Svenningsson P

AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1.

Díaz-Holguín A, Saarinen M, Vo DD, ..., Carlsson J, Svenningsson P

Sci Adv 10 (32) eadn1524 [2024-08-09; online 2024-08-07]

Drug Discovery and Development (DDD) [Service]

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

He Y, Kaya I, Shariatgorji R, ..., Andren PE, Svenningsson P

Nat Commun 14 (1) 5804 [2023-09-19; online 2023-09-19]

Spatial Mass Spectrometry [Collaborative]

Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson's disease.

Paslawski W, Khosousi S, Hertz E, ..., Boxer A, Svenningsson P

Transl Neurodegener 12 (1) 42 [2023-09-04; online 2023-09-04]

Affinity Proteomics Stockholm [Service]

Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson's disease primate model.

Kaya I, Nilsson A, Luptáková D, ..., Bezard E, Andrén PE

NPJ Parkinsons Dis 9 (1) 118 [2023-07-26; online 2023-07-26]

Spatial Mass Spectrometry [Technology development]

PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons.

Toskas K, Yaghmaeian-Salmani B, Skiteva O, ..., Perlmann T, Holmberg J

Sci Adv 8 (34) eabo1543 [2022-08-26; online 2022-08-26]

Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Collaborative]

Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia.

Fridjonsdottir E, Shariatgorji R, Nilsson A, ..., Bezard E, Andrén PE

Sci Adv 7 (2) - [2021-01-00; online 2021-01-06]

Spatial Mass Spectrometry [Technology development]