Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

Narwal M, Jemth AS, Gustafsson R, Almlöf I, Warpman Berglund U, Helleday T, Stenmark P

Biochemistry - (-) - [2018-01-16; online 2018-01-16]

Protein Science Facility (PSF) [Service]

QC bibliography QC xrefs

PubMed 29281266

DOI 10.1021/acs.biochem.7b01163

Crossref 10.1021/acs.biochem.7b01163

PDB 5MZF [Crystal structure of dog MTH1 protein]

PDB 5MZG [Crystal structure of mouse MTH1 in complex with TH588]

PDB 6EHH [Crystal structure of mouse MTH1 mutant L116M with inhibitor TH588]

PDB 5MZE [Crystal structure of mouse MTH1 with 8-oxo-dGTP]