Larsson NG

Small molecules restore mutant mitochondrial DNA polymerase activity.

Valenzuela S, Zhu X, Macao B, ..., Gustafsson CM, Falkenberg M

Nature 642 (8067) 501-507 [2025-06-00; online 2025-04-09]

Cryo-EM [Service] Integrated Microscopy Technologies Gothenburg [Service]

LRPPRC and SLIRP synergize to maintain sufficient and orderly mammalian mitochondrial translation.

Rubalcava-Gracia D, Bubb K, Levander F, ..., Koolmeister C, Larsson NG

Nucleic Acids Res. 52 (18) 11266-11282 [2024-10-14; online 2024-08-01]

Bioinformatics (NBIS) [Collaborative] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] CRISPR Functional Genomics [Service]

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.

Filograna R, Lee S, Tiklová K, ..., Perlmann T, Larsson NG

PLoS Genet. 17 (9) e1009822 [2021-09-00; online 2021-09-27]

Bioinformatics (NBIS) [Collaborative] Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative]

The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.

Jiang M, Xie X, Zhu X, ..., Larsson NG, Falkenberg M

Sci Adv 7 (27) - [2021-07-00; online 2021-07-02]

Integrated Microscopy Technologies Gothenburg [Service]