The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
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Hagberg N, Joelsson M, Leonard D, Reid S, Eloranta M, Mo J, Nilsson MK, Syvänen A, Bryceson YT, Rönnblom L
Ann. Rheum. Dis. - (-) - [2018-02-23; online 2018-02-23]
Genetic variants in the transcription factor Peripheral blood mononuclear cells (PBMCs) were isolated from 52 genotyped patients with SLE. Phosphorylation of STAT4 (pSTAT4) and STAT1 (pSTAT1) in response to interferon (IFN)-α, IFN-γ or interleukin (IL)-12, total levels of STAT4, STAT1 and T-bet, and frequency of IFN-γ In resting PBMCs, the T cells from patients with SLE carrying the
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PubMed 29475858
DOI 10.1136/annrheumdis-2017-212794
Crossref 10.1136/annrheumdis-2017-212794
annrheumdis-2017-212794