Altun M

NUDT5 regulates the global efficacy of nucleoside analog drugs by coordinating purine synthesis and PRPP allocation

Valerie NCK, Alam S, Hormann FM, ..., Arvidsson PI, Altun M

- - (-) - [2025-11-20; online 2025-11-20]

Chemical Proteomics [Collaborative]

A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs

Alam S, Pires MJ, Tidestav G, ..., Valerie NCK, Altun M

- - (-) - [2025-06-19; online 2025-06-19]

Chemical Proteomics [Collaborative]

Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells.

Pires MJ, Alam S, Lovric A, ..., Altun M, Valerie NCK

J. Biol. Chem. - (-) 108361 [2025-02-26; online 2025-02-26]

Chemical Biology Consortium Sweden [Service]

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

Nat Commun 15 (1) 10347 [2024-12-06; online 2024-12-06]

Chemical Biology Consortium Sweden [Service]

Single-cell sequencing deconvolutes cellular responses to exercise in human skeletal muscle.

Lovrić A, Rassolie A, Alam S, ..., Gustafsson T, Rullman E

Commun Biol 5 (1) 1121 [2022-10-22; online 2022-10-22]

Eukaryotic Single Cell Genomics (ESCG) [Service] NGI Short read [Service] NGI Single cell [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound.

Giovannucci TA, Salomons FA, Haraldsson M, ..., Johnsen JI, Dantuma NP

Cell Death Dis 12 (10) 914 [2021-10-06; online 2021-10-06]

CRISPR Functional Genomics [Service] Chemical Biology Consortium Sweden [Collaborative] Global Proteomics and Proteogenomics [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.

Kanellis DC, Espinoza JA, Zisi A, ..., Lindström MS, Bartek J

Sci Adv 7 (32) - [2021-08-00; online 2021-08-04]

Global Proteomics and Proteogenomics [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

Development of a chemical probe against NUDT15.

Zhang SM, Desroses M, Hagenkort A, ..., Stenmark P, Helleday T

Nat. Chem. Biol. 16 (10) 1120-1128 [2020-10-00; online 2020-07-20]

Chemical Biology Consortium Sweden [Collaborative] Protein Science Facility (PSF) [Service]

Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics.

Herr P, Boström J, Rullman E, ..., Maddalo G, Altun M

Mol. Cell Proteomics 19 (4) 608-623 [2020-04-00; online 2020-02-12]

Global Proteomics and Proteogenomics [Collaborative]

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H, Koolmeister T, Jemth A, ..., Berglund UW, Helleday T

Nature 508 (7495) 215-221 [2014-04-10; online 2014-04-02]

Chemical Biology Consortium Sweden [Collaborative] Drug Discovery and Development [Collaborative] Protein Science Facility (PSF)