Marttila P

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.

Green AC, Marttila P, Kiweler N, ..., Henriksson M, Meiser J

Nat Metab 5 (4) 642-659 [2023-04-00; online 2023-04-03]

Drug Discovery and Development (DDD) [Collaborative] Swedish Metabolomics Centre (SMC) [Collaborative]

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.

Bonagas N, Gustafsson NMS, Henriksson M, ..., Homan EJ, Helleday T

Nat Cancer 3 (2) 156-172 [2022-02-00; online 2022-02-28]

Drug Discovery and Development (DDD) [Collaborative]

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.

Škerlová J, Unterlass J, Göttmann M, ..., Jemth AS, Stenmark P

J. Biol. Chem. 295 (33) 11656-11668 [2020-08-14; online 2020-06-22]

Protein Science Facility (PSF) [Service]