Helleday T

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Family name Helleday
Given name Thomas
Initials T
ORCID

ORCID 0000-0002-7384-092X
Affiliations Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

49 publications

PubMed DOI Crossref
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.
Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M
Nat Commun 15 (1) 10347 [2024-12-06; online 2024-12-06]
Chemical Biology Consortium Sweden [Service]
PubMed DOI Crossref
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue.
Zhang N, Harbers L, Simonetti M, ..., Bienko M, Crosetto N
Nat Commun 15 (1) 3475 [2024-04-24; online 2024-04-24]
Bioinformatics Support for Computational Resources [Service] NGI Short read [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Green AC, Marttila P, Kiweler N, ..., Henriksson M, Meiser J
Nat Metab 5 (4) 642-659 [2023-04-00; online 2023-04-03]
Drug Discovery and Development [Collaborative] Swedish Metabolomics Centre [Collaborative]
PubMed DOI Crossref
Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones.
Marklund M, Schultz N, Friedrich S, ..., Sonnhammer E, Lundeberg J
Nat Commun 13 (1) 5475 [2022-09-17; online 2022-09-17]
NGI Short read [Service] NGI Spatial omics NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
Spatially resolved clonal copy number alterations in benign and malignant tissue.
Erickson A, He M, Berglund E, ..., Lamb AD, Lundeberg J
Nature 608 (7922) 360-367 [2022-08-00; online 2022-08-10]
NGI Short read [Service] NGI Spatial omics [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Bonagas N, Gustafsson NMS, Henriksson M, ..., Homan EJ, Helleday T
Nat Cancer 3 (2) 156-172 [2022-02-00; online 2022-02-28]
Drug Discovery and Development [Collaborative]
PubMed DOI Crossref
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses.
Tampere M, Pettke A, Salata C, ..., Jafari R, Puumalainen MR
Viruses 12 (12) 1423 [2020-12-10; online 2020-12-10]
Global Proteomics and Proteogenomics [Service]
PubMed DOI Crossref
Development of a chemical probe against NUDT15.
Zhang SM, Desroses M, Hagenkort A, ..., Stenmark P, Helleday T
Nat. Chem. Biol. 16 (10) 1120-1128 [2020-10-00; online 2020-07-20]
Chemical Biology Consortium Sweden [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Škerlová J, Unterlass J, Göttmann M, ..., Jemth AS, Stenmark P
J. Biol. Chem. 295 (33) 11656-11668 [2020-08-14; online 2020-06-22]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
High content drug screening for Fanconi anemia therapeutics.
Montanuy H, Camps-Fajol C, Carreras-Puigvert J, ..., Minguillón J, Surrallés J
Orphanet J Rare Dis 15 (1) 170 [2020-06-30; online 2020-06-30]
Drug Discovery and Development
PubMed DOI Crossref
In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization.
Michel M, Homan EJ, Wiita E, ..., Helleday T, Warpman Berglund U
Front. Chem. 8 (-) 443 [2020-05-29; online 2020-05-29]
Chemical Biology Consortium Sweden [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS
J. Biol. Chem. 295 (15) 4761-4772 [2020-04-10; online 2020-03-06]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds.
Peuget S, Zhu J, Sanz G, ..., Zubarev R, Selivanova G
Cancer Res. 80 (7) 1538-1550 [2020-04-01; online 2020-02-04]
Chemical Proteomics [Collaborative]
PubMed DOI Crossref
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics.
Herr P, Boström J, Rullman E, ..., Maddalo G, Altun M
Mol. Cell Proteomics 19 (4) 608-623 [2020-04-00; online 2020-02-12]
Global Proteomics and Proteogenomics [Collaborative]
PubMed DOI Crossref
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
Rudd SG, Tsesmetzis N, Sanjiv K, ..., Helleday T, Herold N
EMBO Mol Med 12 (3) e10419 [2020-03-06; online 2020-01-17]
Chemical Biology Consortium Sweden [Collaborative]
PubMed DOI Crossref
The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
Scaletti E, Claesson M, Helleday T, Jemth AS, Stenmark P
J. Mol. Biol. 432 (4) 1126-1142 [2020-02-14; online 2020-01-15]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Computational and Experimental Druggability Assessment of Human DNA Glycosylases.
Michel M, Visnes T, Homan EJ, ..., Warpman Berglund U, Helleday T
ACS Omega 4 (7) 11642-11656 [2019-07-31; online 2019-07-05]
Chemical Biology Consortium Sweden [Collaborative] Swedish NMR Centre [Collaborative]
PubMed DOI Crossref
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
Scaletti E, Jemth AS, Helleday T, Stenmark P
FEBS Lett. 593 (14) 1863-1873 [2019-07-00; online 2019-06-10]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P
Biochemistry 58 (7) 887-899 [2019-02-19; online 2019-01-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
Gustafsson NMS, Färnegårdh K, Bonagas N, ..., Olin T, Helleday T
Nat Commun 9 (1) - [2018-12-00; online 2018-09-24]
Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden [Service] Drug Discovery and Development [Collaborative]
PubMed DOI Crossref
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Visnes T, Cázares-Körner A, Hao W, ..., Boldogh I, Helleday T
Science 362 (6416) 834-839 [2018-11-16; online 2018-11-18]
Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden [Collaborative] Chemical Proteomics [Collaborative] Drug Discovery and Development [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Jemth AS, Gustafsson R, Bräutigam L, ..., Stenmark P, Helleday T
Nucleic Acids Res. 46 (20) 10888-10904 [2018-11-16; online 2018-10-12]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions.
Desroses M, Busker S, Astorga-Wells J, ..., Grandér D, Page BDG
Journal of Pharmaceutical and Biomedical Analysis 160 (-) 80-88 [2018-10-25; online 2018-07-17]
Chemical Proteomics [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
An orthotopic glioblastoma animal model suitable for high-throughput screenings.
Pudelko L, Edwards S, Balan M, ..., Helleday T, Bräutigam L
Neuro-oncology 20 (11) 1475-1484 [2018-10-09; online 2018-05-12]
Integrated Microscopy Technologies Stockholm [Collaborative]
PubMed DOI Crossref
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma.
Einarsdottir BO, Karlsson J, Söderberg EMV, ..., Helleday T, Nilsson JA
Cell Death Dis 9 (8) 810 [2018-07-24; online 2018-07-24]
Bioinformatics Support for Computational Resources [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Berglund E, Maaskola J, Schultz N, ..., Helleday T, Lundeberg J
Nat Commun 9 (1) 2419 [2018-06-20; online 2018-06-20]
Bioinformatics Support for Computational Resources [Service] NGI Stockholm (Genomics Applications) [Service] NGI Stockholm (Genomics Production) [Service] National Genomics Infrastructure [Service]
PubMed DOI Crossref
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Narwal M, Jemth AS, Gustafsson R, ..., Helleday T, Stenmark P
Biochemistry 57 (5) 593-603 [2018-02-06; online 2018-01-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
Carter M, Jemth AS, Carreras-Puigvert J, ..., Helleday T, Stenmark P
Structure 26 (2) 295-303.e6 [2018-02-06; online 2018-02-08]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
Glimelius B, Melin B, Enblad G, ..., Palmqvist R, Sjöblom T
Acta Oncol 57 (2) 187-194 [2018-02-00; online 2017-06-20]
Tissue Profiling [Collaborative]
PubMed DOI Crossref
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page BDG, Valerie NCK, Wright RHG, ..., Beato M, Helleday T
Nat Commun 9 (1) 250 [2018-01-17; online 2018-01-17]
Bioinformatics Support for Computational Resources [Service] Chemical Biology Consortium Sweden [Collaborative] Drug Discovery and Development [Service] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Carreras-Puigvert J, Zitnik M, Jemth AS, ..., Zupan B, Helleday T
Nat Commun 8 (1) - [2017-12-00; online 2017-11-16]
BioImage Informatics [Collaborative] Bioinformatics (NBIS) [Collaborative] Drug Discovery and Development [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.
Pudelko L, Rouhi P, Sanjiv K, ..., Helleday T, Bräutigam L
Oncotarget 8 (49) 84671-84684 [2017-10-17; online 2017-07-20]
Integrated Microscopy Technologies Stockholm [Collaborative]
PubMed DOI Crossref
Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.
Llona-Minguez S, Throup A, Steiner E, ..., Jenmalm-Jensen A, Helleday T
Org. Biomol. Chem. 15 (37) 7758-7764 [2017-09-26; online 2017-09-12]
Chemical Biology Consortium Sweden [Collaborative]
PubMed DOI Crossref
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.
Asim M, Tarish F, Zecchini HI, ..., Neal D, Helleday T
Nat Commun 8 (1) 374 [2017-08-29; online 2017-08-29]
Advanced FISH Technologies [Collaborative]
PubMed DOI Crossref
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.
Llona-Minguez S, Häggblad M, Martens U, ..., Scobie M, Helleday T
Bioorg. Med. Chem. Lett. 27 (16) 3897-3904 [2017-08-15; online 2017-06-16]
Drug Discovery and Development [Collaborative]
PubMed DOI Crossref
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.
Llona-Minguez S, Häggblad M, Martens U, ..., Scobie M, Helleday T
Bioorg. Med. Chem. Lett. 27 (15) 3219-3225 [2017-08-01; online 2017-06-15]
Chemical Biology Consortium Sweden [Collaborative] Drug Discovery and Development [Service]
PubMed DOI Crossref
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines.
Llona-Minguez S, Ghassemian A, Baranczewski P, ..., Scobie M, Helleday T
Med. Chem. Commun. 8 (7) 1553-1560 [2017-07-01; online 2017-07-04]
Drug Discovery and Development [Collaborative]
PubMed DOI Crossref
Identification of novel small molecules that inhibit STAT3-dependent transcription and function.
Kolosenko I, Yu Y, Busker S, ..., Page BDG, Grander D
PLoS ONE 12 (6) e0178844 [2017-06-21; online 2017-06-21]
Chemical Biology Consortium Sweden [Collaborative]
PubMed DOI Crossref
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez S, Höglund A, Ghassemian A, ..., Scobie M, Helleday T
J. Med. Chem. 60 (10) 4279-4292 [2017-05-25; online 2017-05-16]
Chemical Biology Consortium Sweden [Collaborative] Drug Discovery and Development [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
dUTPase inhibition augments replication defects of 5-Fluorouracil.
Hagenkort A, Paulin CBJ, Desroses M, ..., Scobie M, Helleday T
Oncotarget 8 (14) 23713-23726 [2017-04-04; online 2017-04-21]
Chemical Biology Consortium Sweden [Collaborative]
PubMed DOI Crossref
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Wiita E, ..., Scobie M, Helleday T
J. Med. Chem. 60 (5) 2148-2154 [2017-03-09; online 2017-02-15]
Chemical Biology Consortium Sweden [Collaborative] Drug Discovery and Development [Service]
PubMed DOI Crossref
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Gustafsson R, Jemth AS, Gustafsson NM, ..., Helleday T, Stenmark P
Cancer Res. 77 (4) 937-948 [2017-02-15; online 2016-11-29]
Drug Discovery and Development [Collaborative]
PubMed DOI Crossref
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N, Rudd SG, Ljungblad L, ..., Helleday T, Schaller T
Nat. Med. 23 (2) 256-263 [2017-02-00; online 2017-01-09]
Chemical Biology Consortium Sweden [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Validation and development of MTH1 inhibitors for treatment of cancer.
Warpman Berglund U, Sanjiv K, Gad H, ..., Scobie M, Helleday T
Ann. Oncol. 27 (12) 2275-2283 [2016-12-00; online 2016-11-08]
Advanced Mass Spectrometry Proteomics [Collaborative] Bioinformatics (NBIS) [Collaborative] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Chemical Biology Consortium Sweden [Collaborative] Chemical Proteomics [Service] Clinical Proteomics Mass spectrometry [Collaborative] Drug Discovery and Development [Collaborative]
PubMed DOI Crossref
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Valerie NC, Hagenkort A, Page BD, ..., Jemth AS, Helleday T
Cancer Res. 76 (18) 5501-5511 [2016-09-15; online 2016-08-16]
Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Llona-Minguez S, Höglund A, Jacques SA, ..., Scobie M, Helleday T
J. Med. Chem. 59 (3) 1140-1148 [2016-02-11; online 2016-01-27]
Chemical Biology Consortium Sweden [Collaborative] Drug Discovery and Development [Collaborative] Protein Science Facility (PSF) [Service]
PubMed DOI Crossref
PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription.
Zhao H, Sifakis EG, Sumida N, ..., Imreh MP, Göndör A
Mol. Cell 59 (6) 984-997 [2015-09-17; online 2015-08-27]
NGI Stockholm (Genomics Applications) NGI Stockholm (Genomics Production) National Genomics Infrastructure
PubMed DOI Crossref
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Carter M, Jemth AS, Hagenkort A, ..., Helleday T, Stenmark P
Nat Commun 6 (-) 7871 [2015-08-04; online 2015-08-04]
Protein Science Facility (PSF)
PubMed DOI Crossref
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad H, Koolmeister T, Jemth A, ..., Berglund UW, Helleday T
Nature 508 (7495) 215-221 [2014-04-10; online 2014-04-02]
Chemical Biology Consortium Sweden [Collaborative] Drug Discovery and Development [Collaborative] Protein Science Facility (PSF)
SciLifeLab Data Centre
Publications 9.5.1