Chemical Biology Consortium Sweden (CBCS)

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Publications

2019 (14)

2018 (540)

2017 (601)

2016 (632)

2015 (423)

2014 (374)

2013 (318)

2012 (243)

2011 (164)

2010 (139)

All (3448)


Labels

Journals

131 publications

Year 2018

DOI Crossref
Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries
Fritzell K, Xu LD, Otrocka M, Andréasson C, Öhman M
Nucleic Acids Res - (-) - [2018-12-22; online 2018-12-22]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Red Fluorescent Chlamydia trachomatis Applied to Live Cell Imaging and Screening for Antibacterial Agents
Mojica SA, Eriksson AU, Davis RA, ..., Elofsson M, Gylfe Å
Front Microbiol 9 (-) - [2018-12-18; online 2018-12-18]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
A drug screening assay on cancer cells chronically adapted to acidosis
Pellegrini P, Serviss JT, Lundbäck T, ..., Linder S, De Milito A
Cancer Cell Int 18 (1) - [2018-12-00; online 2018-09-25]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
Gustafsson NMS, Färnegårdh K, Bonagas N, ..., Olin T, Helleday T
PDB
Nat Commun 9 (1) - [2018-12-00; online 2018-09-24]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis
Tenland E, Krishnan N, Rönnholm A, ..., Robertson BD, Godaly G
Tuberculosis 113 (-) 231-238 [2018-12-00; online 2018-12-00]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds MJGW, van Leeuwen IMM, Drummond CJ, ..., McCormack E, Laín S
PDB GEO
Nat Commun 9 (1) - [2018-12-00; online 2018-03-16]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound
Islam MK, Strand M, Saleeb M, ..., Elofsson M, Evander M
Sci Rep 8 (1) - [2018-12-00; online 2018-01-31]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Service]
DOI Crossref
A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats
Corman A, Jung B, Häggblad M, ..., Carreras-Puigvert J, Fernandez-Capetillo O
Cell Chem Biol - (-) - [2018-12-00; online 2018-12-00]
Chemical Biology Consortium Sweden (CBCS) [Service]
PubMed DOI Crossref
Quantitative Interpretation of Intracellular Drug Binding and Kinetics Using the Cellular Thermal Shift Assay
Seashore-Ludlow B, Axelsson H, Almqvist H, ..., Jonsson M, Lundbäck T
Biochemistry - (-) - [2018-11-19; online 2018-11-19]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Visnes T, Cázares-Körner A, Hao W, ..., Boldogh I, Helleday T
Science 362 (6416) 834-839 [2018-11-16; online 2018-11-15]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
Dyczynski M, Yu Y, Otrocka M, ..., De Milito A, Pokrovskaja Tamm K
Cancer Letters 435 (-) 32-43 [2018-10-00; online 2018-10-00]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Screening for Inhibitors of Acetaldehyde Dehydrogenase (AdhE) from Enterohemorrhagic Escherichia coli (EHEC)
Zetterström CE, Uusitalo P, Qian W, ..., Grundström C, Elofsson M
SLAS DISCOVERY: Advancing Life Sciences R&D 23 (8) 815-822 [2018-09-00; online 2018-04-09]
Chemical Biology Consortium Sweden (CBCS) [Service]
DOI Crossref
The structure-activity relationship of the salicylimide derived inhibitors of UDP-sugar producing pyrophosphorylases
Decker D, Öberg C, Kleczkowski LA
Plant Signal Behav - (-) 1-3 [2018-08-20; online 2018-08-20]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Identification of inhibitors of Tartrate-resistant acid phosphatase (TRAP/ACP5 ) activity by small-molecule screening
Reithmeier A, Lundbäck T, Haraldsson M, ..., Gustavsson AL, Andersson G
Chem Biol Drug Des 92 (1) 1255-1271 [2018-07-00; online 2018-03-30]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5
Rossi Sebastiano M, Doak BC, Backlund M, ..., Matsson P, Kihlberg J
J. Med. Chem. 61 (9) 4189-4202 [2018-05-10; online 2018-04-02]
Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol
Ekblad T, Verheugd P, Lindgren AE, ..., Elofsson M, Schüler H
SLAS DISCOVERY: Advancing Life Sciences R&D 23 (4) 353-362 [2018-04-00; online 2018-01-09]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF) [Collaborative]
PubMed DOI Crossref
In Situ Target Engagement Studies in Adherent Cells
Axelsson H, Almqvist H, Otrocka M, ..., Lundbäck T, Seashore-Ludlow B
ACS Chem. Biol. - (-) - [2018-02-21; online 2018-02-21]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration
Pettersson-Klein AT, Izadi M, Ferreira DMS, ..., Griffin PR, Ruas JL
Mol Metab - (-) - [2018-02-00; online 2018-02-00]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1
Ahlstedt J, Förnvik K, Zolfaghari S, ..., Salford LG, Redebrandt HN
Oncotarget - (-) - [2018-01-03; online 2018-01-03]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Natural product inspired library synthesis - Identification of 2,3-diarylbenzofuran and 2,3-dihydrobenzofuran based inhibitors of Chlamydia trachomatis
Saleeb M, Mojica S, Eriksson AU, ..., Gylfe Å, Elofsson M
European Journal of Medicinal Chemistry 143 (-) 1077-1089 [2018-01-00; online 2018-01-00]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Year 2017

PubMed DOI Crossref
A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth.
Pinheiro T, Otrocka M, Seashore-Ludlow B, ..., Simon A, Kirkham M
Biochem. Biophys. Res. Commun. 494 (3-4) 477-483 [2017-12-16; online 2017-10-21]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Tang J, Tanoli ZuR, Ravikumar B, ..., Wennerberg K, Aittokallio T
Cell Chem Biol - (-) - [2017-12-00; online 2017-12-00]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
A Drosophila female pheromone elicits species-specific long-range attraction via an olfactory channel with dual specificity for sex and food
Lebreton S, Borrero-Echeverry F, Gonzalez F, ..., Becher PG, Witzgall P
BMC Biol. 15 (1) - [2017-12-00; online 2017-09-29]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Increasing the permeability of Escherichia coli using MAC13243
Muheim C, Götzke H, Eriksson AU, ..., Nørholm MHH, Daley DO
Sci Rep 7 (1) - [2017-12-00; online 2017-12-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Motivating students with authentic science experiences: changes in motivation for school science
Hellgren JM, Lindberg S
Research in Science & Technological Education 35 (4) 409-426 [2017-10-02; online 2017-05-03]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration.
Skogh A, Lesniak A, Gaugaz FZ, ..., Hallberg M, Sandström A
Eur J Pharm Sci 109 (-) 533-540 [2017-09-05; online 2017-09-05]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.
Karlgren M, Simoff I, Backlund M, ..., Oswald S, Artursson P
J Pharm Sci 106 (9) 2909-2913 [2017-09-00; online 2017-04-24]
Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Technology development] Drug Discovery and Development (DDD) [Technology development] NGI Uppsala (Uppsala Genome Center) [Service]
PubMed DOI Crossref
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.
Llona-Minguez S, Häggblad M, Martens U, ..., Scobie M, Helleday T
Bioorg. Med. Chem. Lett. 27 (15) 3219-3225 [2017-08-01; online 2017-06-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery
Mateus A, Gordon LJ, Wayne GJ, ..., Hann MM, Artursson P
Proc Natl Acad Sci USA 114 (30) E6231-E6239 [2017-07-25; online 2017-07-12]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Identification of novel small molecules that inhibit STAT3-dependent transcription and function
Kolosenko I, Yu Y, Busker S, ..., Page BDG, Grander D
PLoS ONE 12 (6) e0178844 [2017-06-21; online 2017-06-21]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Identification and characterization of inhibitors of UDP-glucose and UDP-sugar pyrophosphorylases for in vivo studies
Decker D, Öberg C, Kleczkowski LA
Plant J 90 (6) 1093-1107 [2017-06-00; online 2017-04-13]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors
Llona-Minguez S, Höglund A, Ghassemian A, ..., Scobie M, Helleday T
J. Med. Chem. 60 (10) 4279-4292 [2017-05-25; online 2017-05-16]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
dUTPase inhibition augments replication defects of 5-Fluorouracil.
Hagenkort A, Paulin CBJ, Desroses M, ..., Scobie M, Helleday T
pmc
Oncotarget 8 (14) 23713-23726 [2017-04-04; online 2017-04-21]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.
Niklasson M, Maddalo G, Sramkova Z, ..., Enger PØ, Andäng M
Cancer Res. 77 (7) 1741-1752 [2017-04-01; online 2017-01-13]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Wiita E, ..., Scobie M, Helleday T
J. Med. Chem. 60 (5) 2148-2154 [2017-03-09; online 2017-02-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold N, Rudd SG, Ljungblad L, ..., Helleday T, Schaller T
Nat Med 23 (2) 256-263 [2017-01-09; online 2017-01-09]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
High-affinity recognition of the human C-reactive protein independent of phosphocholine
Yang J, Gustavsson AL, Haraldsson M, ..., Norberg T, Baltzer L
Org. Biomol. Chem. 15 (21) 4644-4654 [2017-00-00; online 2017-00-00]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Swedish NMR Centre (SNC) [Service]

Year 2016

PubMed DOI Crossref
Identification of Compounds that Selectively Stabilize Specific G-Quadruplex Structures by Using a Thioflavin T-Displacement Assay as a Tool.
Jamroskovic J, Livendahl M, Eriksson J, Chorell E, Sabouri N
Chemistry 22 (52) 18932-18943 [2016-12-23; online 2016-11-20]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Early Perspective
Seashore-Ludlow B, Lundbäck T
J Biomol Screen 21 (10) 1019-1033 [2016-12-00; online 2016-12-00]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Structural and conformational determinants of macrocycle cell permeability.
Over B, Matsson P, Tyrchan C, ..., Duvall JR, Kihlberg J
PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance PubChem-Substance
Nat. Chem. Biol. 12 (12) 1065-1074 [2016-12-00; online 2016-10-17]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Validation and development of MTH1 inhibitors for treatment of cancer.
Warpman Berglund U, Sanjiv K, Gad H, ..., Scobie M, Helleday T
Ann. Oncol. 27 (12) 2275-2283 [2016-12-00; online 2016-11-08]
Advanced Mass Spectrometry Proteomics [Collaborative] Bioinformatics Support and Infrastructure [Collaborative] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Chemical Proteomics & Proteogenomics [Collaborative] Clinical Proteomics Mass spectrometry [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Identification and Characterization of Novel Compounds Blocking Shiga Toxin Expression in Escherichia coli O157:H7.
Huerta-Uribe A, Marjenberg ZR, Yamaguchi N, ..., Gally DL, Roe AJ
pmc
Front Microbiol 7 (-) 1930 [2016-11-30; online 2016-11-30]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes.
Engdahl C, Knutsson S, Ekström F, Linusson A
J. Med. Chem. 59 (20) 9409-9421 [2016-10-27; online 2016-09-07]
Chemical Biology Consortium Sweden (CBCS) [Service]
PubMed DOI Crossref
Auxotrophy-based High Throughput Screening assay for the identification of Bacillus subtilis stringent response inhibitors.
Andresen L, Varik V, Tozawa Y, ..., Tenson T, Hauryliuk V
pmc
Sci Rep 6 (-) 35824 [2016-10-24; online 2016-10-24]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.
Diwakarla S, Nylander E, Grönbladh A, ..., Chai SY, Hallberg M
ACS Chem Neurosci 7 (10) 1383-1392 [2016-10-19; online 2016-08-08]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features.
Hammarström LG, Harmel RK, Granath M, ..., Lehmann F, Ernfors P
J. Med. Chem. 59 (18) 8577-8592 [2016-09-22; online 2016-09-09]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
PubMed DOI Crossref
Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures.
Livendahl M, Jamroskovic J, Ivanova S, ..., Sabouri N, Chorell E
Chemistry 22 (37) 13004-13009 [2016-09-05; online 2016-07-20]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.
Brunner K, Maric S, Reshma RS, ..., Schnell R, Schneider G
J. Med. Chem. 59 (14) 6848-6859 [2016-07-28; online 2016-07-13]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells.
Pellegrini P, Dyczynski M, Sbrana FV, ..., Kharaziha P, De Milito A
pmc
Oncotarget 7 (24) 35703-35723 [2016-06-14; online 2016-06-02]
Chemical Biology Consortium Sweden (CBCS) [Service]
PubMed DOI Crossref
Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity.
Nilsson L, Larsson A, Begum A, ..., Sauer-Eriksson AE, Olofsson A
pmc
PLoS ONE 11 (4) e0153112 [2016-04-06; online 2016-04-06]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening.
Engen K, Rosenström U, Axelsson H, ..., Lundbäck T, Larhed M
Assay Drug Dev Technol 14 (3) 180-193 [2016-04-00; online 2016-04-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density.
Diwakarla S, Nylander E, Grönbladh A, ..., Chai SY, Hallberg M
Mol. Pharmacol. 89 (4) 413-424 [2016-04-00; online 2016-01-16]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
High-Throughput Screening Using a Whole-Cell Virus Replication Reporter Gene Assay to Identify Inhibitory Compounds against Rift Valley Fever Virus Infection.
Islam MK, Baudin M, Eriksson J, ..., Ahlm C, Evander M
J Biomol Screen 21 (4) 354-362 [2016-04-00; online 2016-01-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
Almqvist H, Axelsson H, Jafari R, ..., Lundbäck T, Nordlund P
pmc
Nat Commun 7 (-) 11040 [2016-03-24; online 2016-03-24]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.
Good JA, Silver J, Núñez-Otero C, ..., Bergström S, Almqvist F
J. Med. Chem. 59 (5) 2094-2108 [2016-03-10; online 2016-02-22]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach
Vildhede A, Mateus A, Khan EK, ..., Artursson P, Kjellsson MC
Drug Metab. Dispos. 44 (4) 505-516 [2016-02-26; online 2016-02-03]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Llona-Minguez S, Höglund A, Jacques SA, ..., Scobie M, Helleday T
J. Med. Chem. 59 (3) 1140-1148 [2016-02-11; online 2016-02-11]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Complete Knockout of Endogenous Mdr1 ( Abcb1 ) in MDCK Cells by CRISPR-Cas9
Simoff I, Karlgren M, Backlund M, ..., Matsson P, Artursson P
Journal of Pharmaceutical Sciences 105 (2) 1017-1021 [2016-02-00; online 2016-02-00]
Chemical Biology Consortium Sweden (CBCS) [Technology development] NGI Uppsala (Uppsala Genome Center) [Service]
PubMed DOI Crossref
Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability
Gordon LJ, Allen M, Artursson P, ..., Wayne GJ, West A
J Biomol Screen 21 (2) 156-164 [2016-02-00; online 2015-09-03]
Chemical Biology Consortium Sweden (CBCS) [Technology development]

Year 2015

PubMed DOI Crossref
Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo.
Caraballo R, Larsson M, Nilsson SK, ..., Enquist P, Elofsson M
Eur J Med Chem 103 (-) 191-209 [2015-10-20; online 2015-09-12]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis.
Hakala E, Hanski L, Uvell H, ..., Elofsson M, Vuorela PM
J. Antibiot. 68 (10) 609-614 [2015-10-00; online 2015-05-07]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates
Svensson F, Engen K, Lundbäck T, Larhed M, Sköld C
J. Chem. Inf. Model. 55 (9) 1984-1993 [2015-09-28; online 2015-09-28]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase
Kleinschmidt TK, Haraldsson M, Basavarajappa D, ..., Lindbom L, Haeggstrom JZ
Journal of Pharmacology and Experimental Therapeutics 355 (1) 108-116 [2015-09-08; online 2015-08-17]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors
Ferreira R, Nilsson JR, Solano C, Andréasson J, Grøtli M
Sci Rep 5 (1) - [2015-09-00; online 2015-05-06]
Chemical Biology Consortium Sweden (CBCS) [Service]
PubMed DOI Crossref
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate
Trésaugues L, Lundbäck T, Welin M, ..., Gräslund S, Nordlund P
PDB PDB
PLoS ONE 10 (6) e0131507 [2015-06-29; online 2015-06-29]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF)
PubMed DOI Crossref
CETSA: a target engagement assay with potential to transform drug discovery
Jensen AJ, Molina DM, Lundbäck T
Future Medicinal Chemistry 7 (8) 975-978 [2015-06-00; online 2015-06-00]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis
Poyraz Ö, Brunner K, Lohkamp B, ..., Schnell R, Schneider G
PDB PDB PDB PDB
PLoS ONE 10 (3) e0121494 [2015-03-25; online 2015-03-25]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF)
PubMed DOI Crossref
Preclinical characterization of acyl sulfonimidamides: potential carboxylic acid bioisosteres with tunable properties.
Borhade SR, Svensson R, Brandt P, ..., Arvidsson PI, Sandström A
ChemMedChem 10 (3) 455-460 [2015-03-00; online 2015-01-30]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Novel high-throughput screening method for identification of fungal dimorphism blockers.
Stylianou M, Uvell H, Lopes JP, ..., Elofsson M, Urban CF
J Biomol Screen 20 (2) 285-291 [2015-02-00; online 2014-10-05]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Year 2014

PubMed DOI Crossref
Inhibitory Activity of the Isoflavone Biochanin A on Intracellular Bacteria of Genus Chlamydia and Initial Development of a Buccal Formulation
Hanski L, Genina N, Uvell H, ..., Sandler N, Vuorela PM
PLoS ONE 9 (12) e115115 [2014-12-16; online 2014-12-16]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Exploration and Pharmacokinetic Profiling of Phenylalanine Based Carbamates as Novel Substance P 1–7 Analogues
Fransson R, Nordvall G, Bylund J, ..., Hallberg M, Sandström A
ACS Med Chem Lett 5 (12) 1272-1277 [2014-12-11; online 2014-12-11]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.
Lampa A, Alogheli H, Ehrenberg AE, ..., Karlén A, Sandström A
Bioorg. Med. Chem. 22 (23) 6595-6615 [2014-12-01; online 2014-12-03]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides.
Borhade SR, Rosenström U, Sävmarker J, ..., Larhed M, Hallberg M
pmc
ChemistryOpen 3 (6) 256-263 [2014-12-00; online 2014-11-21]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]
DOI Crossref
Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors
Engen K, Sävmarker J, Rosenström U, ..., Jenmalm-Jensen A, Larhed M
Org. Process Res. Dev. 18 (11) 1582-1588 [2014-11-21; online 2014-11-21]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Controversies inASSAY and Drug Development Technologies: A Focus on Assessing Irreproducibility
Glickman JF, Lundbäck T, Napper AD, ..., Zaman GJR, Osada H
ASSAY and Drug Development Technologies 12 (8) 443-451 [2014-10-00; online 2014-10-00]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Design of a general-purpose European compound screening library for EU-OPENSCREEN.
Horvath D, Lisurek M, Rupp B, ..., Quintana J, Frank R
ChemMedChem 9 (10) 2309-2326 [2014-10-00; online 2014-07-22]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
The cellular thermal shift assay for evaluating drug target interactions in cells
Jafari R, Almqvist H, Axelsson H, ..., Nordlund P, Molina DM
Nat Protoc 9 (9) 2100-2122 [2014-08-07; online 2014-08-07]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo.
Larsson M, Caraballo R, Ericsson M, ..., Nilsson SK, Olivecrona G
Biochem. Biophys. Res. Commun. 450 (2) 1063-1069 [2014-07-25; online 2014-07-02]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Screening for inhibition of Vibrio cholerae VipA-VipB interaction identifies small-molecule compounds active against type VI secretion.
Sun K, Bröms J, Lavander M, ..., Elofsson M, Sjöstedt A
pmc GENBANK GENBANK
Antimicrob. Agents Chemother. 58 (7) 4123-4130 [2014-07-00; online 2014-05-07]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
CXCR4 Antagonists
Castaldo C, Benicchi T, Otrocka M, ..., Varrone M, Porcari V
J Biomol Screen 19 (6) 859-869 [2014-07-00; online 2014-07-00]
Chemical Biology Consortium Sweden (CBCS) [Service]
PubMed DOI Crossref
Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation.
Theorell J, Gustavsson A, Tesi B, ..., Lundbäck T, Bryceson YT
Cancer Immunol. Immunother. 63 (6) 627-641 [2014-06-00; online 2014-03-30]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions
Vildhede A, Karlgren M, Svedberg EK, ..., Noren A, Artursson P
Drug Metab. Dispos. 42 (7) 1210-1218 [2014-05-30; online 2014-05-05]
Chemical Biology Consortium Sweden (CBCS) [Service]
PubMed DOI Crossref
Structure and inhibition of mouse leukotriene C4 synthase.
Niegowski D, Kleinschmidt T, Ahmad S, ..., Rinaldo-Matthis A, Haeggström JZ
pmc
PLoS ONE 9 (5) e96763 [2014-05-08; online 2014-05-08]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF)
PubMed DOI Crossref
N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.
Marwaha S, Uvell H, Salin O, ..., Elofsson M, Gylfe A
pmc
Antimicrob. Agents Chemother. 58 (5) 2968-2971 [2014-05-00; online 2014-02-26]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.
Kitambi SS, Toledo EM, Usoskin D, ..., Hammarström LGJ, Ernfors P
Cell 157 (2) 313-328 [2014-04-10; online 2014-03-25]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth A, ..., Berglund UW, Helleday T
Nature 508 (7495) 215-221 [2014-04-10; online 2014-04-02]
Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF)
DOI Crossref
A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain
Mateus A, Matsson P, Artursson P
J. Med. Chem. 57 (7) 3005-3010 [2014-04-10; online 2014-04-10]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity.
Dang HT, Chorell E, Uvell H, ..., Hultgren SJ, Almqvist F
pmc mid
Org. Biomol. Chem. 12 (12) 1942-1956 [2014-03-28; online 2014-02-18]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.
Over B, McCarren P, Artursson P, ..., Duvall JR, Kihlberg J
pmc
J. Med. Chem. 57 (6) 2746-2754 [2014-03-27; online 2014-02-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region
Lampa AK, Bergman SM, Gustafsson SS, ..., Karlén A, Sandström A
ACS Med Chem Lett 5 (3) 249-254 [2014-03-13; online 2014-03-13]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket.
Gising J, Belfrage AK, Alogheli H, ..., Larhed M, Sandström A
J. Med. Chem. 57 (5) 1790-1801 [2014-03-13; online 2013-03-23]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
2′-(Z)-Cinnamoylsalicortin: A novel salicinoid isolated from Populus tremula
Keefover-Ring K, Carlsson M, Albrectsen BR
Phytochemistry Letters 7 (-) 212-216 [2014-02-00; online 2014-02-00]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria.
Strand M, Carlsson M, Uvell H, ..., Wadell G, Almqvist F
pmc
Mar Drugs 12 (2) 799-821 [2014-01-28; online 2014-01-28]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
A luminescence-based assay of UDP-sugar producing pyrophosphorylases
Decker D, Lindberg S, Eriksson J, Kleczkowski LA
Anal. Methods 6 (1) 57-61 [2014-00-00; online 2014-00-00]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Statistical Molecular Design: A Tool to Follow Up Hits from Small-Molecule Screening
Lindgren AEG, Larsson A, Linusson A, Elofsson M
- - (-) 169-188 [2014-00-00; online 2013-11-26]
Chemical Biology Consortium Sweden (CBCS) [Technology development]

Year 2013

PubMed DOI Crossref
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.
Vodnala SK, Lundbäck T, Yeheskieli E, ..., Hammarström LGJ, Rottenberg ME
J. Med. Chem. 56 (24) 9861-9873 [2013-12-27; online 2013-11-29]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
The resveratrol tetramer (-)-hopeaphenol inhibits type III secretion in the gram-negative pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa.
Zetterström CE, Hasselgren J, Salin O, ..., Sundin C, Elofsson M
pmc
PLoS ONE 8 (12) e81969 [2013-12-04; online 2013-12-04]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Combined in vitro-in vivo approach to assess the hepatobiliary disposition of a novel oral thrombin inhibitor.
Matsson EM, Eriksson UG, Palm JE, ..., Schützer K, Lennernäs H
Mol. Pharm. 10 (11) 4252-4262 [2013-11-04; online 2013-10-02]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.
Andersson CD, Forsgren N, Akfur C, ..., Ekström F, Linusson A
J. Med. Chem. 56 (19) 7615-7624 [2013-10-10; online 2013-08-30]
Chemical Biology Consortium Sweden (CBCS) [Service]
DOI Crossref
Ebsulfur Is a Benzisothiazolone Cytocidal Inhibitor Targeting the Trypanothione Reductase ofTrypanosoma brucei
Lu J, Vodnala SK, Gustavsson AL, ..., Rottenberg ME, Holmgren A
J. Biol. Chem. 288 (38) 27456-27468 [2013-09-20; online 2013-07-29]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Structure-Guided Design of Novel Thiazolidine Inhibitors ofO-Acetyl Serine Sulfhydrylase from Mycobacterium tuberculosis
Poyraz Ö, Jeankumar VU, Saxena S, ..., Sriram D, Schneider G
J. Med. Chem. 56 (16) 6457-6466 [2013-08-22; online 2013-08-22]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
An Integratedin VitroModel for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux
Neve EPA, Artursson P, Ingelman-Sundberg M, Karlgren M
Mol. Pharmaceutics 10 (8) 3152-3163 [2013-08-05; online 2013-08-05]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Design of a Highly Selective and Potent Class of Non-planar Estrogen Receptor β Agonists
Sundén H, Ma JN, Hansen LK, ..., Burstein ES, Olsson R
ChemMedChem 8 (8) 1283-1294 [2013-08-00; online 2013-06-19]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Computational Prospecting for Drug–Transporter Interactions
Matsson P, Artursson P
Clin Pharmacol Ther 94 (1) 30-32 [2013-07-00; online 2013-04-02]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability.
Fransson R, Sköld C, Kratz JM, ..., Hallberg M, Sandström A
J. Med. Chem. 56 (12) 4953-4965 [2013-06-27; online 2013-06-06]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Rapid Measurement of Intracellular Unbound Drug Concentrations
Mateus A, Matsson P, Artursson P
Mol. Pharmaceutics 10 (6) 2467-2478 [2013-06-03; online 2013-06-03]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: results from the European Project ACuteTox.
Prieto P, Kinsner-Ovaskainen A, Stanzel S, ..., Zurbano MJ, Kopp-Schneider A
Toxicol In Vitro 27 (4) 1357-1376 [2013-06-00; online 2012-08-28]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice
Tehler U, Fagerberg JH, Svensson R, ..., Artursson P, Bergström CAS
J. Med. Chem. 56 (6) 2690-2694 [2013-03-28; online 2013-03-28]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.
Vodnala SK, Lundbäck T, Sjöberg B, ..., Rottenberg ME, Hammarström LGJ
pmc
Antimicrob. Agents Chemother. 57 (2) 1012-1018 [2013-02-00; online 2012-12-21]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat
Johansson CC, Gennemark P, Artursson P, ..., Ashton M, Jansson-Löfmark R
J Pharmacokinet Pharmacodyn 40 (1) 117-128 [2013-02-00; online 2013-01-10]
Chemical Biology Consortium Sweden (CBCS) [Service]
DOI Crossref
The A-CD analogue of 16β,17α-estriol is a potent and highly selective estrogen receptor β agonist
Sauvée C, Schäfer A, Sundén H, ..., Burstein ES, Olsson R
Med. Chem. Commun. 4 (11) 1439 [2013-00-00; online 2013-00-00]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Year 2012

PubMed DOI Crossref
Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase.
Berg L, Niemiec MS, Qian W, ..., Ekström F, Linusson A
Angew. Chem. Int. Ed. Engl. 51 (51) 12716-12720 [2012-12-14; online 2012-11-20]
Chemical Biology Consortium Sweden (CBCS) [Service]
PubMed DOI Crossref
2-[4,5-Difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid, an antiviral compound with activity against acyclovir-resistant isolates of herpes simplex virus types 1 and 2.
Strand M, Islam K, Edlund K, ..., Elofsson M, Wadell G
pmc
Antimicrob. Agents Chemother. 56 (11) 5735-5743 [2012-11-00; online 2012-08-22]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening
Andersson CD, Karlberg T, Ekblad T, ..., Schüler H, Linusson A
PDB PDB PDB
J. Med. Chem. 55 (17) 7706-7718 [2012-09-13; online 2012-09-13]
Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF)
PubMed DOI Crossref
The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia
Eriksson A, Hermanson M, Wickström M, ..., Parrow V, Höglund M
Blood Cancer J 2 (8) e81 [2012-08-00; online 2012-08-00]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Evidence-based approach to assess passive diffusion and carrier-mediated drug transport
Di L, Artursson P, Avdeef A, ..., Lennernäs H, Sugano K
Drug Discovery Today 17 (15-16) 905-912 [2012-08-00; online 2012-08-00]
Chemical Biology Consortium Sweden (CBCS) [Technology development]
PubMed DOI Crossref
Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents.
Bengtsson C, Lindgren AEG, Uvell H, Almqvist F
Eur J Med Chem 54 (-) 637-646 [2012-08-00; online 2012-07-04]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Small molecule screening for inhibitors of the YopH phosphatase of Yersinia pseudotuberculosis.
Eriksson J, Grundström C, Sauer-Eriksson AE, ..., Wolf-Watz H, Elofsson M
Adv. Exp. Med. Biol. 954 (-) 357-363 [2012-07-12; online 2012-07-12]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Ethanol effects on apparent solubility of poorly soluble drugs in simulated intestinal fluid.
Fagerberg JH, Al-Tikriti Y, Ragnarsson G, Bergström CAS
Mol. Pharm. 9 (7) 1942-1952 [2012-07-02; online 2012-06-02]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR 1
Çevik-Aras H, Kalderén C, Jenmalm Jensen A, ..., Dahlgren C, Forsman H
Biochemical Pharmacology 83 (12) 1655-1662 [2012-06-00; online 2012-06-00]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions
Karlgren M, Vildhede A, Norinder U, ..., Haglund U, Artursson P
J. Med. Chem. 55 (10) 4740-4763 [2012-05-24; online 2012-05-24]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Derivatives of 8-hydroxyquinoline--antibacterial agents that target intra- and extracellular Gram-negative pathogens.
Enquist P, Gylfe A, Hägglund U, ..., Sundin C, Elofsson M
Bioorg. Med. Chem. Lett. 22 (10) 3550-3553 [2012-05-15; online 2012-04-25]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Synthesis, biological evaluation, and structure-activity relationships of 2-[2-(benzoylamino)benzoylamino]benzoic acid analogues as inhibitors of adenovirus replication.
Öberg CT, Strand M, Andersson EK, ..., Wadell G, Elofsson M
J. Med. Chem. 55 (7) 3170-3181 [2012-04-12; online 2012-03-01]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Syntheses of pseudoceramines A-D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges.
Hillgren JM, Oberg CT, Elofsson M
Org. Biomol. Chem. 10 (6) 1246-1254 [2012-02-14; online 2011-12-20]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
DOI Crossref
In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions
Karlgren M, Ahlin G, Bergström CAS, ..., Palm J, Artursson P
Pharm Res 29 (2) 411-426 [2012-02-00; online 2011-08-23]
Chemical Biology Consortium Sweden (CBCS) [Technology development]

Year 2011

PubMed DOI Crossref
Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling.
Berg L, Andersson CD, Artursson E, ..., Linusson A, Ekström F
pmc
PLoS ONE 6 (11) e26039 [2011-11-30; online 2011-11-30]
Chemical Biology Consortium Sweden (CBCS) [Service]
PubMed DOI Crossref
Pseudoceramines A-D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.
Yin S, Davis RA, Shelper T, ..., Sundin C, Quinn RJ
Org. Biomol. Chem. 9 (19) 6755-6760 [2011-10-07; online 2011-08-19]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Structural features determining the intestinal epithelial permeability and efflux of novel HIV-1 protease inhibitors.
Lazorova L, Hubatsch I, Ekegren JK, ..., Larhed M, Artursson P
pmc
J Pharm Sci 100 (9) 3763-3772 [2011-09-00; online 2011-04-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Identification of Bacterial Target Proteins for the Salicylidene Acylhydrazide Class of Virulence-blocking Compounds
Wang D, Zetterström CE, Gabrielsen M, ..., Elofsson M, Roe AJ
J. Biol. Chem. 286 (34) 29922-29931 [2011-08-26; online 2011-07-01]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
PubMed DOI Crossref
Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity.
Chorell E, Bengtsson C, Sainte-Luce Banchelin T, ..., Hultgren SJ, Almqvist F
pmc mid
Eur J Med Chem 46 (4) 1103-1116 [2011-04-00; online 2011-02-15]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Year 2010

PubMed DOI Crossref
Small-molecule screening using a whole-cell viral replication reporter gene assay identifies 2-{[2-(benzoylamino)benzoyl]amino}-benzoic acid as a novel antiadenoviral compound.
Andersson EK, Strand M, Edlund K, ..., Mei Y, Wadell G
pmc
Antimicrob. Agents Chemother. 54 (9) 3871-3877 [2010-09-00; online 2010-06-30]
Chemical Biology Consortium Sweden (CBCS) [Collaborative]
SciLifeLab Publications
SciLifeLab
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