Protein measurements in venous plasma, earlobe capillary plasma and in plasma stored on filter paper.

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Siart B, de Oliveira FMS, Shen Q, Björkesten J, Pekar T, Steinborn R, Nimmerichter A, Kamali-Moghaddam M, Wallner B

Anal. Biochem. 566 (-) 146-150 [2019-02-01; online 2018-11-22]

In this study, levels of inflammatory protein biomarkers in venous plasma, plasma derived from capillary blood from the earlobe, and capillary plasma stored as dried plasma spots (DPS) were compared. Samples from 12 male individuals were assessed with a panel of 92 inflammation-related proteins using multiplex proximity extension assay. Correlations between sample types varied greatly between analytes. A high correlation of ρ > 0.8 was observed between capillary plasma and DPS for 32 analytes. At this level of correlation, 13 analytes correlated between venous and capillary plasma and 5 analytes in the comparison of venous blood with DPS.

Affinity Proteomics Uppsala [Technology development]

PLA and Single Cell Proteomics [Technology development]

PubMed 30472219

DOI 10.1016/j.ab.2018.11.016

Crossref 10.1016/j.ab.2018.11.016

pii: S0003-2697(18)30655-9