Clinical Biomarkers

Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study

Borné Y, Fagerberg B, Sallsten G, ..., Barregard L, Engström G

Clin Proteomics 16 (1) - [2019-12-00; online 2019-05-15]

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum

Rajan MR, Sotak M, Barrenäs F, ..., Lange S, Börgeson E

Sci Rep 9 (1) - [2019-12-00; online 2019-10-28]

Proteomic profiling of extracellular vesicles reveals additional diagnostic biomarkers for myocardial infarction compared to plasma alone

Gidlöf O, Evander M, Rezeli M, ..., Laurell T, Erlinge D

Sci Rep 9 (1) - [2019-12-00; online 2019-06-20]

The associations of self-rated health with cardiovascular risk proteins: a proteomics approach

Bao X, Borné Y, Yin S, ..., Melander O, Engström G

Clin Proteomics 16 (1) - [2019-12-00; online 2019-11-18]

Cardiovascular organ damage in type 2 diabetes mellitus: the role of lipids and inflammation

Kozakova M, Morizzo C, Goncalves I, ..., Nilsson J, Palombo C

Cardiovasc Diabetol 18 (1) - [2019-12-00; online 2019-05-10]

Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders.

Sundberg I, Rasmusson AJ, Ramklint M, ..., Ekselius L, Cunningham JL

pii: S0306-4530(19)31255-7

Psychoneuroendocrinology - (-) 104514 [2019-11-14; online 2019-11-14]

Bioinformatics Support and Infrastructure [Service] Bioinformatics Support, Infrastructure and Training [Service] Clinical Biomarkers [Service]

Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts

Stattin K, Lind L, Elmståhl S, ..., Michaëlsson K, Byberg L

Eur J Prev Cardiolog 26 (17) 1865-1873 [2019-11-00; online 2019-08-14]

Viral antigens elicit augmented immune responses in primary Sjögren’s syndrome

Björk A, Thorlacius GE, Mofors J, ..., Kvarnström M, Wahren-Herlenius M

- - (-) - [2019-10-30; online 2019-10-30]

Associations Between Apolipoprotein A1, High-Density Lipoprotein Cholesterol, and Urinary Cytokine Levels in Elderly Males and Females

Fellström B, Helmersson-Karlqvist J, Lind L, ..., Ärnlöv J, Larsson A

Journal of Interferon & Cytokine Research - (-) - [2019-10-10; online 2019-10-10]

Proteomic Analysis of Longitudinal Changes in Blood Pressure

Lin YT, Fall T, Hammar U, ..., Engström G, Sundström J

J Clin Med 8 (10) 1585 [2019-10-02; online 2019-10-02]

Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death

Grufman H, Yndigegn T, Gonçalves I, Nilsson J, Schiopu A

Cytokine 122 (-) 154208 [2019-10-00; online 2019-10-00]

Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22–27 weeks’ gestation

Olsson KW, Larsson A, Jonzon A, Sindelar R

Pediatr Res 86 (3) 333-338 [2019-09-00; online 2018-09-18]

In search of causal pathways in diabetes: a study using proteomics and genotyping data from a cross-sectional study.

Beijer K, Nowak C, Sundström J, ..., Fall T, Lind L

pii: 10.1007/s00125-019-4960-8

Diabetologia - (-) - [2019-08-24; online 2019-08-24]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Circulating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes: A Population-Based Cohort Study

Muhammad IF, Borné Y, Bao X, ..., Nilsson J, Engström G

Dia Care 42 (8) 1582-1588 [2019-08-00; online 2019-06-14]

sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events

Gonçalves I, Singh P, Tengryd C, ..., Nilsson J, Edsfeldt A

Stroke 50 (8) 1989-1996 [2019-08-00; online 2019-08-00]

Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung.

Djureinovic D, Pontén V, Landelius P, ..., Micke P, Ståhle E

pii: 10.1186/s12885-019-5943-3 pmc: PMC6664554

BMC Cancer 19 (1) 741 [2019-07-29; online 2019-07-29]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Dietary Pattern Specific Protein Biomarkers for Cardiovascular Disease: A Cross‐Sectional Study in 2 Independent Cohorts

Warensjö Lemming E, Byberg L, Stattin K, ..., Wolk A, Michaëlsson K

J Am Heart Assoc 8 (11) - [2019-06-04; online 2019-06-04]

A targeted proteomics approach reveals a serum protein signature as diagnostic biomarker for resectable gastric cancer.

Shen Q, Polom K, Williams C, ..., Roviello F, Kamali-Moghaddam M

pii: S2352-3964(19)30352-4 pmc: PMC6606959

EBioMedicine 44 (-) 322-333 [2019-06-00; online 2019-05-28]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] Glycoproteomics [Collaborative] PLA and Single Cell Proteomics [Technology development]

Circulating mast cell progenitors correlate with reduced lung function in allergic asthma

Salomonsson M, Malinovschi A, Kalm‐Stephens P, ..., Alving K, Hallgren J

Clin Exp Allergy 49 (6) 874-882 [2019-06-00; online 2019-06-03]

Elevated circulating effector memory T cells but similar levels of regulatory T cells in patients with type 2 diabetes mellitus and cardiovascular disease

Rattik S, Engelbertsen D, Wigren M, ..., Nilsson J, Björkbacka H

Diabetes and Vascular Disease Research 16 (3) 270-280 [2019-05-00; online 2018-12-21]

Increased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke

Berntsson J, Smith JG, Johnson LSB, ..., Nilsson J, Engström G

Heart 105 (7) 553-558 [2019-04-00; online 2018-10-16]

High Serum sCD40 and a Distinct Colonic T Cell Profile in Ulcerative Colitis Associated With Primary Sclerosing Cholangitis

Lampinen M, Vessby J, Fredricsson A, ..., Rorsman F, Carlson M

- 13 (3) 341-350 [2019-03-26; online 2018-10-20]

Longitudinal effects of aging on plasma proteins levels in older adults – associations with kidney function and hemoglobin levels

Lind L, Sundström J, Larsson A, ..., Ärnlöv J, Ingelsson E

PLoS ONE 14 (2) e0212060 [2019-02-25; online 2019-02-25]

High Levels of Soluble Lectinlike Oxidized Low‐Density Lipoprotein Receptor‐1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke

Markstad H, Edsfeldt A, Yao Mattison I, ..., Engström G, Gonçalves I

J Am Heart Assoc 8 (4) - [2019-02-19; online 2019-02-19]

Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease

Feldreich T, Nowak C, Fall T, ..., Green D, Ärnlöv J

J Nephrol 32 (1) 111-119 [2019-02-00; online 2018-11-29]

Metformin is the key factor in elevated plasma growth differentiation factor-15 levels in type 2 diabetes: A nested, case-control study

Natali A, Nesti L, Venturi E, ..., Nilsson J, None

Diabetes Obes Metab 21 (2) 412-416 [2019-02-00; online 2018-10-02]

Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years

Schulz CA, Engström G, Nilsson J, ..., Melander O, Orho-Melander M

- - (-) - [2019-01-09; online 2019-01-09]

AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis

Ek M, Roth B, Engström G, Ohlsson B

Int J Mol Sci 20 (1) 189 [2019-01-07; online 2019-01-07]

Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins

Almén MS, Björk J, Nyman U, ..., Christensson A, Grubb A

Kidney International Reports 4 (1) 67-79 [2019-01-00; online 2019-01-00]

Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmö Diet and Cancer–Cardiovascular Cohort

Bao X, Borné Y, Muhammad IF, ..., Orho-Melander M, Engström G

Diabetologia 62 (1) 78-86 [2019-01-00; online 2018-10-22]

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome

Lovric A, Granér M, Bjornson E, ..., Mardinoglu A, Boren J

Sci Rep 8 (1) - [2018-12-00; online 2018-09-21]

Protein profiling of fine-needle aspirates reveals subtype-associated immune signatures and involvement of chemokines in breast cancer.

Franzén B, Alexeyenko A, Kamali-Moghaddam M, ..., Landegren U, Lewensohn R

Mol Oncol 13 (2) 376-391 [2018-11-19; online 2018-11-19]

Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Technology development]

Markers of Basement Membrane Remodeling Are Associated With Higher Mortality in Patients With Known Atherosclerosis

Holm Nielsen S, Tengryd C, Edsfeldt A, ..., Nilsson J, Goncalves I

J Am Heart Assoc 7 (21) - [2018-11-06; online 2018-11-06]

Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study

Shore AC, Colhoun HM, Natali A, ..., Björkbacka H, Nilsson J

Dia Care 41 (10) 2212-2219 [2018-10-00; online 2018-07-30]

Associations of Circulating Protein Levels With Lipid Fractions in the General Population

Figarska SM, Gustafsson S, Sundström J, ..., Lind L, Ingelsson E

Arterioscler Thromb Vasc Biol 38 (10) 2505-2518 [2018-10-00; online 2018-10-00]

Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality

Fernandez C, Rysä J, Almgren P, ..., Ruskoaho H, Melander O

J Intern Med 284 (4) 377-387 [2018-10-00; online 2018-07-02]

Inflammatory markers in women with postpartum depressive symptoms

Bränn E, Fransson E, White RA, ..., Sundström-Poromaa I, Skalkidou A

J Neuro Res - (-) - [2018-09-05; online 2018-09-05]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke

Muhammad IF, Borné Y, Melander O, ..., Söderholm M, Engström G

Stroke 49 (9) 2224-2226 [2018-09-00; online 2018-09-00]

A fine-needle aspiration-based protein signature discriminates benign from malignant breast lesions

Franzén B, Kamali-Moghaddam M, Alexeyenko A, ..., Landegren U, Lewensohn R

Mol Oncol 12 (9) 1415-1428 [2018-09-00; online 2018-08-09]

Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Technology development]

Proteomic Biomarkers for Incident Aortic Stenosis Requiring Valvular Replacement

Ljungberg J, Janiec M, Bergdahl IA, ..., Fall T, Söderberg S

Circulation 138 (6) 590-599 [2018-08-07; online 2018-08-07]

Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer

Birgisson H, Tsimogiannis K, Freyhult E, Kamali-Moghaddam M

Transl Oncol 11 (4) 1034-1043 [2018-08-00; online 2018-08-00]

Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Service]

Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing

Aqrawi LA, Ivanchenko M, Björk A, ..., Skarstein K, Wahren-Herlenius M

Clin Exp Immunol 192 (3) 259-270 [2018-06-00; online 2018-03-24]

Inflammatory biomarker profiling in classical orthostatic hypotension: Insights from the SYSTEMA cohort

Johansson M, Ricci F, Aung N, ..., Melander O, Fedorowski A

International Journal of Cardiology 259 (-) 192-197 [2018-05-00; online 2018-05-00]

Identification of novel diagnostic biomarkers for deep venous thrombosis

Memon AA, Sundquist K, PirouziFard M, ..., Sundquist J, Zöller B

Br J Haematol 181 (3) 378-385 [2018-05-00; online 2018-04-19]

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4 + T Cells and Is Immunosuppressive in Type 1 Diabetes

Bhandage AK, Jin Z, Korol SV, ..., Kamali-Moghaddam M, Birnir B

EBioMedicine 30 (-) 283-294 [2018-04-00; online 2018-04-00]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome

Ramqvist T, Näsman A, Franzén B, ..., Dalianis T, Munck-Wikland E

Int J Mol Sci 19 (4) 978 [2018-03-25; online 2018-03-25]

Bioinformatics Compute and Storage [Service] Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service]

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

Mardinoglu A, Wu H, Bjornson E, ..., Taskinen MR, Borén J

Cell Metabolism 27 (3) 559-571.e5 [2018-03-00; online 2018-03-00]

Proteomic Profiling for Cardiovascular Biomarker Discovery in Orthostatic Hypotension

Johansson M, Ricci F, Aung N, ..., Melander O, Fedorowski A

Hypertension 71 (3) 465-472 [2018-03-00; online 2018-03-00]

Galectin-3 levels relate in children to total body fat, abdominal fat, body fat distribution, and cardiac size

Dencker M, Arvidsson D, Karlsson MK, ..., Andersen LB, Thorsson O

Eur J Pediatr 177 (3) 461-467 [2018-03-00; online 2018-01-11]

Cardiovascular disease in systemic lupus erythematosus is associated with increased levels of biomarkers reflecting receptor-activated apoptosis

Wigren M, Svenungsson E, Mattisson IY, ..., Fredrikson GN, Nilsson J

Atherosclerosis 270 (-) 1-7 [2018-03-00; online 2018-03-00]

Vascular Endothelial Growth Factor D, Pulmonary Congestion, and Incidence of Heart Failure

Borné Y, Gränsbo K, Nilsson J, ..., Smith JG, Engström G

Journal of the American College of Cardiology 71 (5) 580-582 [2018-02-00; online 2018-02-00]

Spotty Carotid Plaques Are Associated with Inflammation and the Occurrence of Cerebrovascular Symptoms

Halak S, Östling G, Edsfeldt A, ..., Gonçalves I, Asciutto G

Cerebrovasc Dis Extra 8 (1) 16-25 [2018-01-15; online 2018-01-15]

Effect of food intake on biomarkers for cardiovascular disease and inflammation analyzed with the Proseek Multiplex CVD II kit

Dencker M, GAAyrdinger Y, BjAAlrgell O, Hlebowicz J

gmr 17 (1) - [2018-00-00; online 2018-00-00]

High levels of cerebrospinal fluid chemokines point to the presence of neuroinflammation in peripheral neuropathic pain

Bäckryd E, Lind AL, Thulin M, ..., Gerdle B, Gordh T

PAIN 158 (12) 2487-2495 [2017-12-00; online 2017-12-00]

Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Schiza A, Wenthe J, Mangsbo S, ..., Loskog A, Ullenhag G

J Transl Med 15 (1) - [2017-12-00; online 2017-04-20]

Alterations of anti-inflammatory lipids in plasma from women with chronic widespread pain - a case control study

Stensson N, Ghafouri B, Gerdle B, Ghafouri N

Lipids Health Dis 16 (1) - [2017-12-00; online 2017-06-12]

IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation

Jónsdóttir B, Jaworowski Å, San Miguel C, Melander O

BMC Pulm Med 17 (1) - [2017-12-00; online 2017-02-08]

Elevated Markers of Death Receptor-Activated Apoptosis are Associated with Increased Risk for Development of Diabetes and Cardiovascular Disease

Mattisson IY, Björkbacka H, Wigren M, ..., Almgren P, Nilsson J

EBioMedicine 26 (-) 187-197 [2017-12-00; online 2017-12-00]

Autoantibodies against aldehyde-modified collagen type IV are associated with risk of development of myocardial infarction

Vallejo J, Dunér P, Fredrikson GN, Nilsson J, Bengtsson E

J Intern Med 282 (6) 496-507 [2017-12-00; online 2017-09-25]

Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue

Boldrup L, Troiano G, Gu X, ..., Wang L, Nylander K

Oncotarget 8 (61) - [2017-11-28; online 2017-10-01]

Targeted proteomic analysis of habitual coffee consumption.

Cornelis MC, Gustafsson S, Ärnlöv J, ..., Lind L, Ingelsson E

J. Intern. Med. - (-) - [2017-10-16; online 2017-10-16]

Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles

Andersson E, Bergemalm D, Kruse R, ..., Repsilber D, Halfvarson J

PLoS ONE 12 (10) e0186142 [2017-10-05; online 2017-10-05]

Circulating proteins as predictors of incident heart failure in the elderly.

Stenemo M, Nowak C, Byberg L, ..., Fall T, Ärnlöv J

Eur. J. Heart Fail. - (-) - [2017-10-02; online 2017-10-02]

Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke.

Sundström J, Söderholm M, Borné Y, ..., Orho-Melander M, Engström G

pii: STROKEAHA.117.018450

Stroke 48 (10) 2686-2692 [2017-10-00; online 2017-09-13]

GDF-15 and TRAIL-R2 are powerful predictors of long-term mortality in patients with acute myocardial infarction.

Skau E, Henriksen E, Wagner P, ..., Siegbahn A, Leppert J

Eur J Prev Cardiol 24 (15) 1576-1583 [2017-10-00; online 2017-08-01]

Tumor Necrosis Factor Receptor 1 and 2 Are Associated With Risk of Intracerebral Hemorrhage.

Svensson EH, Söderholm M, Abul-Kasim K, Engström G

pii: STROKEAHA.117.017849

Stroke 48 (10) 2710-2715 [2017-10-00; online 2017-08-22]

Plasma stem cell factor levels are associated with risk of cardiovascular disease and death

Björkbacka H, Yao Mattisson I, Wigren M, ..., Engström G, Nilsson J

J Intern Med - (-) - [2017-09-21; online 2017-09-21]

Effect of food intake on 92 neurological biomarkers in plasma

Dencker M, Björgell O, Hlebowicz J

Brain Behav 7 (9) e00747 [2017-09-00; online 2017-08-01]

Proteomics in Hypothermia as Adjunctive Therapy in Patients with ST-Segment Elevation Myocardial Infarction: A CHILL-MI Substudy.

Mohammad MA, Noc M, Lang I, ..., Metzler B, Erlinge D

pii: 10.1089/ther.2016.0041

Ther Hypothermia Temp Manag 7 (3) 152-161 [2017-09-00; online 2017-03-02]

Use of Proteomics To Investigate Kidney Function Decline over 5 Years.

Carlsson AC, Ingelsson E, Sundström J, ..., Lind L, Ärnlöv J

pii: CJN.08780816 pmc: PMC5544512

Clin J Am Soc Nephrol 12 (8) 1226-1235 [2017-08-07; online 2017-07-21]

Circulating GDF-15 levels predict future secondary manifestations of cardiovascular disease explicitly in women but not men with atherosclerosis

Gohar A, Gonçalves I, Vrijenhoek J, ..., Björkbacka H, de Jager SCA

International Journal of Cardiology 241 (-) 430-436 [2017-08-00; online 2017-08-00]

Effect of food intake on 92 biomarkers for cardiovascular disease

Dencker M, Gårdinger Y, Björgell O, Hlebowicz J

PLoS ONE 12 (6) e0178656 [2017-06-06; online 2017-06-06]

Lower inflammatory markers in women with antenatal depression brings the M1/M2 balance into focus from a new direction

Edvinsson Å, Bränn E, Hellgren C, ..., Cunningham JL, Sundström-Poromaa I

Psychoneuroendocrinology 80 (-) 15-25 [2017-06-00; online 2017-06-00]

Bioinformatics Support and Infrastructure [Collaborative] Bioinformatics Support, Infrastructure and Training [Collaborative] Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients

Molin CJ, Westerberg E, Punga AR

Sci Rep 7 (1) - [2017-05-00; online 2017-01-03]

Inflammatory markers in late pregnancy in association with postpartum depression—A nested case-control study

Bränn E, Papadopoulos F, Fransson E, ..., Sundström-Poromaa I, Skalkidou A

Psychoneuroendocrinology 79 (-) 146-159 [2017-05-00; online 2017-05-00]

Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

FADD, Caspase-3, and Caspase-8 and Incidence of Coronary Events.

Xue L, Borné Y, Mattisson IY, ..., Nilsson J, Engström G

pii: ATVBAHA.117.308995

Arterioscler. Thromb. Vasc. Biol. 37 (5) 983-989 [2017-05-00; online 2017-03-16]

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.

Folkersen L, Fauman E, Sabater-Lleal M, ..., Hamsten A, Mälarstig A

pii: PGENETICS-D-16-01965 pmc: PMC5393901

PLoS Genet. 13 (4) e1006706 [2017-04-00; online 2017-04-03]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Cardiometabolic biomarkers are predictors of readmission and death in patients hospitalized for acute dyspnea

Lund N, Gränsbo K, Wernersson C, Melander O

The American Journal of Emergency Medicine 35 (4) 610-614 [2017-04-00; online 2017-04-00]

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma

Bäckryd E, Tanum L, Lind AL, Larsson A, Gordh T

J Pain Res Volume 10 (-) 515-525 [2017-03-00; online 2017-03-00]

Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip.

Lind L, Sundström J, Stenemo M, Hagström E, Ärnlöv J

pii: heartjnl-2016-309764

Heart 103 (5) 377-382 [2017-03-00; online 2016-09-10]

Use of a proximity extension assay proteomics chip to discover new biomarkers associated with albuminuria.

Carlsson AC, Sundström J, Carrero JJ, ..., Lind L, Ärnlöv J

pii: 2047487316676134

Eur J Prev Cardiol 24 (4) 340-348 [2017-03-00; online 2016-10-28]

Signs of ongoing inflammation in female patients with chronic widespread pain

Gerdle B, Ghafouri B, Ghafouri N, Bäckryd E, Gordh T

Medicine 96 (9) e6130 [2017-03-00; online 2017-03-00]

Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children

Dencker M, Danielson A, Karlsson MK, ..., Andersen LB, Thorsson O

- 30 (4) - [2017-01-01; online 2017-01-01]

Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes

Gonçalves I, None , Edsfeldt A, ..., Schnecke V, Nilsson J

BMC Cardiovasc Disord 16 (1) - [2016-12-00; online 2016-09-05]

DcR3, TFF3, and Midkine Are Novel Serum Biomarkers in Small Intestinal Neuroendocrine Tumors.

Edfeldt K, Daskalakis K, Bäcklin C, ..., Hellman P, Stålberg P

pii: 000452891

Neuroendocrinology 105 (2) 170-181 [2016-11-09; online 2016-11-09]

Effects of cigarette smoking on cardiovascular-related protein profiles in two community-based cohort studies.

Huang B, Svensson P, Ärnlöv J, ..., Lind L, Ingelsson E

pii: S0021-9150(16)31328-4

Atherosclerosis 254 (-) 52-58 [2016-11-00; online 2016-09-30]

Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study.

Nowak C, Salihovic S, Ganna A, ..., Ingelsson E, Fall T

pii: PGENETICS-D-16-00940 pmc: PMC5074591

PLoS Genet. 12 (10) e1006379 [2016-10-00; online 2016-10-21]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Associations Between Macrophage Colony‐Stimulating Factor and Monocyte Chemotactic Protein 1 in Plasma and First‐Time Coronary Events: A Nested Case–Control Study

Schiopu A, Bengtsson E, Gonçalves I, ..., Fredrikson GN, Björkbacka H

J Am Heart Assoc 5 (9) e002851 [2016-09-00; online 2016-09-13]

Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up.

Grönberg C, Asciutto G, Persson A, ..., Gonçalves I, Björkbacka H

pii: S1043-4666(16)30137-5

Cytokine 85 (-) 137-139 [2016-09-00; online 2016-06-28]

Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients

Loskog A, Maleka A, Mangsbo S, ..., Tötterman TH, Ullenhag G

Br J Cancer 114 (8) 872-880 [2016-04-00; online 2016-03-31]

Decreased levels of stem cell factor in subjects with incident coronary events.

Wigren M, Rattik S, Hultman K, ..., Gonçalves I, Nilsson J

J. Intern. Med. 279 (2) 180-191 [2016-02-00; online 2015-10-14]

High levels of cathepsin D and cystatin B are associated with increased risk of coronary events

Gonçalves I, Hultman K, Dunér P, ..., Nilsson J, Bengtsson E

Open Heart 3 (1) e000353 [2016-01-00; online 2016-01-27]

Protein Detection Using the Multiplexed Proximity Extension Assay (PEA) from Plasma and Vaginal Fluid Applied to the Indicating FTA Elute Micro Card™

Berggrund M, Ekman D, Gustavsson I, ..., Enroth S, Gyllensten U

Journal of Circulating Biomarkers 5 (-) 9 [2016-01-00; online 2016-01-00]

Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts.

Nowak C, Sundström J, Gustafsson S, ..., Ingelsson E, Fall T

pii: db15-0881

Diabetes 65 (1) 276-284 [2016-01-00; online 2015-10-01]

Bioinformatics Compute and Storage [Service] Clinical Biomarkers NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Inflammatory Serum Protein Profiling of Patients with Lumbar Radicular Pain One Year after Disc Herniation

Moen A, Lind AL, Thulin M, ..., Gjerstad J, Gordh T

Int J Inflam 2016 (-) 1-8 [2016-00-00; online 2016-00-00]

Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy

Edsfeldt A, Bengtsson E, Asciutto G, ..., Nilsson J, Goncalves I

Cerebrovasc Dis 41 (3-4) 199-203 [2016-00-00; online 2016-01-27]

Protein profiling reveals consequences of lifestyle choices on predicted biological aging.

Enroth S, Enroth SB, Johansson Å, Gyllensten U

pii: srep17282 pmc: PMC4664859

Sci Rep 5 (-) 17282 [2015-12-01; online 2015-12-01]

Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction.

Helseth R, Weiss TW, Opstad TB, ..., Arnesen H, Seljeflot S

pii: S0049-3848(15)30137-7

Thromb. Res. 136 (6) 1240-1244 [2015-12-00; online 2015-10-08]

The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid

Larsson A, Carlsson L, Lind AL, ..., Kamali-Moghaddam M, Thulin M

Cytokine 76 (2) 514-518 [2015-12-00; online 2015-12-00]

Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip.

Lind L, Siegbahn A, Lindahl B, ..., Sundström J, Ärnlöv J

pii: STROKEAHA.115.010829

Stroke 46 (12) 3340-3347 [2015-12-00; online 2015-11-07]

Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP).

Enroth S, Bosdotter Enroth S, Johansson Å, Gyllensten U

Biomarkers 20 (6-7) 355-364 [2015-11-09; online 2015-11-09]

Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) National Genomics Infrastructure

Fibroblast Growth Factor 23 and Incidence of Subarachnoid Hemorrhage: Nested Case-Control Study.

Söderholm M, Engström G

pii: STROKEAHA.115.010565

Stroke 46 (11) 3260-3262 [2015-11-00; online 2015-09-22]

The effects of age and gender on plasma levels of 63 cytokines

Larsson A, Carlsson L, Gordh T, ..., Thulin M, Kamali-Moghaddam M

Journal of Immunological Methods 425 (-) 58-61 [2015-10-00; online 2015-10-00]

Clinical Biomarkers [Service] PLA and Single Cell Proteomics [Collaborative]

Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis.

Lind L, Ärnlöv J, Lindahl B, ..., Sundström J, Ingelsson E

pii: S0021-9150(15)30043-5

Atherosclerosis 242 (1) 205-210 [2015-09-00; online 2015-07-24]

Evaluation of the protein biomarkers and the analgesic response to systemic methylene blue in patients with refractory neuropathic pain: a double-blind, controlled study.

Miclescu AA, Svahn M, Gordh TE

pii: jpr-8-387 pmc: PMC4509536

J Pain Res 8 (-) 387-397 [2015-07-15; online 2015-07-15]

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 DiabetesSignificance

Goncalves I, Bengtsson E, Colhoun HM, ..., Schnecke V, Nilsson J

Arterioscler Thromb Vasc Biol 35 (7) 1723-1731 [2015-07-00; online 2015-05-07]

Low Elastin Content of Carotid Plaques Is Associated with Increased Risk of Ipsilateral Stroke

Asciutto G, Dias NV, Edsfeldt A, ..., Nilsson J, Gonçalves I

PLoS ONE 10 (3) e0121086 [2015-03-24; online 2015-03-24]

High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events

Rattik S, Wigren M, Bjorkbacka H, ..., Goncalves I, Nilsson J

Arterioscler Thromb Vasc Biol 35 (1) 222-228 [2015-01-01; online 2014-10-30]

Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs

Enroth S, Johansson Å, Enroth SB, Gyllensten U

Nat Commun 5 (1) - [2014-12-00; online 2014-08-22]

Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease.

Ganna A, Salihovic S, Sundström J, ..., Fall T, Ingelsson E

pii: PGENETICS-D-14-01896 pmc: PMC4263376

PLoS Genet. 10 (12) e1004801 [2014-12-00; online 2014-12-11]

Clinical Biomarkers [Service] NGI Uppsala (SNP&SEQ Technology Platform) [Service] National Genomics Infrastructure [Service]

Growth differentiation factor 15, a marker of oxidative stress and inflammation, for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.

Wallentin L, Hijazi Z, Andersson U, ..., Siegbahn A, ARISTOTLE Investigators

pii: CIRCULATIONAHA.114.011204 ClinicalTrials.gov: NCT00412984

Circulation 130 (21) 1847-1858 [2014-11-18; online 2014-10-09]

A Universal Approach to Prepare Reagents for DNA-Assisted Protein Analysis

Yan J, Gu GJ, Jost C, ..., Landegren U, Kamali-Moghaddam M

PLoS ONE 9 (9) e108061 [2014-09-18; online 2014-09-18]

Clinical Biomarkers PLA and Single Cell Proteomics [Technology development]

Sensitive detection of aggregated prion protein via proximity ligation

Hammond M, Wik L, Deslys JP, ..., Landegren U, Kamali-Moghaddam M

Prion 8 (3) 261-265 [2014-05-04; online 2014-11-00]

Clinical Biomarkers PLA and Single Cell Proteomics [Technology development]

Identification of novel downstream molecules of tissue factor activation by comparative proteomic analysis.

Kask L, Jorsback A, Winkvist M, ..., Bergquist J, Siegbahn A

J. Proteome Res. 13 (2) 477-488 [2014-02-07; online 2013-11-28]

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.

Gu GJ, Lund H, Wu D, ..., Sunnemark D, Kamali-Moghaddam M

Neuromolecular Med. 15 (3) 458-469 [2013-09-00; online 2013-05-15]

Clinical Biomarkers PLA and Single Cell Proteomics

Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease.

Gu GJ, Wu D, Lund H, ..., Landegren U, Kamali-Moghaddam M

pii: C06R73LN268U5222

J. Alzheimers Dis. 33 (3) 699-713 [2012-09-25; online 2012-09-25]

Clinical Biomarkers PLA and Single Cell Proteomics