Na+-K+-ATPase, a new class of plasma membrane receptors.

Aperia A, Akkuratov EE, Fontana JM, Brismar H

Am. J. Physiol., Cell Physiol. 310 (7) C491-C495 [2016-04-01; online 2016-01-23]

The Na(+)-K(+)-ATPase (NKA) differs from most other ion transporters, not only in its capacity to maintain a steep electrochemical gradient across the plasma membrane, but also as a receptor for a family of cardiotonic steroids, to which ouabain belongs. Studies from many groups, performed during the last 15 years, have demonstrated that ouabain, a member of the cardiotonic steroid family, can activate a network of signaling molecules, and that NKA will also serve as a signal transducer that can provide a feedback loop between NKA and the mitochondria. This brief review summarizes the current knowledge and controversies with regard to the understanding of NKA signaling.

Integrated Microscopy Technologies Stockholm [Collaborative]

PubMed 26791490

DOI 10.1152/ajpcell.00359.2015

Crossref 10.1152/ajpcell.00359.2015

pii: ajpcell.00359.2015

Publications 9.5.0