Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022.

Golparian D, Vestberg N, Södersten W, Jacobsson S, Ohnishi M, Fang H, Bhattarai KH, Unemo M

Euro Surveill. 28 (10) - [2023-03-00; online 2023-03-10]

We report a ceftriaxone-resistant, multidrug-resistant urogenital Neisseria gonorrhoeae in a female sex worker in Sweden, September 2022, who was treated with ceftriaxone 1 g, but did not return for test-of-cure. Whole genome sequencing of isolate SE690 identified MLST ST8130, NG-STAR CC1885 (new NG-STAR ST4859) and mosaic penA-60.001. The latter, causing ceftriaxone resistance in the internationally spreading FC428 clone, has now also spread to the more antimicrobial-susceptible genomic lineage B, showing that strains across the gonococcal phylogeny can develop ceftriaxone resistance.

Clinical Genomics Örebro [Collaborative]

PubMed 36892469

DOI 10.2807/1560-7917.ES.2023.28.10.2300125

Crossref 10.2807/1560-7917.ES.2023.28.10.2300125

pmc: PMC9999460

Publications 9.5.0