Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

Narwal M, Jemth AS, Gustafsson R, Almlöf I, Warpman Berglund U, Helleday T, Stenmark P

Biochemistry - (-) - [2018-01-16; online 2018-01-16]

Protein Science Facility (PSF) [Service]

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PubMed 29281266

DOI 10.1021/acs.biochem.7b01163

Crossref 10.1021/acs.biochem.7b01163

PDB: 5MZE Crystal structure of mouse MTH1 with 8-oxo-dGTP
PDB: 5MZF Crystal structure of dog MTH1 protein
PDB: 5MZG Crystal structure of mouse MTH1 in complex with TH588
PDB: 6EHH Crystal structure of mouse MTH1 mutant L116M with inhibitor TH588