z, ..., Ekselius L, Birnir B
Int J Mol Sci 20 (24) 6172 [2019-12-06; online 2019-12-06]
PLA and Single Cell Proteomics [Collaborative]
TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
Aripaka K, Gudey SK, Zang G, ..., von Hofsten J, Landström M
EBioMedicine 45 (-) 192-207 [2019-07-00; online 2019-07-00]
PLA and Single Cell Proteomics [Service]
Protein measurements in venous plasma, earlobe capillary plasma and in plasma stored on filter paper.
Siart B, de Oliveira FMS, Shen Q, ..., Kamali-Moghaddam M, Wallner B
pii: S0003-2697(18)30655-9
Anal. Biochem. 566 (-) 146-150 [2019-02-01; online 2018-11-22]
PLA and Single Cell Proteomics [Technology development]

Year 2018

Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes.
Klaesson A, Grannas K, Ebai T, ..., Söderberg O, Landegren U
pii: 10.1038/s41598-018-23582-1 pmc: PMC5876389
Sci Rep 8 (1) 5400 [2018-03-29; online 2018-03-29]
PLA and Single Cell Proteomics [Technology development]

Year 2017

Stability of Proteins in Dried Blood Spot Biobanks
Björkesten J, Enroth S, Shen Q, ..., Kamali-Moghaddam M, Landegren U
Mol Cell Proteomics 16 (7) 1286-1296 [2017-07-00; online 2017-05-13]
PLA and Single Cell Proteomics [Technology development]
Structural Diversity of Human Gastric Mucin Glycans.
Jin C, Kenny DT, Skoog EC, ..., Lindén SK, Karlsson NG
pii: 16/5/743 pmc: PMC5417818
Mol. Cell Proteomics 16 (5) 743-758 [2017-05-00; online 2017-05-04]
Glycoproteomics [Service] PLA and Single Cell Proteomics [Service]

Year 2016

Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis.
Landegren N, Pourmousa Lindberg M, Skov J, ..., Fenton RA, Kämpe O
pii: ASN.2015101126 pmc: PMC5042672
J. Am. Soc. Nephrol. 27 (10) 3220-3228 [2016-10-00; online 2016-03-18]
PLA and Single Cell Proteomics [Service]
Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation
Watanabe Y, Papoutsoglou P, Maturi V, ..., Heldin CH, Moustakas A
J. Biol. Chem. 291 (24) 12706-12723 [2016-06-10; online 2016-04-21]
PLA and Single Cell Proteomics [Service]
Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay
Blokzijl A, Chen LE, Gustafsdottir SM, ..., Kamali-Moghaddam M, Hedstrand H
PLoS ONE 11 (4) e0154214 [2016-04-25; online 2016-04-25]
PLA and Single Cell Proteomics [Collaborative]
Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells.
Darmanis S, Gallant CJ, Marinescu VD, ..., Westermark B, Landegren U
pii: S2211-1247(15)01434-5 pmc: PMC4713867
Cell Rep 14 (2) 380-389 [2016-01-12; online 2016-01-11]
PLA and Single Cell Proteomics [Technology development]

Year 2015

Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome
Gu Urban GJ, Friedman M, Ren P, ..., Landegren U, Kamali-Moghaddam M
Sci Rep 5 (1) - [2015-09-00; online 2015-06-16]
PLA and Single Cell Proteomics [Technology development]
Proximity-dependent initiation of hybridization chain reaction
Koos B, Cane G, Grannas K, ..., Kamali-Moghaddam M, Söderberg O
Nat Commun 6 (-) 7294 [2015-06-12; online 2015-06-12]
PLA and Single Cell Proteomics [Technology development]
The Biobanking Analysis Resource Catalogue (BARCdb): a new research tool for the analysis of biobank samples.
Galli J, Oelrich J, Taussig MJ, ..., Ortega-Paino E, Landegren U
pii: gku1008 pmc: PMC4383877
Nucleic Acids Res. 43 (Database issue) D1158-D1162 [2015-01-00; online 2014-10-23]
PLA and Single Cell Proteomics

Year 2014

Tyrosine phosphorylation profiling via in situ proximity ligation assay.
Elfineh L, Classon C, Asplund A, ..., Kamali-Moghaddam M, Lind SB
pii: 1471-2407-14-435 pmc: PMC4072613
BMC Cancer 14 (-) 435 [2014-06-13; online 2014-06-13]
PLA and Single Cell Proteomics
Protein biomarker validation via proximity ligation assays.
Blokzijl A, Nong R, Darmanis S, ..., Landegren U, Kamali-Moghaddam M
pii: S1570-9639(13)00288-4
Biochim. Biophys. Acta 1844 (5) 933-939 [2014-05-00; online 2013-08-13]
PLA and Single Cell Proteomics

Year 2013

A tosyl-activated magnetic bead cellulose as solid support for sensitive protein detection.
Yan J, Horák D, Lenfeld J, Hammond M, Kamali-Moghaddam M
pii: S0168-1656(13)00266-6
J. Biotechnol. 167 (3) 235-240 [2013-09-10; online 2013-07-03]
PLA and Single Cell Proteomics
Offshoots of the ESF functional genomics programme.
Landegren U
pii: S1871-6784(12)00900-4
N Biotechnol 30 (3) 296-298 [2013-03-25; online 2013-01-09]
PLA and Single Cell Proteomics
Workshop on laboratory protocol standards for the Molecular Methods Database.
Klingström T, Soldatova L, Stevens R, ..., Landegren U, Bongcam-Rudloff E
pii: S1871-6784(12)00121-5
N Biotechnol 30 (2) 109-113 [2013-01-25; online 2012-06-13]
PLA and Single Cell Proteomics
Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation.
Gu GJ, Friedman M, Jost C, ..., Landegren U, Söderberg O
pii: S1871-6784(12)00107-0
N Biotechnol 30 (2) 144-152 [2013-01-25; online 2012-06-06]
PLA and Single Cell Proteomics
Multiplex protein detection with DNA readout via mass spectrometry.
Flanigon J, Kamali-Moghaddam M, Burbulis I, ..., Landegren U, Cantor C
pii: S1871-6784(12)00860-6 pmc: PMC3616745 mid: NIHMS425130
N Biotechnol 30 (2) 153-158 [2013-01-25; online 2012-12-04]
PLA and Single Cell Proteomics

Year 2012

PCR-based multiparametric assays in single cells.
Darmanis S, Gallant C, Landegren U
pii: clinchem.2012.195867
Clin. Chem. 58 (12) 1618-1619 [2012-12-00; online 2012-10-17]
PLA and Single Cell Proteomics
Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease.
Gu GJ, Wu D, Lund H, ..., Landegren U, Kamali-Moghaddam M
pii: C06R73LN268U5222
J. Alzheimers Dis. 33 (3) 699-713 [2012-09-25; online 2012-09-25]
Clinical Biomarkers PLA and Single Cell Proteomics
Molecular tools for companion diagnostics.
Zieba A, Grannas K, Söderberg O, ..., Nilsson M, Landegren U
pii: S1871-6784(12)00088-X
N Biotechnol 29 (6) 634-640 [2012-09-15; online 2012-05-29]
PLA and Single Cell Proteomics
Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
Teranishi Y, Hur JY, Gu GJ, ..., Frykman S, Tjernberg LO
pii: S0006-291X(12)01239-9
Biochem. Biophys. Res. Commun. 424 (3) 476-481 [2012-08-03; online 2012-07-10]
PLA and Single Cell Proteomics
Profiling cellular protein complexes by proximity ligation with dual tag microarray readout.
Hammond M, Nong RY, Ericsson O, Pardali K, Landegren U
pii: PONE-D-12-05955 pmc: PMC3393744
PLoS ONE 7 (7) e40405 [2012-07-10; online 2012-07-10]
PLA and Single Cell Proteomics
Visualising individual sequence-specific protein-DNA interactions in situ.
Weibrecht I, Gavrilovic M, Lindbom L, ..., Wählby C, Söderberg O
pii: S1871-6784(11)00186-5
N Biotechnol 29 (5) 589-598 [2012-06-15; online 2011-09-13]
BioImage Informatics [Collaborative] PLA and Single Cell Proteomics

Year 2011

Western blotting via proximity ligation for high performance protein analysis.
Liu Y, Gu J, Hagner-McWhirter Å, ..., Ivansson D, Landegren U
pii: O111.011031 pmc: PMC3226413
Mol. Cell Proteomics 10 (11) O111.011031 [2011-11-00; online 2011-08-05]
PLA and Single Cell Proteomics
Increasing the dynamic range of in situ PLA.
Clausson C, Allalou A, Weibrecht I, ..., Wählby C, Söderberg O
pii: nmeth.1743
Nat. Methods 8 (11) 892-893 [2011-10-28; online 2011-10-28]
BioImage Informatics [Collaborative] PLA and Single Cell Proteomics
ProteinSeq: high-performance proteomic analyses by proximity ligation and next generation sequencing.
Darmanis S, Nong RY, Vänelid J, ..., Kamali-Moghaddam M, Landegren U
pii: PONE-D-11-10457 pmc: PMC3183061
PLoS ONE 6 (9) e25583 [2011-09-29; online 2011-09-29]
PLA and Single Cell Proteomics
Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer.
Tavoosidana G, Ronquist G, Darmanis S, ..., Landegren UD, Kamali-Moghaddam M
pii: 1019330108 pmc: PMC3102389
Proc. Natl. Acad. Sci. U.S.A. 108 (21) 8809-8814 [2011-05-24; online 2011-05-11]
Clinical Biomarkers PLA and Single Cell Proteomics

Year 2010

Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease.
Kamali-Moghaddam M, Pettersson FE, Wu D, ..., Lannfelt L, Landegren U
pii: 1471-2202-11-124 pmc: PMC2959092
BMC Neurosci 11 (-) 124 [2010-10-05; online 2010-10-05]
PLA and Single Cell Proteomics
Sensitive plasma protein analysis by microparticle-based proximity ligation assays.
Darmanis S, Nong RY, Hammond M, ..., Landegren U, Kamali-Moghaddam M
pii: M900248-MCP200 pmc: PMC2830843
Mol. Cell Proteomics 9 (2) 327-335 [2010-02-00; online 2009-12-04]
PLA and Single Cell Proteomics