Chemical Biology Consortium Sweden (CBCS) (115 publications)

115 publications

Year 2018

DOI Crossref

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds MJGW, van Leeuwen IMM, ..., McCormack E, Laín S

Nat Commun 9 (1) - [2018-12-00; online 2018-03-16]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Page BDG, Valerie NCK, ..., Beato M, Helleday T

Nat Commun 9 (1) - [2018-12-00; online 2018-01-17]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

DOI Crossref

Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol

Ekblad T, Verheugd P, ..., Elofsson M, Schüler H

SLAS DISCOVERY: Advancing Life Sciences R&D 23 (4) 353-362 [2018-04-00; online 2018-01-09]

Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF) [Collaborative]

DOI Crossref

In Situ Target Engagement Studies in Adherent Cells

Axelsson H, Almqvist H, ..., Lundbäck T, Seashore-Ludlow B

ACS Chem. Biol. - (-) - [2018-02-21; online 2018-02-21]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

DOI Crossref

Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1

Ahlstedt J, Förnvik K, ..., Salford LG, Redebrandt HN

Oncotarget - (-) - [2018-01-03; online 2018-01-03]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Year 2017

PubMed DOI Crossref

A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth.

Pinheiro T, Otrocka M, ..., Simon A, Kirkham M

Biochem. Biophys. Res. Commun. 494 (3-4) 477-483 [2017-12-16; online 2017-10-21]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

Tang J, Tanoli ZuR, ..., Wennerberg K, Aittokallio T

Cell Chem Biol - (-) - [2017-12-00; online 2017-12-00]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

A Drosophila female pheromone elicits species-specific long-range attraction via an olfactory channel with dual specificity for sex and food

Lebreton S, Borrero-Echeverry F, ..., Becher PG, Witzgall P

BMC Biol. 15 (1) - [2017-12-00; online 2017-09-29]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Increasing the permeability of Escherichia coli using MAC13243

Muheim C, Götzke H, ..., Nørholm MHH, Daley DO

Sci Rep 7 (1) - [2017-12-00; online 2017-12-15]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Motivating students with authentic science experiences: changes in motivation for school science

Hellgren JM, Lindberg S

Research in Science & Technological Education 35 (4) 409-426 [2017-10-02; online 2017-05-03]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration.

Skogh A, Lesniak A, ..., Hallberg M, Sandström A

Eur J Pharm Sci 109 (-) 533-540 [2017-09-05; online 2017-09-05]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]

PubMed DOI Crossref

A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Karlgren M, Simoff I, ..., Oswald S, Artursson P

J Pharm Sci 106 (9) 2909-2913 [2017-09-00; online 2017-04-24]

Bioinformatics Compute and Storage [Service] Chemical Biology Consortium Sweden (CBCS) [Technology development] Drug Discovery and Development (DDD) [Technology development] NGI Uppsala (Uppsala Genome Center) [Service]

PubMed DOI Crossref

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.

Llona-Minguez S, Häggblad M, ..., Scobie M, Helleday T

Bioorg. Med. Chem. Lett. 27 (15) 3219-3225 [2017-08-01; online 2017-06-15]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]

PubMed DOI Crossref

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery

Mateus A, Gordon LJ, ..., Hann MM, Artursson P

Proc Natl Acad Sci USA 114 (30) E6231-E6239 [2017-07-25; online 2017-07-12]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Identification of novel small molecules that inhibit STAT3-dependent transcription and function

Kolosenko I, Yu Y, ..., Page BDG, Grander D

PLoS ONE 12 (6) e0178844 [2017-06-21; online 2017-06-21]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Llona-Minguez S, Höglund A, ..., Scobie M, Helleday T

J. Med. Chem. 60 (10) 4279-4292 [2017-05-25; online 2017-05-16]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]

PubMed DOI Crossref

dUTPase inhibition augments replication defects of 5-Fluorouracil.

Hagenkort A, Paulin CBJ, ..., Scobie M, Helleday T

Oncotarget 8 (14) 23713-23726 [2017-04-04; online 2017-04-21]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.

Niklasson M, Maddalo G, ..., Enger PØ, Andäng M

Cancer Res. 77 (7) 1741-1752 [2017-04-01; online 2017-01-13]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.

Llona-Minguez S, Höglund A, ..., Scobie M, Helleday T

J. Med. Chem. 60 (5) 2148-2154 [2017-03-09; online 2017-02-15]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]

PubMed DOI Crossref

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

Herold N, Rudd SG, ..., Helleday T, Schaller T

Nat Med 23 (2) 256-263 [2017-01-09; online 2017-01-09]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

PubMed DOI Crossref

High-affinity recognition of the human C-reactive protein independent of phosphocholine

Yang J, Gustavsson AL, ..., Norberg T, Baltzer L

Org. Biomol. Chem. 15 (21) 4644-4654 [2017-00-00; online 2017-00-00]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Swedish NMR Centre (SNC) [Service]

Year 2016

PubMed DOI Crossref

Identification of Compounds that Selectively Stabilize Specific G-Quadruplex Structures by Using a Thioflavin T-Displacement Assay as a Tool.

Jamroskovic J, Livendahl M, ..., Chorell E, Sabouri N

Chemistry 22 (52) 18932-18943 [2016-12-23; online 2016-11-20]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Early Perspective

Seashore-Ludlow B, Lundbäck T

J Biomol Screen 21 (10) 1019-1033 [2016-12-00; online 2016-12-00]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Structural and conformational determinants of macrocycle cell permeability.

Over B, Matsson P, ..., Duvall JR, Kihlberg J

Nat. Chem. Biol. 12 (12) 1065-1074 [2016-12-00; online 2016-10-17]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Validation and development of MTH1 inhibitors for treatment of cancer.

Warpman Berglund U, Sanjiv K, ..., Scobie M, Helleday T

Ann. Oncol. 27 (12) 2275-2283 [2016-12-00; online 2016-11-08]

Advanced Mass Spectrometry Proteomics [Collaborative] Bioinformatics Support and Infrastructure [Collaborative] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Chemical Proteomics & Proteogenomics [Service] Clinical Proteomics Mass spectrometry [Collaborative] Drug Discovery and Development (DDD) [Collaborative]

PubMed DOI Crossref

Identification and Characterization of Novel Compounds Blocking Shiga Toxin Expression in Escherichia coli O157:H7.

Huerta-Uribe A, Marjenberg ZR, ..., Gally DL, Roe AJ

Front Microbiol 7 (-) 1930 [2016-11-30; online 2016-11-30]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes.

Engdahl C, Knutsson S, Ekström F, Linusson A

J. Med. Chem. 59 (20) 9409-9421 [2016-10-27; online 2016-09-07]

Chemical Biology Consortium Sweden (CBCS) [Service]

PubMed DOI Crossref

Auxotrophy-based High Throughput Screening assay for the identification of Bacillus subtilis stringent response inhibitors.

Andresen L, Varik V, ..., Tenson T, Hauryliuk V

Sci Rep 6 (-) 35824 [2016-10-24; online 2016-10-24]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.

Diwakarla S, Nylander E, ..., Chai SY, Hallberg M

ACS Chem Neurosci 7 (10) 1383-1392 [2016-10-19; online 2016-08-08]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]

PubMed DOI Crossref

The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features.

Hammarström LG, Harmel RK, ..., Lehmann F, Ernfors P

J. Med. Chem. 59 (18) 8577-8592 [2016-09-22; online 2016-09-09]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]

PubMed DOI Crossref

Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures.

Livendahl M, Jamroskovic J, ..., Sabouri N, Chorell E

Chemistry 22 (37) 13004-13009 [2016-09-05; online 2016-07-20]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.

Brunner K, Maric S, ..., Schnell R, Schneider G

J. Med. Chem. 59 (14) 6848-6859 [2016-07-28; online 2016-07-13]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

PubMed DOI Crossref

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells.

Pellegrini P, Dyczynski M, ..., Kharaziha P, De Milito A

Oncotarget 7 (24) 35703-35723 [2016-06-14; online 2016-06-02]

Chemical Biology Consortium Sweden (CBCS) [Service]

PubMed DOI Crossref

Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity.

Nilsson L, Larsson A, ..., Sauer-Eriksson AE, Olofsson A

PLoS ONE 11 (4) e0153112 [2016-04-06; online 2016-04-06]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening.

Engen K, Rosenström U, ..., Lundbäck T, Larhed M

Assay Drug Dev Technol 14 (3) 180-193 [2016-04-00; online 2016-04-15]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]

PubMed DOI Crossref

Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density.

Diwakarla S, Nylander E, ..., Chai SY, Hallberg M

Mol. Pharmacol. 89 (4) 413-424 [2016-04-00; online 2016-01-16]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

High-Throughput Screening Using a Whole-Cell Virus Replication Reporter Gene Assay to Identify Inhibitory Compounds against Rift Valley Fever Virus Infection.

Islam MK, Baudin M, ..., Ahlm C, Evander M

J Biomol Screen 21 (4) 354-362 [2016-04-00; online 2016-01-15]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.

Almqvist H, Axelsson H, ..., Lundbäck T, Nordlund P

Nat Commun 7 (-) 11040 [2016-03-24; online 2016-03-24]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

PubMed DOI Crossref

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.

Good JA, Silver J, ..., Bergström S, Almqvist F

J. Med. Chem. 59 (5) 2094-2108 [2016-03-10; online 2016-02-22]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Vildhede A, Mateus A, ..., Artursson P, Kjellsson MC

Drug Metab. Dispos. 44 (4) 505-516 [2016-02-26; online 2016-02-03]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Llona-Minguez S, Höglund A, ..., Scobie M, Helleday T

J. Med. Chem. 59 (3) 1140-1148 [2016-02-11; online 2016-02-11]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) [Service]

PubMed DOI Crossref

Complete Knockout of Endogenous Mdr1 ( Abcb1 ) in MDCK Cells by CRISPR-Cas9

Simoff I, Karlgren M, ..., Matsson P, Artursson P

Journal of Pharmaceutical Sciences 105 (2) 1017-1021 [2016-02-00; online 2016-02-00]

Chemical Biology Consortium Sweden (CBCS) [Technology development] NGI Uppsala (Uppsala Genome Center) [Service]

PubMed DOI Crossref

Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Gordon LJ, Allen M, ..., Wayne GJ, West A

J Biomol Screen 21 (2) 156-164 [2016-02-00; online 2015-09-03]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

Year 2015

PubMed DOI Crossref

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo.

Caraballo R, Larsson M, ..., Enquist P, Elofsson M

Eur J Med Chem 103 (-) 191-209 [2015-10-20; online 2015-09-12]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis.

Hakala E, Hanski L, ..., Elofsson M, Vuorela PM

J. Antibiot. 68 (10) 609-614 [2015-10-00; online 2015-05-07]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Svensson F, Engen K, ..., Larhed M, Sköld C

J. Chem. Inf. Model. 55 (9) 1984-1993 [2015-09-28; online 2015-09-28]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase

Kleinschmidt TK, Haraldsson M, ..., Lindbom L, Haeggstrom JZ

Journal of Pharmacology and Experimental Therapeutics 355 (1) 108-116 [2015-09-08; online 2015-08-17]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors

Ferreira R, Nilsson JR, ..., Andréasson J, Grøtli M

Sci Rep 5 (1) - [2015-09-00; online 2015-05-06]

Chemical Biology Consortium Sweden (CBCS) [Service]

PubMed DOI Crossref

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

Trésaugues L, Lundbäck T, ..., Gräslund S, Nordlund P

PLoS ONE 10 (6) e0131507 [2015-06-29; online 2015-06-29]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) []

PubMed DOI Crossref

CETSA: a target engagement assay with potential to transform drug discovery

Jensen AJ, Molina DM, Lundbäck T

Future Medicinal Chemistry 7 (8) 975-978 [2015-06-00; online 2015-06-00]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis

Poyraz Ö, Brunner K, ..., Schnell R, Schneider G

PLoS ONE 10 (3) e0121494 [2015-03-25; online 2015-03-25]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) []

PubMed DOI Crossref

Preclinical characterization of acyl sulfonimidamides: potential carboxylic acid bioisosteres with tunable properties.

Borhade SR, Svensson R, ..., Arvidsson PI, Sandström A

ChemMedChem 10 (3) 455-460 [2015-03-00; online 2015-01-30]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Novel high-throughput screening method for identification of fungal dimorphism blockers.

Stylianou M, Uvell H, ..., Elofsson M, Urban CF

J Biomol Screen 20 (2) 285-291 [2015-02-00; online 2014-10-05]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Year 2014

PubMed DOI Crossref

Inhibitory Activity of the Isoflavone Biochanin A on Intracellular Bacteria of Genus Chlamydia and Initial Development of a Buccal Formulation

Hanski L, Genina N, ..., Sandler N, Vuorela PM

PLoS ONE 9 (12) e115115 [2014-12-16; online 2014-12-16]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Exploration and Pharmacokinetic Profiling of Phenylalanine Based Carbamates as Novel Substance P 1–7 Analogues

Fransson R, Nordvall G, ..., Hallberg M, Sandström A

ACS Med Chem Lett 5 (12) 1272-1277 [2014-12-11; online 2014-12-11]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.

Lampa A, Alogheli H, ..., Karlén A, Sandström A

Bioorg. Med. Chem. 22 (23) 6595-6615 [2014-12-01; online 2014-12-03]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides.

Borhade SR, Rosenström U, ..., Larhed M, Hallberg M

ChemistryOpen 3 (6) 256-263 [2014-12-00; online 2014-11-21]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]

DOI Crossref

Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors

Engen K, Sävmarker J, ..., Jenmalm-Jensen A, Larhed M

Org. Process Res. Dev. 18 (11) 1582-1588 [2014-11-21; online 2014-11-21]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Controversies inASSAY and Drug Development Technologies: A Focus on Assessing Irreproducibility

Glickman JF, Lundbäck T, ..., Zaman GJR, Osada H

ASSAY and Drug Development Technologies 12 (8) 443-451 [2014-10-00; online 2014-10-00]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

Horvath D, Lisurek M, ..., Quintana J, Frank R

ChemMedChem 9 (10) 2309-2326 [2014-10-00; online 2014-07-22]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

The cellular thermal shift assay for evaluating drug target interactions in cells

Jafari R, Almqvist H, ..., Nordlund P, Molina DM

Nat Protoc 9 (9) 2100-2122 [2014-08-07; online 2014-08-07]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo.

Larsson M, Caraballo R, ..., Nilsson SK, Olivecrona G

Biochem. Biophys. Res. Commun. 450 (2) 1063-1069 [2014-07-25; online 2014-07-02]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Screening for inhibition of Vibrio cholerae VipA-VipB interaction identifies small-molecule compounds active against type VI secretion.

Sun K, Bröms J, ..., Elofsson M, Sjöstedt A

Antimicrob. Agents Chemother. 58 (7) 4123-4130 [2014-07-00; online 2014-05-07]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

CXCR4 Antagonists

Castaldo C, Benicchi T, ..., Varrone M, Porcari V

J Biomol Screen 19 (6) 859-869 [2014-07-00; online 2014-07-00]

Chemical Biology Consortium Sweden (CBCS) [Service]

PubMed DOI Crossref

Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation.

Theorell J, Gustavsson A, ..., Lundbäck T, Bryceson YT

Cancer Immunol. Immunother. 63 (6) 627-641 [2014-06-00; online 2014-03-30]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Vildhede A, Karlgren M, ..., Noren A, Artursson P

Drug Metab. Dispos. 42 (7) 1210-1218 [2014-05-30; online 2014-05-05]

Chemical Biology Consortium Sweden (CBCS) [Service]

PubMed DOI Crossref

Structure and inhibition of mouse leukotriene C4 synthase.

Niegowski D, Kleinschmidt T, ..., Rinaldo-Matthis A, Haeggström JZ

PLoS ONE 9 (5) e96763 [2014-05-08; online 2014-05-08]

Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF) []

PubMed DOI Crossref

N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.

Marwaha S, Uvell H, ..., Elofsson M, Gylfe A

Antimicrob. Agents Chemother. 58 (5) 2968-2971 [2014-05-00; online 2014-02-26]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.

Kitambi SS, Toledo EM, ..., Hammarström LGJ, Ernfors P

Cell 157 (2) 313-328 [2014-04-10; online 2014-03-25]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H, Koolmeister T, ..., Berglund UW, Helleday T

Nature 508 (7495) 215-221 [2014-04-10; online 2014-04-02]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative] Protein Science Facility (PSF) []

DOI Crossref

A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the Brain

Mateus A, Matsson P, Artursson P

J. Med. Chem. 57 (7) 3005-3010 [2014-04-10; online 2014-04-10]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity.

Dang HT, Chorell E, ..., Hultgren SJ, Almqvist F

Org. Biomol. Chem. 12 (12) 1942-1956 [2014-03-28; online 2014-02-18]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.

Over B, McCarren P, ..., Duvall JR, Kihlberg J

J. Med. Chem. 57 (6) 2746-2754 [2014-03-27; online 2014-02-15]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Lampa AK, Bergman SM, ..., Karlén A, Sandström A

ACS Med Chem Lett 5 (3) 249-254 [2014-03-13; online 2014-03-13]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket.

Gising J, Belfrage AK, ..., Larhed M, Sandström A

J. Med. Chem. 57 (5) 1790-1801 [2014-03-13; online 2013-03-23]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

2′-(Z)-Cinnamoylsalicortin: A novel salicinoid isolated from Populus tremula

Keefover-Ring K, Carlsson M, Albrectsen BR

Phytochemistry Letters 7 (-) 212-216 [2014-02-00; online 2014-02-00]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria.

Strand M, Carlsson M, ..., Wadell G, Almqvist F

Mar Drugs 12 (2) 799-821 [2014-01-28; online 2014-01-28]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

A luminescence-based assay of UDP-sugar producing pyrophosphorylases

Decker D, Lindberg S, Eriksson J, Kleczkowski LA

Anal. Methods 6 (1) 57-61 [2014-00-00; online 2014-00-00]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Statistical Molecular Design: A Tool to Follow Up Hits from Small-Molecule Screening

Lindgren AEG, Larsson A, Linusson A, Elofsson M

- - (-) 169-188 [2014-00-00; online 2013-11-26]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

Year 2013

PubMed DOI Crossref

Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.

Vodnala SK, Lundbäck T, ..., Hammarström LGJ, Rottenberg ME

J. Med. Chem. 56 (24) 9861-9873 [2013-12-27; online 2013-11-29]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

The resveratrol tetramer (-)-hopeaphenol inhibits type III secretion in the gram-negative pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa.

Zetterström CE, Hasselgren J, ..., Sundin C, Elofsson M

PLoS ONE 8 (12) e81969 [2013-12-04; online 2013-12-04]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Combined in vitro-in vivo approach to assess the hepatobiliary disposition of a novel oral thrombin inhibitor.

Matsson EM, Eriksson UG, ..., Schützer K, Lennernäs H

Mol. Pharm. 10 (11) 4252-4262 [2013-11-04; online 2013-10-02]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.

Andersson CD, Forsgren N, ..., Ekström F, Linusson A

J. Med. Chem. 56 (19) 7615-7624 [2013-10-10; online 2013-08-30]

Chemical Biology Consortium Sweden (CBCS) [Service]

DOI Crossref

Ebsulfur Is a Benzisothiazolone Cytocidal Inhibitor Targeting the Trypanothione Reductase ofTrypanosoma brucei

Lu J, Vodnala SK, ..., Rottenberg ME, Holmgren A

J. Biol. Chem. 288 (38) 27456-27468 [2013-09-20; online 2013-07-29]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Structure-Guided Design of Novel Thiazolidine Inhibitors ofO-Acetyl Serine Sulfhydrylase from Mycobacterium tuberculosis

Poyraz Ö, Jeankumar VU, ..., Sriram D, Schneider G

J. Med. Chem. 56 (16) 6457-6466 [2013-08-22; online 2013-08-22]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

An Integratedin VitroModel for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Neve EPA, Artursson P, Ingelman-Sundberg M, Karlgren M

Mol. Pharmaceutics 10 (8) 3152-3163 [2013-08-05; online 2013-08-05]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Design of a Highly Selective and Potent Class of Non-planar Estrogen Receptor β Agonists

Sundén H, Ma JN, ..., Burstein ES, Olsson R

ChemMedChem 8 (8) 1283-1294 [2013-08-00; online 2013-06-19]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Computational Prospecting for Drug–Transporter Interactions

Matsson P, Artursson P

Clin Pharmacol Ther 94 (1) 30-32 [2013-07-00; online 2013-04-02]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability.

Fransson R, Sköld C, ..., Hallberg M, Sandström A

J. Med. Chem. 56 (12) 4953-4965 [2013-06-27; online 2013-06-06]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Rapid Measurement of Intracellular Unbound Drug Concentrations

Mateus A, Matsson P, Artursson P

Mol. Pharmaceutics 10 (6) 2467-2478 [2013-06-03; online 2013-06-03]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: results from the European Project ACuteTox.

Prieto P, Kinsner-Ovaskainen A, ..., Zurbano MJ, Kopp-Schneider A

Toxicol In Vitro 27 (4) 1357-1376 [2013-06-00; online 2012-08-28]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler U, Fagerberg JH, ..., Artursson P, Bergström CAS

J. Med. Chem. 56 (6) 2690-2694 [2013-03-28; online 2013-03-28]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.

Vodnala SK, Lundbäck T, ..., Rottenberg ME, Hammarström LGJ

Antimicrob. Agents Chemother. 57 (2) 1012-1018 [2013-02-00; online 2012-12-21]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat

Johansson CC, Gennemark P, ..., Ashton M, Jansson-Löfmark R

J Pharmacokinet Pharmacodyn 40 (1) 117-128 [2013-02-00; online 2013-01-10]

Chemical Biology Consortium Sweden (CBCS) [Service]

DOI Crossref

The A-CD analogue of 16β,17α-estriol is a potent and highly selective estrogen receptor β agonist

Sauvée C, Schäfer A, ..., Burstein ES, Olsson R

Med. Chem. Commun. 4 (11) 1439 [2013-00-00; online 2013-00-00]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Year 2012

PubMed DOI Crossref

Berg L, Niemiec MS, ..., Ekström F, Linusson A

Angew. Chem. Int. Ed. Engl. 51 (51) 12716-12720 [2012-12-14; online 2012-11-20]

Chemical Biology Consortium Sweden (CBCS) [Service]

PubMed DOI Crossref

2-[4,5-Difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid, an antiviral compound with activity against acyclovir-resistant isolates of herpes simplex virus types 1 and 2.

Strand M, Islam K, ..., Elofsson M, Wadell G

Antimicrob. Agents Chemother. 56 (11) 5735-5743 [2012-11-00; online 2012-08-22]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening

Andersson CD, Karlberg T, ..., Schüler H, Linusson A

J. Med. Chem. 55 (17) 7706-7718 [2012-09-13; online 2012-09-13]

Chemical Biology Consortium Sweden (CBCS) [Service] Protein Science Facility (PSF) []

PubMed DOI Crossref

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

Eriksson A, Hermanson M, ..., Parrow V, Höglund M

Blood Cancer J 2 (8) e81 [2012-08-00; online 2012-08-00]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Di L, Artursson P, ..., Lennernäs H, Sugano K

Drug Discovery Today 17 (15-16) 905-912 [2012-08-00; online 2012-08-00]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

PubMed DOI Crossref

Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents.

Bengtsson C, Lindgren AEG, Uvell H, Almqvist F

Eur J Med Chem 54 (-) 637-646 [2012-08-00; online 2012-07-04]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Small molecule screening for inhibitors of the YopH phosphatase of Yersinia pseudotuberculosis.

Eriksson J, Grundström C, ..., Wolf-Watz H, Elofsson M

Adv. Exp. Med. Biol. 954 (-) 357-363 [2012-07-12; online 2012-07-12]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Ethanol effects on apparent solubility of poorly soluble drugs in simulated intestinal fluid.

Fagerberg JH, Al-Tikriti Y, Ragnarsson G, Bergström CAS

Mol. Pharm. 9 (7) 1942-1952 [2012-07-02; online 2012-06-02]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR 1

Çevik-Aras H, Kalderén C, ..., Dahlgren C, Forsman H

Biochemical Pharmacology 83 (12) 1655-1662 [2012-06-00; online 2012-06-00]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions

Karlgren M, Vildhede A, ..., Haglund U, Artursson P

J. Med. Chem. 55 (10) 4740-4763 [2012-05-24; online 2012-05-24]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Derivatives of 8-hydroxyquinoline--antibacterial agents that target intra- and extracellular Gram-negative pathogens.

Enquist P, Gylfe A, ..., Sundin C, Elofsson M

Bioorg. Med. Chem. Lett. 22 (10) 3550-3553 [2012-05-15; online 2012-04-25]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Synthesis, biological evaluation, and structure-activity relationships of 2-[2-(benzoylamino)benzoylamino]benzoic acid analogues as inhibitors of adenovirus replication.

Öberg CT, Strand M, ..., Wadell G, Elofsson M

J. Med. Chem. 55 (7) 3170-3181 [2012-04-12; online 2012-03-01]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Syntheses of pseudoceramines A-D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges.

Hillgren JM, Oberg CT, Elofsson M

Org. Biomol. Chem. 10 (6) 1246-1254 [2012-02-14; online 2011-12-20]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

DOI Crossref

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions

Karlgren M, Ahlin G, ..., Palm J, Artursson P

Pharm Res 29 (2) 411-426 [2012-02-00; online 2011-08-23]

Chemical Biology Consortium Sweden (CBCS) [Technology development]

Year 2011

PubMed DOI Crossref

Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling.

Berg L, Andersson CD, ..., Linusson A, Ekström F

PLoS ONE 6 (11) e26039 [2011-11-30; online 2011-11-30]

Chemical Biology Consortium Sweden (CBCS) [Service]

PubMed DOI Crossref

Pseudoceramines A-D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.

Yin S, Davis RA, ..., Sundin C, Quinn RJ

Org. Biomol. Chem. 9 (19) 6755-6760 [2011-10-07; online 2011-08-19]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Structural features determining the intestinal epithelial permeability and efflux of novel HIV-1 protease inhibitors.

Lazorova L, Hubatsch I, ..., Larhed M, Artursson P

J Pharm Sci 100 (9) 3763-3772 [2011-09-00; online 2011-04-15]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Identification of Bacterial Target Proteins for the Salicylidene Acylhydrazide Class of Virulence-blocking Compounds

Wang D, Zetterström CE, ..., Elofsson M, Roe AJ

J. Biol. Chem. 286 (34) 29922-29931 [2011-08-26; online 2011-07-01]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity.

Chorell E, Bengtsson C, ..., Hultgren SJ, Almqvist F

Eur J Med Chem 46 (4) 1103-1116 [2011-04-00; online 2011-02-15]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

Year 2010

PubMed DOI Crossref

Small-molecule screening using a whole-cell viral replication reporter gene assay identifies 2-{[2-(benzoylamino)benzoyl]amino}-benzoic acid as a novel antiadenoviral compound.

Andersson EK, Strand M, ..., Mei Y, Wadell G

Antimicrob. Agents Chemother. 54 (9) 3871-3877 [2010-09-00; online 2010-06-30]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]