Extracellular Vesicle-Associated TWEAK Contributes to Vascular Inflammation and Remodeling During Acute Cellular Rejection.

Celik S, Sadrian J, Grossi M, Czuba T, Lundgren J, Rådegran G, Laurell T, Smith JG, Gidlöf O

JACC Basic Transl Sci 8 (5) 439-456 [2023-05-00; online 2023-01-11]

Acute cellular rejection (ACR) is a leading cause of graft loss and death after heart transplantation despite effective immunosuppressive therapies. The identification of factors that impair graft vascular barrier function or promote immune cell recruitment during ACR could provide new therapeutic opportunities for the treatment of patients who receive transplants. In 2 ACR cohorts, we found the extracellular vesicle-associated cytokine TWEAK to be elevated during ACR. Vesicular TWEAK promoted expression of proinflammatory genes and the release of chemoattractant cytokines from human cardiac endothelial cells. We conclude that vesicular TWEAK is a novel target with potential therapeutic implications in ACR.

Affinity Proteomics Uppsala [Service]

PubMed 37325400

DOI 10.1016/j.jacbts.2022.09.014

Crossref 10.1016/j.jacbts.2022.09.014

pmc: PMC10264567
pii: S2452-302X(22)00381-3