J. Antimicrob. Chemother.

Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections.

Hernández-Lozano I, Aranzana-Climent V, Cao S, ..., Vingsbo Lundberg C, Friberg LE

J. Antimicrob. Chemother. 80 (1) 301-310 [2025-01-03; online 2024-11-16]

Bioinformatics Support for Computational Resources [Service]

In silico gepotidacin target mining among 33 213 global Neisseria gonorrhoeae genomes from 1928 to 2023 combined with gepotidacin MIC testing of 22 gonococcal isolates with different GyrA and ParC substitutions.

David A, Golparian D, Jacobsson S, ..., Davies C, Unemo M

J. Antimicrob. Chemother. 79 (9) 2221-2226 [2024-09-03; online 2024-07-15]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.

Unemo M, Sánchez-Busó L, Golparian D, ..., Wi T, Lahra MM

J. Antimicrob. Chemother. 79 (8) 1885-1899 [2024-08-01; online 2024-06-18]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

Pharmacodynamic evaluation of ceftriaxone single-dose therapy (0.125-1 g) to eradicate ceftriaxone-susceptible and ceftriaxone-resistant Neisseria gonorrhoeae strains in a hollow fibre infection model for gonorrhoea.

Unemo M, Golparian D, Oxelbark J, ..., Drusano G, Jacobsson S

J. Antimicrob. Chemother. 79 (5) 1006-1013 [2024-05-02; online 2024-03-18]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

Recent dynamics in Neisseria gonorrhoeae genomic epidemiology in Brazil: antimicrobial resistance and genomic lineages in 2017-20 compared to 2015-16.

Golparian D, Bazzo ML, Ahlstrand J, ..., Unemo M, Brazilian-GASP Network

J. Antimicrob. Chemother. 79 (5) 1081-1092 [2024-05-02; online 2024-03-22]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

Genomic surveillance and antimicrobial resistance determinants in Neisseria gonorrhoeae isolates from Uganda, Malawi and South Africa, 2015-20.

Kakooza F, Golparian D, Matoga M, ..., Wi T, Unemo M

J. Antimicrob. Chemother. 78 (8) 1982-1991 [2023-08-02; online 2023-06-23]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

High-level in vitro resistance to gentamicin acquired in a stepwise manner in Neisseria gonorrhoeae.

Golparian D, Jacobsson S, Holley CL, Shafer WM, Unemo M

J. Antimicrob. Chemother. 78 (7) 1769-1778 [2023-07-05; online 2023-05-30]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

GyrB in silico mining in 27 151 global gonococcal genomes from 1928-2021 combined with zoliflodacin in vitro testing of 71 international gonococcal isolates with different GyrB, ParC and ParE substitutions confirms high susceptibility.

Golparian D, Jacobsson S, Sánchez-Busó L, ..., Ohnishi M, Unemo M

J. Antimicrob. Chemother. - (-) - [2022-10-29; online 2022-10-29]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

Genomic surveillance and antimicrobial resistance in Neisseria gonorrhoeae isolates in Bangkok, Thailand in 2018.

Golparian D, Kittiyaowamarn R, Paopang P, ..., Wi T, Unemo M

J. Antimicrob. Chemother. 77 (8) 2171-2182 [2022-07-28; online 2022-05-12]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance (NG-STAR) clonal complexes are consistent with genomic phylogeny and provide simple nomenclature, rapid visualization and antimicrobial resistance (AMR) lineage predictions.

Golparian D, Sánchez-Busó L, Cole M, Unemo M

J. Antimicrob. Chemother. 76 (4) 940-944 [2021-03-12; online 2021-01-08]

Clinical Genomics [Technology development] Clinical Genomics Örebro [Technology development]

Genomic epidemiology of Neisseria gonorrhoeae elucidating the gonococcal antimicrobial resistance and lineages/sublineages across Brazil, 2015-16.

Golparian D, Bazzo ML, Golfetto L, ..., Unemo M, Brazilian-GASP Network

J. Antimicrob. Chemother. 75 (11) 3163-3172 [2020-11-01; online 2020-08-14]

Clinical Genomics [Technology development] Clinical Genomics Örebro [Technology development]

Genomic analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Vietnam in 2011 and 2015-16.

Lan PT, Golparian D, Ringlander J, ..., Van Thuong N, Unemo M

J. Antimicrob. Chemother. 75 (6) 1432-1438 [2020-06-01; online 2020-02-19]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

Genome-based epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates with decreased susceptibility and resistance to extended-spectrum cephalosporins in Argentina in 2011-16.

Gianecini RA, Golparian D, Zittermann S, ..., Galarza P, Gonococcal Antimicrobial Susceptibility Surveillance Programme-Argentina (GASSP-AR) Working Group

J. Antimicrob. Chemother. 74 (6) 1551-1559 [2019-06-01; online 2019-03-02]

Clinical Genomics [Collaborative] Clinical Genomics Örebro [Collaborative]

Clonality of erythromycin resistance in Francisella tularensis.

Karlsson E, Golovliov I, Lärkeryd A, ..., Forsman M, Johansson A

J. Antimicrob. Chemother. 71 (10) 2815-2823 [2016-10-00; online 2016-06-24]

Bioinformatics Support for Computational Resources [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Isolation of novel IncA/C and IncN fluoroquinolone resistance plasmids from an antibiotic-polluted lake.

Flach CF, Johnning A, Nilsson I, ..., Kristiansson E, Larsson DG

J. Antimicrob. Chemother. 70 (10) 2709-2717 [2015-10-00; online 2015-07-01]

NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure

NOTA: a potent metallo-β-lactamase inhibitor.

Somboro AM, Tiwari D, Bester LA, ..., Naicker T, Essack SY

J. Antimicrob. Chemother. 70 (5) 1594-1596 [2015-05-00; online 2015-01-06]

Drug Discovery and Development (DDD) [Collaborative]

Compensatory mutations in agrC partly restore fitness in vitro to peptide deformylase inhibitor-resistant Staphylococcus aureus.

Zorzet A, Andersen JM, Nilsson AI, Møller NF, Andersson DI

J. Antimicrob. Chemother. 67 (8) 1835-1842 [2012-08-00; online 2012-05-12]

NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure

Relationship between antibiotic feeding in animals and emergence of bacterial resistance in man.

Pohl P

J. Antimicrob. Chemother. 3 Suppl C (-) 67-72 [1977-11-00; online 1977-11-01]

Glycoproteomics and MS Proteomics [Service]