Nat Commun

ISSN	2041-1723
ISSN-L	2041-1723
IUID	a574eb04884e4c0aaf82a210844daf7c
Modified	2020-11-27T13:14:08.691Z
Created	2017-05-09T09:12:08.433Z

PubMed DOI Crossref

Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters.

García Casas P, Rossini M, Påvénius L, ..., Pizzo P, Filadi R

Nat Commun 15 (1) 9775 [2024-11-12; online 2024-11-12]

Integrated Microscopy Technologies Stockholm [Collaborative]

PubMed DOI Crossref

A unique symbiosome in an anaerobic single-celled eukaryote.

Jerlström-Hultqvist J, Gallot-Lavallée L, Salas-Leiva DE, ..., Archibald JM, Roger AJ

Nat Commun 15 (1) 9726 [2024-11-09; online 2024-11-09]

Integrated Microscopy Technologies Umeå [Service]

PubMed DOI Crossref

The structure and function of P5A-ATPases.

Li P, Bågenholm V, Hägglund P, ..., Wang K, Gourdon P

Nat Commun 15 (1) 9605 [2024-11-06; online 2024-11-06]

Cryo-EM [Service]

PubMed DOI Crossref

High-parametric protein maps reveal the spatial organization in early-developing human lung.

Sariyar S, Sountoulidis A, Hansen JN, ..., Lundberg E, Ayoglu B

Nat Commun 15 (1) 9381 [2024-10-30; online 2024-10-30]

BioImage Informatics [Service]

PubMed DOI Crossref

Integrative spatial and genomic analysis of tumor heterogeneity with Tumoroscope.

Shafighi S, Geras A, Jurzysta B, ..., Lagergren J, Szczurek E

Nat Commun 15 (1) 9343 [2024-10-29; online 2024-10-29]

NGI Other [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors.

Bian X, Piipponen M, Liu Z, ..., Halle M, Xu Landén N

Nat Commun 15 (1) 9286 [2024-10-28; online 2024-10-28]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma.

Karlsson J, Yasui H, Mañas A, ..., Bexell D, Gisselsson D

Nat Commun 15 (1) 8992 [2024-10-18; online 2024-10-18]

Clinical Genomics Lund [Service]

PubMed DOI Crossref

Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19.

Jernbom AF, Skoglund L, Pin E, ..., Månberg A, Nilsson P

Nat Commun 15 (1) 8941 [2024-10-17; online 2024-10-17]

Autoimmunity and Serology Profiling [Collaborative]

PubMed DOI Crossref

De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast.

Jiao X, Fu X, Li Q, ..., Nielsen J, Chen Y

Nat Commun 15 (1) 8759 [2024-10-09; online 2024-10-09]

Integrated Microscopy Technologies Gothenburg [Service]

PubMed DOI Crossref

Unmasking AlphaFold to integrate experiments and predictions in multimeric complexes.

Mirabello C, Wallner B, Nystedt B, Azinas S, Carroni M

Nat Commun 15 (1) 8724 [2024-10-09; online 2024-10-09]

Bioinformatics Support, Infrastructure and Training [Technology development] Cryo-EM [Service]

PubMed DOI Crossref

The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing.

Li D, Liu Z, Zhang L, ..., Sommar P, Xu Landén N

Nat Commun 15 (1) 8637 [2024-10-05; online 2024-10-05]

NGI Short read [Service] NGI Single cell [Service] NGI Spatial omics [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

The single-cell transcriptomic atlas iPain identifies senescence of nociceptors as a therapeutical target for chronic pain treatment.

Techameena P, Feng X, Zhang K, Hadjab S

Nat Commun 15 (1) 8585 [2024-10-04; online 2024-10-04]

NGI Single cell [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Claustrum and dorsal endopiriform cortex complex cell-identity is determined by Nurr1 and regulates hallucinogenic-like states in mice.

Mantas I, Flais I, Masarapu Y, ..., Perlmann T, Svenningsson P

Nat Commun 15 (1) 8176 [2024-09-18; online 2024-09-18]

NGI Other [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor.

Pandiloski N, Horváth V, Karlsson O, ..., Jakobsson J, Douse CH

Nat Commun 15 (1) 7534 [2024-08-30; online 2024-08-30]

Clinical Genomics Lund [Service] NGI Long read [Service] NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

An intronic copy number variation in Syntaxin 17 determines speed of greying and melanoma incidence in Grey horses.

Rubin CJ, Hodge M, Naboulsi R, ..., Lindgren G, Andersson L

Nat Commun 15 (1) 7510 [2024-08-29; online 2024-08-29]

NGI Short read [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Structural basis of frizzled 7 activation and allosteric regulation.

Bous J, Kinsolving J, Grätz L, ..., Adebali O, Schulte G

Nat Commun 15 (1) 7422 [2024-08-28; online 2024-08-28]

Cryo-EM [Service]

PubMed DOI Crossref

BaTwa populations from Zambia retain ancestry of past hunter-gatherer groups.

Breton G, Barham L, Mudenda G, ..., Schlebusch CM, Jakobsson M

Nat Commun 15 (1) 7307 [2024-08-24; online 2024-08-24]

Clinical Genomics Gothenburg [Collaborative] NGI SNP genotyping [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species.

Song J, Li Z, Zhou L, ..., Rasmussen LJ, Dai F

Nat Commun 15 (1) 7144 [2024-08-21; online 2024-08-21]

NGI SNP genotyping [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Motor innervation directs the correct development of the mouse sympathetic nervous system.

Erickson AG, Motta A, Kastriti ME, ..., Bonanomi D, Adameyko I

Nat Commun 15 (1) 7065 [2024-08-16; online 2024-08-16]

Integrated Microscopy Technologies Stockholm [Collaborative]

PubMed DOI Crossref

Ecological genomics in the Northern krill uncovers loci for local adaptation across ocean basins.

Unneberg P, Larsson M, Olsson A, ..., Meyer B, Wallberg A

Nat Commun 15 (1) 6297 [2024-08-01; online 2024-08-01]

Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] NGI Uppsala (Uppsala Genome Center) [Collaborative] National Genomics Infrastructure [Service]

PubMed DOI Crossref

A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis.

Pahlevan Kakhki M, Giordano A, Starvaggi Cucuzza C, ..., Kular L, Jagodic M

Nat Commun 15 (1) 6419 [2024-07-30; online 2024-07-30]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques.

Mandolesi M, Das H, de Vries L, ..., Murrell B, Karlsson Hedestam GB

Nat Commun 15 (1) 6338 [2024-07-27; online 2024-07-27]

NGI Single cell [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Long-range charge transfer mechanism of the III2IV2 mycobacterial supercomplex.

Riepl D, Gamiz-Hernandez AP, Kovalova T, ..., Brzezinski P, Kaila VRI

Nat Commun 15 (1) 5276 [2024-06-20; online 2024-06-20]

Cryo-EM [Service]

PubMed DOI Crossref

descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques.

Otomo K, Omura T, Nozawa Y, ..., Brismar H, Susaki EA

Nat Commun 15 (1) 4941 [2024-06-12; online 2024-06-12]

Integrated Microscopy Technologies Stockholm [Collaborative]

PubMed DOI Crossref

Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice.

Masarapu Y, Cekanaviciute E, Andrusivova Z, ..., Costes SV, Giacomello S

Nat Commun 15 (1) 4778 [2024-06-11; online 2024-06-11]

Bioinformatics Long-term Support WABI [Service] Bioinformatics Support, Infrastructure and Training [Service]

PubMed DOI Crossref

ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers.

Zhang Y, Xie G, Lee JE, ..., Ge K, Kutateladze TG

Nat Commun 15 (1) 4883 [2024-06-07; online 2024-06-07]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Structure and mechanism of the K+/H+ exchanger KefC.

Gulati A, Kokane S, Perez-Boerema A, ..., Matsuoka R, Drew D

Nat Commun 15 (1) 4751 [2024-06-04; online 2024-06-04]

Cryo-EM [Service]

PubMed DOI Crossref

Structural conversion of the spidroin C-terminal domain during assembly of spider silk fibers.

De Oliveira DH, Gowda V, Sparrman T, ..., Lendel C, Hedhammar M

Nat Commun 15 (1) 4670 [2024-05-31; online 2024-05-31]

Swedish NMR Centre (SNC) [Collaborative]

PubMed DOI Crossref

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.

Izadi A, Karami Y, Bratanis E, ..., Malmström L, Nordenfelt P

Nat Commun 15 (1) 3600 [2024-04-27; online 2024-04-27]

Drug Discovery and Development (DDD) [Service]

PubMed DOI Crossref

Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.

Papakyriacou I, Kutkaite G, Rúbies Bedós M, ..., Menden MP, Mao Y

Nat Commun 15 (1) 3581 [2024-04-27; online 2024-04-27]

CRISPR Functional Genomics [Service]

PubMed DOI Crossref

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue.

Zhang N, Harbers L, Simonetti M, ..., Bienko M, Crosetto N

Nat Commun 15 (1) 3475 [2024-04-24; online 2024-04-24]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner.

ElBeck Z, Hossain MB, Siga H, ..., Végvári Á, Betsholtz C

Nat Commun 15 (1) 2358 [2024-03-20; online 2024-03-20]

BioImage Informatics [Service] Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative]

PubMed DOI Crossref

fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles.

Dennhag N, Kahsay A, Nissen I, ..., von Hofsten J, Pedrosa Domellöf F

Nat Commun 15 (1) 1950 [2024-03-02; online 2024-03-02]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Prediction of plasma ctDNA fraction and prognostic implications of liquid biopsy in advanced prostate cancer.

Fonseca NM, Maurice-Dror C, Herberts C, ..., Chi KN, Wyatt AW

Nat Commun 15 (1) 1828 [2024-02-28; online 2024-02-28]

Clinical Genomics Stockholm [Service]

PubMed DOI Crossref

scCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells.

Chen JP, Diekmann C, Wu H, ..., Bienko M, Crosetto N

Nat Commun 15 (1) 1768 [2024-02-27; online 2024-02-27]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF.

Kvedaraite E, Lourda M, Mouratidou N, ..., Henter JI, Svensson M

Nat Commun 15 (1) 1752 [2024-02-26; online 2024-02-26]

Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1.

Bacic L, Gaullier G, Mohapatra J, ..., Sabantsev A, Deindl S

Nat Commun 15 (1) 1000 [2024-02-02; online 2024-02-02]

Cryo-EM [Service]

PubMed DOI Crossref

A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection.

von Beek C, Fahlgren A, Geiser P, ..., Pejler G, Sellin ME

Nat Commun 15 (1) 904 [2024-01-30; online 2024-01-30]

NGI Short read [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis.

Drexhage LZ, Zhang S, Dupont M, ..., Karaji N, Sattentau QJ

Nat Commun 15 (1) 541 [2024-01-15; online 2024-01-15]

Integrated Microscopy Technologies Stockholm [Service]

PubMed DOI Crossref

Nuclear Hsp104 safeguards the dormant translation machinery during quiescence.

Kohler V, Kohler A, Berglund LL, ..., Andréasson C, Büttner S

Nat Commun 15 (1) 315 [2024-01-05; online 2024-01-05]

Global Proteomics and Proteogenomics [Service]

PubMed DOI Crossref

Blue-shift photoconversion of near-infrared fluorescent proteins for labeling and tracking in living cells and organisms.

Pennacchietti F, Alvelid J, Morales RA, ..., Verkhusha VV, Testa I

Nat Commun 14 (1) 8402 [2023-12-19; online 2023-12-19]

Integrated Microscopy Technologies Stockholm [Service]

PubMed DOI Crossref

Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans.

Pu L, Wang J, Lu Q, ..., Henriksson J, Chen C

Nat Commun 14 (1) 8410 [2023-12-18; online 2023-12-18]

Bioinformatics Support for Computational Resources [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

CENP-A and CENP-B collaborate to create an open centromeric chromatin state.

Nagpal H, Ali-Ahmad A, Hirano Y, ..., Sekulić N, Fierz B

Nat Commun 14 (1) 8227 [2023-12-12; online 2023-12-12]

Cryo-EM [Service]

PubMed DOI Crossref

Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes.

Rönn T, Ofori JK, Perfilyev A, ..., Bacos K, Ling C

Nat Commun 14 (1) 8040 [2023-12-12; online 2023-12-12]

Swedish Metabolomics Centre (SMC) [Collaborative]

PubMed DOI Crossref

The formation of the Indo-Pacific montane avifauna.

Reeve AH, Kennedy JD, Pujolar JM, ..., Nylander JAA, Jønsson KA

Nat Commun 14 (1) 8215 [2023-12-11; online 2023-12-11]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation.

Mälarstig A, Grassmann F, Dahl L, ..., Czene K, Hedman ÅK

Nat Commun 14 (1) 7680 [2023-11-24; online 2023-11-24]

Affinity Proteomics Uppsala [Service] Bioinformatics Support for Computational Resources [Service]

PubMed DOI Crossref

The heat shock protein LarA activates the Lon protease in response to proteotoxic stress.

Omnus DJ, Fink MJ, Kallazhi A, ..., Landreh M, Jonas K

Nat Commun 14 (1) 7636 [2023-11-22; online 2023-11-22]

Global Proteomics and Proteogenomics [Service]

PubMed DOI Crossref

Development of mesothelioma-specific oncolytic immunotherapy enabled by immunopeptidomics of murine and human mesothelioma tumors.

Chiaro J, Antignani G, Feola S, ..., Lehtiö J, Cerullo V

Nat Commun 14 (1) 7056 [2023-11-03; online 2023-11-03]

Global Proteomics and Proteogenomics [Technology development]

PubMed DOI Crossref

Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis.

Åkesson J, Hojjati S, Hellberg S, ..., Ernerudh J, Gustafsson M

Nat Commun 14 (1) 6903 [2023-10-30; online 2023-10-30]

Affinity Proteomics Uppsala [Service] NGI Proteomics [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Low mutation rate in epaulette sharks is consistent with a slow rate of evolution in sharks.

Sendell-Price AT, Tulenko FJ, Pettersson M, ..., Andersson L, Schartl M

Nat Commun 14 (1) 6628 [2023-10-19; online 2023-10-19]

Bioinformatics Support for Computational Resources [Service]

PubMed DOI Crossref

Design, structure and plasma binding of ancestral β-CoV scaffold antigens.

Hueting D, Schriever K, Sun R, ..., Andréll J, Syrén PO

Nat Commun 14 (1) 6527 [2023-10-16; online 2023-10-16]

Cryo-EM [Service] Drug Discovery and Development (DDD) [Service]

PubMed DOI Crossref

Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication.

Chakraborty C, Nissen I, Vincent CA, ..., Hörnblad A, Remeseiro S

Nat Commun 14 (1) 6446 [2023-10-13; online 2023-10-13]

Bioinformatics Long-term Support WABI [Service] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Service]

PubMed DOI Crossref

Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs.

Petruk G, Puthia M, Samsudin F, ..., Lindstedt S, Schmidtchen A

Nat Commun 14 (1) 6097 [2023-09-29; online 2023-09-29]

Clinical Genomics Lund [Service] Structural Proteomics [Collaborative]

PubMed DOI Crossref

A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils.

Xu Z, Xu B, Lundström SL, ..., Zubarev RA, Holmdahl R

Nat Commun 14 (1) 5949 [2023-09-23; online 2023-09-23]

Drug Discovery and Development (DDD) [Collaborative]

PubMed DOI Crossref

Comprehensive proteomics and meta-analysis of COVID-19 host response.

Babačić H, Christ W, Araújo JE, ..., Klingström J, Pernemalm M

Nat Commun 14 (1) 5921 [2023-09-22; online 2023-09-22]

Global Proteomics and Proteogenomics [Collaborative]

PubMed DOI Crossref

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

He Y, Kaya I, Shariatgorji R, ..., Andren PE, Svenningsson P

Nat Commun 14 (1) 5804 [2023-09-19; online 2023-09-19]

Spatial Mass Spectrometry [Collaborative]

PubMed DOI Crossref

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

Mihalič F, Benz C, Kassa E, ..., Jemth P, Ivarsson Y

Nat Commun 14 (1) 5636 [2023-09-13; online 2023-09-13]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development.

Witman N, Zhou C, Häneke T, ..., Chien KR, Sahara M

Nat Commun 14 (1) 5435 [2023-09-05; online 2023-09-05]

Eukaryotic Single Cell Genomics (ESCG) [Service] NGI Short read [Service] NGI Single cell [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis.

Schoeler M, Ellero-Simatos S, Birkner T, ..., Burcelin R, Caesar R

Nat Commun 14 (1) 5329 [2023-09-01; online 2023-09-01]

Chalmers Mass Spectrometry Infrastructure [Service]

PubMed DOI Crossref

Long-read whole-genome analysis of human single cells.

Hård J, Mold JE, Eisfeldt J, ..., Michaëlsson J, Ameur A

Nat Commun 14 (1) 5164 [2023-08-24; online 2023-08-24]

Bioinformatics Support for Computational Resources [Service] NGI Long read [Technology development] NGI Single cell [Technology development] NGI Stockholm (Genomics Applications) [Collaborative] NGI Uppsala (Uppsala Genome Center) [Technology development] National Genomics Infrastructure [Technology development]

PubMed DOI Crossref

Atomic-level structure determination of amorphous molecular solids by NMR.

Cordova M, Moutzouri P, Nilsson Lill SO, ..., Schantz S, Emsley L

Nat Commun 14 (1) 5138 [2023-08-23; online 2023-08-23]

Swedish NMR Centre (SNC) [Collaborative]

PubMed DOI Crossref

An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.

Fernández Moro C, Geyer N, Harrizi S, ..., Bozóky B, Gerling M

Nat Commun 14 (1) 5024 [2023-08-18; online 2023-08-18]

CRISPR Functional Genomics [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

GATA2 mitotic bookmarking is required for definitive haematopoiesis.

Silvério-Alves R, Kurochkin I, Rydström A, ..., Martin-Gonzalez J, Pereira CF

Nat Commun 14 (1) 4645 [2023-08-14; online 2023-08-14]

Clinical Genomics Lund [Service]

PubMed DOI Crossref

Complementarity-determining region clustering may cause CAR-T cell dysfunction.

Sarén T, Saronio G, Marti Torrell P, ..., Yu D, Essand M

Nat Commun 14 (1) 4732 [2023-08-10; online 2023-08-10]

Bioinformatics Support for Computational Resources [Service] Drug Discovery and Development (DDD) [Collaborative] Global Proteomics and Proteogenomics [Service]

PubMed DOI Crossref

Genetic insights into resting heart rate and its role in cardiovascular disease.

van de Vegte YJ, Eppinga RN, van der Ende MY, ..., Verweij N, van der Harst P

Nat Commun 14 (1) 4646 [2023-08-02; online 2023-08-02]

Clinical Genomics Gothenburg [Collaborative] NGI SNP genotyping [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Patrilocality and hunter-gatherer-related ancestry of populations in East-Central Europe during the Middle Bronze Age.

Chyleński M, Makarowicz P, Juras A, ..., Jakobsson M, Malmström H

Nat Commun 14 (1) 4395 [2023-08-01; online 2023-08-01]

Bioinformatics Support for Computational Resources [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Salicylic acid metabolism and signalling coordinate senescence initiation in aspen in nature.

Lihavainen J, Šimura J, Bag P, ..., Ljung K, Jansson S

Nat Commun 14 (1) 4288 [2023-07-18; online 2023-07-18]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service] Swedish Metabolomics Centre (SMC) [Service]

PubMed DOI Crossref

Next generation pan-cancer blood proteome profiling using proximity extension assay.

Álvez MB, Edfors F, von Feilitzen K, ..., Fagerberg L, Uhlén M

Nat Commun 14 (1) 4308 [2023-07-18; online 2023-07-18]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Support for Computational Resources [Service] NGI Proteomics [Collaborative] NGI Uppsala (SNP&SEQ Technology Platform) [Collaborative] National Genomics Infrastructure [Collaborative]

PubMed DOI Crossref

Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses.

Hellgren F, Cagigi A, Arcoverde Cerveira R, ..., Petsch B, Loré K

Nat Commun 14 (1) 3713 [2023-06-22; online 2023-06-22]

Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Service]

PubMed DOI Crossref

Flavodiiron-mediated O2 photoreduction at photosystem I acceptor-side provides photoprotection to conifer thylakoids in early spring.

Bag P, Shutova T, Shevela D, ..., Messinger J, Jansson S

Nat Commun 14 (1) 3210 [2023-06-03; online 2023-06-03]

Swedish Metabolomics Centre (SMC) [Service]

PubMed DOI Crossref

Directionality of developing skeletal muscles is set by mechanical forces.

Sunadome K, Erickson AG, Kah D, ..., Fried K, Adameyko I

Nat Commun 14 (1) 3060 [2023-05-27; online 2023-05-27]

Integrated Microscopy Technologies Stockholm [Service]

PubMed DOI Crossref

Cisplatin toxicity is counteracted by the activation of the p38/ATF-7 signaling pathway in post-mitotic C. elegans.

Raj D, Kraish B, Martikainen J, ..., Kao G, Naredi P

Nat Commun 14 (1) 2886 [2023-05-20; online 2023-05-20]

Clinical Genomics Gothenburg [Collaborative] Glycoproteomics and MS Proteomics [Service] Integrated Microscopy Technologies Gothenburg [Service]

PubMed DOI Crossref

Base-resolution UV footprinting by sequencing reveals distinctive damage signatures for DNA-binding proteins.

Elliott K, Singh VK, Boström M, Larsson E

Nat Commun 14 (1) 2701 [2023-05-11; online 2023-05-11]

NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study.

Grahnemo L, Nethander M, Coward E, ..., Hveem K, Ohlsson C

Nat Commun 14 (1) 2250 [2023-04-20; online 2023-04-20]

Clinical Genomics Gothenburg [Collaborative]

PubMed DOI Crossref

Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19.

Yu M, Charles A, Cagigi A, ..., Loré K, Smed-Sörensen A

Nat Commun 14 (1) 2164 [2023-04-15; online 2023-04-15]

Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative]

DOI Crossref

Type I interferon shapes brain distribution and tropism of tick-borne flavivirus

Chotiwan N, Rosendal E, Willekens SMA, ..., Marcellino D, Överby AK

Nat Commun 14 (1) - [2023-04-10; online 2023-04-10]

Integrated Microscopy Technologies Umeå [Service]

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Nat Commun 14 (1) 1833 [2023-04-01; online 2023-04-01]

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Lundberg M, Mackintosh A, Petri A, Bensch S

Nat Commun 14 (1) 452 [2023-01-27; online 2023-01-27]

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Tislevoll BS, Hellesøy M, Fagerholt OHE, ..., Blaser N, Gjertsen BT

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Angelini G, Castagneto-Gissey L, Salinari S, ..., Tremaroli V, Mingrone G

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Wahlgren WY, Claesson E, Tuure I, ..., Takala H, Westenhoff S

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Ruiz M, Devkota R, Panagaki D, ..., Borén J, Pilon M

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Jespersen N, Ehrenbolger K, Winiger RR, ..., Vossbrinck CR, Barandun J

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Maurya DK, Berghard A, Bohm S

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Liu L, Khan A, Sanchez-Rodriguez E, ..., Gharavi AG, Kiryluk K

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FRET-FISH probes chromatin compaction at individual genomic loci in single cells.

Mota A, Berezicki S, Wernersson E, ..., Crosetto N, Bienko M

Nat Commun 13 (1) 6680 [2022-11-05; online 2022-11-05]

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Herbst SA, Vesterlund M, Helmboldt AJ, ..., Lehtiö J, Dietrich S

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Kandavalli V, Karempudi P, Larsson J, Elf J

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Tobiasson V, Berzina I, Amunts A

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Nat Commun 13 (1) 6020 [2022-10-14; online 2022-10-14]

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Hill J, Lillie M, Pettersson ME, ..., Andersson L, Jern P

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Dahmane S, Kerviel A, Morado DR, ..., Altan-Bonnet N, Carlson LA

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Marklund M, Schultz N, Friedrich S, ..., Sonnhammer E, Lundeberg J

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Nat Commun 13 (1) 4837 [2022-08-17; online 2022-08-17]

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Raykova D, Kermpatsou D, Malmqvist T, ..., Kampf C, Söderberg O

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Kuhl H, Du K, Schartl M, ..., Stöck M, Lamatsch DK

Nat Commun 13 (1) 4092 [2022-07-14; online 2022-07-14]

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Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification.

Petitpré C, Faure L, Uhl P, ..., Hadjab S, Lallemend F

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Domenzain I, Sánchez B, Anton M, ..., Sonnenschein N, Nielsen J

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Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery.

Alekseenko Z, Dias JM, Adler AF, ..., Parmar M, Ericson J

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Bioinformatics Support for Computational Resources [Service] Swedish Metabolomics Centre (SMC) [Service]

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NGI Long read [Service] NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]

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Nat Commun 13 (1) 2700 [2022-05-16; online 2022-05-16]

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Nat Commun 13 (1) 2634 [2022-05-12; online 2022-05-12]

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Kierczak M, Rafati N, Höglund J, ..., Karlsson T, Johansson Å

Nat Commun 13 (1) 2532 [2022-05-09; online 2022-05-09]

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Lu X, Maturi NP, Jarvius M, ..., Uhrbom L, Chen X

Nat Commun 13 (1) 2236 [2022-04-25; online 2022-04-25]

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Kennedy B, Fitipaldi H, Hammar U, ..., Franks PW, Fall T

Nat Commun 13 (1) 2110 [2022-04-21; online 2022-04-21]

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Crowe-McAuliffe C, Murina V, Turnbull KJ, ..., Wilson DN, Hauryliuk V

Nat Commun 13 (1) 1860 [2022-04-06; online 2022-04-06]

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Metelev M, Lundin E, Volkov IL, ..., Elf J, Johansson M

Nat Commun 13 (1) 1852 [2022-04-06; online 2022-04-06]

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Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Leo IR, Aswad L, Stahl M, ..., Vesterlund M, Jafari R

Nat Commun 13 (1) 1691 [2022-03-30; online 2022-03-30]

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Norway spruce postglacial recolonization of Fennoscandia.

Nota K, Klaminder J, Milesi P, ..., Suyama Y, Parducci L

Nat Commun 13 (1) 1333 [2022-03-14; online 2022-03-14]

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The spatial transcriptomic landscape of the healing mouse intestine following damage.

Parigi SM, Larsson L, Das S, ..., Lundeberg J, Villablanca EJ

Nat Commun 13 (1) 828 [2022-02-11; online 2022-02-11]

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CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations.

Höijer I, Emmanouilidou A, Östlund R, ..., den Hoed M, Ameur A

Nat Commun 13 (1) 627 [2022-02-02; online 2022-02-02]

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Rush JS, Parajuli P, Ruda A, ..., Widmalm G, Korotkova N

Nat Commun 13 (1) 590 [2022-02-01; online 2022-02-01]

Swedish NMR Centre (SNC)

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The formation of avian montane diversity across barriers and along elevational gradients.

Pujolar JM, Blom MPK, Reeve AH, ..., Irestedt M, Jønsson KA

Nat Commun 13 (1) 268 [2022-01-12; online 2022-01-12]

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Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site.

Chachoua I, Tzelepis I, Dai H, ..., Mehmood R, Göndör A

Nat Commun 13 (1) 204 [2022-01-11; online 2022-01-11]

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Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.

Tin A, Schlosser P, Matias-Garcia PR, ..., Teumer A, Köttgen A

Nat Commun 12 (1) 7173 [2021-12-09; online 2021-12-09]

NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Meta-analyses identify DNA methylation associated with kidney function and damage.

Schlosser P, Tin A, Matias-Garcia PR, ..., Köttgen A, Teumer A

Nat Commun 12 (1) 7174 [2021-12-09; online 2021-12-09]

NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

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Structural basis for transthyretin amyloid formation in vitreous body of the eye.

Iakovleva I, Hall M, Oelker M, ..., Anan I, Sauer-Eriksson AE

Nat Commun 12 (1) 7141 [2021-12-08; online 2021-12-08]

Cryo-EM [Collaborative] Structural Proteomics [Service]

PubMed DOI Crossref

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver.

Hildebrandt F, Andersson A, Saarenpää S, ..., Lundeberg J, Ankarklev J

Nat Commun 12 (1) 7046 [2021-12-02; online 2021-12-02]

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ATR inhibition enables complete tumour regression in ALK-driven NB mouse models.

Szydzik J, Lind DE, Arefin B, ..., Hallberg B, Palmer RH

Nat Commun 12 (1) 6813 [2021-11-24; online 2021-11-24]

Glycoproteomics and MS Proteomics [Service]

PubMed DOI Crossref

Single cell genomics reveals plastid-lacking Picozoa are close relatives of red algae.

Schön ME, Zlatogursky VV, Singh RP, ..., Wideman JG, Burki F

Nat Commun 12 (1) 6651 [2021-11-17; online 2021-11-17]

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Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.

Grosche S, Marenholz I, Esparza-Gordillo J, ..., Xu C, Lee Y

Nat Commun 12 (1) 6618 [2021-11-16; online 2021-11-16]

NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation.

Sabatier P, Beusch CM, Saei AA, ..., Rodin S, Zubarev RA

Nat Commun 12 (1) 6558 [2021-11-12; online 2021-11-12] Open Access

Chemical Proteomics [Technology development]

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Elevated circulating follistatin associates with an increased risk of type 2 diabetes.

Wu C, Borné Y, Gao R, ..., Groop L, De Marinis Y

Nat Commun 12 (1) 6486 [2021-11-10; online 2021-11-10]

Affinity Proteomics Stockholm [Collaborative] Affinity Proteomics Uppsala [Service]

PubMed DOI Crossref

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories.

Liu Q, Liu Y, Li G, ..., Chen Y, Nielsen J

Nat Commun 12 (1) 6085 [2021-10-19; online 2021-10-19]

Chalmers Mass Spectrometry Infrastructure [Service]

PubMed DOI Crossref

Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions.

Andersson A, Larsson L, Stenbeck L, ..., Engblom C, Lundeberg J

Nat Commun 12 (1) 6012 [2021-10-14; online 2021-10-14]

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Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.

Bedoya-Reina OC, Li W, Arceo M, ..., Kogner P, Schlisio S

Nat Commun 12 (1) 5309 [2021-09-07; online 2021-09-07]

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Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion.

Škerlová J, Berndtsson J, Nolte H, Ott M, Stenmark P

Nat Commun 12 (1) 5277 [2021-09-06; online 2021-09-06]

Cryo-EM [Service]

PubMed DOI Crossref

Amnion signals are essential for mesoderm formation in primates.

Yang R, Goedel A, Kang Y, ..., Niu Y, Chien KR

Nat Commun 12 (1) 5126 [2021-08-26; online 2021-08-26]

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A simple pressure-assisted method for MicroED specimen preparation.

Zhao J, Xu H, Lebrette H, ..., Högbom M, Zou X

Nat Commun 12 (1) 5036 [2021-08-19; online 2021-08-19]

Cryo-EM [Collaborative]

PubMed DOI Crossref

Energy efficiency and biological interactions define the core microbiome of deep oligotrophic groundwater.

Mehrshad M, Lopez-Fernandez M, Sundh J, ..., Bertilsson S, Dopson M

Nat Commun 12 (1) 4253 [2021-07-12; online 2021-07-12]

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A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.

Jhun M, Mendelson M, Wilson R, ..., Irvin MR, Assimes TL

Nat Commun 12 (1) 3987 [2021-06-28; online 2021-06-28]

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Structure and transport mechanism of P5B-ATPases.

Li P, Wang K, Salustros N, Grønberg C, Gourdon P

Nat Commun 12 (1) 3973 [2021-06-25; online 2021-06-25]

Cryo-EM [Service]

PubMed DOI Crossref

COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance.

Simonetti M, Zhang N, Harbers L, ..., Ghisetti V, Crosetto N

Nat Commun 12 (1) 3903 [2021-06-23; online 2021-06-23]

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Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.

Roxhed N, Bendes A, Dale M, ..., Fredolini C, Schwenk JM

Nat Commun 12 (1) 3695 [2021-06-17; online 2021-06-17]

Affinity Proteomics Stockholm [Technology development]

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Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.

Crowe-McAuliffe C, Murina V, Turnbull KJ, ..., Hauryliuk V, Wilson DN

Nat Commun 12 (1) 3577 [2021-06-11; online 2021-06-11]

Cryo-EM [Service]

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Karampelias C, Rezanejad H, Rosko M, ..., Korbutt GS, Andersson O

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Bioinformatics Support for Computational Resources [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

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Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

de Rojas I, Moreno-Grau S, Tesi N, ..., van der Lee SJ, Ruiz A

Nat Commun 12 (1) 3417 [2021-06-07; online 2021-06-07]

NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

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Avican K, Aldahdooh J, Togninalli M, ..., Rhen M, Fällman M

Nat Commun 12 (1) 3282 [2021-06-02; online 2021-06-02]

NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

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Salmón P, Jacobs A, Ahrén D, ..., Visser ME, Isaksson C

Nat Commun 12 (1) 2983 [2021-05-20; online 2021-05-20]

Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative]

PubMed DOI Crossref

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von Seth J, Dussex N, Díez-Del-Molino D, ..., Götherström A, Dalén L

Nat Commun 12 (1) 2393 [2021-04-26; online 2021-04-26]

Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Collaborative] NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure

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Phenological shifts in lake stratification under climate change.

Woolway RI, Sharma S, Weyhenmeyer GA, ..., Thiery W, Jennings E

Nat Commun 12 (1) 2318 [2021-04-19; online 2021-04-19]

Bioinformatics Support for Computational Resources [Service]

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Strassert JFH, Irisarri I, Williams TA, Burki F

Nat Commun 12 (1) 1879 [2021-03-25; online 2021-03-25]

Bioinformatics Support for Computational Resources [Service]

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Kupari J, Usoskin D, Parisien M, ..., Diatchenko L, Ernfors P

Nat Commun 12 (1) 1510 [2021-03-08; online 2021-03-08]

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System-wide identification and prioritization of enzyme substrates by thermal analysis.

Saei AA, Beusch CM, Sabatier P, ..., Schüler H, Zubarev RA

Nat Commun 12 (1) 1296 [2021-02-26; online 2021-02-26] Open Access

Chemical Proteomics [Technology development]

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Mer AS, Heath EM, Madani Tonekaboni SA, ..., Schimmer AD, Haibe-Kains B

Nat Commun 12 (1) 1054 [2021-02-16; online 2021-02-16]

Bioinformatics Support for Computational Resources [Service]

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Asymmetric introgression reveals the genetic architecture of a plumage trait.

Semenov GA, Linck E, Enbody ED, ..., Andersson L, Taylor SA

Nat Commun 12 (1) 1019 [2021-02-15; online 2021-02-15]

Bioinformatics Support for Computational Resources [Service] NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure

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Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice.

Wu H, Petitpré C, Fontanet P, ..., Hadjab S, Lallemend F

Nat Commun 12 (1) 1026 [2021-02-15; online 2021-02-15]

Bioinformatics Support for Computational Resources [Service] Eukaryotic Single Cell Genomics (ESCG) [Service] NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure

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Eriksson D, Røyrvik EC, Aranda-Guillén M, ..., Kämpe O, Husebye ES

Nat Commun 12 (1) 959 [2021-02-11; online 2021-02-11]

Bioinformatics Support for Computational Resources [Service]

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Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.

Norin U, Rintisch C, Meng L, ..., Bäckdahl L, Holmdahl R

Nat Commun 12 (1) 610 [2021-01-27; online 2021-01-27]

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Structure of a full-length bacterial polysaccharide co-polymerase.

Wiseman B, Nitharwal RG, Widmalm G, Högbom M

Nat Commun 12 (1) 369 [2021-01-14; online 2021-01-14]

Cryo-EM [Service]

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Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution.

Cunha ES, Chen X, Sanz-Gaitero M, Mills DJ, Luecke H

Nat Commun 12 (1) 230 [2021-01-11; online 2021-01-11]

Cryo-EM [Service]

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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Lagou V, Mägi R, Hottenga JJ, ..., Prokopenko I, Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)

Nat Commun 12 (1) 24 [2021-01-05; online 2021-01-05]

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Direct energy transfer from photosystem II to photosystem I confers winter sustainability in Scots Pine.

Bag P, Chukhutsina V, Zhang Z, ..., Holzwarth AR, Jansson S

Nat Commun 11 (1) 6388 [2020-12-15; online 2020-12-15]

Integrated Microscopy Technologies Umeå [Service]

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Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Floriddia EM, Lourenço T, Zhang S, ..., Nilsson M, Castelo-Branco G

Nat Commun 11 (1) 5860 [2020-11-17; online 2020-11-17]

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Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells.

Tarbier M, Mackowiak SD, Frade J, ..., Gallant CJ, Friedländer MR

Nat Commun 11 (1) 5445 [2020-10-28; online 2020-10-28]

Bioinformatics Support for Computational Resources [Service] Eukaryotic Single Cell Genomics (ESCG) [Service]

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Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.

Flygaard RK, Mühleip A, Tobiasson V, Amunts A

Nat Commun 11 (1) 5342 [2020-10-22; online 2020-10-22]

Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]

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A high-stringency blueprint of the human proteome.

Adhikari S, Nice EC, Deutsch EW, ..., Aebersold R, Baker MS

Nat Commun 11 (1) 5301 [2020-10-16; online 2020-10-16]

Affinity Proteomics Stockholm [Collaborative]

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Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins.

Nowak K, Rosenthal F, Karlberg T, ..., Leslie Pedrioli DM, Hottiger MO

Nat Commun 11 (1) 5199 [2020-10-15; online 2020-10-15]

Protein Science Facility (PSF) [Service]

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Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.

Itoh Y, Naschberger A, Mortezaei N, Herrmann JM, Amunts A

Nat Commun 11 (1) 5187 [2020-10-14; online 2020-10-14]

Cryo-EM [Service] Global Proteomics and Proteogenomics [Service]

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An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility.

Navarro C, Lyu J, Katsori AM, Caridha R, Elsässer SJ

Nat Commun 11 (1) 5095 [2020-10-09; online 2020-10-09]

Protein Science Facility (PSF) [Service]

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SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.

Rudberg AS, Havervall S, Månberg A, ..., Hober S, Thålin C

Nat Commun 11 (1) 5064 [2020-10-08; online 2020-10-08]

Autoimmunity and Serology Profiling [Collaborative]

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Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.

Wang T, Hoekzema K, Vecchio D, ..., Xia K, Eichler EE

Nat Commun 11 (1) 4932 [2020-10-01; online 2020-10-01]

Clinical Genomics Stockholm [Service]

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Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.

Krivanek J, Soldatov RA, Kastriti ME, ..., Kharchenko PV, Adameyko I

Nat Commun 11 (1) 4816 [2020-09-23; online 2020-09-23]

Eukaryotic Single Cell Genomics (ESCG) [Service]

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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

Bailey MH, Meyerson WU, Dursi LJ, ..., Ding L, PCAWG Consortium

Nat Commun 11 (1) 4748 [2020-09-21; online 2020-09-21]

Clinical Genomics Uppsala [Service]

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Integration of molecular profiles in a longitudinal wellness profiling cohort.

Tebani A, Gummesson A, Zhong W, ..., Uhlen M, Fagerberg L

Nat Commun 11 (1) 4487 [2020-09-08; online 2020-09-08]

Affinity Proteomics Stockholm [Collaborative] Autoimmunity and Serology Profiling [Collaborative] Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Collaborative] Cellular Immunomonitoring [Collaborative] Swedish Metabolomics Centre (SMC) [Collaborative]

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An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.

Hanke L, Vidakovics Perez L, Sheward DJ, ..., Murrell B, McInerney GM

Nat Commun 11 (1) 4420 [2020-09-04; online 2020-09-04]

Bioinformatics Support for Computational Resources [Service] Protein Science Facility (PSF) [Service]

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Sex differences in oncogenic mutational processes.

Li CH, Prokopec SD, Sun RX, ..., Boutros PC, PCAWG Consortium

Nat Commun 11 (1) 4330 [2020-08-28; online 2020-08-28]

Clinical Genomics Uppsala [Service]

PubMed DOI Crossref

Cell-surface receptors enable perception of extracellular cytokinins.

Antoniadi I, Novák O, Gelová Z, ..., Ljung K, Turnbull C

Nat Commun 11 (1) 4284 [2020-08-27; online 2020-08-27]

Swedish Metabolomics Centre (SMC) [Service]

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Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates.

Faure L, Wang Y, Kastriti ME, ..., Adameyko I, Hadjab S

Nat Commun 11 (1) 4175 [2020-08-21; online 2020-08-21]

Bioinformatics Support for Computational Resources [Service] Eukaryotic Single Cell Genomics (ESCG) [Service]

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Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis.

Carlström KE, Zhu K, Ewing E, ..., Castelo-Branco G, Piehl F

Nat Commun 11 (1) 4071 [2020-08-13; online 2020-08-13]

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Discovery and population genomics of structural variation in a songbird genus.

Weissensteiner MH, Bunikis I, Catalán A, ..., Warmuth VM, Wolf JBW

Nat Commun 11 (1) 3403 [2020-07-07; online 2020-07-07]

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Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.

Wilkes MC, Siva K, Chen J, ..., Flygare J, Sakamoto KM

Nat Commun 11 (1) 3344 [2020-07-03; online 2020-07-03]

Chemical Biology Consortium Sweden (CBCS) [Collaborative]

PubMed DOI Crossref

Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.

Ciudad S, Puig E, Botzanowski T, ..., Bardiaux B, Carulla N

Nat Commun 11 (1) 3014 [2020-06-15; online 2020-06-15]

Swedish NMR Centre (SNC) [Collaborative]

PubMed DOI Crossref

Distinct pre-initiation steps in human mitochondrial translation.

Khawaja A, Itoh Y, Remes C, ..., Amunts A, Rorbach J

Nat Commun 11 (1) 2932 [2020-06-10; online 2020-06-10]

Cryo-EM [Service]

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CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment.

Hagey DW, Topcic D, Kee N, ..., Perlmann T, Muhr J

Nat Commun 11 (1) 2898 [2020-06-09; online 2020-06-09]

Bioinformatics Support for Computational Resources [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

Ntalla I, Weng LC, Cartwright JH, ..., Lubitz SA, Munroe PB

Nat Commun 11 (1) 2542 [2020-05-21; online 2020-05-21]

NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease.

Tiklová K, Nolbrant S, Fiorenzano A, ..., Perlmann T, Parmar M

Nat Commun 11 (1) 2434 [2020-05-15; online 2020-05-15]

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Molecular profiling of driver events in metastatic uveal melanoma.

Karlsson J, Nilsson LM, Mitra S, ..., Olofsson Bagge R, Nilsson JA

Nat Commun 11 (1) 1894 [2020-04-20; online 2020-04-20]

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Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia.

Halvorsen M, Huh R, Oskolkov N, ..., Sullivan PF, Szatkiewicz JP

Nat Commun 11 (1) 1842 [2020-04-15; online 2020-04-15]

Bioinformatics Long-term Support WABI [Collaborative] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Collaborative] NGI Uppsala (SNP&SEQ Technology Platform) [Service] NGI Uppsala (Uppsala Genome Center) [Collaborative] National Genomics Infrastructure [Service] Systems Biology [Collaborative]

PubMed DOI Crossref

Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells.

Plaza Reyes A, Petrus-Reurer S, Padrell Sánchez S, ..., Kvanta A, Lanner F

Nat Commun 11 (1) 1609 [2020-03-30; online 2020-03-30]

Bioinformatics Support for Computational Resources [Service] Eukaryotic Single Cell Genomics (ESCG) [Service]

PubMed DOI Crossref

Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.

Madru C, Henneke G, Raia P, ..., Carroni M, Sauguet L

Nat Commun 11 (1) 1591 [2020-03-27; online 2020-03-27]

Cryo-EM [Collaborative]

PubMed DOI Crossref

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy.

Rendo V, Stoimenov I, Mateus A, ..., Cheong I, Sjöblom T

Nat Commun 11 (1) 1308 [2020-03-11; online 2020-03-11]

Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden (CBCS) [Collaborative] Drug Discovery and Development (DDD) [Service]

PubMed DOI Crossref

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells.

Wagner M, Yoshihara M, Douagi I, ..., Lanner F, Damdimopoulou P

Nat Commun 11 (1) 1147 [2020-03-02; online 2020-03-02]

Bioinformatics Support for Computational Resources [Service] Eukaryotic Single Cell Genomics (ESCG) [Service]

PubMed DOI Crossref

Primary cell wall inspired micro containers as a step towards a synthetic plant cell.

Paulraj T, Wennmalm S, Wieland DCF, ..., Cárdenas M, Svagan AJ

Nat Commun 11 (1) 958 [2020-02-19; online 2020-02-19]

Integrated Microscopy Technologies Stockholm [Collaborative]

PubMed DOI Crossref

Clonal competition within complex evolutionary hierarchies shapes AML over time.

Sandén C, Lilljebjörn H, Orsmark Pietras C, ..., Ågerstam H, Fioretos T

Nat Commun 11 (1) 579 [2020-02-05; online 2020-02-05]

Clinical Genomics Lund

PubMed DOI Crossref

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity.

Pillon NJ, Gabriel BM, Dollet L, ..., Krook A, Zierath JR

Nat Commun 11 (1) 470 [2020-01-24; online 2020-01-24]

Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service]

PubMed DOI Crossref

The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly.

Pinese M, Lacaze P, Rath EM, ..., Dinger ME, Thomas DM

Nat Commun 11 (1) 435 [2020-01-23; online 2020-01-23]

NGI Uppsala (Uppsala Genome Center) [Collaborative] National Genomics Infrastructure [Collaborative]

PubMed DOI Crossref

A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice.

Purhonen J, Grigorjev V, Ekiert R, ..., Fellman V, Kallijärvi J

Nat Commun 11 (1) 322 [2020-01-16; online 2020-01-16]

Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.

Shah S, Henry A, Roselli C, ..., Swerdlow DI, Lumbers RT

Nat Commun 11 (1) 163 [2020-01-09; online 2020-01-09]

NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Integrative discovery of treatments for high-risk neuroblastoma.

Almstedt E, Elgendy R, Hekmati N, ..., Krona C, Nelander S

Nat Commun 11 (1) 71 [2020-01-03; online 2020-01-03]

Genome Engineering Zebrafish [Service]

PubMed DOI Crossref

A transposable element insertion is associated with an alternative life history strategy.

Woronik A, Tunström K, Perry MW, ..., Käkelä R, Wheat CW

Nat Commun 10 (1) 5757 [2019-12-17; online 2019-12-17]

NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila.

Ueberschär M, Wang H, Zhang C, ..., Wen J, Dai Q

Nat Commun 10 (1) 5700 [2019-12-13; online 2019-12-13]

NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery

Saei AA, Beusch CM, Chernobrovkin A, ..., Végvári Á, Zubarev RA

Nat Commun 10 (1) 5715 [2019-12-00; online 2019-12-16]

Chemical Proteomics [Technology development]

PubMed DOI Crossref

A cell fitness selection model for neuronal survival during development

Wang Y, Wu H, Fontanet P, ..., Hadjab S, Lallemend F

Nat Commun 10 (1) - [2019-12-00; online 2019-09-12]

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PubMed DOI Crossref

iFISH is a publically available resource enabling versatile DNA FISH to study genome architecture

Gelali E, Girelli G, Matsumoto M, ..., Crosetto N, Bienko M

Nat Commun 10 (1) - [2019-12-00; online 2019-04-09]

Advanced FISH Technologies [Technology development] Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service]

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Towards a standardized bioinformatics infrastructure for N- and O-glycomics

Rojas-Macias MA, Mariethoz J, Andersson P, ..., Lisacek F, Karlsson NG

Nat Commun 10 (1) - [2019-12-00; online 2019-07-22]

Bioinformatics Support and Infrastructure [Technology development] Bioinformatics Support, Infrastructure and Training [Technology development] Glycoproteomics and MS Proteomics [Technology development]

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Programmed DNA elimination of germline development genes in songbirds.

Kinsella CM, Ruiz-Ruano FJ, Dion-Côté AM, ..., Forstmeier W, Suh A

Nat Commun 10 (1) 5468 [2019-11-29; online 2019-11-29]

NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Associations of autozygosity with a broad range of human phenotypes.

Clark DW, Okada Y, Moore KHS, ..., Kubo M, Wilson JF

Nat Commun 10 (1) 4957 [2019-10-31; online 2019-10-31]

NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Puma genomes from North and South America provide insights into the genomic consequences of inbreeding.

Saremi NF, Supple MA, Byrne A, ..., Wilmers CC, Shapiro B

Nat Commun 10 (1) 4769 [2019-10-18; online 2019-10-18]

NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Microbe-host interplay in atopic dermatitis and psoriasis.

Fyhrquist N, Muirhead G, Prast-Nielsen S, ..., Andersson B, Alenius H

Nat Commun 10 (1) 4703 [2019-10-16; online 2019-10-16]

Bioinformatics Support for Computational Resources [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Teumer A, Li Y, Ghasemi S, ..., Pattaro C, Köttgen A

Nat Commun 10 (1) 4130 [2019-09-11; online 2019-09-11]

NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.

Akula MK, Ibrahim MX, Ivarsson EG, ..., Sayin VI, Bergo MO

Nat Commun 10 (1) 3975 [2019-09-04; online 2019-09-04]

Glycoproteomics and MS Proteomics [Service]

PubMed DOI Crossref

Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells.

Marquardt N, Kekäläinen E, Chen P, ..., Ljunggren HG, Michaëlsson J

Nat Commun 10 (1) 3841 [2019-08-26; online 2019-08-26]

NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Profiling surface proteins on individual exosomes using a proximity barcoding assay.

Wu D, Yan J, Shen X, ..., Landegren U, Kamali-Moghaddam M

Nat Commun 10 (1) 3854 [2019-08-26; online 2019-08-26]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Support for Computational Resources [Service] PLA and Single Cell Proteomics [Technology development]

PubMed DOI Crossref

Genome-wide systematic identification of methyltransferase recognition and modification patterns.

Jensen TØ, Tellgren-Roth C, Redl S, ..., Pedersen LE, Nielsen AT

Nat Commun 10 (1) 3311 [2019-08-19; online 2019-08-19]

NGI Uppsala (Uppsala Genome Center) [Collaborative] National Genomics Infrastructure [Collaborative]

PubMed DOI Crossref

PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer.

Costa TDF, Zhuang T, Lorent J, ..., Defilippi P, Strömblad S

Nat Commun 10 (1) 3589 [2019-08-09; online 2019-08-09]

NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC.

Nirwan N, Itoh Y, Singh P, ..., Amunts A, Saikrishnan K

Nat Commun 10 (1) 3058 [2019-07-11; online 2019-07-11]

Cryo-EM [Service]

PubMed DOI Crossref

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.

Shungin D, Haworth S, Divaris K, ..., Timpson NJ, Johansson I

Nat Commun 10 (1) 2773 [2019-06-24; online 2019-06-24]

NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

PubMed DOI Crossref

A quantitative Streptococcus pyogenes-human protein-protein interaction map reveals localization of opsonizing antibodies.

Happonen L, Hauri S, Svensson Birkedal G, ..., Malmström L, Malmström J

Nat Commun 10 (1) 2727 [2019-06-21; online 2019-06-21]

Structural Proteomics [Technology development]

PubMed DOI Crossref

The viral protein corona directs viral pathogenesis and amyloid aggregation.

Ezzat K, Pernemalm M, Pålsson S, ..., Spetz AL, El Andaloussi S

Nat Commun 10 (1) 2331 [2019-05-27; online 2019-05-27]

Bioinformatics Support for Computational Resources [Service] Global Proteomics and Proteogenomics [Technology development]

PubMed DOI Crossref

Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma.

Carow B, Hauling T, Qian X, ..., Nilsson M, Rottenberg ME

Nat Commun 10 (1) 1823 [2019-04-23; online 2019-04-23]

In Situ Sequencing (ISS) [Collaborative]

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NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

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Bioinformatics Support for Computational Resources [Service] NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]

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Bioinformatics Support for Computational Resources [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

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NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

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Bioinformatics Support for Computational Resources [Service] NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]

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Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization.

Bemark M, Hazanov H, Strömberg A, ..., Mehr R, Lycke NY

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Clinical Genomics Gothenburg [Collaborative]

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Bioinformatics and Expression Analysis (BEA) [Service]

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NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.

Mitchell JS, Li N, Weinhold N, ..., Nilsson B, Houlston RS

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Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.

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Nat Commun 7 (-) 11790 [2016-06-06; online 2016-06-06]

Clinical Genomics Lund [Collaborative]

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Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses.

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Nat Commun 7 (-) 11567 [2016-05-16; online 2016-05-16]

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A combined computational and structural model of the full-length human prolactin receptor.

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Nat Commun 7 (-) 11578 [2016-05-13; online 2016-05-13]

Swedish NMR Centre (SNC) [Service]

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Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells.

Bourseau-Guilmain E, Menard JA, Lindqvist E, ..., Welinder C, Belting M

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Structural Proteomics [Service]

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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.

Almqvist H, Axelsson H, Jafari R, ..., Lundbäck T, Nordlund P

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Chemical Biology Consortium Sweden (CBCS) [Collaborative] Protein Science Facility (PSF) [Service]

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VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread.

Li X, Padhan N, Sjöström EO, ..., Jansson L, Claesson-Welsh L

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Bioinformatics Support and Infrastructure [Service] Bioinformatics Support for Computational Resources [Service] Bioinformatics Support, Infrastructure and Training [Service] NGI Uppsala (Uppsala Genome Center) [Service] National Genomics Infrastructure [Service]

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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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Bioinformatics Support for Computational Resources [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

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Bioinformatics Support for Computational Resources [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

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Nat Commun 7 (1) 10023 [2016-01-21; online 2016-01-21]

Bioinformatics Support for Computational Resources [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

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NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure

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Structural insights into the DNA-binding specificity of E2F family transcription factors.

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Karolinska High Throughput Center (KHTC) Protein Science Facility (PSF)

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Mutation Analysis Facility (MAF)

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