Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals.

Siino V, Ali A, Accardi G, Aiello A, Ligotti ME, Mosquim Junior S, Candore G, Caruso C, Levander F, Vasto S

Aging Cell 21 (9) e13684 [2022-09-00; online 2022-08-06]

The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.

Bioinformatics Support and Infrastructure [Collaborative]

Bioinformatics Support, Infrastructure and Training [Collaborative]

PubMed 35932462

DOI 10.1111/acel.13684

Crossref 10.1111/acel.13684

pmc: PMC9470904

Publications 9.5.0