Deindl S

Massively parallel analysis of single-molecule dynamics on next-generation sequencing chips.

Aguirre Rivera J, Mao G, Sabantsev A, ..., Jinek M, Deindl S

Science 385 (6711) 892-898 [2024-08-23; online 2024-08-22]

NGI Short read [Technology development] NGI Uppsala (SNP&SEQ Technology Platform) [Technology development] National Genomics Infrastructure [Technology development]

Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1.

Bacic L, Gaullier G, Mohapatra J, ..., Sabantsev A, Deindl S

Nat Commun 15 (1) 1000 [2024-02-02; online 2024-02-02]

Cryo-EM [Service]

Sequence specificity in DNA binding is mainly governed by association.

Marklund E, Mao G, Yuan J, ..., Deindl S, Elf J

Science 375 (6579) 442-445 [2022-01-28; online 2022-01-27]

Bioinformatics Support for Computational Resources [Service] Drug Discovery and Development (DDD) [Collaborative]

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.

Bacic L, Gaullier G, Sabantsev A, ..., Boulton SJ, Deindl S

Elife 10 (-) - [2021-09-06; online 2021-09-06]

Cryo-EM [Service]

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.

Lehmann LC, Bacic L, Hewitt G, ..., Boulton SJ, Deindl S

Cell Rep 33 (12) 108529 [2020-12-22; online 2020-12-29]

Cryo-EM [Service]

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Lehmann LC, Hewitt G, Aibara S, ..., Boulton SJ, Deindl S

Molecular Cell 68 (5) 847-859.e7 [2017-12-00; online 2017-12-00]

Cryo-EM [Service] Protein Science Facility (PSF) [Service]