Clinical Biomarkers

Viral antigens elicit augmented immune responses in primary Sjögren's syndrome.

Björk A, Thorlacius GE, Mofors J, ..., Kvarnström M, Wahren-Herlenius M

Rheumatology (Oxford) 59 (7) 1651-1661 [2020-07-01; online 2019-10-31]

Inflammatory markers in women with postpartum depressive symptoms.

Bränn E, Fransson E, White RA, ..., Sundström-Poromaa I, Skalkidou A

J Neuro Res 98 (7) 1309-1321 [2020-07-00; online 2018-09-05]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service]

Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years.

Schulz CA, Engström G, Nilsson J, ..., Melander O, Orho-Melander M

Nephrol Dial Transplant 35 (2) 265-273 [2020-02-01; online 2019-01-11]

Associations Between Apolipoprotein A1, High-Density Lipoprotein Cholesterol, and Urinary Cytokine Levels in Elderly Males and Females.

Fellström B, Helmersson-Karlqvist J, Lind L, ..., Ärnlöv J, Larsson A

Journal of Interferon & Cytokine Research 40 (2) 71-74 [2020-02-00; online 2019-10-10]

Identification of novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm.

Memon AA, Zarrouk M, Ågren-Witteschus S, ..., Gottsäter A, Sundquist K

Eur J Prev Cardiol 27 (2) 132-142 [2020-01-00; online 2019-08-29]

Protein and DNA methylation-based scores as surrogate markers for interferon system activation in patients with primary Sjögren’s syndrome

Björk A, Richardsdotter Andersson E, Imgenberg-Kreuz J, ..., Nordmark G, Wahren-Herlenius M

RMD Open 6 (1) e000995 [2020-01-00; online 2020-01-07]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Year 2019

The associations of self-rated health with cardiovascular risk proteins: a proteomics approach.

Bao X, Borné Y, Yin S, ..., Melander O, Engström G

Clin Proteomics 16 (1) 40 [2019-11-18; online 2019-11-18]

Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders.

Sundberg I, Rasmusson AJ, Ramklint M, ..., Ekselius L, Cunningham JL

Psychoneuroendocrinology 112 (-) 104514 [2019-11-14; online 2019-11-14]

Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service] Clinical Biomarkers [Service]

Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts.

Stattin K, Lind L, Elmståhl S, ..., Michaëlsson K, Byberg L

Eur J Prev Cardiol 26 (17) 1865-1873 [2019-11-00; online 2019-08-14]

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum.

Rajan MR, Sotak M, Barrenäs F, ..., Lange S, Börgeson E

Sci Rep 9 (1) 15385 [2019-10-28; online 2019-10-28]

Proteomic Analysis of Longitudinal Changes in Blood Pressure.

Lin YT, Fall T, Hammar U, ..., Engström G, Sundström J

J Clin Med 8 (10) 1585 [2019-10-02; online 2019-10-02]

Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death.

Grufman H, Yndigegn T, Gonçalves I, Nilsson J, Schiopu A

Cytokine 122 (-) 154208 [2019-10-00; online 2018-02-07]

Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation.

Olsson KW, Larsson A, Jonzon A, Sindelar R

Pediatr. Res. 86 (3) 333-338 [2019-09-00; online 2018-09-18]

In search of causal pathways in diabetes: a study using proteomics and genotyping data from a cross-sectional study.

Beijer K, Nowak C, Sundström J, ..., Fall T, Lind L

Diabetologia - (-) - [2019-08-24; online 2019-08-24]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Circulating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes: A Population-Based Cohort Study.

Muhammad IF, Borné Y, Bao X, ..., Nilsson J, Engström G

Diabetes Care 42 (8) 1582-1588 [2019-08-00; online 2019-06-14]

sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events.

Gonçalves I, Singh P, Tengryd C, ..., Nilsson J, Edsfeldt A

Stroke 50 (8) 1989-1996 [2019-08-00; online 2019-07-05]

Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung.

Djureinovic D, Pontén V, Landelius P, ..., Micke P, Ståhle E

BMC Cancer 19 (1) 741 [2019-07-29; online 2019-07-29]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service]

Proteomic profiling of extracellular vesicles reveals additional diagnostic biomarkers for myocardial infarction compared to plasma alone.

Gidlöf O, Evander M, Rezeli M, ..., Laurell T, Erlinge D

Sci Rep 9 (1) 8991 [2019-06-20; online 2019-06-20]

Dietary Pattern Specific Protein Biomarkers for Cardiovascular Disease: A Cross-Sectional Study in 2 Independent Cohorts.

Warensjö Lemming E, Byberg L, Stattin K, ..., Wolk A, Michaëlsson K

J Am Heart Assoc 8 (11) e011860 [2019-06-04; online 2019-06-01]

A targeted proteomics approach reveals a serum protein signature as diagnostic biomarker for resectable gastric cancer.

Shen Q, Polom K, Williams C, ..., Roviello F, Kamali-Moghaddam M

EBioMedicine 44 (-) 322-333 [2019-06-00; online 2019-05-28]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] Glycoproteomics [Collaborative]

Circulating mast cell progenitors correlate with reduced lung function in allergic asthma.

Salomonsson M, Malinovschi A, Kalm-Stephens P, ..., Alving K, Hallgren J

Clin Exp Allergy 49 (6) 874-882 [2019-06-00; online 2019-03-21]

Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study.

Borné Y, Fagerberg B, Sallsten G, ..., Barregard L, Engström G

Clin Proteomics 16 (1) 21 [2019-05-15; online 2019-05-15]

Cardiovascular organ damage in type 2 diabetes mellitus: the role of lipids and inflammation.

Kozakova M, Morizzo C, Goncalves I, ..., Nilsson J, Palombo C

Cardiovasc Diabetol 18 (1) 61 [2019-05-10; online 2019-05-10]

Elevated circulating effector memory T cells but similar levels of regulatory T cells in patients with type 2 diabetes mellitus and cardiovascular disease.

Rattik S, Engelbertsen D, Wigren M, ..., Nilsson J, Björkbacka H

Diabetes and Vascular Disease Research 16 (3) 270-280 [2019-05-00; online 2018-12-21]

Increased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke.

Berntsson J, Smith JG, Johnson LSB, ..., Nilsson J, Engström G

Heart 105 (7) 553-558 [2019-04-00; online 2018-10-16]

High Serum sCD40 and a Distinct Colonic T Cell Profile in Ulcerative Colitis Associated With Primary Sclerosing Cholangitis.

Lampinen M, Vessby J, Fredricsson A, ..., Rorsman F, Carlson M

J Crohns Colitis 13 (3) 341-350 [2019-03-26; online 2018-11-02]

Longitudinal effects of aging on plasma proteins levels in older adults - associations with kidney function and hemoglobin levels.

Lind L, Sundström J, Larsson A, ..., Ärnlöv J, Ingelsson E

PLoS ONE 14 (2) e0212060 [2019-02-25; online 2019-02-25]

High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke.

Markstad H, Edsfeldt A, Yao Mattison I, ..., Engström G, Gonçalves I

J Am Heart Assoc 8 (4) e009874 [2019-02-19; online 2019-02-13]

Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease.

Feldreich T, Nowak C, Fall T, ..., Green D, Ärnlöv J

J Nephrol 32 (1) 111-119 [2019-02-00; online 2018-11-29]

Metformin is the key factor in elevated plasma growth differentiation factor-15 levels in type 2 diabetes: A nested, case-control study.

Natali A, Nesti L, Venturi E, ..., Nilsson J, SUMMIT consortium

Diabetes Obes Metab 21 (2) 412-416 [2019-02-00; online 2018-10-02]

AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis.

Ek M, Roth B, Engström G, Ohlsson B

Int J Mol Sci 20 (1) 189 [2019-01-07; online 2019-01-07]

Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins.

Almén MS, Björk J, Nyman U, ..., Christensson A, Grubb A

Kidney International Reports 4 (1) 67-79 [2019-01-00; online 2018-09-13]

Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmö Diet and Cancer-Cardiovascular Cohort.

Bao X, Borné Y, Muhammad IF, ..., Orho-Melander M, Engström G

Diabetologia 62 (1) 78-86 [2019-01-00; online 2018-10-22]

Year 2018

Protein profiling of fine-needle aspirates reveals subtype-associated immune signatures and involvement of chemokines in breast cancer.

Franzén B, Alexeyenko A, Kamali-Moghaddam M, ..., Landegren U, Lewensohn R

Mol Oncol 13 (2) 376-391 [2018-11-19; online 2018-11-19]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service]

Markers of Basement Membrane Remodeling Are Associated With Higher Mortality in Patients With Known Atherosclerosis.

Holm Nielsen S, Tengryd C, Edsfeldt A, ..., Nilsson J, Goncalves I

J Am Heart Assoc 7 (21) e009193 [2018-11-06; online 2019-01-05]

Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study.

Shore AC, Colhoun HM, Natali A, ..., Nilsson J, SUMMIT Consortium

Diabetes Care 41 (10) 2212-2219 [2018-10-00; online 2018-07-30]

Associations of Circulating Protein Levels With Lipid Fractions in the General Population.

Figarska SM, Gustafsson S, Sundström J, ..., Lind L, Ingelsson E

Arterioscler. Thromb. Vasc. Biol. 38 (10) 2505-2518 [2018-10-00; online 2018-10-26]

Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality.

Fernandez C, Rysä J, Almgren P, ..., Ruskoaho H, Melander O

J. Intern. Med. 284 (4) 377-387 [2018-10-00; online 2018-07-02]

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.

Lovric A, Granér M, Bjornson E, ..., Mardinoglu A, Boren J

Sci Rep 8 (1) 14200 [2018-09-21; online 2018-09-21]

FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke.

Muhammad IF, Borné Y, Melander O, ..., Söderholm M, Engström G

Stroke 49 (9) 2224-2226 [2018-09-00; online 2018-10-26]

A fine-needle aspiration-based protein signature discriminates benign from malignant breast lesions

Franzén B, Kamali-Moghaddam M, Alexeyenko A, ..., Landegren U, Lewensohn R

Mol Oncol 12 (9) 1415-1428 [2018-09-00; online 2018-08-09]

Affinity Proteomics Uppsala [Technology development] Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service]

Proteomic Biomarkers for Incident Aortic Stenosis Requiring Valvular Replacement.

Ljungberg J, Janiec M, Bergdahl IA, ..., Fall T, Söderberg S

Circulation 138 (6) 590-599 [2018-08-07; online 2018-03-01]

Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer

Birgisson H, Tsimogiannis K, Freyhult E, Kamali-Moghaddam M

Transl Oncol 11 (4) 1034-1043 [2018-08-00; online 2018-08-00]

Affinity Proteomics Uppsala [Service] Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service]

Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing.

Aqrawi LA, Ivanchenko M, Björk A, ..., Skarstein K, Wahren-Herlenius M

Clin. Exp. Immunol. 192 (3) 259-270 [2018-06-00; online 2018-03-24]

Inflammatory biomarker profiling in classical orthostatic hypotension: Insights from the SYSTEMA cohort.

Johansson M, Ricci F, Aung N, ..., Melander O, Fedorowski A

Int. J. Cardiol. 259 (-) 192-197 [2018-05-15; online 2018-03-27]

Identification of novel diagnostic biomarkers for deep venous thrombosis.

Memon AA, Sundquist K, PirouziFard M, ..., Sundquist J, Zöller B

Br. J. Haematol. 181 (3) 378-385 [2018-05-00; online 2018-04-19]

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4 + T Cells and Is Immunosuppressive in Type 1 Diabetes

Bhandage AK, Jin Z, Korol SV, ..., Kamali-Moghaddam M, Birnir B

EBioMedicine 30 (-) 283-294 [2018-04-00; online 2018-04-00]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service]

Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome

Ramqvist T, Näsman A, Franzén B, ..., Dalianis T, Munck-Wikland E

Int J Mol Sci 19 (4) 978 [2018-03-25; online 2018-03-25]

Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service]

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

Mardinoglu A, Wu H, Bjornson E, ..., Taskinen MR, Borén J

Cell Metab. 27 (3) 559-571.e5 [2018-03-06; online 2018-02-15]

Proteomic Profiling for Cardiovascular Biomarker Discovery in Orthostatic Hypotension.

Johansson M, Ricci F, Aung N, ..., Melander O, Fedorowski A

Hypertension 71 (3) 465-472 [2018-03-00; online 2018-01-02]

Galectin-3 levels relate in children to total body fat, abdominal fat, body fat distribution, and cardiac size.

Dencker M, Arvidsson D, Karlsson MK, ..., Andersen LB, Thorsson O

Eur J Pediatr 177 (3) 461-467 [2018-03-00; online 2018-01-11]

Cardiovascular disease in systemic lupus erythematosus is associated with increased levels of biomarkers reflecting receptor-activated apoptosis

Wigren M, Svenungsson E, Mattisson IY, ..., Fredrikson GN, Nilsson J

Atherosclerosis 270 (-) 1-7 [2018-03-00; online 2018-03-00]

Vascular Endothelial Growth Factor D, Pulmonary Congestion, and Incidence of Heart Failure.

Borné Y, Gränsbo K, Nilsson J, ..., Smith JG, Engström G

J. Am. Coll. Cardiol. 71 (5) 580-582 [2018-02-06; online 2018-02-07]

Spotty Carotid Plaques Are Associated with Inflammation and the Occurrence of Cerebrovascular Symptoms.

Halak S, Östling G, Edsfeldt A, ..., Gonçalves I, Asciutto G

Cerebrovasc Dis Extra 8 (1) 16-25 [2018-01-15; online 2018-01-15]

Year 2017

High levels of cerebrospinal fluid chemokines point to the presence of neuroinflammation in peripheral neuropathic pain: a cross-sectional study of 2 cohorts of patients compared with healthy controls.

Bäckryd E, Lind AL, Thulin M, ..., Gerdle B, Gordh T

Pain 158 (12) 2487-2495 [2017-12-00; online 2017-09-21]

Elevated Markers of Death Receptor-Activated Apoptosis are Associated with Increased Risk for Development of Diabetes and Cardiovascular Disease.

Mattisson IY, Björkbacka H, Wigren M, ..., Almgren P, Nilsson J

EBioMedicine 26 (-) 187-197 [2017-12-00; online 2017-11-24]

Autoantibodies against aldehyde-modified collagen type IV are associated with risk of development of myocardial infarction.

Vallejo J, Dunér P, Fredrikson GN, Nilsson J, Bengtsson E

J. Intern. Med. 282 (6) 496-507 [2017-12-00; online 2017-09-25]

Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue.

Boldrup L, Troiano G, Gu X, ..., Wang L, Nylander K

Oncotarget 8 (61) 103437-103448 [2017-11-28; online 2017-09-30]

Targeted proteomic analysis of habitual coffee consumption.

Cornelis MC, Gustafsson S, Ärnlöv J, ..., Lind L, Ingelsson E

J. Intern. Med. - (-) - [2017-10-16; online 2017-10-16]

Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles.

Andersson E, Bergemalm D, Kruse R, ..., Repsilber D, Halfvarson J

PLoS ONE 12 (10) e0186142 [2017-10-05; online 2017-10-05]

Circulating proteins as predictors of incident heart failure in the elderly.

Stenemo M, Nowak C, Byberg L, ..., Fall T, Ärnlöv J

Eur. J. Heart Fail. - (-) - [2017-10-02; online 2017-10-02]

Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke.

Sundström J, Söderholm M, Borné Y, ..., Orho-Melander M, Engström G

Stroke 48 (10) 2686-2692 [2017-10-00; online 2017-09-13]

GDF-15 and TRAIL-R2 are powerful predictors of long-term mortality in patients with acute myocardial infarction.

Skau E, Henriksen E, Wagner P, ..., Siegbahn A, Leppert J

Eur J Prev Cardiol 24 (15) 1576-1583 [2017-10-00; online 2017-08-01]

Tumor Necrosis Factor Receptor 1 and 2 Are Associated With Risk of Intracerebral Hemorrhage.

Svensson EH, Söderholm M, Abul-Kasim K, Engström G

Stroke 48 (10) 2710-2715 [2017-10-00; online 2017-08-22]

Plasma stem cell factor levels are associated with risk of cardiovascular disease and death

Björkbacka H, Yao Mattisson I, Wigren M, ..., Engström G, Nilsson J

J Intern Med - (-) - [2017-09-21; online 2017-09-21]

Effect of food intake on 92 neurological biomarkers in plasma.

Dencker M, Björgell O, Hlebowicz J

Brain Behav 7 (9) e00747 [2017-09-00; online 2017-08-01]

Proteomics in Hypothermia as Adjunctive Therapy in Patients with ST-Segment Elevation Myocardial Infarction: A CHILL-MI Substudy.

Mohammad MA, Noc M, Lang I, ..., Metzler B, Erlinge D

Ther Hypothermia Temp Manag 7 (3) 152-161 [2017-09-00; online 2017-03-02]

Circulating GDF-15 levels predict future secondary manifestations of cardiovascular disease explicitly in women but not men with atherosclerosis.

Gohar A, Gonçalves I, Vrijenhoek J, ..., Björkbacka H, de Jager SCA

Int. J. Cardiol. 241 (-) 430-436 [2017-08-15; online 2017-03-22]

Use of Proteomics To Investigate Kidney Function Decline over 5 Years.

Carlsson AC, Ingelsson E, Sundström J, ..., Lind L, Ärnlöv J

Clin J Am Soc Nephrol 12 (8) 1226-1235 [2017-08-07; online 2017-07-21]

Alterations of anti-inflammatory lipids in plasma from women with chronic widespread pain - a case control study.

Stensson N, Ghafouri B, Gerdle B, Ghafouri N

Lipids Health Dis 16 (1) 112 [2017-06-12; online 2017-06-12]

Effect of food intake on 92 biomarkers for cardiovascular disease.

Dencker M, Gårdinger Y, Björgell O, Hlebowicz J

PLoS ONE 12 (6) e0178656 [2017-06-06; online 2017-06-06]

Lower inflammatory markers in women with antenatal depression brings the M1/M2 balance into focus from a new direction

Edvinsson Å, Bränn E, Hellgren C, ..., Cunningham JL, Sundström-Poromaa I

Psychoneuroendocrinology 80 (-) 15-25 [2017-06-00; online 2017-06-00]

Affinity Proteomics Uppsala [Collaborative] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service]

Inflammatory markers in late pregnancy in association with postpartum depression-A nested case-control study.

Bränn E, Papadopoulos F, Fransson E, ..., Sundström-Poromaa I, Skalkidou A

Psychoneuroendocrinology 79 (-) 146-159 [2017-05-00; online 2017-02-28]

Affinity Proteomics Uppsala [Collaborative] Clinical Biomarkers [Service]

FADD, Caspase-3, and Caspase-8 and Incidence of Coronary Events.

Xue L, Borné Y, Mattisson IY, ..., Nilsson J, Engström G

Arterioscler. Thromb. Vasc. Biol. 37 (5) 983-989 [2017-05-00; online 2017-03-16]

Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients.

Schiza A, Wenthe J, Mangsbo S, ..., Loskog A, Ullenhag G

J Transl Med 15 (1) 79 [2017-04-20; online 2017-04-20]

Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children.

Dencker M, Danielson A, Karlsson MK, ..., Andersen LB, Thorsson O

J Pediatr Endocrinol Metab 30 (4) 375-382 [2017-04-01; online 2017-01-14]

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.

Folkersen L, Fauman E, Sabater-Lleal M, ..., Hamsten A, Mälarstig A

PLoS Genet. 13 (4) e1006706 [2017-04-00; online 2017-04-03]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Cardiometabolic biomarkers are predictors of readmission and death in patients hospitalized for acute dyspnea.

Lund N, Gränsbo K, Wernersson C, Melander O

The American Journal of Emergency Medicine 35 (4) 610-614 [2017-04-00; online 2016-12-22]

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma.

Bäckryd E, Tanum L, Lind AL, Larsson A, Gordh T

J Pain Res 10 (-) 515-525 [2017-03-03; online 2017-03-03]

Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip.

Lind L, Sundström J, Stenemo M, Hagström E, Ärnlöv J

Heart 103 (5) 377-382 [2017-03-00; online 2016-09-10]

Use of a proximity extension assay proteomics chip to discover new biomarkers associated with albuminuria.

Carlsson AC, Sundström J, Carrero JJ, ..., Lind L, Ärnlöv J

Eur J Prev Cardiol 24 (4) 340-348 [2017-03-00; online 2016-10-28]

Signs of ongoing inflammation in female patients with chronic widespread pain: A multivariate, explorative, cross-sectional study of blood samples.

Gerdle B, Ghafouri B, Ghafouri N, Bäckryd E, Gordh T

Medicine 96 (9) e6130 [2017-03-00; online 2017-03-02]

IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation.

Jónsdóttir B, Jaworowski Å, San Miguel C, Melander O

BMC Pulm Med 17 (1) 35 [2017-02-08; online 2017-02-08]

Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.

Molin CJ, Westerberg E, Punga AR

Sci Rep 7 (1) 39716 [2017-01-03; online 2017-01-03]

Year 2016

Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes

Gonçalves I, None , Edsfeldt A, ..., Schnecke V, Nilsson J

BMC Cardiovasc Disord 16 (1) - [2016-12-00; online 2016-09-05]

DcR3, TFF3, and Midkine Are Novel Serum Biomarkers in Small Intestinal Neuroendocrine Tumors.

Edfeldt K, Daskalakis K, Bäcklin C, ..., Hellman P, Stålberg P

Neuroendocrinology 105 (2) 170-181 [2016-11-09; online 2016-11-09]

Effects of cigarette smoking on cardiovascular-related protein profiles in two community-based cohort studies.

Huang B, Svensson P, Ärnlöv J, ..., Lind L, Ingelsson E

Atherosclerosis 254 (-) 52-58 [2016-11-00; online 2016-09-30]

Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study.

Nowak C, Salihovic S, Ganna A, ..., Ingelsson E, Fall T

PLoS Genet. 12 (10) e1006379 [2016-10-00; online 2016-10-21]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Associations Between Macrophage Colony-Stimulating Factor and Monocyte Chemotactic Protein 1 in Plasma and First-Time Coronary Events: A Nested Case-Control Study.

Schiopu A, Bengtsson E, Gonçalves I, ..., Fredrikson GN, Björkbacka H

J Am Heart Assoc 5 (9) e002851 [2016-09-13; online 2016-09-13]

Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up.

Grönberg C, Asciutto G, Persson A, ..., Gonçalves I, Björkbacka H

Cytokine 85 (-) 137-139 [2016-09-00; online 2016-06-28]

Inflammatory Serum Protein Profiling of Patients with Lumbar Radicular Pain One Year after Disc Herniation.

Moen A, Lind AL, Thulin M, ..., Gjerstad J, Gordh T

Int J Inflam 2016 (-) 3874964 [2016-05-11; online 2016-05-11]

Affinity Proteomics Uppsala [Collaborative] Clinical Biomarkers [Service]

Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients.

Loskog A, Maleka A, Mangsbo S, ..., Tötterman TH, Ullenhag G

Br. J. Cancer 114 (8) 872-880 [2016-04-12; online 2016-03-31]

Decreased levels of stem cell factor in subjects with incident coronary events.

Wigren M, Rattik S, Hultman K, ..., Gonçalves I, Nilsson J

J. Intern. Med. 279 (2) 180-191 [2016-02-00; online 2015-10-14]

High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.

Gonçalves I, Hultman K, Dunér P, ..., Nilsson J, Bengtsson E

Open Heart 3 (1) e000353 [2016-01-27; online 2016-01-27]

High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy.

Edsfeldt A, Bengtsson E, Asciutto G, ..., Nilsson J, Goncalves I

Cerebrovasc Dis 41 (3-4) 199-203 [2016-01-27; online 2016-01-27]

Protein Detection Using the Multiplexed Proximity Extension Assay (PEA) from Plasma and Vaginal Fluid Applied to the Indicating FTA Elute Micro Card™.

Berggrund M, Ekman D, Gustavsson I, ..., Enroth S, Gyllensten U

Journal of Circulating Biomarkers 5 (-) 9 [2016-01-01; online 2016-01-01]

Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts.

Nowak C, Sundström J, Gustafsson S, ..., Ingelsson E, Fall T

Diabetes 65 (1) 276-284 [2016-01-00; online 2015-10-01]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Year 2015

Protein profiling reveals consequences of lifestyle choices on predicted biological aging.

Enroth S, Enroth SB, Johansson Å, Gyllensten U

Sci Rep 5 (-) 17282 [2015-12-01; online 2015-12-01]

Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction.

Helseth R, Weiss TW, Opstad TB, ..., Arnesen H, Seljeflot S

Thromb. Res. 136 (6) 1240-1244 [2015-12-00; online 2015-10-08]

The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid

Larsson A, Carlsson L, Lind AL, ..., Kamali-Moghaddam M, Thulin M

Cytokine 76 (2) 514-518 [2015-12-00; online 2015-12-00]

Affinity Proteomics Uppsala [Collaborative] Clinical Biomarkers [Service]

Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip.

Lind L, Siegbahn A, Lindahl B, ..., Sundström J, Ärnlöv J

Stroke 46 (12) 3340-3347 [2015-12-00; online 2015-11-07]

Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP).

Enroth S, Bosdotter Enroth S, Johansson Å, Gyllensten U

Biomarkers 20 (6-7) 355-364 [2015-11-09; online 2015-11-09]

Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure

Fibroblast Growth Factor 23 and Incidence of Subarachnoid Hemorrhage: Nested Case-Control Study.

Söderholm M, Engström G

Stroke 46 (11) 3260-3262 [2015-11-00; online 2015-09-22]

The effects of age and gender on plasma levels of 63 cytokines

Larsson A, Carlsson L, Gordh T, ..., Thulin M, Kamali-Moghaddam M

Journal of Immunological Methods 425 (-) 58-61 [2015-10-00; online 2015-10-00]

Affinity Proteomics Uppsala [Collaborative] Clinical Biomarkers [Service]

Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis.

Lind L, Ärnlöv J, Lindahl B, ..., Sundström J, Ingelsson E

Atherosclerosis 242 (1) 205-210 [2015-09-00; online 2015-07-24]

Evaluation of the protein biomarkers and the analgesic response to systemic methylene blue in patients with refractory neuropathic pain: a double-blind, controlled study.

Miclescu AA, Svahn M, Gordh TE

J Pain Res 8 (-) 387-397 [2015-07-15; online 2015-07-15]

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Goncalves I, Bengtsson E, Colhoun HM, ..., Nilsson J, SUMMIT Consortium

Arterioscler. Thromb. Vasc. Biol. 35 (7) 1723-1731 [2015-07-00; online 2015-05-07]

Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke.

Asciutto G, Dias NV, Edsfeldt A, ..., Nilsson J, Gonçalves I

PLoS ONE 10 (3) e0121086 [2015-03-24; online 2015-03-24]

High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events

Rattik S, Wigren M, Bjorkbacka H, ..., Goncalves I, Nilsson J

Arterioscler Thromb Vasc Biol 35 (1) 222-228 [2015-01-01; online 2014-10-30]

Year 2014

Sensitive detection of aggregated prion protein via proximity ligation.

Hammond M, Wik L, Deslys JP, ..., Landegren U, Kamali-Moghaddam M

Prion 8 (3) 261-265 [2014-12-09; online 2014-12-09]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers

Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease.

Ganna A, Salihovic S, Sundström J, ..., Fall T, Ingelsson E

PLoS Genet. 10 (12) e1004801 [2014-12-00; online 2014-12-11]

Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Growth differentiation factor 15, a marker of oxidative stress and inflammation, for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.

Wallentin L, Hijazi Z, Andersson U, ..., Siegbahn A, ARISTOTLE Investigators

Circulation 130 (21) 1847-1858 [2014-11-18; online 2014-10-09]

A universal approach to prepare reagents for DNA-assisted protein analysis.

Yan J, Gu GJ, Jost C, ..., Landegren U, Kamali-Moghaddam M

PLoS ONE 9 (9) e108061 [2014-09-18; online 2014-09-18]

Affinity Proteomics Uppsala [Technology development] Clinical Biomarkers

Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs.

Enroth S, Johansson A, Enroth SB, Gyllensten U

Nat Commun 5 (1) 4684 [2014-08-22; online 2014-08-22]

Identification of novel downstream molecules of tissue factor activation by comparative proteomic analysis.

Kask L, Jorsback A, Winkvist M, ..., Bergquist J, Siegbahn A

J. Proteome Res. 13 (2) 477-488 [2014-02-07; online 2013-11-28]

Year 2013

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.

Gu GJ, Lund H, Wu D, ..., Sunnemark D, Kamali-Moghaddam M

Neuromolecular Med. 15 (3) 458-469 [2013-09-00; online 2013-05-12]

Affinity Proteomics Uppsala Clinical Biomarkers

Year 2012

Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease.

Gu GJ, Wu D, Lund H, ..., Landegren U, Kamali-Moghaddam M

J. Alzheimers Dis. 33 (3) 699-713 [2012-09-25; online 2012-09-25]

Affinity Proteomics Uppsala Clinical Biomarkers

Year 2011