Cryo-EM

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SciLifeLab Infrastructure Unit Since 2016.

Primary: Shown in the list of current labels, if end date is not specified.

Started: 2016

Ended: Current

Year 2024

PubMed DOI Crossref
Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism.
Li P, Liu S, Wallerstein J, ..., Liin SI, Gourdon P
Nat. Struct. Mol. Biol. - (-) - [2024-11-28; online 2024-11-28]
Cryo-EM [Service]
PubMed DOI Crossref
Inhibition mechanism of potential antituberculosis compound lansoprazole sulfide.
Kovalova T, Król S, Gamiz-Hernandez AP, ..., Brzezinski P, Högbom M
Proc. Natl. Acad. Sci. U.S.A. 121 (47) e2412780121 [2024-11-19; online 2024-11-12]
Cryo-EM [Service]
DOI Crossref
Combining live cell fluorescence imaging within situcryo electron tomography sheds light on the septation process inDeinococcus radiodurans
Gaifas L, Kleman JP, Lacroix F, ..., Gutsche I, Timmins J
- - (-) - [2024-11-18; online 2024-11-18]
Cryo-EM [Collaborative] Integrated Microscopy Technologies Umeå [Service]
PubMed DOI Crossref
Cryo-EM structures of a bathy phytochrome histidine kinase reveal a unique light-dependent activation mechanism.
Bódizs S, Mészáros P, Grunewald L, Takala H, Westenhoff S
Structure 32 (11) 1952-1962.e3 [2024-11-07; online 2024-08-30]
Cryo-EM [Service]
PubMed DOI Crossref
The structure and function of P5A-ATPases.
Li P, Bågenholm V, Hägglund P, ..., Wang K, Gourdon P
Nat Commun 15 (1) 9605 [2024-11-06; online 2024-11-06]
Cryo-EM [Service]
PubMed DOI Crossref
Modification of xylan in secondary walls alters cell wall biosynthesis and wood formation programs and improves saccharification.
Sivan P, Urbancsok J, Donev EN, ..., Vilaplana F, Mellerowicz EJ
Plant Biotechnol. J. - (-) - [2024-10-22; online 2024-10-22]
Cryo-EM [Service] Swedish Metabolomics Centre (SMC) [Service]
DOI Crossref
Dephosphorylation and ion binding in prokaryotic calcium transport
Prabudiansyah I, Orädd F, Magkakis K, ..., Levantino M, Andersson M
Sci Adv 10 (41) - [2024-10-11; online 2024-10-11]
Cryo-EM [Service]
PubMed DOI Crossref
Unmasking AlphaFold to integrate experiments and predictions in multimeric complexes.
Mirabello C, Wallner B, Nystedt B, Azinas S, Carroni M
Nat Commun 15 (1) 8724 [2024-10-09; online 2024-10-09]
Bioinformatics Support, Infrastructure and Training [Technology development] Cryo-EM [Service]
PubMed DOI Crossref
Structure of the iminium reaction intermediate in an engineered aldolase explains the carboligation activity toward arylated ketones and aldehydes.
Hebert H, Sönmez E, Purhonen P, Widersten M
Structure 32 (9) 1322-1326.e4 [2024-09-05; online 2024-07-15]
Cryo-EM [Service]
PubMed DOI Crossref
On the structure refinement of metal complexes against 3D electron diffraction data using multipolar scattering factors.
Pacoste L, Ignat'ev VM, Dominiak PM, Zou X
Int Union Crystallogr J IUCr J Int Union Cryst J IUCrJ 11 (Pt 5) 878-890 [2024-09-01; online 2024-09-01]
Cryo-EM [Service]
PubMed DOI Crossref
Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly.
Li Y, Pacoste LC, Gu W, ..., Xu H, Nanson JD
Acta Crystallogr D Struct Biol 80 (Pt 9) 699-712 [2024-09-01; online 2024-09-04]
Cryo-EM [Service]
DOI Crossref
pH‐Responsive Virus‐Based Colloidal Crystals for Advanced Material Platforms
Tran B, Watts S, Valentin JDP, ..., Ramstedt M, Salentinig S
Adv Funct Materials 34 (37) - [2024-09-00; online 2024-04-26]
Cryo-EM [Service]
PubMed DOI Crossref
Structural basis of frizzled 7 activation and allosteric regulation.
Bous J, Kinsolving J, Grätz L, ..., Adebali O, Schulte G
Nat Commun 15 (1) 7422 [2024-08-28; online 2024-08-28]
Cryo-EM [Service]
PubMed DOI Crossref
Structural basis for lipid transfer by the ATG2A-ATG9A complex.
Wang Y, Dahmane S, Ti R, ..., Carlson LA, Stjepanovic G
Nat. Struct. Mol. Biol. - (-) - [2024-08-22; online 2024-08-22]
Cryo-EM [Service]
PubMed DOI Crossref
Breaking barriers: pCF10 type 4 secretion system relies on a self-regulating muramidase to modulate the cell wall.
Sun W, Torrens G, Ter Beek J, Cava F, Berntsson RP
MBio 15 (8) e0048824 [2024-08-14; online 2024-06-28]
Cryo-EM [Service] Integrated Microscopy Technologies Umeå [Service]
PubMed DOI Crossref
Activity of botulinum neurotoxin X and its structure when shielded by a non-toxic non-hemagglutinin protein.
Martínez-Carranza M, Škerlová J, Lee PG, ..., Dong M, Stenmark P
Commun Chem 7 (1) 179 [2024-08-13; online 2024-08-13]
Cryo-EM [Service]
PubMed DOI Crossref
In vitro reconstitution reveals membrane clustering and RNA recruitment by the enteroviral AAA+ ATPase 2C.
Shankar K, Sorin MN, Sharma H, ..., Nenzén L, Carlson LA
PLoS Pathog. 20 (8) e1012388 [2024-08-00; online 2024-08-05]
Cryo-EM [Service]
PubMed DOI Crossref
Nematocida displodere mechanosensitive ion channel of small conductance 2 assembles into a unique 6-channel super-structure in vitro.
Berg A, Berntsson RP, Barandun J
PLoS ONE 19 (7) e0301951 [2024-07-22; online 2024-07-22]
Cryo-EM [Service]
DOI Crossref
Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding
Bimai O, Banerjee I, Rozman Grinberg I, ..., Sjöberg BM, Logan DT
Elife 12 (-) - [2024-07-05; online 2024-07-05]
Cryo-EM [Service] Structural Proteomics [Service]
PubMed DOI Crossref
Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain.
Chen G, Wang Y, Zheng Z, ..., Knight SD, Johansson J
Protein Sci. 33 (7) e5063 [2024-07-00; online 2024-06-12]
Cryo-EM [Service]
PubMed DOI Crossref
Cryo-electron microscopy reveals hydrogen positions and water networks in photosystem II.
Hussein R, Graça A, Forsman J, ..., Zouni A, Schröder WP
Science 384 (6702) 1349-1355 [2024-06-21; online 2024-06-20]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane.
González-López A, Larsson DSD, Koripella RK, ..., Sanyal S, Selmer M
Sci Rep 14 (1) 14253 [2024-06-20; online 2024-06-20]
Cryo-EM [Service]
PubMed DOI Crossref
Long-range charge transfer mechanism of the III2IV2 mycobacterial supercomplex.
Riepl D, Gamiz-Hernandez AP, Kovalova T, ..., Brzezinski P, Kaila VRI
Nat Commun 15 (1) 5276 [2024-06-20; online 2024-06-20]
Cryo-EM [Service]
PubMed DOI Crossref
Structure and mechanism of the K+/H+ exchanger KefC.
Gulati A, Kokane S, Perez-Boerema A, ..., Matsuoka R, Drew D
Nat Commun 15 (1) 4751 [2024-06-04; online 2024-06-04]
Cryo-EM [Service]
DOI Crossref
A CRISPR homing screen finds a chloroquine resistance transporter-like protein of thePlasmodiumoocyst essential for mosquito transmission of malaria
Balakrishnan A, Hunziker M, Tiwary P, ..., Drew D, Billker O
- - (-) - [2024-06-02; online 2024-06-02]
Cryo-EM [Service] Integrated Microscopy Technologies Umeå [Service]
PubMed DOI Crossref
Structure and interactions of the endogenous human Commander complex.
Laulumaa S, Kumpula EP, Huiskonen JT, Varjosalo M
Nat. Struct. Mol. Biol. 31 (6) 925-938 [2024-06-00; online 2024-03-08]
Cryo-EM [Service]
PubMed DOI Crossref
Retron-Eco1 assembles NAD+-hydrolyzing filaments that provide immunity against bacteriophages.
Carabias A, Camara-Wilpert S, Mestre MR, ..., Pinilla-Redondo R, Montoya G
Mol. Cell - (-) - [2024-05-18; online 2024-05-18]
Cryo-EM [Service]
PubMed DOI Crossref
A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation.
Knyazeva A, Li S, Corkery DP, ..., Waldmann H, Wu YW
Proc. Natl. Acad. Sci. U.S.A. 121 (17) e2317680121 [2024-04-23; online 2024-04-18]
Chemical Proteomics [Collaborative] Cryo-EM [Service]
DOI Crossref
Histones are exosome membrane proteins regulated by cell stress
Singh B, Sundbom MF, Muthukrishnan U, ..., Haney M, Gilthorpe JD
- - (-) - [2024-04-08; online 2024-04-08]
Cryo-EM [Collaborative] Integrated Microscopy Technologies Umeå [Collaborative]
PubMed DOI Crossref
Functional redundancy revealed by the deletion of the mimivirus GMC-oxidoreductase genes.
Alempic JM, Bisio H, Villalta A, ..., Couté Y, Abergel C
Microlife 5 (-) uqae006 [2024-04-05; online 2024-04-05]
Cryo-EM [Service]
PubMed DOI Crossref
Biohybrid Energy Storage Circuits Based on Electronically Functionalized Plant Roots.
Parker D, Dar AM, Armada-Moreira A, ..., Mantione D, Stavrinidou E
ACS Appl Mater Interfaces - (-) - [2024-03-05; online 2024-03-05]
Cryo-EM [Service] Integrated Microscopy Technologies Umeå [Service]
PubMed DOI Crossref
Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7.
Kinsolving J, Bous J, Kozielewicz P, ..., Dong M, Schulte G
Cell Rep 43 (2) 113727 [2024-02-27; online 2024-02-02]
Cryo-EM [Service]
PubMed DOI Crossref
Molecular basis for human aquaporin inhibition.
Huang P, Åbacka H, Wilson CJ, ..., Venskutonytė R, Lindkvist-Petersson K
Proc. Natl. Acad. Sci. U.S.A. 121 (7) e2319682121 [2024-02-13; online 2024-02-06]
Cryo-EM [Service]
PubMed DOI Crossref
Colony phase variation switch modulates antimicrobial tolerance and biofilm formation in Acinetobacter baumannii.
Mushtaq F, Nadeem A, Yabrag A, ..., Uhlin BE, Ahmad I
Microbiol Spectr 12 (2) e0295623 [2024-02-06; online 2024-01-11]
Cryo-EM [Service]
PubMed DOI Crossref
Exploring TRF2-Dependent DNA Distortion Through Single-DNA Manipulation Studies.
Zhao X, Vogirala VK, Liu M, ..., Sandin S, Yan J
Commun Biol 7 (1) 148 [2024-02-03; online 2024-02-03]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1.
Bacic L, Gaullier G, Mohapatra J, ..., Sabantsev A, Deindl S
Nat Commun 15 (1) 1000 [2024-02-02; online 2024-02-02]
Cryo-EM [Service]
PubMed DOI Crossref
Ultrastructural insights into the microsporidian infection apparatus reveal the kinetics and morphological transitions of polar tube and cargo during host cell invasion.
Sharma H, Jespersen N, Ehrenbolger K, Carlson LA, Barandun J
PLoS Biol. 22 (2) e3002533 [2024-02-00; online 2024-02-29]
Cryo-EM [Service] Glycoproteomics and MS Proteomics [Service]
PubMed DOI Crossref
The cryo-EM structure of the BoNT/Wo-NTNH complex reveals two immunoglobulin-like domains.
Košenina S, Škerlová J, Zhang S, Dong M, Stenmark P
FEBS J. 291 (4) 676-689 [2024-02-00; online 2023-09-29]
Cryo-EM [Service]
DOI Crossref
Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
Bergh C, Rovšnik U, Howard R, Lindahl E
Elife 12 (-) - [2024-01-30; online 2024-01-30]
Cryo-EM [Service]
PubMed DOI Crossref
METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
Ast T, Itoh Y, Sadre S, ..., Amunts A, Mootha VK
Mol. Cell - (-) - [2024-01-04; online 2024-01-04]
Cryo-EM [Service]

Year 2023

DOI Crossref
Giardia intestinalisdeoxyadenosine kinase has a unique tetrameric structure that enables high substrate affinity and makes the parasite sensitive to deoxyadenosine analogues
Ranjbarian F, Rafie K, Shankar K, ..., Carlson LA, Hofer A
- - (-) - [2023-12-18; online 2023-12-18]
Cryo-EM [Service]
PubMed DOI Crossref
CENP-A and CENP-B collaborate to create an open centromeric chromatin state.
Nagpal H, Ali-Ahmad A, Hirano Y, ..., Sekulić N, Fierz B
Nat Commun 14 (1) 8227 [2023-12-12; online 2023-12-12]
Cryo-EM [Service]
DOI Crossref
Structural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12
Martinez A, Tai MD, Ochoa L, ..., Valpuesta J, Cuellar J
- - (-) - [2023-12-06; online 2023-12-06]
Cryo-EM [Service]
DOI Crossref
Structures of theStaphylococcus aureusribosome inhibited by fusidic acid and fusidic acid cyclopentane
González-López A, Larsson DSD, Koripella RK, ..., Sanyal S, Selmer M
- - (-) - [2023-11-20; online 2023-11-20]
Cryo-EM [Service]
PubMed DOI Crossref
Structure and function of the S. pombe III-IV-cyt c supercomplex.
Moe A, Dimogkioka AR, Rapaport D, Öjemyr LN, Brzezinski P
Proc. Natl. Acad. Sci. U.S.A. 120 (46) e2307697120 [2023-11-14; online 2023-11-08]
Cryo-EM [Service]
DOI Crossref
High-resolution comparative atomic structures of two Giardiavirus prototypes infectingG. duodenalisparasite
Wang H, Gianluca M, Munke A, ..., Lalle M, Okamoto K
- - (-) - [2023-11-02; online 2023-11-02]
Cryo-EM [Service]
PubMed DOI Crossref
Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor.
Cowgill J, Fan C, Haloi N, ..., Howard RJ, Lindahl E
Neuron 111 (21) 3450-3464.e5 [2023-11-01; online 2023-09-01]
Cryo-EM [Service]
PubMed DOI Crossref
Structure and electromechanical coupling of a voltage-gated Na+/H+ exchanger.
Yeo H, Mehta V, Gulati A, Drew D
Nature 623 (7985) 193-201 [2023-11-00; online 2023-10-25]
Cryo-EM [Service]
DOI Crossref
Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter
Currie MJ, Davies JS, Scalise M, ..., Dobson RCJ, North RA
- - (-) - [2023-10-30; online 2023-10-30]
Cryo-EM [Service]
PubMed DOI Crossref
Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation, and virulence.
Sun WS, Lassinantti L, Järvå M, ..., Ter Beek J, Berntsson RP
Elife 12 (-) - [2023-10-20; online 2023-10-20]
Cryo-EM [Service]
PubMed DOI Crossref
Design, structure and plasma binding of ancestral β-CoV scaffold antigens.
Hueting D, Schriever K, Sun R, ..., Andréll J, Syrén PO
Nat Commun 14 (1) 6527 [2023-10-16; online 2023-10-16]
Cryo-EM [Service] Drug Discovery and Development (DDD) [Service]
PubMed DOI Crossref
Apilactobacillus kunkeei releases RNA-associated membrane vesicles and proteinaceous nanoparticles.
Seeger C, Dyrhage K, Näslund K, Andersson SGE
Microlife 4 (-) uqad037 [2023-08-29; online 2023-08-29]
Cryo-EM [Service]
PubMed DOI Crossref
Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase.
Andriianov A, Trigüis S, Drobiazko A, ..., Severinov K, Isaev A
Cell Rep 42 (8) 112972 [2023-08-13; online 2023-08-13]
Cryo-EM [Service]
DOI Crossref
The structure of immature tick-borne encephalitis virus
Anastasina M, Füzik T, Domanska A, ..., Plevka P, Butcher SJ
- - (-) - [2023-08-04; online 2023-08-04]
Cryo-EM [Service]
PubMed DOI Crossref
Alternating L4 loop architecture of the bacterial polysaccharide co-polymerase WzzE.
Wiseman B, Widmalm G, Högbom M
Commun Biol 6 (1) 802 [2023-08-02; online 2023-08-02]
Cryo-EM [Service]
PubMed DOI Crossref
The organization of double-stranded RNA in the chikungunya virus replication organelle.
Laurent T, Carlson L
PLoS Negl Trop Dis 17 (7) e0011404 [2023-07-00; online 2023-07-05]
Cryo-EM [Service]
PubMed DOI Crossref
Accurate structure models and absolute configuration determination using dynamical effects in continuous-rotation 3D electron diffraction data.
Klar PB, Krysiak Y, Xu H, ..., Zou X, Palatinus L
Nat Chem 15 (6) 848-855 [2023-06-00; online 2023-04-20]
Cryo-EM [Service]
PubMed DOI Crossref
Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR.
Obana N, Takada H, Crowe-McAuliffe C, ..., Wilson DN, Hauryliuk V
Nucleic Acids Res. 51 (9) 4536-4554 [2023-05-22; online 2023-03-24]
Cryo-EM [Service]
DOI Crossref
Phase identification and discovery of hidden crystal forms in a polycrystalline pharmaceutical sample using high-throughput 3D electron diffraction
Lightowler M, Li S, Ou X, ..., Lu M, Xu H
- - (-) - [2023-05-19; online 2023-05-19]
Cryo-EM [Technology development]
DOI Crossref
Bile acids accumulate norovirus-like particles and enhance binding to and entry into human enteric epithelial cells
Palm E, Danskog K, Nord S, ..., Lenman A, Arnberg N
- - (-) - [2023-05-01; online 2023-05-01]
Cryo-EM [Collaborative]
DOI Crossref
No fitness impact of the knockout of the two main components of mimivirus genomic fiber and fibril layer
Alempic JM, Bisio H, Villalta A, ..., Couté Y, Abergel C
- - (-) - [2023-04-28; online 2023-04-28]
Cryo-EM [Service]
PubMed DOI Crossref
Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.
Majumdar S, Emmerich A, Krakovka S, ..., Svärd SG, Sanyal S
Nucleic Acids Res. 51 (7) 3436-3451 [2023-04-24; online 2023-03-14]
Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]
PubMed DOI Crossref
The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins.
Gallego P, Garcia-Bonete MJ, Trillo-Muyo S, ..., Johansson MEV, Hansson GC
Nat Commun 14 (1) 1969 [2023-04-08; online 2023-04-08]
Cryo-EM [Service]
PubMed DOI Crossref
Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants.
Mäkelä AR, Uğurlu H, Hannula L, ..., Rissanen I, Saksela K
Nat Commun 14 (1) 1637 [2023-03-24; online 2023-03-24]
Cryo-EM [Service]
PubMed DOI Crossref
Structural basis of mitochondrial membrane bending by the I-II-III2-IV2 supercomplex.
Mühleip A, Flygaard RK, Baradaran R, ..., Sharma V, Amunts A
Nature 615 (7954) 934-938 [2023-03-00; online 2023-03-22]
Cryo-EM [Service]
PubMed DOI Crossref
Insights into the structure-function relationship of the NorQ/NorD chaperones from Paracoccus denitrificans reveal shared principles of interacting MoxR AAA+/VWA domain proteins.
Kahle M, Appelgren S, Elofsson A, Carroni M, Ädelroth P
BMC Biol. 21 (1) 47 [2023-02-28; online 2023-02-28]
Cryo-EM [Service]
PubMed DOI Crossref
Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter.
Davies JS, Currie MJ, North RA, ..., Mace PD, Dobson RCJ
Nat Commun 14 (1) 1120 [2023-02-27; online 2023-02-27]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria.
Parajuli NP, Emmerich A, Mandava CS, Pavlov MY, Sanyal S
Nat Commun 14 (1) 918 [2023-02-17; online 2023-02-17]
Cryo-EM [Service]
PubMed DOI Crossref
Cryo-EM structure and function of S. pombe complex IV with bound respiratory supercomplex factor.
Moe A, Ädelroth P, Brzezinski P, Näsvik Öjemyr L
Commun Chem 6 (1) 32 [2023-02-16; online 2023-02-16]
Cryo-EM [Service]
PubMed DOI Crossref
Cryo-EM structure supports a role of AQP7 as a junction protein.
Huang P, Venskutonytė R, Prasad RB, ..., Artner I, Lindkvist-Petersson K
Nat Commun 14 (1) 600 [2023-02-03; online 2023-02-03]
Cryo-EM [Service]
PubMed DOI Crossref
Direct structure determination of vemurafenib polymorphism from compact spherulites using 3D electron diffraction.
Li S, Lightowler M, Ou X, ..., Xu H, Lu M
Commun Chem 6 (1) 18 [2023-01-23; online 2023-01-23]
Cryo-EM [Service]

Year 2022

PubMed DOI Crossref
Structural mechanism of signal transduction in a phytochrome histidine kinase.
Wahlgren WY, Claesson E, Tuure I, ..., Takala H, Westenhoff S
Nat Commun 13 (1) 7673 [2022-12-12; online 2022-12-12]
Cryo-EM [Service]
PubMed DOI Crossref
Endoreplication mediates cell size control via mechanochemical signaling from cell wall.
Ma Y, Jonsson K, Aryal B, ..., Hamant O, Bhalerao RP
Sci Adv 8 (49) eabq2047 [2022-12-09; online 2022-12-09]
Cryo-EM [Service]
PubMed DOI Crossref
V. cholerae MakA is a cholesterol-binding pore-forming toxin that induces non-canonical autophagy.
Jia X, Knyazeva A, Zhang Y, ..., Corkery DP, Wu YW
J. Cell Biol. 221 (12) - [2022-12-05; online 2022-10-04]
Cryo-EM [Service]
PubMed DOI Crossref
Isolation and characterization of a main porin from the outer membrane of Salinibacter ruber.
Farci D, Cocco E, Tanas M, ..., Schröder WP, Piano D
J Bioenerg Biomembr 54 (5-6) 273-281 [2022-12-00; online 2022-10-13]
Cryo-EM [Service]
PubMed DOI Crossref
Deep mutational scan of a drug efflux pump reveals its structure-function landscape.
Meier G, Thavarasah S, Ehrenbolger K, ..., Barandun J, Seeger MA
Nat. Chem. Biol. - (-) - [2022-11-28; online 2022-11-28]
Cryo-EM [Service]
PubMed DOI Crossref
Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores.
Jespersen N, Ehrenbolger K, Winiger RR, ..., Vossbrinck CR, Barandun J
Nat Commun 13 (1) 6962 [2022-11-15; online 2022-11-15]
Cryo-EM [Service]
PubMed DOI Crossref
Structural Consequences of Deproteinating the 50S Ribosome.
Larsson DSD, Kanchugal P S, Selmer M
Biomolecules 12 (11) - [2022-10-31; online 2022-10-31]
Cryo-EM [Service]
PubMed DOI Crossref
Structural Insights into Common and Host-Specific Receptor-Binding Mechanisms in Algal Picorna-like Viruses.
Wang H, Munke A, Li S, Tomaru Y, Okamoto K
Viruses 14 (11) - [2022-10-27; online 2022-10-27]
Cryo-EM [Service]
PubMed DOI Crossref
Architecture of the chikungunya virus replication organelle.
Laurent T, Kumar P, Liese S, ..., Carlson A, Carlson LA
Elife 11 (-) - [2022-10-19; online 2022-10-19]
Cryo-EM [Service]
PubMed DOI Crossref
Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements.
Tobiasson V, Berzina I, Amunts A
Nat Commun 13 (1) 6132 [2022-10-17; online 2022-10-17]
Cryo-EM [Service]
PubMed DOI Crossref
SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.
Gui M, Croft JT, Zabeo D, ..., Höög JL, Brown A
Proc. Natl. Acad. Sci. U.S.A. 119 (41) e2207605119 [2022-10-11; online 2022-10-03]
Cryo-EM [Service]
PubMed DOI Crossref
Membrane-assisted assembly and selective secretory autophagy of enteroviruses.
Dahmane S, Kerviel A, Morado DR, ..., Altan-Bonnet N, Carlson LA
Nat Commun 13 (1) 5986 [2022-10-10; online 2022-10-10]
Cryo-EM [Service]
DOI Crossref
Nanobody engineering for SARS-CoV-2 neutralization and detection
Hannula L, Kuivanen S, Lasham J, ..., Huiskonen JT, Rissanen I
- - (-) - [2022-09-14; online 2022-09-14]
Cryo-EM [Service]
PubMed DOI Crossref
Archaic chaperone-usher pili self-secrete into superelastic zigzag springs.
Pakharukova N, Malmi H, Tuittila M, ..., Jensen G, Zavialov AV
Nature 609 (7926) 335-340 [2022-09-00; online 2022-07-19]
Cryo-EM [Service]
PubMed DOI Crossref
Primordial Capsid and Spooled ssDNA Genome Structures Unravel Ancestral Events of Eukaryotic Viruses.
Munke A, Kimura K, Tomaru Y, ..., Hongo Y, Okamoto K
MBio 13 (4) e0015622 [2022-08-30; online 2022-07-20]
Cryo-EM [Service]
PubMed DOI Crossref
Staphylococcal self-loading helicases couple the staircase mechanism with inter domain high flexibility.
Qiao C, Debiasi-Anders G, Mir-Sanchis I
Nucleic Acids Res. 50 (14) 8349-8362 [2022-08-12; online 2022-07-25]
Cryo-EM [Service]
PubMed DOI Crossref
Detailed Characterization of the Cell Wall Structure and Composition of Nordic Green Microalgae.
Spain O, Funk C
J. Agric. Food Chem. 70 (31) 9711-9721 [2022-08-10; online 2022-07-27]
Cryo-EM [Service] Integrated Microscopy Technologies Umeå [Service] Swedish Metabolomics Centre (SMC) [Service]
PubMed DOI Crossref
Polymer Dots as Photoactive Membrane Vesicles for [FeFe]-Hydrogenase Self-Assembly and Solar-Driven Hydrogen Evolution.
Pavliuk MV, Lorenzi M, Morado DR, ..., Berggren G, Tian H
J. Am. Chem. Soc. 144 (30) 13600-13611 [2022-08-03; online 2022-07-21]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria.
Li P, Hendricks AL, Wang Y, ..., Wang K, Gourdon P
Nat Commun 13 (1) 4339 [2022-07-27; online 2022-07-27]
Cryo-EM
PubMed DOI Crossref
Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.
Kotila T, Wioland H, Selvaraj M, ..., Romet-Lemonne G, Lappalainen P
Nat Commun 13 (1) 3442 [2022-06-15; online 2022-06-15]
Cryo-EM [Service]
PubMed DOI Crossref
Scipion-ED: a graphical user interface for batch processing and analysis of 3D ED/MicroED data.
Bengtsson VEG, Pacoste L, de la Rosa-Trevin JM, ..., Zou X, Xu H
J Appl Crystallogr 55 (Pt 3) 638-646 [2022-06-01; online 2022-04-22]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Itoh Y, Khawaja A, Laptev I, ..., Rorbach J, Amunts A
Nature 606 (7914) 603-608 [2022-06-00; online 2022-06-08]
Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]
PubMed DOI Crossref
A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.
Rozman Grinberg I, Martínez-Carranza M, Bimai O, ..., Sjöberg BM, Stenmark P
Nat Commun 13 (1) 2700 [2022-05-16; online 2022-05-16]
Cryo-EM [Service]
PubMed DOI Crossref
Molecular Organisation of Tick-Borne Encephalitis Virus.
Pulkkinen LIA, Barrass SV, Domanska A, ..., Anastasina M, Butcher SJ
Viruses 14 (4) - [2022-04-11; online 2022-04-11]
Cryo-EM [Service]
PubMed DOI Crossref
Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Crowe-McAuliffe C, Murina V, Turnbull KJ, ..., Wilson DN, Hauryliuk V
Nat Commun 13 (1) 1860 [2022-04-06; online 2022-04-06]
Bioinformatics Support for Computational Resources [Service] Cryo-EM [Service]
PubMed DOI Crossref
Coupling Lipid Nanoparticle Structure and Automated Single Particle Composition Analysis to Design Phospholipase Responsive Nanocarriers.
Barriga HMG, Pence IJ, Holme MN, ..., Carroni M, Stevens MM
Adv Mater - (-) e2200839 [2022-03-31; online 2022-03-31]
Cryo-EM [Collaborative]
PubMed DOI Crossref
The respiratory supercomplex from C. glutamicum.
Moe A, Kovalova T, Król S, ..., Högbom M, Brzezinski P
Structure 30 (3) 338-349.e3 [2022-03-03; online 2021-12-14]
Cryo-EM [Service]
PubMed DOI Crossref
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Stsiapanava A, Xu C, Nishio S, ..., Wu B, Jovine L
Nat. Struct. Mol. Biol. 29 (3) 190-193 [2022-03-00; online 2022-03-10]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae.
Nadeem A, Berg A, Pace H, ..., Uhlin BE, Wai SN
Elife 11 (-) - [2022-02-08; online 2022-02-08]
Cryo-EM [Service] Integrated Microscopy Technologies Umeå [Service] Swedish NMR Centre (SNC) [Collaborative]
PubMed DOI Crossref
Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2.
Matsuoka R, Fudim R, Jung S, ..., Beckstein O, Drew D
Nat. Struct. Mol. Biol. 29 (2) 108-120 [2022-02-00; online 2022-02-16]
Cryo-EM [Service]
PubMed DOI Crossref
Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
Chaptal V, Zampieri V, Wiseman B, ..., Boumendjel A, Falson P
Sci Adv 8 (4) eabg9215 [2022-01-28; online 2022-01-26]
Cryo-EM [Service]

Year 2021

PubMed DOI Crossref
Structural Analysis of Botulinum Neurotoxins Type B and E by Cryo-EM.
Košenina S, Martínez-Carranza M, Davies JR, Masuyer G, Stenmark P
Toxins (Basel) 14 (1) - [2021-12-23; online 2021-12-23]
Cryo-EM [Service]
PubMed DOI Crossref
Structural basis for transthyretin amyloid formation in vitreous body of the eye.
Iakovleva I, Hall M, Oelker M, ..., Anan I, Sauer-Eriksson AE
Nat Commun 12 (1) 7141 [2021-12-08; online 2021-12-08]
Cryo-EM [Collaborative] Structural Proteomics [Service]
PubMed DOI Crossref
A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion.
Nadeem A, Nagampalli R, Toh E, ..., Wai SN, Persson K
Proc. Natl. Acad. Sci. U.S.A. 118 (47) - [2021-11-23; online 2021-11-21]
Cryo-EM [Service]
PubMed DOI Crossref
The structure of neurofibromin isoform 2 reveals different functional states.
Naschberger A, Baradaran R, Rupp B, Carroni M
Nature - (-) - [2021-10-27; online 2021-10-27]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion.
Škerlová J, Berndtsson J, Nolte H, Ott M, Stenmark P
Nat Commun 12 (1) 5277 [2021-09-06; online 2021-09-06]
Cryo-EM [Service]
PubMed DOI Crossref
Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.
Bacic L, Gaullier G, Sabantsev A, ..., Boulton SJ, Deindl S
Elife 10 (-) - [2021-09-06; online 2021-09-06]
Cryo-EM [Service]
PubMed DOI Crossref
The Accessibility of the Cell Wall in Scots Pine (Pinus sylvestris L.) Sapwood to Colloidal Fe3O4 Nanoparticles.
Garskaite E, Stoll SL, Forsberg F, ..., Liu K, Sandberg D
ACS Omega 6 (33) 21719-21729 [2021-08-24; online 2021-08-10]
Cryo-EM [Service]
PubMed DOI Crossref
RqcH and RqcP catalyze processive poly-alanine synthesis in a reconstituted ribosome-associated quality control system.
Takada H, Crowe-McAuliffe C, Polte C, ..., Wilson DN, Hauryliuk V
Nucleic Acids Res. 49 (14) 8355-8369 [2021-08-20; online 2021-07-14]
Cryo-EM [Service]
PubMed DOI Crossref
A simple pressure-assisted method for MicroED specimen preparation.
Zhao J, Xu H, Lebrette H, ..., Högbom M, Zou X
Nat Commun 12 (1) 5036 [2021-08-19; online 2021-08-19]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Antimicrobial peptide induced colloidal transformations in bacteria-mimetic vesicles: Combining in silico tools and experimental methods.
Freire RVM, Pillco-Valencia Y, da Hora GCA, ..., Soares TA, Salentinig S
Journal of Colloid and Interface Science 596 (-) 352-363 [2021-08-15; online 2021-03-16]
Cryo-EM [Collaborative]
PubMed DOI Crossref
High-resolution model of Arabidopsis Photosystem II reveals the structural consequences of digitonin-extraction.
Graça AT, Hall M, Persson K, Schröder WP
Sci Rep 11 (1) 15534 [2021-07-30; online 2021-07-30]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Solution Structure of the dATP-Inactivated Class I Ribonucleotide Reductase From Leeuwenhoekiella blandensis by SAXS and Cryo-Electron Microscopy.
Hasan M, Banerjee I, Rozman Grinberg I, Sjöberg BM, Logan DT
Front Mol Biosci 8 (-) 713608 [2021-07-26; online 2021-07-26]
Cryo-EM [Service]
PubMed DOI Crossref
Structure and transport mechanism of P5B-ATPases.
Li P, Wang K, Salustros N, Grønberg C, Gourdon P
Nat Commun 12 (1) 3973 [2021-06-25; online 2021-06-25]
Cryo-EM [Service]
PubMed DOI Crossref
Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.
Crowe-McAuliffe C, Murina V, Turnbull KJ, ..., Hauryliuk V, Wilson DN
Nat Commun 12 (1) 3577 [2021-06-11; online 2021-06-11]
Cryo-EM [Service]
PubMed DOI Crossref
Silica Particles Trigger the Exopolysaccharide Production of Harsh Environment Isolates of Growth-Promoting Rhizobacteria and Increase Their Ability to Enhance Wheat Biomass in Drought-Stressed Soils.
Fetsiukh A, Conrad J, Bergquist J, Timmusk S
Int J Mol Sci 22 (12) 6201 [2021-06-08; online 2021-06-08]
Cryo-EM [Collaborative]
PubMed DOI Crossref
CryoEM reveals BIN1 (isoform 8) does not bind to single actin filaments in vitro.
Wang Z, Mim C
MicroPubl Biol 2021 (-) - [2021-06-04; online 2021-06-04]
Cryo-EM [Service]
PubMed DOI Crossref
Crystal structure of a homotrimeric verrucomicrobial exo-β-1,4-mannosidase active in the hindgut of the wood-feeding termite Reticulitermes flavipes.
Kalyani DC, Reichenbach T, Keskitalo MM, ..., Aspeborg H, Divne C
Journal of Structural Biology: X 5 (-) 100048 [2021-05-24; online 2021-05-24]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Cryo-Electron Microscopy of Arabidopsis thaliana Phytochrome A in Its Pr State Reveals Head-to-Head Homodimeric Architecture.
Wahlgren WY, Golonka D, Westenhoff S, Möglich A
Front Plant Sci 12 (-) 663751 [2021-04-21; online 2021-04-21]
Cryo-EM [Service] Integrated Microscopy Technologies Gothenburg [Technology development]
PubMed DOI Crossref
Using RELION software within the Scipion framework.
Sharov G, Morado DR, Carroni M, de la Rosa-Trevín JM
Acta Crystallogr D Struct Biol 77 (4) 403-410 [2021-04-01; online 2021-03-30]
Cryo-EM [Technology development]
PubMed DOI Crossref
Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses.
Flatt JW, Domanska A, Seppälä AL, Butcher SJ
Commun Biol 4 (1) 250 [2021-02-26; online 2021-02-26]
Cryo-EM [Service]
PubMed DOI Crossref
Peptidoglycan-Binding Anchor Is a Pseudomonas aeruginosa OmpA Family Lipoprotein With Importance for Outer Membrane Vesicles, Biofilms, and the Periplasmic Shape.
Paulsson M, Kragh KN, Su YC, ..., Bjarnsholt T, Riesbeck K
Front Microbiol 12 (-) 639582 [2021-02-25; online 2021-02-25]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Porphyromonas gingivalis fimbrial protein Mfa5 contains a von Willebrand factor domain and an intramolecular isopeptide.
Heidler TV, Ernits K, Ziolkowska A, Claesson R, Persson K
Commun Biol 4 (1) 106 [2021-01-25; online 2021-01-25]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46.
Persson BD, John L, Rafie K, ..., Carlson LA, Arnberg N
Proc. Natl. Acad. Sci. U.S.A. 118 (3) - [2021-01-19; online 2021-01-02]
Cryo-EM [Service]
PubMed DOI Crossref
Structure of a full-length bacterial polysaccharide co-polymerase.
Wiseman B, Nitharwal RG, Widmalm G, Högbom M
Nat Commun 12 (1) 369 [2021-01-14; online 2021-01-14]
Cryo-EM [Service]
PubMed DOI Crossref
Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution.
Cunha ES, Chen X, Sanz-Gaitero M, Mills DJ, Luecke H
Nat Commun 12 (1) 230 [2021-01-11; online 2021-01-11]
Cryo-EM [Service]
PubMed DOI Crossref
Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP.
Crowe-McAuliffe C, Takada H, Murina V, ..., Wilson DN, Hauryliuk V
Mol. Cell 81 (1) 115-126.e7 [2021-01-07; online 2020-11-30]
Cryo-EM [Service]
PubMed DOI Crossref
The structure of enteric human adenovirus 41-A leading cause of diarrhea in children.
Rafie K, Lenman A, Fuchs J, ..., Arnberg N, Carlson LA
Sci Adv 7 (2) - [2021-01-00; online 2021-01-08]
Cryo-EM [Service] Glycoproteomics and MS Proteomics [Collaborative]

Year 2020

PubMed DOI Crossref
Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
Lehmann LC, Bacic L, Hewitt G, ..., Boulton SJ, Deindl S
Cell Rep 33 (12) 108529 [2020-12-22; online 2020-12-29]
Cryo-EM [Service]
PubMed DOI Crossref
Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9.
Winklemann I, Matsuoka R, Meier PF, ..., Beckstein O, Drew D
EMBO J. 39 (24) e105908 [2020-12-15; online 2020-10-29]
Cryo-EM [Service]
PubMed DOI Crossref
Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.
Stsiapanava A, Xu C, Brunati M, ..., Wu B, Jovine L
EMBO J. 39 (24) e106807 [2020-12-15; online 2020-11-16]
Cryo-EM [Collaborative]
PubMed DOI Crossref
α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice.
Mucibabic M, Steneberg P, Lidh E, ..., Lindahl E, Edlund H
Sci Rep 10 (1) 20438 [2020-11-24; online 2020-11-24]
Cryo-EM [Service]
PubMed DOI Crossref
A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site.
Martínez-Carranza M, Jonna VR, Lundin D, ..., Stenmark P, Hofer A
J. Biol. Chem. 295 (46) 15576-15587 [2020-11-13; online 2020-09-03]
Bioinformatics Support for Computational Resources [Service] Cryo-EM [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.
Flygaard RK, Mühleip A, Tobiasson V, Amunts A
Nat Commun 11 (1) 5342 [2020-10-22; online 2020-10-22]
Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]
PubMed DOI Crossref
Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.
Itoh Y, Naschberger A, Mortezaei N, Herrmann JM, Amunts A
Nat Commun 11 (1) 5187 [2020-10-14; online 2020-10-14]
Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]
PubMed DOI Crossref
Exploring the bacterial nano-universe.
Söderholm N, Singh B, Uhlin BE, Sandblad L
Curr. Opin. Struct. Biol. 64 (-) 166-173 [2020-10-00; online 2020-08-23]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome.
Ehrenbolger K, Jespersen N, Sharma H, ..., Vossbrinck CR, Barandun J
PLoS Biol. 18 (10) e3000958 [2020-10-00; online 2020-10-30]
Cryo-EM [Service]
PubMed DOI Crossref
Bilayer-Coated Nanoparticles Reveal How Influenza Viral Entry Depends on Membrane Deformability but Not Curvature.
Villamil Giraldo AM, Kasson PM
J Phys Chem Lett 11 (17) 7190-7196 [2020-09-03; online 2020-08-19]
Cryo-EM [Service]
PubMed DOI Crossref
Evolutionary Remodeling of the Cell Envelope in Bacteria of the Planctomycetes Phylum.
Mahajan M, Seeger C, Yee B, Andersson SGE
Genome Biol Evol 12 (9) 1528-1548 [2020-09-01; online 2020-08-08]
Bioinformatics Support for Computational Resources [Service] Cryo-EM [Service] Integrated Microscopy Technologies Umeå [Service]
PubMed DOI Crossref
Structural basis of mitochondrial translation
Aibara S, Singh V, Modelska A, Amunts A
Elife 9 (-) 1-17 [2020-08-19; online 2020-08-19]
Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]
PubMed DOI Crossref
Ciliate mitoribosome illuminates evolutionary steps of mitochondrial translation.
Tobiasson V, Amunts A
Elife 9 (-) 1-15 [2020-06-18; online 2020-06-18]
Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]
PubMed DOI Crossref
Distinct pre-initiation steps in human mitochondrial translation.
Khawaja A, Itoh Y, Remes C, ..., Amunts A, Rorbach J
Nat Commun 11 (1) 2932 [2020-06-10; online 2020-06-10]
Cryo-EM [Service]
PubMed DOI Crossref
Capsid Structure of a Marine Algal Virus of the Order Picornavirales.
Munke A, Kimura K, Tomaru Y, Okamoto K
J. Virol. 94 (9) - [2020-04-16; online 2020-04-16]
Cryo-EM [Service]
PubMed DOI Crossref
Effect of sample preparation techniques upon single cell chemical imaging: A practical comparison between synchrotron radiation based X-ray fluorescence (SR-XRF) and Nanoscopic Secondary Ion Mass Spectrometry (nano-SIMS).
De Samber B, De Rycke R, De Bruyne M, ..., Polerecky L, Vincze L
Anal. Chim. Acta 1106 (-) 22-32 [2020-04-15; online 2020-01-24]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Development of basic building blocks for cryo-EM: the emcore and emvis software libraries.
de la Rosa-Trevín JM, Hernández Viga PA, Otón J, Lindahl E
Acta Crystallogr D Struct Biol 76 (Pt 4) 350-356 [2020-04-01; online 2020-03-31]
Cryo-EM [Technology development]
PubMed DOI Crossref
Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.
Madru C, Henneke G, Raia P, ..., Carroni M, Sauguet L
Nat Commun 11 (1) 1591 [2020-03-27; online 2020-03-27]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Structure of a minimal photosystem I from the green alga Dunaliella salina.
Perez-Boerema A, Klaiman D, Caspy I, ..., Amunts A, Nelson N
NPLANTS 6 (3) 321-327 [2020-03-00; online 2020-03-02]
Cryo-EM [Service]
PubMed DOI Crossref
Distinct structural modulation of photosystem I and lipid environment stabilizes its tetrameric assembly.
Chen M, Perez-Boerema A, Zhang L, ..., Li S, Amunts A
NPLANTS 6 (3) 314-320 [2020-03-00; online 2020-03-09]
Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]
PubMed DOI Crossref
Apolipoprotein E impairs amyloid-β fibril elongation and maturation.
Islam T, Gharibyan AL, Golchin SA, ..., Olofsson L, Olofsson A
FEBS J. 287 (6) 1208-1219 [2020-03-00; online 2019-10-09]
Cryo-EM [Service]

Year 2019

PubMed DOI Crossref
Morphological analysis of Apolipoprotein E binding to Aβ Amyloid using a combination of Surface Plasmon Resonance, Immunogold Labeling and Scanning Electron Microscopy.
Islam T, Gharibyan AL, Lee CC, Olofsson A
BMC Biotechnol. 19 (1) 97 [2019-12-11; online 2019-12-11]
Cryo-EM [Technology development] Integrated Microscopy Technologies Umeå [Collaborative]
PubMed DOI Crossref
Structure of a mitochondrial ATP synthase with bound native cardiolipin.
Mühleip A, McComas SE, Amunts A
Elife 8 (-) - [2019-11-18; online 2019-11-18]
Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]
PubMed DOI Crossref
Amyloid fibrils prepared using an acetylated and methyl amidated peptide model of the α-Synuclein NAC 71-82 amino acid stretch contain an additional cross-β structure also found in prion proteins.
Näsström T, Andersson PO, Lejon C, Karlsson BCG
Sci Rep 9 (1) 15949 [2019-11-04; online 2019-11-04]
Cryo-EM [Service]
PubMed DOI Crossref
Dynamic Nanocellulose Networks for Thermoset-like yet Recyclable Plastics with a High Melt Stiffness and Creep Resistance.
Peterson A, Östergren I, Lotsari A, ..., Boldizar A, Müller C
Biomacromolecules 20 (10) 3924-3932 [2019-10-14; online 2019-09-17]
Cryo-EM [Technology development]
PubMed DOI Crossref
Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication.
Yau WL, Nguyen-Dinh V, Larsson E, ..., Överby AK, Lundmark R
J. Virol. 93 (18) - [2019-09-15; online 2019-08-28]
Bioinformatics Support for Computational Resources [Service] Cryo-EM [Service] Integrated Microscopy Technologies Umeå [Collaborative]
PubMed DOI Crossref
Electron cryo-microscopy of bacteriophage PR772 reveals the elusive vertex complex and the capsid architecture.
Reddy HK, Carroni M, Hajdu J, Svenda M
Elife 8 (-) - [2019-09-12; online 2019-09-12]
Cryo-EM [Service]
PubMed DOI Crossref
Toxic Activation of an AAA+ Protease by the Antibacterial Drug Cyclomarin A.
Maurer M, Linder D, Franke KB, ..., Bukau B, Mogk A
Cell Chem Biol 26 (8) 1169-1179.e4 [2019-08-15; online 2019-06-13]
Cryo-EM [Service]
PubMed DOI Crossref
Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.
Nirwan N, Itoh Y, Singh P, ..., Amunts A, Saikrishnan K
Nat Commun 10 (1) 3058 [2019-07-11; online 2019-07-11]
Cryo-EM [Service]
PubMed DOI Crossref
Global gene expression analysis in etiolated and de-etiolated seedlings in conifers.
Ranade SS, Delhomme N, García-Gil MR
PLoS ONE 14 (7) e0219272 [2019-07-05; online 2019-07-05]
Bioinformatics Support for Computational Resources [Service] Cryo-EM [Service] Integrated Microscopy Technologies Umeå [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain
Bigalke JM, Aibara S, Roth R, ..., Amunts A, Sandmark J
Sci Adv 5 (7) eaau4202 [2019-07-05; online 2019-07-05]
Cryo-EM [Service]
PubMed DOI Crossref
Specific amino acid substitutions in β strand S2 of FtsZ cause spiraling septation and impair assembly cooperativity in Streptomyces spp.
Sen BC, Wasserstrom S, Findlay K, ..., von Wachenfeldt C, Flärdh K
Mol. Microbiol. 112 (1) 184-198 [2019-07-00; online 2019-05-17]
Cryo-EM [Collaborative] Integrated Microscopy Technologies Umeå
PubMed DOI Crossref
DSeg: A Dynamic Image Segmentation Program to Extract Backbone Patterns for Filamentous Bacteria and Hyphae Structures.
Zhang H, Söderholm N, Sandblad L, Wiklund K, Andersson M
Microsc Microanal 25 (3) 711-719 [2019-06-00; online 2019-03-21]
Cryo-EM [Technology development]
PubMed DOI Crossref
Assembly mechanisms of the bacterial cytoskeletal protein FilP.
Javadi A, Söderholm N, Olofsson A, Flärdh K, Sandblad L
Life Sci. Alliance 2 (3) e201800290 [2019-06-00; online 2019-06-26]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Axonemal doublet microtubules can split into two complete singlets in human sperm flagellum tips.
Zabeo D, Croft JT, Höög JL
FEBS Lett. 593 (9) 892-902 [2019-05-00; online 2019-04-19]
Cryo-EM [Service]
PubMed DOI Crossref
Pyridine-Fused 2-Pyridones via Povarov and A 3 Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding.
Singh P, Adolfsson DE, Ådén J, ..., Olofsson A, Almqvist F
J. Org. Chem. 84 (7) 3887-3903 [2019-04-05; online 2019-03-20]
Cryo-EM [Service] Swedish NMR Centre (SNC) [Service]
PubMed DOI Crossref
Zinc depletion does not necessarily induce ribosome hibernation in mycobacteria.
Tobiasson V, Dow A, Prisic S, Amunts A
Proc. Natl. Acad. Sci. U.S.A. 116 (7) 2395-2397 [2019-02-12; online 2019-01-25]
Cryo-EM [Service]
PubMed DOI Crossref
Structure of the DP1–DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases
Raia P, Carroni M, Henry E, ..., Delarue M, Sauguet L
PLoS Biol. 17 (1) e3000122 [2019-01-18; online 2019-01-18]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Cryo-EM structure of the yeast respiratory supercomplex.
Rathore S, Berndtsson J, Marin-Buera L, ..., Brzezinski P, Ott M
Nat. Struct. Mol. Biol. 26 (1) 50-57 [2019-01-00; online 2018-12-31]
Cryo-EM [Collaborative]

Year 2018

PubMed DOI Crossref
Structure of a functional obligate complex III 2IV2 respiratory supercomplex from Mycobacterium smegmatis.
Wiseman B, Nitharwal RG, Fedotovskaya O, ..., Brzezinski P, Högbom M
Nat. Struct. Mol. Biol. 25 (12) 1128-1136 [2018-12-00; online 2018-12-05]
Cryo-EM [Service]
PubMed DOI Crossref
Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin
Johansson HJ, Vallhov H, Holm T, ..., Lehtiö J, Scheynius A
Sci Rep 8 (1) - [2018-12-00; online 2018-06-15]
Bioinformatics Support for Computational Resources [Service] Cryo-EM [Service] Global Proteomics and Proteogenomics [Collaborative] Integrated Microscopy Technologies Stockholm [Collaborative]
PubMed DOI Crossref
Folding pathway of an Ig domain is conserved on and off the ribosome.
Tian P, Steward A, Kudva R, ..., Clarke J, Best RB
Proc. Natl. Acad. Sci. U.S.A. 115 (48) E11284-E11293 [2018-11-27; online 2018-11-09]
Cryo-EM [Service]
PubMed DOI Crossref
The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding.
Kudva R, Tian P, Pardo-Avila F, ..., Bernstein HD, von Heijne G
Elife 7 (-) - [2018-11-26; online 2018-11-26]
Cryo-EM [Service]
PubMed DOI Crossref
New tools for automated high-resolution cryo-EM structure determination in RELION-3
Zivanov J, Nakane T, Forsberg BO, ..., Lindahl E, Scheres SH
Elife 7 (-) - [2018-11-09; online 2018-11-09]
Cryo-EM [Technology development]
PubMed DOI Crossref
Affinity to cellulose is a shared property among coiled-coil domains of intermediate filaments and prokaryotic intermediate filament-like proteins.
Söderholm N, Javadi A, Flores IS, Flärdh K, Sandblad L
Sci Rep 8 (1) 16524 [2018-11-08; online 2018-11-08]
Cryo-EM [Service]
PubMed DOI Crossref
Role of OmpA1 and OmpA2 in Aggregatibacter actinomycetemcomitans and Aggregatibacter aphrophilus serum resistance.
Lindholm M, Min Aung K, Nyunt Wai S, Oscarsson J
Journal of Oral Microbiology 11 (1) 1536192 [2018-10-26; online 2018-10-26]
Cryo-EM [Service]
PubMed DOI Crossref
Using Scipion for stream image processing at Cryo-EM facilities
Gómez-Blanco J, de la Rosa-Trevín JM, Marabini R, ..., Conesa P, Carazo JM
Journal of Structural Biology - (-) - [2018-10-00; online 2018-10-00]
Cryo-EM [Technology development]
PubMed DOI Crossref
Transthyretin Interferes with Aβ Amyloid Formation by Redirecting Oligomeric Nuclei into Non-Amyloid Aggregates.
Nilsson L, Pamrén A, Islam T, ..., Gharibyan AL, Olofsson A
J. Mol. Biol. 430 (17) 2722-2733 [2018-08-17; online 2018-06-08]
Cryo-EM [Service]
PubMed DOI Crossref
Scanning electron microscopy as a tool for evaluating morphology of amyloid structures formed on surface plasmon resonance chips.
Bra Nnstro M K, Gharibyan AL, Islam T, ..., Pamren A, Olofsson A
Data Brief 19 (-) 1166-1170 [2018-08-00; online 2018-05-26]
Cryo-EM [Technology development]
PubMed DOI Crossref
ClpB mutants of Francisella tularensis subspecies holarctica and tularensis are defective for type VI secretion and intracellular replication.
Alam A, Golovliov I, Javed E, Sjöstedt A
Sci Rep 8 (1) 11324 [2018-07-27; online 2018-07-27]
Cryo-EM [Service]
PubMed DOI Crossref
Bacterial Outer Membrane Vesicles Induce Vitronectin Release Into the Bronchoalveolar Space Conferring Protection From Complement-Mediated Killing.
Paulsson M, Che KF, Ahl J, ..., Lindén A, Riesbeck K
Front Microbiol 9 (-) 1559 [2018-07-13; online 2018-07-13]
Cryo-EM [Service]
PubMed DOI Crossref
Enteric Species F Human Adenoviruses use Laminin-Binding Integrins as Co-Receptors for Infection of Ht-29 Cells.
Rajan A, Persson BD, Frängsmyr L, ..., Gall J, Arnberg N
Sci Rep 8 (1) 10019 [2018-07-03; online 2018-07-03]
Cryo-EM [Service]
PubMed DOI Crossref
The Properties of Amyloid-β Fibrils Are Determined by their Path of Formation.
Brännström K, Islam T, Gharibyan AL, ..., Pamrén A, Olofsson A
J. Mol. Biol. 430 (13) 1940-1949 [2018-06-22; online 2018-05-09]
Cryo-EM [Service]
PubMed DOI Crossref
Ethylene signaling induces gelatinous layers with typical features of tension wood in hybrid aspen.
Felten J, Vahala J, Love J, ..., Mellerowicz EJ, Sundberg B
New Phytol. 218 (3) 999-1014 [2018-05-00; online 2018-03-12]
Cryo-EM [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor
Perez Boerema A, Aibara S, Paul B, ..., Lindahl E, Amunts A
NPLANTS 4 (4) 212-217 [2018-04-02; online 2018-04-02]
Cryo-EM [Service]
PubMed DOI Crossref
Establishment of Photosynthesis through Chloroplast Development Is Controlled by Two Distinct Regulatory Phases.
Dubreuil C, Jin X, Barajas-López JD, ..., Small I, Strand Å
Plant Physiol. 176 (2) 1199-1214 [2018-02-00; online 2017-06-16]
Cryo-EM [Service]
PubMed DOI Crossref
Alpha-actinin of the chlorarchiniophyte Bigelowiella natans.
Backman L
PeerJ 6 (-) e4288 [2018-01-17; online 2018-01-17]
Cryo-EM [Service]
PubMed DOI Crossref
The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
Norlin S, Parekh V, Edlund H
Development 145 (1) dev154468 [2018-01-03; online 2018-01-03]
Cryo-EM [Service]

Year 2017

PubMed DOI Crossref
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
Lehmann LC, Hewitt G, Aibara S, ..., Boulton SJ, Deindl S
Molecular Cell 68 (5) 847-859.e7 [2017-12-00; online 2017-12-00]
Cryo-EM [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control.
Carroni M, Franke KB, Maurer M, ..., Bukau B, Mogk A
Elife 6 (-) - [2017-11-22; online 2017-11-22]
Cryo-EM [Collaborative]
PubMed DOI Crossref
Cryo-EM reconstruction of the chlororibosome to 3.2 Å resolution within 24 h
Forsberg BO, Aibara S, Kimanius D, ..., Lindahl E, Amunts A
Int Union Crystallogr J IUCr J Int Union Cryst J IUCrJ 4 (6) 723-727 [2017-11-01; online 2017-09-22]
Cryo-EM [Service]
PubMed DOI Crossref
Structures of the human mitochondrial ribosome in native states of assembly
Brown A, Rathore S, Kimanius D, ..., Amunts A, Ramakrishnan V
Nat Struct Mol Biol 24 (10) 866-869 [2017-10-00; online 2017-09-11]
Cryo-EM [Service]
PubMed DOI Crossref
The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus
Matzov D, Aibara S, Basu A, ..., Amunts A, Yonath AE
Nat Commun 8 (1) 723 [2017-09-28; online 2017-09-28]
Cryo-EM [Service]
PubMed DOI Crossref
The structure of the tetanus toxin reveals pH-mediated domain dynamics.
Masuyer G, Conrad J, Stenmark P
EMBO Rep. 18 (8) 1306-1317 [2017-08-00; online 2017-06-23]
Cryo-EM [Service]
PubMed DOI Crossref
Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.
Deville C, Carroni M, Franke KB, ..., Mogk A, Saibil HR
Sci Adv 3 (8) e1701726 [2017-08-00; online 2017-08-04]
Cryo-EM [Service]
PubMed DOI Crossref
Establishment of photosynthesis is controlled by two distinct regulatory phases
Dubreuil C, Jin X, Barajas-López JdD, ..., Small ID, Strand A
Plant Physiol. - (-) pp.00435.2017 [2017-06-16; online 2017-06-16]
Cryo-EM [Service] Swedish Metabolomics Centre (SMC) [Service]
SciLifeLab Data Centre
Publications 9.5.1