Danielson UH

Monitoring drug-target interactions through target engagement-mediated amplification on arrays and in situ.

Al-Amin RA, Johansson L, Abdurakhmanov E, ..., Lundbäck T, Landegren U

Nucleic Acids Res. 50 (22) e129 [2022-12-09; online 2022-10-04]

Autoimmunity and Serology Profiling [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Collaborative]

Sensitive Protein Detection Using Site-Specifically Oligonucleotide-Conjugated Nanobodies.

Al-Amin RA, Muthelo PM, Abdurakhmanov E, ..., Danielson UH, Landegren U

Anal. Chem. 94 (28) 10054-10061 [2022-07-19; online 2022-07-05]

Drug Discovery and Development (DDD) [Collaborative]

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.

Luttens A, Gullberg H, Abdurakhmanov E, ..., Danielson UH, Carlsson J

J. Am. Chem. Soc. 144 (7) 2905-2920 [2022-02-23; online 2022-02-10]

Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD) [Collaborative]

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase.

Talibov VO, Fabini E, FitzGerald EA, ..., Del Rio A, Danielson UH

ChemBioChem 22 (9) 1597-1608 [2021-05-04; online 2021-02-11]

Drug Discovery and Development (DDD) [Service]

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald EA, Butko MT, Boronat P, ..., Young T, Danielson UH

RSC Adv. 11 (13) 7527-7537 [2021-00-00; online 2021-00-00]

Chemical Biology Consortium Sweden (CBCS) [Service] Drug Discovery and Development (DDD)

Establishing Trypanosoma cruzi farnesyl pyrophosphate synthase as a viable target for biosensor driven fragment-based lead discovery.

Opassi G, Nordström H, Lundin A, ..., Klebe G, Danielson UH

Protein Sci. 29 (4) 991-1003 [2020-04-00; online 2020-02-07]

Drug Discovery and Development (DDD)

Estimating Detection Limits of Potentiometric DNA Sensors Using Surface Plasmon Resonance Analyses.

Xu X, Makaraviciute A, Abdurakhmanov E, ..., Nyholm L, Zhang Z

ACS Sens. 5 (1) 217-224 [2020-01-24; online 2019-12-23]

Drug Discovery and Development (DDD) [Technology development]

Structural Changes of Mercaptohexanol Self-Assembled Monolayers on Gold and Their Influence on Impedimetric Aptamer Sensors.

Xu X, Makaraviciute A, Kumar S, ..., Nyholm L, Zhang Z

Anal. Chem. 91 (22) 14697-14704 [2019-11-19; online 2019-11-07]

Drug Discovery and Development (DDD) [Technology development]

Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.

Linkuvienė V, Talibov VO, Danielson UH, Matulis D

J. Med. Chem. 61 (6) 2292-2302 [2018-03-22; online 2018-03-02]

Drug Discovery and Development (DDD) [Service]

Proximity-dependent initiation of hybridization chain reaction.

Koos B, Cane G, Grannas K, ..., Kamali-Moghaddam M, Söderberg O

Nat Commun 6 (-) 7294 [2015-06-12; online 2015-06-12]

Affinity Proteomics Uppsala [Service] PLA and Single Cell Proteomics [Service]