Stenmark P

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

Nat Commun 15 (1) 10347 [2024-12-06; online 2024-12-06]

Chemical Biology Consortium Sweden (CBCS) [Service]

Activity of botulinum neurotoxin X and its structure when shielded by a non-toxic non-hemagglutinin protein.

Martínez-Carranza M, Škerlová J, Lee PG, ..., Dong M, Stenmark P

Commun Chem 7 (1) 179 [2024-08-13; online 2024-08-13]

The cryo-EM structure of the BoNT/Wo-NTNH complex reveals two immunoglobulin-like domains.

Košenina S, Škerlová J, Zhang S, Dong M, Stenmark P

FEBS J. 291 (4) 676-689 [2024-02-00; online 2023-09-29]

A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.

Rozman Grinberg I, Martínez-Carranza M, Bimai O, ..., Sjöberg BM, Stenmark P

Nat Commun 13 (1) 2700 [2022-05-16; online 2022-05-16]

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.

Bonagas N, Gustafsson NMS, Henriksson M, ..., Homan EJ, Helleday T

Nat Cancer 3 (2) 156-172 [2022-02-00; online 2022-02-28]

Drug Discovery and Development (DDD) [Collaborative]

Structural Analysis of Botulinum Neurotoxins Type B and E by Cryo-EM.

Košenina S, Martínez-Carranza M, Davies JR, Masuyer G, Stenmark P

Toxins (Basel) 14 (1) - [2021-12-23; online 2021-12-23]

Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion.

Škerlová J, Berndtsson J, Nolte H, Ott M, Stenmark P

Nat Commun 12 (1) 5277 [2021-09-06; online 2021-09-06]

A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site.

Martínez-Carranza M, Jonna VR, Lundin D, ..., Stenmark P, Hofer A

J. Biol. Chem. 295 (46) 15576-15587 [2020-11-13; online 2020-09-03]

Bioinformatics Support for Computational Resources [Service] Cryo-EM [Service] Protein Science Facility (PSF) [Service]

Development of a chemical probe against NUDT15.

Zhang SM, Desroses M, Hagenkort A, ..., Stenmark P, Helleday T

Nat. Chem. Biol. 16 (10) 1120-1128 [2020-10-00; online 2020-07-20]

Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.

Škerlová J, Unterlass J, Göttmann M, ..., Jemth AS, Stenmark P

J. Biol. Chem. 295 (33) 11656-11668 [2020-08-14; online 2020-06-22]

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.

Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS

J. Biol. Chem. 295 (15) 4761-4772 [2020-04-10; online 2020-03-06]

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.

Scaletti E, Jemth AS, Helleday T, Stenmark P

FEBS Lett. 593 (14) 1863-1873 [2019-07-00; online 2019-06-10]

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.

Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P

Biochemistry 58 (7) 887-899 [2019-02-19; online 2019-01-16]

Cotranslational Folding of a Pentarepeat β-Helix Protein.

Notari L, Martínez-Carranza M, Farías-Rico JA, Stenmark P, von Heijne G

J. Mol. Biol. 430 (24) 5196-5206 [2018-12-07; online 2018-10-27]

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.

Visnes T, Cázares-Körner A, Hao W, ..., Boldogh I, Helleday T

Science 362 (6416) 834-839 [2018-11-16; online 2018-11-18]

Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Chemical Proteomics [Collaborative] Drug Discovery and Development (DDD) [Service] Protein Science Facility (PSF) [Service]

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.

Narwal M, Jemth AS, Gustafsson R, ..., Helleday T, Stenmark P

Biochemistry 57 (5) 593-603 [2018-02-06; online 2018-01-16]

Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.

Llona-Minguez S, Throup A, Steiner E, ..., Jenmalm-Jensen A, Helleday T

Org. Biomol. Chem. 15 (37) 7758-7764 [2017-09-26; online 2017-09-12]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

The structure of the tetanus toxin reveals pH-mediated domain dynamics.

Masuyer G, Conrad J, Stenmark P

EMBO Rep. 18 (8) 1306-1317 [2017-08-00; online 2017-06-23]