Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.

JSON

Rozman Grinberg I, Lundin D, Hasan M, Crona M, Jonna VR, Loderer C, Sahlin M, Markova N, Borovok I, Berggren G, Hofer A, Logan DT, Sjöberg BM

Elife 7 (-) - [2018-02-01; online 2018-02-01]

Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, we discovered ATP-cones in the radical-generating subunit. The ATP-cone in the

Protein Science Facility (PSF) [Service]

PubMed 29388911

DOI 10.7554/eLife.31529

Crossref 10.7554/eLife.31529

pii: 31529
pmc: PMC5794259